1.Agents increasing intracellular calcium levels ameliorate the antodepressant-induced reduction of submandibular salivation in cast.
Jae Hyun YOUN ; Won Jae KIM ; Sun Youl RYU
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1997;23(1):17-26
Tri- and tetra-cyclic antidepressants are known to cause dry mouth among other several major complications. The present study was designed to compare the degree of reduced salivation due to antidepressants and to explore whether intracellular calcium-increasing agents ameliorate the salivation. Effects of antidepressants and agents increasing intracellular calcium on the cholinergic submandibular secretion and blood flow induced by the chorda stimulation or intra-arterial acetylcholine were observed in anesthetized cats. Effects of antidepressants and calcium-mobilizing agents on K+ efflux were also observed in excised gland slices. The results obtained were as follows: 1. Salivary secretion in response to the chorda stimulation (3 V, 20 Hz, 1 msec) was significantly attenuated by antidepressants in a dose-dependent manner, whereas the blood flow was not affected. 2. Salivary secretion and increased blood flow evoked by intra-arterial acetylcholine (20 microgram/kg) were markedly diminished by antidepressants, the magnitude of which was amitryptyline>imipramine >mianserin in order. 3. Cholinergic salivation was significantly decrease by cyclopiazonic acid, a calcium pump inhibitor of the endoplasmic reticulum, or by BAPTA/AM, a specific intracellular calcium chelator. 4. Caffeine and ryanodine potentiated the cholinergic salivation and ameliorated the depressed salivary secreation due to antidepressants. 5. Calcium ionophore A 23187 ameliorated the depressed salivation due to antidepressants. 6. Antidepressants inhibited the K+ efflux, which were restored by caffeine or A 23187. These results suggest that the depressed salivary secreation due to antidepressants is ameliorated by increasing intracellular calcium levels.
Acetylcholine
;
Animals
;
Antidepressive Agents
;
Caffeine
;
Calcimycin
;
Calcium*
;
Cats
;
Endoplasmic Reticulum
;
Mouth
;
Ryanodine
;
Salivation*
2.Expression of antigens during HL-60 cell differentiation.
Jong Suk OH ; In Chol KANG ; Phil Youl RYU ; Boo Ahn SHIN ; Hyun Chul LEE
Journal of the Korean Cancer Association 1991;23(3):536-543
No abstract available.
HL-60 Cells*
;
Humans
3.Neurilemmoma of the infratemporal fossa: report of a case.
Sun Youl RYU ; Hee Kyun OH ; Geon Jung KIM ; Jae Hyun YUN ; Hong Ran CHOI
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1992;18(4):81-87
No abstract available.
Neurilemmoma*
4.Correction: Need Assessment for Smartphone-Based Cardiac Telerehabilitation.
Ji Su KIM ; Doeun YUN ; Hyun Joo KIM ; Ho Youl RYU ; Jaewon OH ; Seok Min KANG
Healthcare Informatics Research 2019;25(1):57-57
The final degrees of education for the third and fourth authors were mutually misplaced.
6.Effects of Osseointegration According to Implant Placement Timing in the Distracted Alveolar Bone of Dogs.
Hyun JUNG ; Hee Kyun OH ; Sun Youl RYU
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2000;26(3):238-244
The present study was aimed to investigate the effect of osseointegration according to implant placement timing in the distracted alveolar bone using intraoral distraction device. Six adult mongrel dogs of either sex, weighing about 15kg, were used. The animals were divided into 4-week and 8-week groups according to the timing of implant installation. The left upper and lower premolars and first molars were extracted and an alveoloplasty was performed to simulate an atrophic ridge. After 12 weeks of healing, a segmental osteotomy was made and an intraoral distraction device which was designed for augmentation of vertical height of the edentulous ridge was applied. Latency period was allowed for 5 days and then distraction was made at a rate of 1.2mm/day for 8 days. Four or eight weeks after distraction, implants were installed. Twelve weeks after implant installation, the animals were sacrificed. Macroscopic, radiographic, and histologic examinations of distracted alveolar ridge were performed. No significant abnormalities such as infection and dehiscence of overlying soft tissue were observed. Radiographically, there was slight bone resorption around the medial and distal edges of the alveolar bone segment, and a new bone deposition was observed in the neighboring alveolar crest area in the both groups. The satisfactory osseointegration was achieved in the distracted gap of the both groups, but fibrous tissue appeared on the buccal side of implant in the distracted gap in 4-week group. These results suggest that proper timing of implant installation is 8 weeks rather than 4 weeks after distraction when dental implant is to be placed onto the distracted bone.
Adult
;
Alveolar Process
;
Alveoloplasty
;
Animals
;
Bicuspid
;
Bone Resorption
;
Dental Implants
;
Dogs*
;
Humans
;
Latency Period (Psychology)
;
Molar
;
Osseointegration*
;
Osteotomy
7.The Role of Vibrio vulnificus Capsular Polysaccharide as a Virulence Factor.
Sun Sik CHUNG ; Hyun Chul LEE ; Boo Ahn SHIN ; Shee Eun LEE ; Phil Youl RYU ; Won Seok KIM
Journal of the Korean Society for Microbiology 1998;33(5):425-434
To evaluate the role of capsular polysaccharide (CPS) as a virulence factor, the interaction of V. vulnificus with mouse peritoneal macrophages and serum, which are involved in the clearance of bacteria from blood and other tissues, were examined. In this study, MO6-24/0 (wild strain; hemolysin- and capsule-positive), MO6-24/I' (acapsular spontaneous mutant), CVD 752 (acapsular transposon mutant), and CVD 707 (hemolysin-negative and capsule-positive mutant) were used. The strain with CPS (MO6-24/0 and CVD 707) were more resistant to phagocytosis by mouse peritoneal macrophages compared with acapsular strains (MO6-24/T and CVD 752), and the resistance to phagocytosis was not changed by serum opsonin in the capsular strains. Acapsular strains were more susceptible to serum bactericidal activity than the capsular strains through the classical complement pathway. MO6-24/0 strain were detected in blood, spleen, liver and lung at 4 hours after intraperitoneally infection, whereas CVD 752 were not detected. All tested strains could induced the transcription of inflammatory cytokine gene such as IL-1, IL-6, IL-10 and TNF-u, and their inductions were not decreased by cytochalasin B treatment. This results demonstrate that CPS of V. vulnificus plays an important role in V. vulnificus infection through interfering nonspecific host defense system such as blood clearance and phagocytosis.
Animals
;
Bacteria
;
Complement Pathway, Classical
;
Cytochalasin B
;
Interleukin-1
;
Interleukin-10
;
Interleukin-6
;
Liver
;
Lung
;
Macrophages, Peritoneal
;
Mice
;
Phagocytosis
;
Spleen
;
Vibrio vulnificus*
;
Vibrio*
;
Virulence*
8.Congenital infiltrating lipomatosis of the face: report of a case.
Sun Youl RYU ; Seok In PARK ; Hee Kyun OH ; Young Soo YUN ; Jae Hyun YOON ; Hong Ran CHOI
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1992;18(4):137-144
No abstract available.
Lipomatosis*
9.Erratum: Environmental Heavy Metal Exposure and Chronic Kidney Disease in the General Population.
Nam Hee KIM ; Young Youl HYUN ; Kyu Beck LEE ; Yoosoo CHANG ; Seungho RYU ; Kook Hwan OH ; Curie AHN
Journal of Korean Medical Science 2015;30(4):507-507
One author's name is misspelled. Correct Seungho Rhu into Seungho Ryu.
10.Effects of cAMP and cGMP on the blockade of TCR-CD3-mediated cytoplasmic free calcium increased by cholera toxin in human peripheral blood T lymphocytes.
Boo Ahn SHIN ; Phil Youl RYU ; Shee Eun LEE ; Mee Young JANG ; Hyuck IM ; Hyun Chul LEE
Korean Journal of Immunology 1992;14(2):287-295
No abstract available.
Calcium*
;
Cholera Toxin*
;
Cholera*
;
Cytoplasm*
;
Humans*
;
T-Lymphocytes*