The effect of radiation therapy, either alone or combined with surgery or chemotherapy is accepted well in the treatment of metastatic carcinoma, multiple myeloma, reticulum cell sarcoma and Ewing's sarcoma. But its effect on osteosarcoma and chondrosarcoma is less clear. The authors reviewed 90 patients treated with radiation therapy, 62 cases with primary bone tumor and 28 cases with multiple myeloma, from 1969 to 1988. There were 20 Ewing's sarcoma, 12 osteosarcoma, 12 chondrosarcoma, 9 Histiocytosis-X and 3 reticulum cell sarcoma among 62 primary bone tumors. And 40 patients with more than three months follow-up were analyzed for the primary response of tumor three months after radiation therapy and the long term effect of the radiation therapy. When the radiation therapy was done alone, the primary response was poor in osteogenic sarcoma, chondrosarcoma, Ewing's sarcoma and reticulum cell sarcoma. But with the multimodal therapy, the primary response was rslatively good in reticulum cell sarcoma and chondrosarcoma. In 15 patients, more than one year follow-up was done. The status of these patients at the last follow-up was poor in all cases trearted with radiation therapy alone than the multimodal therapy except Histiocytosis-X. In multiple myeloma, the effect of radiation therapy for the relief of pain was analyzed. There were complete relief of pain in 14.3%, partial relief in 71.4% and no relief in 10.7%.
Chondrosarcoma ; Drug Therapy ; Follow-Up Studies ; Histiocytosis, Langerhans-Cell ; Humans ; Lymphoma, Non-Hodgkin ; Multiple Myeloma ; Osteosarcoma ; Sarcoma, Ewing

No abstract available

The antihypertensive effect of Minizide(0.5mg prazosin hydrochloride and 0.25mg polythiazide per tablet)was evaluated in 30 patients with essential hypertension with a dosage of one tablet a day for four weeks. The results were as follows : 1) Of 30 patients treated with Minizide, 21 patients(70.0%) achieved normalization of blood pressure and 5 patients(16.7%) had good response. 2) Mean drop in systolic and diastolic pressure were 29.0mmHg and 15.9mmHg respectively in supine position(P<0.005). 3) Mean drop in systolic and diastolic pressure were 28.5mmHg and 16.2mmhg respectively in sitting position(P<0.005). 4) In 14 patients(46.7%) among 30 patients treated with Minizide adverse reactions developed. The most frequent one was postural dizziness(23.3%). 5) Most adverse reactions were transient and tolerable. However, in three patients(two patients with postural dizziness and one patient with dry mouth) the medication was stopped due to adverse reactions.
Blood Pressure ; Dizziness ; Humans ; Hypertension ; Polythiazide ; Prazosin

No abstract available.
Osteoarthritis*

This study was conducted to evaluate the differences of scores in overall health-promoting behavior between residents in the Seoul area and rural inhabitants : and to examine the relationship between socio-demographic characteristics and the level of practical performance of the six dimension subscales of the Health-Promoting Lifestyles Profile (HPLP). Data were collected by questionnaire survey over a period of 2 months from July 1st to August 31st, 1997. Subjects chosen for this study consisted of 170 individuals, including 85 Seoul dwellers and 85 rural occupants in Korea. These were sampled from the Seoul and the local adult populations, using a random sampling method. However, the actual number of subjects put into the analyses was 151, including 68 Seoul residents and 83 rural inhabitants. Data were analysed by the SAS program. Statistical methods employed for this study were frequency, t-test, one/two-way ANOVA and MANOVA. The results were as follows : 1. It was revealed that there was a statistically significant difference between Seoul dwellers and rural inhabitants in the scores of health promoting life style activities, that is, Seoul area and rural inhabitants ; and to examine the relationship between socio-demographic characteristics and the level of practical performance of the six dimension subscales of the Health-Promoting Lifestyles Profile (HPLP). Data were collected by questionnaire survey over a period of 2 months from July 1st August 31st, 1997. Subjects chosen for this study consisted of 170 individuals, including 85 Seoul dwellers and 85 rural occupants in Korea. These were sampled from the Seoul and the local adult populations, using a random sampling method. However, the actual number of subjects put into the analyses was 151, including 68 Seoul residents and 83 rural inhabitants. Data were analysed by the SAS program. Statistical methods employed for this study were frequency, t-test, one/two-way ANOVA and MANOVA. The results were as follows : 1. It was revealed that there was a statistically significant difference between Seoul dwellers and rural inhabitants in the scores of health promoting life style activities, that is, Seoul occupants had higher scores in overall health promoting life styles than did the local residents. 2. The male population showed higher scores in overall health promoting life styles including self-actualization, health responsibility, interpersonal support and stress management than did the female. 3. The middle aged group (40-49 year old) showed higher scores in overall health promoting life styles than any other age group. 4. The married sample showed higher scores in health responsibility and nutrition than did the unmarried, the divorced, or the widowee/widower. The scores were almost the same between the married and the unmarried group, even though the unmarried group had slightly higher scores in self-actualization, exercise, interpersonal support, and stress management of the HPLP than did the married. 5. Public officials and clerical workers showed higher scores in overall health promoting lifestyles than did the others including house wives, farmers, business-men, or professionals. But in the analysis of mutual interactions of both age and occupation, business-men, merchants, public officials and clerical workers in 40-49 years of age with their health responsibility showed higher scores in overall health promoting lifestyles than did the others, while professionals showed lower scores relatively. While professionals showed lower scores relatively. 6. A person who earned over 1,500,000 Won as a monthly income showed higher scores in overall health promoting life styles than the person who earned under 1,500,000 Won, 7. A statistical significance was not found in the difference between the socio-demographic variables, such as levels of education and HPLP scores in overall health promoting life styles. These findings differed from the existing previous study's results in which the higher educational levels contributed to the health promoting behaviors. Therefore, the author suggested that the level of formal education can not playn and important role in the practical performance of health promoting behaviors, at present, because of the more effective community-based health education through the mass media such as TV and video.
Adult ; Divorce ; Education ; Female ; Health Education ; Humans ; Korea* ; Life Style* ; Male ; Mass Media ; Middle Aged ; Occupations ; Seoul ; Single Person ; Spouses ; Surveys and Questionnaires

Abnormalities of the short arm of chromosome 12 are relatively common in childhood ALL. Approximately 5~7% of children with ALL have cytogenetic evidence of a translocation involving 12p, whereas 3~5% have deletions which suggest the presence of a tumor suppressor gene at this location. Through the use of sensitive molecular techniques, 12p or 12p 12~13 loss of heterozygosity (LOH) has been demonstrated in approximately 25 oyo of childhood ALL cases. FISH mapping has detected a minimum region of overlap for the 12p deletions between the TEL(ETV6) and CDKN1B(KIP1) geness). Recently, chromosomal translocations involving the TEL gene at 12p13 have been cloned in several hematopoietic disorders. In ALL cells with thet(12;21)(p13;q22), the 5' part of TEL is fused with the AML1 gene. Abnormalities of 12p, especially the t(12 ; 21), are more reliably detected by FISH than by classical cytogenetics because the translocated portions 12p and 21q are virtually identical cytologically. When FISH was combined with Southern blotting and RT-PCR, the t(12;21) was identified as a recur-ring chromosomal abnormality in 16~25% of childhood B-lineage ALL. Despite the identification of the fusion partners in the t(12;21), the actual function of the TEL-AML1 and AML1-TEL fusion proteins in promoting malignant transformation is unclear. Whether the TEL-AML1 fusion alone is necessary and sufficient for malignant transformation in ALL and whether TEL inactivation has a role in leukemogenesis is currently unknown. Loss of the CDKN2(p16) gene at 9p21 is a common genetic abnormality in ALL and a variety of other malignancies. Homozygous CDKN2 deketions have been deteced in approximate 15% of B-lineage ALL and 75% of T-lineage ALL cases. The p16 protein functions as an inhibitor of cyclin-dependent kinase 4, and normally acts to stop cell cycle progression. Whether loss of p16 alone is necessary and sufficient for malignant transformation in childhood ALL has not been determined.
Arm ; Blotting, Southern ; Cell Cycle ; Child ; Chromosome Aberrations ; Chromosomes, Human, Pair 12 ; Clone Cells ; Cyclin-Dependent Kinase 4 ; Cytogenetics ; Genes, Tumor Suppressor ; Humans ; Loss of Heterozygosity ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Translocation, Genetic

No abstract available.
Maxillary Sinus* ; Wegener Granulomatosis*

No abstract available.
Antigens, Human Platelet* ; Blood Platelets*

No abstract available.
Clinical Study* ; Female* ; Humans

Dementia as a public health problem looms as an epidemic of the 21st century. The aging population places an increasing number of individuals at risk for dementia. It is predicted that the proportion of the population over 65 years will exceed 14% by 2022 in Korea. This paper aims at summarizing epidemiologic characteristics of dementia in the general population in Korea, which are essential to develop a preventive strategy to this dreadful disease. The prevalence of dementia has been estimated in several studies in Korea and was found to be around 9.5 to 13.0% among individuals aged 65 years and over, which appears a little higher than those reported in other countries. According to the etiologic subtypes, more than half of the cases are reported to be Alzheimer's disease (AD) in most studies, especially in studies conducted in rural areas. These results are similar to those reported in the western countries, with AD being more common. In Asia, it was expected that vascular dementia would be much more common than AD due to the high prevalence of cerebrovascular accidents. Women have a much higher prevalence rate than men in all studies, presumably due to the higher prevalence of AD among the oldest aged 80 and over. These phenomena may be related with the high rate of illiteracy and low level of education among women in this country. Further epidemiologic studies on the subtype and risk factors of dementia are necessary to develop a comprehensive strategy for prevention of this disease in Korea.
Aging ; Alzheimer Disease ; Asia ; Dementia* ; Dementia, Vascular ; Education ; Epidemiologic Studies ; Epidemiology* ; Female ; Humans ; Korea* ; Literacy ; Male ; Prevalence ; Public Health ; Risk Factors ; Stroke