1.Mediating Effects of Sleep Quality on the Relationship between Job Stress and Stress Response of Shift-Working Nurses
Suk Yong KIL ; Won Oak OH ; Yoo Jin HEO ; Min Hyun SUK
Journal of Korean Biological Nursing Science 2019;21(4):266-274
PURPOSE: The aim of this research was to identify the mediating effect of sleep quality on the relationship between job stress and stress response of shift-working nurses.METHODS: The participants in this study were 150 nurses who had more than 6 months of shift-working experience. A survey was conducted from May to June 2017 in a hospital in Gyeonggi-do, South Korea. The data were collected through self-report questionnaires. The collected data were analyzed using SAS 9.4 program. The analysis was based on Baron and Kenny's model to examine the mediating effects of sleep quality on the relationship between job stress and stress response of shift-working nurses.RESULTS: In the first and second steps, job stress was identified as a significant predictor of sleep quality (β=.29, p=.001) and stress response (β=.24, p=.004). In the third step, sleep (β=.55, p < .001) was observed as a significant predictor of stress response, and the direct relationship between job stress and stress response was not significant (β=.07, p=.291). Sleep quality was found to exhibit complete mediating effect on the relationship between job stress and stress response.CONCLUSION: The results of this study suggest that strategies for managing the stress of shift-working nurses should include effective ways to ensure sleep quality.
Gyeonggi-do
;
Korea
;
Negotiating
2.Treatment of Bone Defect with Ilizarov Apparatus in the Tibia
Hyun Duck YOO ; Jang Suk CHOI ; Young Goo LEE ; Seung Seok SEO ; Young Chang KIM ; Hyeon HEO
The Journal of the Korean Orthopaedic Association 1995;30(4):975-982
Bone defect of the long bone continues to challenge orthopedic surgeons. It is usually very difficult to obtain union. Ilizarov ext. fixation has recently gained popularity as a multifactorial approach to the management of tibial bone defect because nonunion, bone defects, limb shortening, and deformity can all be addressed simultaneously with the Ilizarov apparatus. From February 1992 to May 1993 at the department of orthopedic surgery, Inje University Pusan Paik Hospital, 9 patients aged from 8 to 37 years were treated for tibial bone defect. The causes were open comminuted fractures with initial bone loss and bone defect after removal of infected necrotic bone. Bony defect size was ranged from 2cm to 14cm, averaging 7.2cm. Bony defects were gradually closed by the Ilizarov's internal bone transport technique, and final equalization of leg length discrepancy was achieved by means of external lengthening technique. Soft tissue defects were treated with secondary closure, split thickness skin graft, and muscle flap. The average healing index was 42.8 days/cm. According to Paley's classification the complications were developed as follows; The problem included pin tract infection(9), knee flexion contracture(4), and intractable pain(1), the obstacles included delayed union(3) and premature consolidation(1), the complication included nonunion(9) and equinus ankle(1). At an average 1 years follow up, according to Paley and Catagnl's classification, body and functional results were either excellent or good in 7 cases. So, we recommend that Ilizarov technique is very useful treatment for open fracture with bone loss, bone defect after removal of infected necrotic bone and limb shortening.
Busan
;
Classification
;
Congenital Abnormalities
;
Extremities
;
Follow-Up Studies
;
Fractures, Comminuted
;
Fractures, Open
;
Humans
;
Ilizarov Technique
;
Knee
;
Leg
;
Orthopedics
;
Skin
;
Surgeons
;
Tibia
;
Transplants
3.Expression of BMP4, BMP6 following sinus elevation with DBBP in rabbit
Hyun Suk LEE ; Hyun A HEO ; Sung Woon PYO ; Won LEE
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2007;29(6):467-473
0.05). 2. The expression of BMP6 increased at postoperative 1 and 3 days in both DBBP group and AGS group. In AGS group, it decreased at postoperative 5 days, increased again at postoperative 7 days, and decreased at postoperative 9 days. In DBBP group, it increased until postoperative 7 days and decreased at postoperative 9 days. Although the expression of BMP6 was higher in AGS group compared with DBBP group, it was not statistically significant (p>0.05). 3. There was no statistically significant difference in BMP expression in both groups during same period of time. It's probably because DBBP and AGS both functioned as a space retainer so that the BMP expression in blood clot seemed to be similar. 4. Thus, DBBP would not offer many benefits for early bone regeneration compared with AGS. The expression of BMP in early bone formation seems to be more influenced by physical carrier rather than the graft type.]]>
Animals
;
Bone Morphogenetic Proteins
;
Bone Regeneration
;
Chungcheongnam-do
;
Gelatin Sponge, Absorbable
;
Maxillary Sinus
;
Osseointegration
;
Osteogenesis
;
Rabbits
;
RNA
;
Transplants
4.Prognostic factors influencing outcomes in elderly patients with aneurysmal subarachnoid hemorrhage.
Se Hyun JOUNG ; Dong Youl RHEE ; Hwa Seung PARK ; Joon Suk SONG ; Weon HEO ; Do Hyung KIM
Korean Journal of Cerebrovascular Surgery 2007;9(3):198-205
OBJECTIVE: This study evaluated the prognostic factors that influence the surgical outcomes of elderly patients older than 65 years old with an aneurysmal subarachnoid hemorrhage. METHODS: Ninety-two patients older than 65 years old, who were operated in our hospital between 1998 and 2005, were reviewed retrospectively. The clinical outcomes were evaluated using the modified Rankin Scale three months after surgery. RESULTS: The preoperative neurological status, such as the Hunt-Hess grade (p<0.001), World Federation of Neurological Surgeons (WFNS) grade (p<0.001), and the Fisher grade (p=0.001), was significantly associated with the surgical outcomes in this series. The vasospasm (0.016) and ventriculostomy (0.039) are factors influencing the surgical outcomes. However, the other factors including hypertension (0.831), smoking (0.228), accompanying disorder (0.706), size of aneurysms (0.177), location of aneurysms (0.755), shunt operation (0.356), and timing of surgery (0.194) had no influence on the surgical outcome. CONCLUSION: In elderly patients with intracranial aneurysms, the preoperative neurological status, vasospasm, and ventriculostomy are the most significant prognostic factors.
Aged*
;
Aneurysm*
;
Humans
;
Hypertension
;
Intracranial Aneurysm
;
Retrospective Studies
;
Smoke
;
Smoking
;
Subarachnoid Hemorrhage*
;
Ventriculostomy
5.Traumatic Liver Injury: Factors Associated with Mortality.
Youn Suk CHAI ; Jae Kwang LEE ; Seok Jin HEO ; Yeong Ki LEE ; Yong Woo LEE ; Young Hwa JO ; Seong Soo PARK ; Hyun Jin KIM ; In Gu KANG
Korean Journal of Critical Care Medicine 2014;29(4):320-327
BACKGROUND: We postulate that a delay in the implementation of hepatic arterial embolization for traumatic liver injury patients will negatively affect patient prognosis. Our work also seeks to identify factors related to the mortality rate among traumatic liver injury patients. METHODS: From January 2008 to April 2014, patients who had been admitted to the emergency room, were subsequently diagnosed with traumatic liver injury, and later underwent hepatic arterial embolization were included in this retrospective study. RESULTS: Of the 149 patients that underwent hepatic arterial embolization, 86 had the procedure due to traumatic liver injury. Excluding the 3 patients that were admitted to the hospital before procedure, the remaining 83 patients were used as subjects for the study. The average time between emergency room arrival and incidence of procedure was 164 min for the survival group and 132 min for the non-survival group; this was not statistically significant (p = 0.170). The average time to intervention was 182 min for the hemodynamically stable group, and 149 min for the hemodynamically unstable group, the latter having a significantly shorter wait time (p = 0.047). Of the factors related to the mortality rate, the odds ratio of the Glasgow Coma Score (GCS) was 18.48 (p < 0.001), and that of albumin level was 0.368 (p = 0.006). CONCLUSIONS: In analyzing the correlation between mortality rate and the time from patient admission to arrival for hepatic arterial embolization, there was no statistical significance observed. Of the factors related to the mortality rate, GCS and albumin level may be used as prognostic factors in traumatic liver injury.
Coma
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Embolization, Therapeutic
;
Emergency Service, Hospital
;
Humans
;
Incidence
;
Liver*
;
Mortality*
;
Odds Ratio
;
Patient Admission
;
Prognosis
;
Retrospective Studies
;
Time Factors
6.Effects of Argon Laser Iridotomy on the Corneal Endothelium of Pigmented Rabbit Eyes.
Jie Hyun YOUM ; Jeong Hwa HEO ; Hyo Myung KIM ; Jong Suk SONG
Korean Journal of Ophthalmology 2014;28(1):76-82
PURPOSE: In Asian countries, laser iridotomy for the treatment of angle-closure glaucoma is a common cause of bullous keratopathy, which may be associated with a shallow anterior chamber and dark iris pigmentation in Asians. Several cases of corneal decompensation after argon laser iridotomy have been reported. In the present study, we evaluated the harmful effects of argon laser iridotomy on the corneal endothelium. METHODS: Argon laser iridotomy was performed on the right eyes of pigmented rabbits. Changes in corneal thickness and endothelial cell density after laser iridotomy were evaluated. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was performed for assessment of corneal endothelial cell apoptosis. Combined staining with alizarin red and trypan blue, as well as a live/dead cell assay, were performed for evaluation of damage to the corneal endothelium induced by laser iridotomy. RESULTS: Corneal thickness did not change immediately after laser iridotomy; however, a significant increase was observed 24 hours after iridotomy (p = 0.001). The endothelial cell density of laser-treated eyes four days after laser iridotomy was significantly decreased compared with control eyes (p < 0.001). TUNEL staining showed many TUNEL-positive cells in the corneal endothelium and corneal stroma. No endothelial trypan blue-stained cell nuclei were observed after laser iridotomy; however, several large endothelial cells with damaged membrane integrity were observed. The live/dead cell assay clearly showed a large number of dead cells stained red in several areas throughout the entire corneal button 24 hours after iridotomy. CONCLUSIONS: Argon laser iridotomy induces corneal endothelial cell apoptosis in pigmented rabbit eyes, resulting in decreased endothelial cell density.
Animals
;
Apoptosis
;
Corneal Diseases/pathology/*surgery
;
Disease Models, Animal
;
Endothelium, Corneal/*pathology
;
In Situ Nick-End Labeling
;
Iris/*surgery
;
Laser Therapy/*methods
;
Lasers, Gas/*therapeutic use
;
Ophthalmologic Surgical Procedures/*methods
;
Rabbits
7.Effects of Argon Laser Iridotomy on the Corneal Endothelium of Pigmented Rabbit Eyes.
Jie Hyun YOUM ; Jeong Hwa HEO ; Hyo Myung KIM ; Jong Suk SONG
Korean Journal of Ophthalmology 2014;28(1):76-82
PURPOSE: In Asian countries, laser iridotomy for the treatment of angle-closure glaucoma is a common cause of bullous keratopathy, which may be associated with a shallow anterior chamber and dark iris pigmentation in Asians. Several cases of corneal decompensation after argon laser iridotomy have been reported. In the present study, we evaluated the harmful effects of argon laser iridotomy on the corneal endothelium. METHODS: Argon laser iridotomy was performed on the right eyes of pigmented rabbits. Changes in corneal thickness and endothelial cell density after laser iridotomy were evaluated. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was performed for assessment of corneal endothelial cell apoptosis. Combined staining with alizarin red and trypan blue, as well as a live/dead cell assay, were performed for evaluation of damage to the corneal endothelium induced by laser iridotomy. RESULTS: Corneal thickness did not change immediately after laser iridotomy; however, a significant increase was observed 24 hours after iridotomy (p = 0.001). The endothelial cell density of laser-treated eyes four days after laser iridotomy was significantly decreased compared with control eyes (p < 0.001). TUNEL staining showed many TUNEL-positive cells in the corneal endothelium and corneal stroma. No endothelial trypan blue-stained cell nuclei were observed after laser iridotomy; however, several large endothelial cells with damaged membrane integrity were observed. The live/dead cell assay clearly showed a large number of dead cells stained red in several areas throughout the entire corneal button 24 hours after iridotomy. CONCLUSIONS: Argon laser iridotomy induces corneal endothelial cell apoptosis in pigmented rabbit eyes, resulting in decreased endothelial cell density.
Animals
;
Apoptosis
;
Corneal Diseases/pathology/*surgery
;
Disease Models, Animal
;
Endothelium, Corneal/*pathology
;
In Situ Nick-End Labeling
;
Iris/*surgery
;
Laser Therapy/*methods
;
Lasers, Gas/*therapeutic use
;
Ophthalmologic Surgical Procedures/*methods
;
Rabbits
8.Combined Major Vein Resection in Surgery for Biliary-Pancreatic Cancer.
Seung Chul HEO ; Sun Whe KIM ; Ki Hwan KIM ; Kyung Suk SUH ; Kuhn Uk LEE ; Yong Hyun PARK
Journal of the Korean Surgical Society 1998;54(4):570-576
Biliary-pancreatic cancers are frequently associated with vascular invasion, as well as adjacent organ invasion, due to their biologic and anatomical characteristics. These findings preclude the curative resection of these tumors due to the high mortality and morbidity following a combined vascular resection. The object of this study was to assess the safety and the effect on survival of the combined vascular resection for patients with biliary-pancreatic malignancies through an analysis of our experience. Fifteen biliary-pancreatic cancer patients underwent curative surgery, including major vascular resection, during the period from Mar. 1993 to Oct. 1996. The risk factors such as the operative mortality, the morbidity, operative time, demand for transfusion, postoperative hospital stay, and the pathological characteristics for the 12 patients who underwent pancreaticoduodenectomy(PD) with combined vascular resection were compared with those of 75 cases who underwent a PD without vascular resection from 1993 to 1995. After resections and reconstructions of superior mesenteric and portal veins, vascular patencies were mostly well preserved, and there were no damage to the liver function. Combined vascular resection did not increase the mortality, the morbidity, the hospital stay, or the operative risk. With respect to pathologic characteristics, tumors with vascular invasion did not have more metastases to the lymph node, but did have more frequent perineural invasions and were slightly larger in size. Vascular invasion alone is not a contraindication to curative resection of biliary-pancreatic cancers and combined vascular-superior mesenteric and portal vein-resection should be considered in selected cases in which histologically curative resection is possible.
Humans
;
Length of Stay
;
Liver
;
Lymph Nodes
;
Mortality
;
Neoplasm Metastasis
;
Operative Time
;
Pancreaticoduodenectomy
;
Portal Vein
;
Risk Factors
;
Vascular Patency
;
Veins*
9.Catheter-directed Thrombolysis of Below-Knee Deep Venous Thrombosis of the Lower Extremities.
Byung Suk ROH ; Young Jun SOHN ; Eun A HEO ; Hyun Sun CHO ; Seong Hoon PARK ; Young Hwan LEE
Journal of the Korean Radiological Society 2008;58(2):121-125
PURPOSE: To evaluate the technical feasibility and clinical efficacy of the use of local thrombolysis for below-knee deep vein thrombosis (DVT). MATERIALS AND METHODS: From a population of 41 patients with a lower extremity DVT, the prospective clinical trial included 11 patients (7 female, 4 male, average age 61.4 years) treated with catheter-directed thrombolysis with urokinase for below-knee DVT. After removal of the proximal ilofemoral DVT, additional interventional procedures to remove the residual thrombus and restore the venous flow from the below-knee vein were performed in cases of continuous occlusion of venous flow from the popliteal and tibial veins. Under ultrasound (US) guidance, catheter-directed thrombolysis with urokinase was performed through the ipsilateral popliteal vein. After administration of oral anticoagulation therapy, CT and venography were performed to identify patency and the presence of a recurrent thrombosis. RESULTS: Successful removal of the thrombus and restoration of venous flow were achieved in all of the patients (100%). Restoration of flow with a residual thrombus occurred in one case. Focal venous stenosis was discovered in four cases. The duration of urokinase infusion was 1-4 days (average 2.36 days), which was considered long. For 15.2 months, the venous lumen of all cases was preserved without a recurrent thrombosis. CONCLUSION: Catheter-directed thrombolysis is an effective procedure for recanalization of below-knee DVT in patients with a lower extremity DVT.
Constriction, Pathologic
;
Female
;
Humans
;
Lower Extremity
;
Male
;
Phlebography
;
Popliteal Vein
;
Prospective Studies
;
Thrombolytic Therapy
;
Thrombosis
;
Urokinase-Type Plasminogen Activator
;
Veins
;
Venous Thrombosis
10.The Studies on the Development of Human Blastocyst Embryos in IVF-ET Program. II. The Development of Human Blastocyst Embryos by co-culture with Cumulus Cells.
Suk Won LEE ; San Hyun YOON ; Hye Gyun YOON ; Hyon Jin CHO ; Yong Soo HEO ; Hye Jin YOON ; Se Pill PARK ; Won Don LEE ; Jin Ho LIM
Korean Journal of Fertility and Sterility 1998;25(1):35-42
This study was carried out to investigate the development rates of human embryos co-cultured with cumulus cells to each blastocyst stage. Human zygotes were co-cultured on cumulus cell monolayer in YS medium supplemented with 20% hFF. On day 2, if patient had four or more 'good' embryos(regular blastomeres without fragmentation), embryos were further cultured for 72hrs. Blastocysts on day 5 were classified into early blastocyst (ErB), early expanding blastocyst (EEB), middle expanding Blastocyst (MEB), and expanded blastocyst (EdB) on the basis of their morphological aspects of trophectoderm cells and blastocoele. Subsequently, maximum 3 of best blastocysts were transferred in 486 cycles. The results in this study were as follows: Patients who had four or more 'good' embryos on day 2 were 498 persons, but patients whose embryos could not be transferred due to failure in development to the blastocyst stage on day 5 were 12 persons (2.4%). The development rate of embryos to the blastocyst stage was 58.2% (2,885/4,957) on day 5, and the rates that developed to the ErB, EEB, MEB, and EdB stage were 15.0% (743/4,957), 14.9% (739/4,957), 14.4% (714/4,957), and 13.9% (689/4,957), respectively. Total 1366 blastocysts were transferred in 486 cycles (mean number=2.81). The implantation rate and the ongoing implantation rate obtained by observing the number of G-sac and FHB were 29.9% (409/1,366) and 22.5% (308/1,366), respectively. The clinical pregnancy rate was 51.2% (249/486), and the ongoing pregnancy rate was 39.1% (190/486). Among women showing ongoing pregnancy, women with singleton were 50% (95/190), women with twin were 37.9% (72/190), and women with triplet were 12.1% (23/190). Although triplet pregnancy rate in this study was high such as 12.1%, because many blastocysts with high viability were produced in our co-culture system using cumulus cells on day 5, we really believe that a multiple pregnancy except twin should not occur by selecting good embryos for maximum two blastocyst transfer. These results demonstrate that autologous cumulus cells may be used for the production of blastocysts with high developmental competence, and the use of autologous cumulus cells to be collected easily, and to be treated conveniently at OPU must be an effective means for obtaining high implantation and pregnancy rate.
Blastocyst*
;
Blastomeres
;
Coculture Techniques*
;
Cumulus Cells*
;
Embryo Transfer
;
Embryonic Structures*
;
Female
;
Humans*
;
Mental Competency
;
Pregnancy
;
Pregnancy Rate
;
Pregnancy, Multiple
;
Pregnancy, Triplet
;
Triplets
;
Zygote