One hundred and forty-five specimens of positive bacteriology, obtained from patients admitted to the Orthopedic Department of Seoul National University Hospital during the period from January, 1970 to March, 1973, were reviewed with respect to their causative microorganisms and antibiotic sensitivity. The results were also compared with reports previously published from the same department. Following observations were made: 1. The identified microorganisms were of 9 species. Of these, the coagulase positive and negative Staphylococcus continues to be the most frequent offender occupying 62.1% of the total. 2. Of the Staphylococcus, the penicillin-resistant strains were proved in 84.6% of the series, a significant increase over the previous reports. 3. The Streptococcus, formerly the second-most frequent causative organism, occupied only 4.0% of the total suggesting a marked decrease in incidence over the last decade. 4. On the other hand, the Pseudomonas occupied 11.7% of the total when mixed infections are included and together with other Gram-negative bacilli revealed a remarkable increase in incidence during the same period.
Bacteriology ; Coagulase ; Coinfection ; Criminals ; Hand ; Humans ; Incidence ; Orthopedics ; Pseudomonas ; Seoul ; Staphylococcus ; Streptococcus

No abstract available.
Female ; Ovarian Cysts*

Infection is one of the most serious complications following total hip replacement arthroplasty. Many modifications of procedures have been advocated in order to reduce the rate of infection with varying success. Incorporation of antibiotic to bone cement is one such approach. However, there still remains some reluctancy to adopt this method on account of dubious antibiotic effect at the expense of weakening of physical properties. Possible emergence of resistant organisms and hypersensitivity are additional drawbacks to be considered. The present experiments were undertaken to study the effectiveness of antibacterial activity of cement-antibiotic admixtures in vitro and in vivo as well as change of physical properties produced by the incorporation. As conclusions, antibiotic-mixed bone cements have evident effects on growth of inoculated organisms sensitive to added antibiotics whereas cured bone cement itself has been proved not to have any antibacterial activity. The leaching of antibiotics occurs fairly soon, the great majority of the amount within several days. The rest shows slow, delayed leaching over period of three weeks. The weakening of physical properties was not so significant to forbid the application. Resistance to tensile and bending stress was more reduced than that to compression stress. The mixing of two antibiotics(Cephaloridine and Gentamicin powder) together to bone cement revealed double-edged effectiveness to either of gram-positive or negative organisms without any significant illeffects on hardness of cured cement, It is suggested that mixture of two antibiotics to bone cement renders broader blind coverage to unknown causative micro-organisms of postoperative deep infection of total hip replacement arthroplasty.
Anti-Bacterial Agents ; Arthroplasty ; Arthroplasty, Replacement, Hip ; Bone Cements ; Gentamicins ; Hardness ; Hypersensitivity ; In Vitro Techniques ; Methods ; Microbial Viability ; Polymethyl Methacrylate

Neurofibromat osis is a familial discase with widespread manifestations such as lesions of the skin, tumors of the central and peripheral nervous system and abnormalities of bone. The presence of at least two of the following features was considered for diagnostic criteria; positive family history, positive blopsy, a minimum of six cafe-au-lait spots each with a diameter of at least 1.5 cm and multiple subcutaneous nodules. From January 1971 to December 1979, 17 patients of neurofibromatosis and 30 patients of neuro- fibroma treated at Yonsei Medical Center were clinically analized for the study and the results obtained from this study were as follows; 1. Positive family history was obtained In 2 per cent of cases with neurofibromatosis. 2. Cafe-au-lait spots or tumors were the most common findings in neurofibromatosis. The bone changes were presented in 8 patients(45 per cent) and scoliosis has been In 62.5 per cent of them. 3. The location of the neurofibroma was variable. Central nervous sustem was involved in 40.4 per cent and peripheral nervous system in 59.4 per cent. 4. Myelography and determinations of the cerebro-spinal fluid protein concentration led us to a correct diagnosis of the neurofibroma which involved the spinal cord. For the treatment of the neurofibroma, 9 out of 30 patients were performed laminectomies and excision of the intradural masses, and one of them was flxed the spinous processes with a plate and wires after laminectomy for prevent spinal instability. 5. in 3 patients with progressive scoliosis, the best results were obtained with early Harrington instrumentation and posterior fusion.
Cafe-au-Lait Spots ; Chymopapain ; Clinical Study ; Diagnosis ; Fibroma ; Humans ; Laminectomy ; Myelography ; Neurofibroma ; Neurofibromatoses ; Peripheral Nervous System ; Scoliosis ; Skin ; Spinal Cord

The giant cell tumor is a primary. neoplasm of bone characterized histollogically by a vascularized network of plumpish or ovoid stromal cells heavily interposed with multinucleated giant cells. The majority of cases occur in patients between 20 and 40 years old and in the long tubular bones, particuarly in proximity to the epiphysis. A rare case of giant cell tumor involving the patella was recently experienced by authors. Case summary with brief review of reference is presented.
Epiphyses ; Giant Cell Tumors ; Giant Cells ; Humans ; Patella ; Stromal Cells

No abstract available.
Osteogenesis Imperfecta* ; Osteogenesis* ; Osteotomy*

No abstract available.
Female ; Methotrexate* ; Pregnancy ; Pregnancy, Tubal*

PURPOSE: To evaluate the optimal pulse sequences in the detection of erosions and for the discrimination of theeffusion from pannus. MATERIALS AND METHODS: MR studies were performed in thirteen patients with clinical diagnosis of rheumatoid arthritis. We used a 1.5T MR unit with single or dual 3 inch coil. We compared coronal images at the same location, obtained with pulse sequences of T2, T2 with fat saturation, and postcontrast T1 with fat suppression. Erosions were assessed by comparing the count of the numbers of erosions depending on each imaging method. A four point scoring systems was used for the comparison of conspicuitof lesion. RESULTS: T2WI with fat suppression and postcontreat T1WI with fat suppresison were better than conventional T2WI in the detection of erosions. The pannus had a heterogeneous signal on T2WI, some of which were enhanced after the intravenous injection of MR contrast a gents. CONCLUSION: We suggest that the fat suppression TIWI with enhacnement or the fat suppression T2WI were better than conventional T2WI for detecting both bone erosion and pannus. The postcontrast MR imaging may often be helpul in distinguishing pannus from the effusion.
Arthritis, Rheumatoid* ; Diagnosis ; Discrimination (Psychology) ; Humans ; Injections, Intravenous ; Magnetic Resonance Imaging* ; Wrist*

No abstract available.
Diagnosis* ; Magnetic Resonance Imaging* ; Spondylitis*

No abstract available.
Hemorrhage*