1.A STUDY ON THE CHANGE THE UPPER LIP AFTER SAGITTAL SPLIT RAMUS OSTEOTOMY
Soon Seop WOO ; Hyun Chul WE ; Young Soo LEE ; Kwang Sup SHIM
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1999;21(1):35-40
we studied the 12 patients, operated only sagittal split ramus osteotomy without genioplasty or maxillary osteotomy in department of oral and maxillofacial surgery, Hanyang university hospital from 1996.1. 1. to 1998. 7. 20. Preoperative and postoperative cephalometric view was measured to know the change of upper lip position and shape after mandibular setback. The result were obtained as follows. 1. The ratio of upper lip change amount to lower incisor horizontal movement was 15.1%. 2. The ratio of lower facial profile between Sn-Stm and Stm-Mes was changed from 1 : 2.352 to 1 : 2.069 after operation. 3. Post-operative upper lip was flattened 72.4% compared with pre-opreative one. 4. The vermilion zone of the upper lip increased 56% horizontally, 5.8% vertically after operation. 5. The vermilion zone ratio of the lower lip to the upper lip was change from 1 : 1.253 to 1 : 1.348. 6. The distance between esthetic line and Ls was changed from -3.958mm to -1.15mm.]]>
Genioplasty
;
Humans
;
Incisor
;
Lip
;
Maxillary Osteotomy
;
Orthognathic Surgery
;
Osteotomy
;
Osteotomy, Sagittal Split Ramus
;
Prognathism
;
Surgery, Oral
2.Renal Parenchymal Malakoplakia Presenting with Abscesses and Hepatic Extension Misdiagnosed as a Malignant Tumor: A Case Report.
Sun Young YOON ; Hyo Jeong LEE ; Ji Hyun AN ; Su Jeong KIM ; Sang We KIM ; Jun Hee WOO ; Yang Soo KIM
Korean Journal of Medicine 2012;82(6):764-768
Malakoplakia is a chronic inflammatory disorder that usually affects the urinary tract in immunocompromised patients and rarely extends to adjacent organs. Due to its mass-like presentation, malakoplakia is often clinically misdiagnosed as a neoplastic lesion. We describe the case of a 51-year-old female with renal malakoplakia and hepatic extension and large intraperitoneal abscesses that had been misdiagnosed as malignancy. She was diagnosed with myasthenia gravis 12 years prior and had been treated with oral corticosteroids and immunosuppressants. Radical nephrectomy concomitant with abscess drainage was performed. The final pathology was compatible with malakoplakia, and the patient was successfully treated with antibiotics. Although renal malakoplakia is a rare disease, it should be included in the differential diagnosis of patients with a renal mass who have a history of recurrent urinary tract infections or evidence of immunosuppression.
Abscess
;
Adrenal Cortex Hormones
;
Anti-Bacterial Agents
;
Diagnosis, Differential
;
Drainage
;
Female
;
Humans
;
Immunocompromised Host
;
Immunosuppression
;
Immunosuppressive Agents
;
Kidney
;
Liver
;
Malacoplakia
;
Middle Aged
;
Myasthenia Gravis
;
Nephrectomy
;
Rare Diseases
;
Urinary Tract
;
Urinary Tract Infections
3.Survey on the Awareness of Guardians of Young Infants on the Weaning of Food in Pohang and Gyeongju Area.
Hyun Woo WE ; Yu Kyung SEO ; Ae Suk KIM ; Sun Ju LEE ; Sung Min CHO ; Dong Seok LEE ; Doo Kwun KIM ; Sung Min CHOI
Korean Journal of Pediatric Gastroenterology and Nutrition 2006;9(2):233-241
PURPOSE: This study was carried out to investigate the awareness of the weaning of food using questionnaires, and the relationship with the weight gain in young infants. METHODS: From September 2005 to December 2005, we performed a survey on 141 guardians of young infants aged from 6 to 18 months, who visited the pediatric out-patient department at Dongguk University Medical Center. We calculated the total score for each responder from ten questions on the weaning of food and assessed the body weight percentile of each of the young infants. RESULTS: The most commonly reported information source for weaning food was 'the friends around' by 62 respondents (44.0%); 54 (38.3%) responded that the definition of weaning food was the preparatory step before starting a solid diet. Most used a spoon (90.8%) to feed when weaning food with a thin gruel of rice (78.7%). The time for weaning of food was before breast or infant formula feeding (55.3%). Addition of cow's milk was around 12 months (77.3%). The mean score was 6.21; however this did not show a statistically significant correlation with weight gain in young infants. CONCLUSION: The overall awareness of weaning of food has improved; however, information from doctors has decreased. Although the relationship between the awareness of weaning of food and the growth of young infants was not statistically significant, further studies on weaning of food, with larger and controlled sample sizes may provide important information.
Academic Medical Centers
;
Body Weight
;
Breast
;
Surveys and Questionnaires
;
Diet
;
Friends
;
Gyeongsangbuk-do*
;
Humans
;
Infant Formula
;
Infant*
;
Milk
;
Outpatients
;
Sample Size
;
Weaning*
;
Weight Gain
4.A Case of Hereditary C7 Deficiency Associated with Meningococcal Meningitis.
Hyun Woo WE ; Won Duck KIM ; Sun Ju LEE ; Dong Seok LEE ; Doo Kwun KIM ; Sung Min CHOI ; Gyoung Yim HA
Korean Journal of Pediatrics 2004;47(7):799-802
The complement system is composed of more than 25 different proteins and is usually divided into classical and alternative pathways. Complement component 7(C7) is one of the five terminal complement proteins that, upon activation of either the classical or the alternative pathway, interacts sequentially to form a large protein-protein complex, called membrane attack complex(MAC). Assembly of the MAC on target cells results in the formation of transmembrane pores that can lead to the killing of the cells. C7 deficiency is an autosomal recessive disorder that is mostly reported in Caucasians. The gene for C7 has been assigned to chromosome 5p13. To date, 15 different molecular defects leading to total or subtotal C7 deficient defects have been reported. C7 deficiency is associated frequently with recurrently bacterial infections, especially meningitis caused by Neisseria meningitidis. We report a case of a hereditary C7 deficiency associated with meningococcal meningitis.
Bacterial Infections
;
Complement C7
;
Complement System Proteins
;
Homicide
;
Membranes
;
Meningitis
;
Meningitis, Meningococcal*
;
Neisseria meningitidis
5.Renal Parenchymal Malakoplakia Presenting with Abscesses and Hepatic Extension Misdiagnosed as a Malignant Tumor: A Case Report
Sun Young YOON ; Hyo Jeong LEE ; Ji Hyun AN ; Su Jeong KIM ; Sang We KIM ; Jun Hee WOO ; Yang Soo KIM
Korean Journal of Medicine 2012;82(6):764-768
Malakoplakia is a chronic inflammatory disorder that usually affects the urinary tract in immunocompromised patients and rarely extends to adjacent organs. Due to its mass-like presentation, malakoplakia is often clinically misdiagnosed as a neoplastic lesion. We describe the case of a 51-year-old female with renal malakoplakia and hepatic extension and large intraperitoneal abscesses that had been misdiagnosed as malignancy. She was diagnosed with myasthenia gravis 12 years prior and had been treated with oral corticosteroids and immunosuppressants. Radical nephrectomy concomitant with abscess drainage was performed. The final pathology was compatible with malakoplakia, and the patient was successfully treated with antibiotics. Although renal malakoplakia is a rare disease, it should be included in the differential diagnosis of patients with a renal mass who have a history of recurrent urinary tract infections or evidence of immunosuppression.
Abscess
;
Adrenal Cortex Hormones
;
Anti-Bacterial Agents
;
Diagnosis, Differential
;
Drainage
;
Female
;
Humans
;
Immunocompromised Host
;
Immunosuppression
;
Immunosuppressive Agents
;
Kidney
;
Liver
;
Malacoplakia
;
Middle Aged
;
Myasthenia Gravis
;
Nephrectomy
;
Rare Diseases
;
Urinary Tract
;
Urinary Tract Infections
6.Nuclear Hyperploidy of Megakaryocytes and Platelet Aggregation Test in Essential Thrombocythemia.
Young Rok SHIN ; Cheolwon SUH ; Byung Min JUN ; Jeong Hee HAN ; Suk Sue LEE ; Hyun Young KIM ; Tae Won KIM ; Je Hwan LEE ; Sung Bae KIM ; Sang We KIM ; Kyoo Hyung LEE ; Jung Shin LEE ; Woo Kun KIM ; Sang Hee KIM ; Chan Jeoung PARK ; Hyun Sook CHI
Korean Journal of Hematology 1999;34(4):568-572
BACKGROUND: Essential thrombocythemia (ET) is a rare chronic myeloproliferative disorder characterized by an extremely high platelet count in the circulating blood and abnormal proliferation of the megakaryocytes in bone marrow, resulting in splenomegaly, thromboembolic or hemorrhagic complications. We studied the presence of nuclear hyperploidy of the megakaryocytes in bone marrow, the presence of abnormal response to the individual reagent on platelet aggregation test, and its clinical implication. METHODS: We analyzed the 43 cases of ET at the Asan Medical Center between January, 1989 and March, 1999. The Polycythemia Vera Study Group criteria were used to diagnose ET. RESULTS: Nuclear hyperploidy was observed at 43 cases (100%). Platelet aggregation test was done at 32 (74.4%) cases, of which 27 (84.4%) cases showed abnormal response to more than one reagent, 16 (50%) cases to more than two reagents. Abnormal response to epinephrine and collagen was most common, but 5 cases showed normal response. By individual reagent, 1 (3%) cases to adenosine diphosphate, 1 (3%) case to ristocetin, 22 (69%) cases to epinephrine, 19 (59%) cases to collagen showed abnormal response. CONCLUSION: We observe that nuclear hyperploidy of the megakaryocyts and abnormal response on platelet aggregation test are frequent in ET in this study.
Adenosine Diphosphate
;
Blood Platelets*
;
Bone Marrow
;
Chungcheongnam-do
;
Collagen
;
Epinephrine
;
Indicators and Reagents
;
Megakaryocytes*
;
Myeloproliferative Disorders
;
Platelet Aggregation*
;
Platelet Count
;
Polycythemia Vera
;
Ristocetin
;
Splenomegaly
;
Thrombocythemia, Essential*
7.Myelodysplastic syndrome that progressed to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormality: a case report.
Seong Ho KIM ; Cheol Won SUH ; Seong Jun CHOI ; Jung Gyun KIM ; Je Hwan LEE ; Sung Bae KIM ; Sang We KIM ; Kyoo Hyung LEE ; Jung Shin LEE ; Woo Kun KIM ; Sang Hee KIM ; Eul Ju SEO ; Hyun Sook CHI
Journal of Korean Medical Science 1999;14(4):448-450
Myelodysplastic syndrome is a closely related group of acquired bone marrow disorders characterized by ineffective and dysplastic hematopoiesis. These clonal disorders frequently progress to acute leukemia. Acute myelomonocytic leukemia with eosinophilia is characterized by an increase in abnormal eosinophils in the bone marrow, relatively good clinical course and inv (16) chromosomal abnormality. We experienced one case of refractory anemia with excess blasts which progressed to refractory anemia with excess blasts in transformation and finally to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormalities of der (1;7).
Adult
;
Anemia/pathology
;
Anemia/genetics
;
Anemia/etiology
;
Bone Marrow/pathology
;
Case Report
;
Chromosomes, Human, Pair 16*
;
Disease Progression
;
Eosinophilia/pathology
;
Eosinophilia/genetics*
;
Eosinophilia/etiology
;
Human
;
Inversion (Genetics)*
;
Karyotyping
;
Leukemia, Myelocytic, Acute/pathology
;
Leukemia, Myelocytic, Acute/genetics*
;
Leukemia, Myelocytic, Acute/etiology
;
Male
;
Myelodysplastic Syndromes/pathology
;
Myelodysplastic Syndromes/genetics*
;
Myelodysplastic Syndromes/complications
8.Prognostic factors of acute myelocytic leukemia: an analysis of 132 patients in a single institution.
Kyoo Hyung LEE ; Jung Shin LEE ; Cheol Won SUH ; Sang We KIM ; Sung Bae KIM ; Je Hwan LEE ; Dai Young ZANG ; Dong Suk LEE ; Hyun Sook CHI ; Moo Song LEE ; Woo Kun KIM ; Sang Hee KIM
Journal of Korean Medical Science 1996;11(3):222-232
Patients with acute myelocytic leukemia (AML) have varied outlooks for survival after the diagnosis. To identify pretreatment prognostic indicators in AML, we analyzed 132 cases of AML seen at our hospital between June, 1989 and December, 1994. The median age of the patients was 40 years (range, 15-81). There were 63 male and 69 female patients. One hundred eight patients (82%) received induction chemotherapy which was based on cytarabine plus anthracyclines. Sixty six patients achieved complete remission (CR) and the CR rate among the patients given induction chemotherapy was 61%. The median duration of CR was 11.2 months. After median follow up of 6.6 months (range 0.5-51.4), 26 patients (39%) remain in continuous CR. The median duration of overall survival of the patients was 6.7 months. After median follow up of 10.6 months (range, 0.1-52.7), 41 patients (31%) are alive. Variables affecting duration of CR included the age of the patients, performance status of the patients, percentage of blast in the peripheral blood, hemoglobin level, percentage of blast in the bone marrow, FAB subtype, and CD7 marker positivity. Variables affecting survival duration included age of the patients, performance status of the patients, absolute blast count (ABC) in the peripheral blood, bone marrow cellularity, the percentage of blast in the bone marrow, and CD5 marker positivity. Multivariate analysis showed that the age of the patients and percentage of blast in the bone marrow were significant independent indicators for overall survival of the patients. Further studies utilizing cytogenetics and molecular characteristics of leukemic cell are warranted to better define the prognostic factors of patients with AML.
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Aged, 80 and over
;
Female
;
Human
;
Leukemia, Myelocytic, Acute/*mortality
;
Male
;
Middle Age
;
Multivariate Analysis
;
Prognosis
;
Survival Rate
9.High-Dose Chemotherapy of Cyclophosphamide, Thiotepa, and Carboplatin (CTCb) with Autologous Peripheral Blood Stem Cell Transplantation for High-Risk Primary Breast Cancer and Metastatic Breast Cancer.
Young Joo MIN ; Cheol Won SUH ; Je Hwan LEE ; Young Ran CHAE ; Shin KIM ; Chang Whang BAE ; Jin Hee PARK ; Sung Joon CHOI ; Tae Won KIM ; Whan Jung YOON ; Byung Hak JUNG ; Dai Young ZANG ; Jong Soo CHOI ; Sung Bae KIM ; Sang We KIM ; Kyoo Hyung LEE ; Jung Shin LEE ; Woo Kun KIM ; Sei Hyun AHN ; Jung Mi PARK ; Sang Hee KIM
Korean Journal of Medicine 1997;53(4):482-487
OBJECTIVES: Recently high dose chemotherapy with autologous peripheral blood stem cell transplantation (APBSCT) has been investigated with the hope of maximizing tumor response and increasing survival. The purpose of this study is to evaluate the effect, feasibility, and toxicity of high-dose cyclophosphamide, thiotepa, and carboplatin (CTCb) with APBSCT in patients with metastatic or high risk primary breast cancer. METHODS: Four cases of high-risk primary breast cancer (with more than 10 involved axillary nodes) and three cases of metastatic disease in complete or partial response were enrolled. Peripheral blood stem cells were mobilized by G-CSF plus chemotherapy, and median number of collected mononuclear cells was 5.44 X 108/kg(range, 1.95-7.08 X 108/kg). High-dose chemotherapy of cyclophosphamide (1,500mg/m2/day), thiotepa (125mg/m2/day) and carboplatin (200mg/m2/day) was administered for 4 days and peripheral blood stem cells were reinfused to the patients 72 hours after the completion of chemotherapy. RESULTS: The median days of recovery for neutrophil (over 500/mm3) and for platelet (over 50,000/mm3) were 10 (range, 8 to 33) and 30 (range, 10 to 40). One patient suffered from seizure attack and grade 3 hepatotoxicity during high dose chemotherapy, There were no treatment-related death. Four patients with high-risk primary breast cancer remained disease-free at 2, 8, 12 and 19 months post-transplant. In one patient with bone metastasis, complete response was induced following APBSCT. All three patients with metastatic disease remained progression-free at 8, 18 and 19 months post-transplant. CONCLUSION: High-dose chemotherapy and autologous peripheral blood stem cell transplantation was feasible and would be a potentially effective treatment modality in high risk and metastatic breast cancer.
Blood Platelets
;
Breast Neoplasms*
;
Breast*
;
Carboplatin*
;
Cyclophosphamide*
;
Drug Therapy*
;
Granulocyte Colony-Stimulating Factor
;
Hope
;
Humans
;
Neoplasm Metastasis
;
Neutrophils
;
Peripheral Blood Stem Cell Transplantation*
;
Seizures
;
Stem Cells
;
Thiotepa*
10.Postoperative Adjuvant Chemotherapy and Radiotherapy for Stage II and III Non-Small Cell Lung Cancer (NSCLC).
Jin Hong PARK ; Sang Wook LEE ; Eun Kyung CHOI ; Weon Kuu CHUNG ; Kyung Hwan SHIN ; Seung Do AHN ; Jong Hoon KIM ; Sang We KIM ; Cheolwon SUH ; Jung Shin LEE ; Woo Sung KIM ; Dong Soon KIM ; Dong Kwan KIM ; Seung Il PARK ; Kwang Hyun SOHN
Journal of Lung Cancer 2002;1(1):34-40
PURPOSE: The role of postoperative adjuvant chemo-radiotherapy in the treatment of patients with non-small cell lung cancer (NSCLC) remains unclear. This study was undertaken to evaluate the survival outcomes, relapse patterns, prognostic factors and complications of postoperative adjuvant MVP chemotherapy and radiotherapy. MATERIALS AND METHODS: The study involved some 96 patients who had undergone curative resection of stage II and III NSCLC between 1991 and 1996. Among these, 94 patients who completed their adjuvant treatment were analyzed. Surgery consisted of pneumonectomy (33%), single lobectomy (54%) or bilobectomy (13%). Within 4 weeks of curative resection, two cycles of MVP chemotherapy (mitomycin C 8 mg/m2, vinblastine 8 mg/m2, cisplatin 60 mg/m2) were started at 4 weeks intervals. Conventionally fractionated radiotherapy was given 3 weeks after chemotherapy to a total dose of 50 Gy in completely resected patients and 55~60 Gy in patients with positive resection margins. RESULTS: The TNM classification of the AJCC, as revised in 1997, was used for pathologic staging. The number of patients at AJCC stages IIa, IIb, IIIa, and IIIb were 4, 40, 45, and 5, respectively. A pathologically positive bronchial resection margin was found in nine patients. At the time of analysis, death was recorded in 29 patients (31%), though five had died without evidence of lung cancer. Overall 2-year, 3-year, and 5-year survival rates for all patients were 74.2%, 70.2%, and 65%, respectively, locoregional diseasefree survival (LRDFS) rates were 88.6%, 83.7%, 74.3%, at 2-years, 3-years, and 5-years, and distant metastasis disease-free survival (DMDFS) rates were 67.7%, 65.0%, and 63.6%, respectively. In the multivariate model, a primary tumor size of more than 5 cm and the level of pathologically positive nodes were found to be associated with poor overall survival, LRDFS and DMDFS. Although positive bronchial resection margin affected overall survival, LRDFS and DMDFS were unaffected. With respect to the first site of relapse, distant metastasis occurred more frequently (N=33, 35%) than locoregional recurrence (N=15, 16%). Grade 3 esophagitis in two patients and weight loss of more than 10% in five patients were observed during adjuvant treatment. Grade 4 pulmonary toxicity was observed in one patient after radiotherapy and this patient ultimately died 5 months after treatment. CONCLUSION: The postoperative adjuvant MVP chemotherapy and radiotherapy regimen showed relatively low locoregional recurrence and distant metastasis rates and good survival rate with acceptable toxicity. A prospective randomized trial, which compares this regimen to surgery alone or postoperative adjuvant radiotherapy is needed.
Carcinoma, Non-Small-Cell Lung*
;
Chemotherapy, Adjuvant*
;
Cisplatin
;
Classification
;
Disease-Free Survival
;
Drug Therapy
;
Esophagitis
;
Humans
;
Lung Neoplasms
;
Neoplasm Metastasis
;
Pneumonectomy
;
Prospective Studies
;
Radiotherapy*
;
Radiotherapy, Adjuvant
;
Recurrence
;
Survival Rate
;
Vinblastine
;
Weight Loss