1.A case of placenta site trophoblastic tumor(PSTT).
Hyun Tai SHIN ; Seon Kyung LEE ; Chu Yup HUM ; Seung Bo KIM
Korean Journal of Obstetrics and Gynecology 1993;36(12):3976-3982
No abstract available.
Placenta*
;
Trophoblasts*
2.Study on Trends of Multiple Birth in Korea : 1982-1998.
Sang Hwa PARK ; Tai June KIM ; Shin Yong MOON ; Seok Hyun KIM
Korean Journal of Perinatology 2001;12(4):449-452
No abstract available.
Humans
;
Korea*
;
Multiple Birth Offspring*
3.Radiographic Measurement of Normal Adult Cervical Spinal Region in the Korean Population
Young LIM ; Hyun Duck YOO ; Sung Tai SHIN ; Byung Jik KIM ; Kwang Yoon SEO
The Journal of the Korean Orthopaedic Association 1987;22(1):159-162
Radiographic measurement of cervical spine is very important in cervical spine injury especially those without fracture. Authors measured the retropharyngeal space, retrotracheal space, lordortic curve and sagittal diameter of cervical spinal canal in 148 cases of normal adult male. The results are as follows: 1 . In normal Korean adult male maximum retropharyngeal space is 7mm in C, level and Smm in Cs level. Maximum retrotracheal space is 16mm in C, level. 3. Loss of normal lordotic curve is shown in 21 cases(14.2%), 4. Average sagittal diameter of C, level is 21.27mm-it's the largest of all the cervical spinal cana1s, and that of C, level is 16.15mm-it's the smallest.
Adult
;
Humans
;
Male
;
Spinal Canal
;
Spine
4.A case of lipoleiomyoma in uterus.
Hyun Tai SHIN ; Hee Suk JUNG ; Jin Kee HONG ; Chu Yeop HUH ; Seung Bo KIM ; Jae Hyun LEE
Korean Journal of Obstetrics and Gynecology 1993;36(5):711-714
No abstract available.
Uterus*
5.A case of postpartum hemolytic uremic syndrome.
Hyun Chul SHIN ; Jung Jae LEE ; Yeong Kyun SHIN ; Seon Yong KOH ; Kae Hyun NAM ; Kwon Hae LEE ; Tai Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(7):3144-3148
No abstract available.
Hemolytic-Uremic Syndrome*
;
Postpartum Period*
6.Comparative study of transvaginal sonography and endoctyehy for endometrial cancer in postmenopausal women.
Keum Ho HAM ; Young Kyun SHIN ; Kae Hyun NAM ; Soon Gone LEE ; Kwon Hae LEE ; Tai Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(7):1967-1977
No abstract available.
Endometrial Neoplasms*
;
Female
;
Humans
7.The Clinical Study of the Torsion of the Ovarian Tumor in Postmenopausal Women.
Seung Ryong KIM ; Soo Hyun CHO ; Kyung Tai KIM ; Hyung MOON ; Youn Yeung HWANG ; Joong Sik SHIN ; Young Jin MOON
Korean Journal of Obstetrics and Gynecology 2000;43(7):1139-1143
OBJECTIVE: The purpose of this study is to evaluate the clinicopathologic characteristics of the torsion of the ovarian tumor in postmenopausal women. METHODS: We reviewed the medical records of 20 postmenopausal patients with a postoperative diagnosis of torsion of the ovarian tumor in Department of Obstetrics and Gynecology, Hanyang University Hospital from January 1989 to December 1998. RESULTS: The postmenopausal patients with torsion of the ovarian tumor constitute 20/94 (21.3%) of all adnexal torsion patients encountered during this period. The mean (+/-SD) age of the 20 patients was 63.5+/-9.0 years, with a range of 52-90 years. The mean time since menopause was 16.5+/-10.3 years, with a range of 1-39 years. The mean parity was 5.4+/-2.0 (range of 3-10). Lower abdominal pain (65%) was the most frequently presenting symptom, palpable mass(20%) or diagnosed mass(15%) being the second. But, in 20% of cases there was no lower abdominal pain. The torsion occurred at the right side in 11cases (55%) and at the left side in 9 cases. The most frequent degree of torsion was those cases that was rotated twice (720 degrees). The neoplasms undergoing torsion ranged in diameter between 5cm and 30cm and the most prevalent size was 6 to 10 cm (8 cases). Most of the patients (17cases) were treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. The tumors that produce torsion varied histologically and the most common type was cystic teratoma (in 5 cases), simple cyst(in 3 cases), serous cystadenoma(in 2 cases), mucinous cystadenoma(in 2 cases). CONCLUSIONS: In our study, ovarian tumor torsion occurring in postmenopausal patients constituted approximately 20% of all torsion patients, therefore adnexal torsion should be considered when a postmenopausal woman presents with lower abdominal pain. When torsion is diagnosed, total abdominal hysterectomy and bilateral salpingo-oophorectomy is the usual treatment for postmenopausal patients. Histologically, in more than 90% of cases, the tumors that produce torsion were benign. If cancer is evident, more extensive surgery is required.
Abdominal Pain
;
Diagnosis
;
Female
;
Gynecology
;
Humans
;
Hysterectomy
;
Medical Records
;
Menopause
;
Mucins
;
Obstetrics
;
Parity
;
Teratoma
8.Two Cases of Primary Carcinoma of the Peritoneum.
Joong Sik SHIN ; Sam Hyun CHO ; Jung Bae YOO ; Seung Ryong KIM ; Soo Hyun CHO ; Kyung Tai KIM ; Youn Yeung HWANG ; Seok Hoon JEON ; Jung Dal LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(3):248-253
The primary malignant tumor of the peritoneum also known as primary peritoneal carcinoma or primary peritoneal papillary serous carcinoma is rare and involves the peritoneum, especially the pelvic peritoneum of female patients. It is difficult to differentiate histologically between papillary mesothelioma, primary ovarian tumor and primary peritoneal carcinoma. We report two cases of the primary peritoneal carcinoma with clinical presentation and histologic characteristics.
Diagnosis, Differential
;
Female
;
Humans
;
Mesothelioma
;
Peritoneum*
9.Hypertrophic intracranial pachymeningitis associated with chronic otitis media: A case report.
Hyun Jeong HAN ; Tai Yeon LEE ; Dong Ick SHIN ; Sung Hyun LEE ; Sang Soo LEE ; Seol Heui HAN ; Geon Kook LEE
Journal of the Korean Neurological Association 1997;15(4):890-894
A 59-year-old woman was admitted to our hospital because of occipital headache and multiple cranial nerve dysfunction. The patient had been suffered from chronic otitis media. MRI of the brain showed a thickened and markedly enhanced dura mater in the temporal lobe. The patient underwent a left temporal craniectomy and dural biopsy. Histopathological examination revealed thickened duar amter infiltrated with giant cell, lymphocytic and plasma cell infiltration. The fungus, acid-fast and PAS stains were all negative. After administraion of steroid, cranial nerve disturbances and headache improved. The cause of the hypertrophpic intracranial pachymeningitis in this patient was thought to be related with the chronic otitis media, although the clinical course of the patient was similar to the idiopathic hypertrophic pachymeningitis.
Biopsy
;
Brain
;
Coloring Agents
;
Cranial Nerves
;
Dura Mater
;
Female
;
Fungi
;
Giant Cells
;
Headache
;
Humans
;
Magnetic Resonance Imaging
;
Meningitis*
;
Middle Aged
;
Otitis Media*
;
Otitis*
;
Plasma Cells
;
Temporal Lobe
10.T Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Sang-Eun LEE ; A-Ri SHIN ; Hyun-Jung SOHN ; Hyun-Il CHO ; Tai-Gyu KIM
Cancer Research and Treatment 2020;52(3):747-763
Purpose:
Successful tumor eradication primarily depends on generation and maintenance of a large population of tumor-reactive CD8 T cells. Dendritic cells (DCs) are well-known potent antigen-presenting cells and have applied to clinics as potent antitumor therapeutic agents. However, high cost and difficulty in obtaining sufficient amounts for clinical use are the crucial drawbacks of DC-based vaccines. Here, we aimed to develop T cell–based vaccine capable of eliciting potent antitumor therapeutic effects by providing effective costimulatory signals.
Materials and Methods:
Antigenic peptide-loaded T cells transfected with retrovirus encoding costimulatory ligands CD70, CD80, OX40L, or 4-1BBL were assessed for antigen-specific CD8 T-cell responses and evaluated antitumor effects along with immunization of a mixture of synthetic peptides, poly-IC and anti-CD40 antibodies (TriVax).
Results:
T cells expressing CD70 (CD70-T) exhibited similar level of stimulatory functionality and therapeutic efficacy as DCs. Moreover, CD70-T prime followed by TriVax booster heterologous vaccination elicited therapeutic antitumor effect against B16 melanoma where mediated by CD8 T cells but not CD4 T cells or natural killer cells. The combination with programmed death-ligand 1 blockade led to potent therapeutic efficacy which exhibited increased tumor-infiltrating CD8 T cells. CD70-T pulsed with multi-antigenic peptide generated multiple antigen-specific polyvalent CD8 T cells that were capable of inhibiting tumor growth effectively. Moreover, CD70-T vaccination resulted in higher expansion and migration of adoptively transferred T cells into tumor sites and elicits enhanced therapeutic effects with peptide-based booster immu-nization.
Conclusion
These results imply that T cells endowed with CD70 enable the design of effective vaccination strategies against solid cancer, which may overcome current limitations of DC-based vaccines.