No abstract available.
Ciprofloxacin* ; Mycobacterium tuberculosis* ; Mycobacterium*

No abstract available.
Decompression* ; Head* ; Osteonecrosis*

Primary intimal sarcoma of the pulmonary artery is a rare disease and there has been no report of any case originating from the pulmonary valve. Recently we experienced a 62 year-old female patient who had a primary intimal sarcoma of the pulmonary valve with distal metastasis. She was brought to medical attention due to exertional dyspnea facial edema productive coughing and general weakness for 1 month. Chest CT and echocardi-ography suggest an acute pulmonary thromboembolism or tumor. Exploration showed a large polypoid mass arising from the pulmonary leaflets and multiple masses on distal pulmonary arteries. We replaced the pulmonary valve and reconstructed the pulmonary artery. She received radiotherapy 1 month postoperatively and now 4 months after surgery she has begun receiving chemotherapy.
Cough ; Drug Therapy ; Dyspnea ; Edema ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Pulmonary Artery ; Pulmonary Embolism ; Pulmonary Valve* ; Radiotherapy ; Rare Diseases ; Sarcoma* ; Tomography, X-Ray Computed

No abstract available.
Colon*

No abstract available.
Arthritis*

No abstract available.

No abstract available.
Hemorrhagic Fever with Renal Syndrome* ; Humans ; Proteinuria*

No abstract available.
Humans*

BACKGROUND: Ultraviolet B (UVB) irradiation is an important inducer of several biological changes in skin, including sunburn, premature skin aging, and skin cancer, and these changes are mediated mainly by direct DNA damage or production of reactive oxygen species. Chemoprevention with an antioxidant, such as melatonin, may be a useful method to reduce skin damage induced by UVB. These processes are closely related with changes in expressions of many genes in cells. However, the expression profiles of genes in UVB-irradiated fibroblasts, with or without melatonin treatment, is largely unknown. OBJECTIVE: To investigate the expression profiles of genes in UVB-irradiated fibroblasts, with or without melatonin treatment, thereby evaluating the possibility of melatonin for the use as a promising antioxidant. METHODS: We cultured human skin fibroblasts in the presence and abscence of melatonin. Cells were irradiated with UVB (100 mJ/cm2), and the expression profiles of genes in the cells were then evaluated using a cDNA microarray, representing 25,000 genes, and by the RT-PCR method. RESULTS: The expressions of 652 genes with melatonin and 597 genes without melatonin were changed by UVB, and the major genes modified by UVB could be grouped into 4 categories: (1) cell cycle-related genes, (2) genes for structural, extracellular matrix proteins, and cell adhesion-related genes, (3) inflammation-related genes, and (4) oxidation-related genes. CONCLUSION: These results provide the basis for understanding the effect of UVB on human skin fibroblasts and give a new insight into melatonin as an antioxidant.
Chemoprevention ; DNA Damage ; Extracellular Matrix Proteins ; Fibroblasts* ; Gene Expression* ; Humans* ; Melatonin* ; Oligonucleotide Array Sequence Analysis ; Reactive Oxygen Species ; Skin Aging ; Skin Neoplasms ; Skin* ; Sunburn ; Transcriptome*

When about 300mg of L-ascorbic acid was given intravenously to the adults saturated with the vitamin, the increased blood level returned to almost the original level in 3 hours. Also the amounts of the vitamin absorbed by the tissue cells and metabolized in the body or excreted into the gastrointestinal tract were found to average 74.1mg in 3 hours. When about 300mg of L-ascorbic acid was given intravenously twice at intervals of 3 hours, an average of 101 mg of the vitamin was absorbed by the tissue cells and metabolized in the body or excreted into the gastrointestinal tract in 6 hours. When the vitamin was given orally to the saturated adults, the absorption rate increased as the test does increased. When large amounts (3.0gm) of the vitamin were given, the absorption rate reached the maximum. The maximum absorption in 6 hours was estimated as 681 mg of the vitamin.
Adult ; Ascorbic Acid/blood/*metabolism ; Human ; *Intestinal Absorption