The effect of radiation therapy, either alone or combined with surgery or chemotherapy is accepted well in the treatment of metastatic carcinoma, multiple myeloma, reticulum cell sarcoma and Ewing's sarcoma. But its effect on osteosarcoma and chondrosarcoma is less clear. The authors reviewed 90 patients treated with radiation therapy, 62 cases with primary bone tumor and 28 cases with multiple myeloma, from 1969 to 1988. There were 20 Ewing's sarcoma, 12 osteosarcoma, 12 chondrosarcoma, 9 Histiocytosis-X and 3 reticulum cell sarcoma among 62 primary bone tumors. And 40 patients with more than three months follow-up were analyzed for the primary response of tumor three months after radiation therapy and the long term effect of the radiation therapy. When the radiation therapy was done alone, the primary response was poor in osteogenic sarcoma, chondrosarcoma, Ewing's sarcoma and reticulum cell sarcoma. But with the multimodal therapy, the primary response was rslatively good in reticulum cell sarcoma and chondrosarcoma. In 15 patients, more than one year follow-up was done. The status of these patients at the last follow-up was poor in all cases trearted with radiation therapy alone than the multimodal therapy except Histiocytosis-X. In multiple myeloma, the effect of radiation therapy for the relief of pain was analyzed. There were complete relief of pain in 14.3%, partial relief in 71.4% and no relief in 10.7%.
Chondrosarcoma ; Drug Therapy ; Follow-Up Studies ; Histiocytosis, Langerhans-Cell ; Humans ; Lymphoma, Non-Hodgkin ; Multiple Myeloma ; Osteosarcoma ; Sarcoma, Ewing

No abstract available.
Clinical Study* ; Female* ; Humans

No abstract available.
Esophageal and Gastric Varices*

The cause of pemphigus vulgaris is autoimmune. The serum containes antibodies against the intercellular substance of stratified epithelium, as demonstrated by means of immunofluorescent staining. Therefore antigen-antibody reaction takes place in the intercellalar spaces of squamous epithelium and leads to acantholysis. The association of pemphigus with malignant conditions was frequently reported. Thus there is now increasing evidence of an association between malignaney and the production of pemphigus antibodies by a tumor itaelf. By the evidence that pemphigus is autoimmune disease, it is used to treat with corticosteroid and immunosuppressive drugs, such as methotrexate. Very high doses of corticosteroid appear to he necesaary for an adequate control of the disease. Even though large doae repersents an effective treatment of pemphigus vulgaris, side effects from thia form of therapy have heen quite significant. Two cases of pemphigus vulgaris are reported. .First patient, a 33 year-old housewife, with flaccid bullae and rupture to form erosions of 3 months duration especialIy on buccal mueosa and genitlia. Second patient, a 66 year-old female, with above skin lesions of 6 months duration on buccal mucosa and whole body. Clinically and histopathologically their eruptions were consistent with pemphigus vulgaris. Large initial dose of predniaolone was employed in these treatment. These patients were improved with treatment prednisolone. Prednisolone therapy gave rise to a large numbar of side effects of varying degrees of severity, such as iatrogenic diabetea mellitus, oral candidiasis, hypokalemia, and pychosis etc. At admission 57days, first case complained of lower abdominal pain and tenderness. At this point it was found clinically that the mass on vaginal vault is present. Punch biopsy was p rformed and confirmed epidermoid carcinoma poorly differentiated (stage V). Cystoscopy showed tumor mass of cervix with extension to bladder posterior wall. We advised. External radiation therapy for carcinoma for about 5 weeks (5,000 Rads) but hopeless she was discharged. Second. Patient was much improved without recurrence. Side effects of prednisolone were also controlled.
Abdominal Pain ; Acantholysis ; Adult ; Aged ; Antibodies ; Antigen-Antibody Reactions ; Autoimmune Diseases ; Biopsy ; Candidiasis, Oral ; Carcinoma, Squamous Cell ; Cervix Uteri ; Cystoscopy ; Epithelium ; Female ; Humans ; Hypokalemia ; Methotrexate ; Mouth Mucosa ; Pemphigus* ; Prednisolone ; Recurrence ; Rupture ; Skin ; Urinary Bladder

Pretibial myxedema is a rare condition whieh may occur following the active or treated hyperthyroidism. The preeise cause of pretibial myxedema is not known, but it is now established the Long Acting Thyroid Stimulator(LATS) is 7S-gammaglobulin, that it is present in the serum of 80% of patients with hyperthyroidism and that its activity is as being an autoantibody against a thyroid antigen, retroorbital tissues and in the skin. A 28-year old pregnant housewife was well until age 24 when she developed hyperthyroidism with swelling of the thyroid gland, exopbthalmos and clubbing of the fingers. She was treated with subtotal thyroidectomy 2 years ago at other clinic. The skin lesions revealed circumscribed, firm, and elevated nodules with excess hair growth on shin and dorsum of feet since their onset of one and half years to visit to our hospital. The hiatologic findings showed considerable amounts of mucin especially in the midportion of the dermis. The leaions were improved by the local application of 0.01% Fluocinolone acetonide(Synalar') ointment with occlusive dressing technique.
Adult ; Dermis ; Fingers ; Foot ; Hair ; Humans ; Hyperthyroidism ; Mucins ; Myxedema* ; Occlusive Dressings ; Skin ; Thyroid Gland ; Thyroidectomy

No abstract available.
Pyelonephritis*

Cigarette smoke is a complex mixture of 4,000 chemical compounds, including 43 known carcinogens. It is well known that smoke acts as the initiator and promoter in the process of carcinogenesis, and the risk of cancer is directly proportional to the amount and duration of smoking. Tobacco is the cause of 30% of all cancer deaths and one of the major risk factors for coronary heart disease, along with high blood pressure and hyperlipidemia. Cigarette smoking is estimated to be responsible for more than 20% of all coronary heart disease deaths in men over 86 years of age and for approximately 45% of such deaths in men aged less than 65 years. About 80% of mortality from chronic obstructive lung disease is attributable to cigarette smoking, and the age-adjusted death rate for COPD is 10-times higher in current smokers than in nonsmokers. Peptic ulcer disease, osteoporosis, skin wrinkling, and retarded fetal growth are all associated with cigarette smoking. Through passive smoking, 69% of individuals develop eye irritation, 29% have nasal symptoms, 32% have headaches, and 25% develop a cough. The infant admission rate increases with mother’s smoking amount, and the relative risk of lung cancer is 1.8 in smoker’s spouse. Tobacco is the single, chief, avoidable cause of death in our society, and the most important public issue of our time.
Carcinogenesis ; Carcinogens ; Cause of Death ; Coronary Disease ; Cough ; Fetal Development ; Headache ; Humans ; Hyperlipidemias ; Hypertension ; Infant ; Lung Neoplasms ; Male ; Mortality ; Osteoporosis ; Peptic Ulcer ; Pulmonary Disease, Chronic Obstructive ; Risk Factors ; Skin Aging ; Smoke ; Smoking* ; Spouses ; Tobacco ; Tobacco Products* ; Tobacco Smoke Pollution

BACKGROUND: The cuff inflation of laryngeal mask airway (LMA) with excessive volume of air may injure soft tissue and nerves around hypopharynx because of high cuff pressure. But it is not well known about adequate cuff volume of LMA. The cuff inflation of LMA in hypopharynx accomodate pharynx, so various injection volume may differ in sealing effect. This may influence ventilation. This study was proposed to investigate the effect of cuff volume on cuff pressure and ventilation when LMA inserted. METHODS: Fifteen male patients were inserted with #4 LMA, fifteen female patients were inserted #3 LMA. For male patients, 10, 20, 30 and 40 ml of air were injected into cuff of LMA and 10, 15, 20 and 25 ml for female patients. Cuff pressure, minute ventilation and airway pressure were randomly measured. RESULTS: Volume of injected into cuff and cuff pressure of LMA were closly related. But minute ventilation and airway pressure were not related with injected air volume of LMA. CONCLUSION: Excessive volume of air injected to LMA cuff was not beneficial to ventilation. So minimal sealing cuff volume under maximal recommended volume of LMA may reduce the incidence of complications associated with high cuff pressure.
Female ; Humans ; Hypopharynx ; Incidence ; Inflation, Economic ; Laryngeal Masks* ; Male ; Pharynx ; Ventilation*

Abnormalities of the short arm of chromosome 12 are relatively common in childhood ALL. Approximately 5~7% of children with ALL have cytogenetic evidence of a translocation involving 12p, whereas 3~5% have deletions which suggest the presence of a tumor suppressor gene at this location. Through the use of sensitive molecular techniques, 12p or 12p 12~13 loss of heterozygosity (LOH) has been demonstrated in approximately 25 oyo of childhood ALL cases. FISH mapping has detected a minimum region of overlap for the 12p deletions between the TEL(ETV6) and CDKN1B(KIP1) geness). Recently, chromosomal translocations involving the TEL gene at 12p13 have been cloned in several hematopoietic disorders. In ALL cells with thet(12;21)(p13;q22), the 5' part of TEL is fused with the AML1 gene. Abnormalities of 12p, especially the t(12 ; 21), are more reliably detected by FISH than by classical cytogenetics because the translocated portions 12p and 21q are virtually identical cytologically. When FISH was combined with Southern blotting and RT-PCR, the t(12;21) was identified as a recur-ring chromosomal abnormality in 16~25% of childhood B-lineage ALL. Despite the identification of the fusion partners in the t(12;21), the actual function of the TEL-AML1 and AML1-TEL fusion proteins in promoting malignant transformation is unclear. Whether the TEL-AML1 fusion alone is necessary and sufficient for malignant transformation in ALL and whether TEL inactivation has a role in leukemogenesis is currently unknown. Loss of the CDKN2(p16) gene at 9p21 is a common genetic abnormality in ALL and a variety of other malignancies. Homozygous CDKN2 deketions have been deteced in approximate 15% of B-lineage ALL and 75% of T-lineage ALL cases. The p16 protein functions as an inhibitor of cyclin-dependent kinase 4, and normally acts to stop cell cycle progression. Whether loss of p16 alone is necessary and sufficient for malignant transformation in childhood ALL has not been determined.
Arm ; Blotting, Southern ; Cell Cycle ; Child ; Chromosome Aberrations ; Chromosomes, Human, Pair 12 ; Clone Cells ; Cyclin-Dependent Kinase 4 ; Cytogenetics ; Genes, Tumor Suppressor ; Humans ; Loss of Heterozygosity ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Translocation, Genetic

This study was conducted to evaluate the differences of scores in overall health-promoting behavior between residents in the Seoul area and rural inhabitants : and to examine the relationship between socio-demographic characteristics and the level of practical performance of the six dimension subscales of the Health-Promoting Lifestyles Profile (HPLP). Data were collected by questionnaire survey over a period of 2 months from July 1st to August 31st, 1997. Subjects chosen for this study consisted of 170 individuals, including 85 Seoul dwellers and 85 rural occupants in Korea. These were sampled from the Seoul and the local adult populations, using a random sampling method. However, the actual number of subjects put into the analyses was 151, including 68 Seoul residents and 83 rural inhabitants. Data were analysed by the SAS program. Statistical methods employed for this study were frequency, t-test, one/two-way ANOVA and MANOVA. The results were as follows : 1. It was revealed that there was a statistically significant difference between Seoul dwellers and rural inhabitants in the scores of health promoting life style activities, that is, Seoul area and rural inhabitants ; and to examine the relationship between socio-demographic characteristics and the level of practical performance of the six dimension subscales of the Health-Promoting Lifestyles Profile (HPLP). Data were collected by questionnaire survey over a period of 2 months from July 1st August 31st, 1997. Subjects chosen for this study consisted of 170 individuals, including 85 Seoul dwellers and 85 rural occupants in Korea. These were sampled from the Seoul and the local adult populations, using a random sampling method. However, the actual number of subjects put into the analyses was 151, including 68 Seoul residents and 83 rural inhabitants. Data were analysed by the SAS program. Statistical methods employed for this study were frequency, t-test, one/two-way ANOVA and MANOVA. The results were as follows : 1. It was revealed that there was a statistically significant difference between Seoul dwellers and rural inhabitants in the scores of health promoting life style activities, that is, Seoul occupants had higher scores in overall health promoting life styles than did the local residents. 2. The male population showed higher scores in overall health promoting life styles including self-actualization, health responsibility, interpersonal support and stress management than did the female. 3. The middle aged group (40-49 year old) showed higher scores in overall health promoting life styles than any other age group. 4. The married sample showed higher scores in health responsibility and nutrition than did the unmarried, the divorced, or the widowee/widower. The scores were almost the same between the married and the unmarried group, even though the unmarried group had slightly higher scores in self-actualization, exercise, interpersonal support, and stress management of the HPLP than did the married. 5. Public officials and clerical workers showed higher scores in overall health promoting lifestyles than did the others including house wives, farmers, business-men, or professionals. But in the analysis of mutual interactions of both age and occupation, business-men, merchants, public officials and clerical workers in 40-49 years of age with their health responsibility showed higher scores in overall health promoting lifestyles than did the others, while professionals showed lower scores relatively. While professionals showed lower scores relatively. 6. A person who earned over 1,500,000 Won as a monthly income showed higher scores in overall health promoting life styles than the person who earned under 1,500,000 Won, 7. A statistical significance was not found in the difference between the socio-demographic variables, such as levels of education and HPLP scores in overall health promoting life styles. These findings differed from the existing previous study's results in which the higher educational levels contributed to the health promoting behaviors. Therefore, the author suggested that the level of formal education can not playn and important role in the practical performance of health promoting behaviors, at present, because of the more effective community-based health education through the mass media such as TV and video.
Adult ; Divorce ; Education ; Female ; Health Education ; Humans ; Korea* ; Life Style* ; Male ; Mass Media ; Middle Aged ; Occupations ; Seoul ; Single Person ; Spouses ; Surveys and Questionnaires