1.The Influences of Vascular Endothlelial Growth Factor and Endothelin-1 on Speramtogenesis in Testis.
Sung Woo PARK ; Hyun Jun PARK ; Nam Cheol PARK
Korean Journal of Fertility and Sterility 2004;31(4):235-244
OBJECTIVE: The effects on spermatogenesis by expression of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were investigated. MATERIALS AND METHODS: Testicular specimens were obtained from 40 infertile males due to primary testicular failure and from 10 fertile males with other urologic problems. The specimens of infertile males were devided into 4 groups according to histologic findings; Sertoli cell only syndrome (A), maturation arrest (B), hypospermatogenesis (C) and sloughing and disorganization (D). VEGF and ET-1 expression were detected with immunohistochemical stain. RESULTS: VEGF expression on Leydig cell was detected in all cases. But, VEGF expression rates on germ cell were significantly higher in infertile group B, C, D compared to that of the control group (p<0.05). ET-1 expression rates on Leydig cell was significantly lower in all infertile group compared to that of the control group (p<0.05). But, ET-1 expression rates on Sertoli cell was significantly higher in all infertile group compared to that of the control group (p>0.05). In germ cell of infertile group, LH, FSH and prolactin were significantly decreased, and estradiol is increased in positive stain group on ET-1 immunohistochemical stain (p<0.05). VEGF and ET-1 expression were not correlated mean seminiferous tubule diameter (p>0.05). CONCLUSIONS: Abnormal spermatogenesis would be reflected in VEGF expression in germ cell.
Endothelin-1*
;
Estradiol
;
Germ Cells
;
Humans
;
Male
;
Oligospermia
;
Prolactin
;
Seminiferous Tubules
;
Sertoli Cell-Only Syndrome
;
Spermatogenesis
;
Testis*
;
Vascular Endothelial Growth Factor A
2.Surgical treatment of primary lung cancer.
Wook YOUM ; Sang Hyun SUNG ; Sung Hyuk PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(5):373-379
No abstract available.
Lung Neoplasms*
;
Lung*
3.Papular Tuberculid and Suppurative Lymphadenitis After BDG Vaccination.
Tae Hyun PARK ; Sung Nam CHANG ; Soo Chan KIM
Korean Journal of Dermatology 1995;33(6):1138-1142
Various dermatological complications have been reported following the BCG vaccination although this vaccination has been recommended to all healthy infants in our country. A 4-months-old boy, who had a BCG vaccination three weeks after birth, developed erythematous papules and pustules on the whole body, especially on the face and upper extremities. Two erythematous subcutaneous soft nodules were also noted on the left side of the neck. A biopsy specimen from the right forearm revealed caseous necrosis surrounded by a granulomatous inflammation consisting of epithelioid cells and lymphocytes. It was centered along the axis of the damaged pilosebaceous follicle. No acid-fast bacilli could be demonstrated by AFB stain. A marked improvement of his skin eruptions was observed after anti-tuberculosis medication. However, nod-ules in the cervical area perforated spontaneously and healed leaving scars several months after the cutaneous eruptions subsided. The clinical and histologic findings and a good response to anti-tuberculous therapy support the diagnosis of papular tuberculid and suppurative lymphadenitis after BCG vaccination.
Axis, Cervical Vertebra
;
Biopsy
;
Cicatrix
;
Diagnosis
;
Epithelioid Cells
;
Forearm
;
Humans
;
Infant
;
Inflammation
;
Lymphadenitis*
;
Lymphocytes
;
Male
;
Mycobacterium bovis
;
Neck
;
Necrosis
;
Parturition
;
Skin
;
Tuberculosis, Cutaneous*
;
Upper Extremity
;
Vaccination*
4.Kobayashi procedure for esophageal variceal bleeding.
Sung Hoon RHEU ; Jin Hyun PARK ; Byung Chul LEE
Journal of the Korean Surgical Society 1991;40(2):146-152
No abstract available.
Esophageal and Gastric Varices*
5.Comparison of CT scan and chemical composition of gallstone.
Jeong Hyun LEE ; Jeong Mi PARK ; Sung Kyu LEE
Journal of the Korean Surgical Society 1992;42(5):636-642
No abstract available.
Gallstones*
;
Tomography, X-Ray Computed*
6.Surgical management on portal hypertension with esophageal varices.
Hyun Jang KIM ; Ho Chul PARK ; Sung Wha HONG
Journal of the Korean Surgical Society 1992;42(5):607-616
No abstract available.
Esophageal and Gastric Varices*
;
Hypertension, Portal*
7.A Case Dermal Melanocyte Hamartoma.
Jin Gon JANG ; Sung Hyun PARK ; Kwang Hoon LEE
Korean Journal of Dermatology 1988;26(6):956-959
A 26-year-old man presented with a bluish speckled patch on the dorsum of the left hand. It had apperaed at birth as a bluish spot. Since adolescence the lesion extended and at the time of visiting hospital it covered the most part of the dorsum of the left hand and even some palmar aspect. The histopathological and ultrastructural examination revealed numerous dermal melanocytes, mainly in the upper dermis. Clinically and pathologically, the patient was diagnosed as having dermal melanocyte hamartoma, a distinct type of dermal melanocytosis.
Adolescent
;
Adult
;
Dermis
;
Hamartoma*
;
Hand
;
Humans
;
Melanocytes*
;
Parturition
8.A COMPARISON OF MIDAZOLAM AND DIAZEPAM AS SEDATIVES FOR AMBULATORY PLASTIC SURGERY PATIENTS.
Yong Chan CHUN ; Hyun Cheol PARK ; Sung Ho CHOI
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(6):1274-1282
No abstract available.
Diazepam*
;
Humans
;
Hypnotics and Sedatives*
;
Midazolam*
;
Surgery, Plastic*
9.A study on the relationship between fatigue and stress.
Sung Hyun KIM ; Jin Hee YOON ; Hye Soon PARK
Journal of the Korean Academy of Family Medicine 1992;13(3):226-232
No abstract available.
Fatigue*
10.The Distribution of HLA Antigens and Haplotypes in Koreans.
Hyun Soo KIM ; Yoo Sung HWANG ; Myoung Hee PARK
Korean Journal of Clinical Pathology 1997;17(6):1109-1123
BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human and there are characteristic racial differences in the distribution of HLA antigens, alleles, and haplotypes. This study was performed to examine the frequency of HLA antigens, alleles and haplotypes in Koreans. METHODS: Two thousand healthy Koreans registered for unrelated bone marrow donors were subject to the study. HLA-A, B and C antigens were typed by the serological method, and HLA-DR DNA typing (low resolution) was done by PCR and reverse hybridization. HLA allele and haplotype frequencies and linkage disequilibrium values were calculated by the maximun likelihood method using the computer program of the 11th International Histocompatibility Workshop. RESULTS: HLA antigens identified in 2000 Koreans were 14 in A locus, 33 in B locus, 8 in C locus and 12 in DR locus. Alleles showing frequencies of more than 10% in decreasing order of frequency In each HLA locus were A2, A24, A33, All, B44, B62; CBL, Cw3, Cwl, Cw7, DR4, DR2, DRl3, DR8, and DR9. Among A-B, C-B, B-DR 2-locus haplotypes, A33-B44, A30-B13, Al-B37, Cwl-B54, Cw4-B62, B7-DR1, B37-DR10 showed strong positive linkage disequilibrium (Chi-square > 1000). The most common A-B-DR haplotypes in Koreans occurring at frequency of more than 2% were A33-B44-DRl3 (4.8%), A33-B58-DRl3 (3.2%), A33-B44-DR7 (2.6%), All-B62-DR4 (2.3%), A24-B7-DR1 (2.3%), and A30-Bl3-DR7 (2.1%) Comparison of the distribution of A-B-DR haplotypes among east Asian populations reveals that Koreans are most close to Japanese, but show higher degree of polymorphism in the distribution of HLA haplotypes compared to Japanese. CONCLUSIONS: The results obtained in this study can be used as basic data for Koreans in the fields of organ transplantation, disease association studies and anthropologic studies.
Alleles
;
Asian Continental Ancestry Group
;
Bone Marrow
;
DNA Fingerprinting
;
Education
;
Haplotypes*
;
Histocompatibility
;
HLA Antigens*
;
HLA-A Antigens
;
HLA-DR Antigens
;
Humans
;
Linkage Disequilibrium
;
Organ Transplantation
;
Polymerase Chain Reaction
;
Tissue Donors
;
Transplants