1.Effects of Tetrandrine on the Nitric Oxide Production by Vascular Smooth Muscle Cells of the Rat.
Gi Su OH ; Na Young KIM ; Hyun Ock BAE ; Youn Chul KIM ; Jong Hyun HAN ; Young Myung KIM ; Byoung Sun AHN ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):247-252
No abstract available.
Animals
;
Muscle, Smooth, Vascular*
;
Nitric Oxide*
;
Rats*
2.Comparative Effects of Paclitaxel and Nitric Oxide on Superficial Murine Bladder Tumor Cells.
Byoung Sun AHN ; Hyun Jeong KWAK ; Hyun Ock BAE ; Ji Chang YOO ; Chang Duk JUN ; Jeong Sik RIM ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):235-245
No abstract available.
Nitric Oxide*
;
Paclitaxel*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
3.A Case of Incomplete Congenital Duodenal Diaphragm Presented as Hematemesis.
Hee Hyun YEOM ; Ki Beom KWON ; Kyung Bae PARK ; Joon Soo PARK ; Jae Ock PARK ; Young Tong KIM
Korean Journal of Pediatric Gastroenterology and Nutrition 2005;8(1):64-69
We have experienced a case of incomplete congenital duodenal diaphragm with a foreign body (a button), which was found by endoscopy in a 13 month-old girl. She had symptoms of hematemesis, vomiting and bloody stool for a day probably due to foreign body impaction.
Diaphragm*
;
Endoscopy
;
Female
;
Foreign Bodies
;
Hematemesis*
;
Humans
;
Infant
;
Vomiting
4.Effects of Rhodiola Sachalinensis on Nitric Oxide Synthesis by Macrophages, Hepatocytes, and Vascular Smooth Muscle Cells.
Hwa Kyung LEE ; Min Kyo SHIN ; Hyun Ock BAE ; Won Gil SEO ; Gi Su OH ; Byoung Sun AHN ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):229-234
No abstract available.
Hepatocytes*
;
Macrophages*
;
Muscle, Smooth, Vascular*
;
Nitric Oxide*
;
Rhodiola*
5.Factors Influencing Human Papillomavirus Vaccination Adoption Stages Based on the Precaution Adoption Process Model.
Eun Nam LEE ; Sun Hyoung BAE ; Eun Hui CHOI ; Hyun Ju HWANG ; Young Ock LEE ; Jeong Lim CHO
Asian Oncology Nursing 2015;15(2):89-96
PURPOSE: This study aimed to identify the factors influencing human papillomavirus (HPV) vaccination adoption stages using the Precaution Adoption Process model. METHODS: A total of 173 female university students from B metropolitan city participated. Demographics, factors contributing to action, knowledge, health beliefs, and self-efficacy related to the HPV vaccination were measured. The collected data were analyzed using descriptive statistics and multiple logistic regression analysis using SPSS for Windows version 21.0. RESULTS: Factors that contributed to the transition from the unaware and unengaged stages to the undecided about action stage included age, economic status, experience of recommendation from doctors, perceived severity of cervical cancer, and perceived barriers. Factors that contributed to the transition from the undecided about action stage to the deciding to act stage were perceived benefit and self-efficacy of the HPV vaccination. Factors that contributed to the transition from the deciding to act stage to the acting and maintenance stages were experience of recommendation from doctors and perceived severity of cervical cancer. CONCLUSION: These results suggest that aggressive HPV vaccination campaigns increase awareness. Further studies should develop tailored strategies for promoting HPV vaccination that emphasize health beliefs and self-efficacy.
Demography
;
Female
;
Humans
;
Logistic Models
;
Papillomavirus Vaccines
;
Uterine Cervical Neoplasms
;
Vaccination*
6.Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma
Min-Kyung YEO ; Go Eun BAE ; Dong-Hyun KIM ; In-Ock SEONG ; Kwang-Sun SUH
Journal of Pathology and Translational Medicine 2022;56(5):260-269
Background:
Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnosis falls short of a definitive diagnosis of GEA and is often categorized as atypical glandular cells (AGCs). To improve cytologic recognition, cytological findings of HPV-independent GEA were analyzed and the results compared with HPV-associated UEA.
Methods:
Cervical Papanicolaou (Pap) smears from eight patients with a histopathologic diagnosis of GEA and 12 control cases of UEA were reviewed. All slides were conventionally prepared and/or liquid-based prepared (ThinPrep) and stained following the Pap method. A mucinous background, architectural, nuclear, and cytoplasmic features were analyzed and compared with UEA.
Results:
Preoperative cytologic diagnoses of the eight GEA cases were AGCs, favor neoplastic in three cases, adenocarcinoma in situ in one case, and adenocarcinoma in four cases. Cytologically, monolayered honeycomb-like sheets (p = .002) of atypical endocervical cells with vacuolar granular cytoplasm (p = .001) were extensive in GEA, and three-dimensional clusters (p = .010) were extensive in UEA. Although the differences were not statistically significant, background mucin (p = .058), vesicular nuclei (p = .057), and golden-brown intracytoplasmic mucin (p = .089) were also discriminatory findings for GEA versus UEA.
Conclusions
Although GEA is difficult to diagnose on cytologic screening, GEA can be recognized based on cytologic features of monolayered honeycomb sheets of atypical endocervical cells with abundant vacuolar cytoplasm and some golden-brown intracytoplasmic mucin. UEA cases are characterized by three-dimensional clusters.
7.Melatonin Rescues Human Dental Pulp Cells from Premature Senescence Induced by H₂O₂.
Sera PARK ; Kwang Je BAK ; Chang Youp OK ; Hyun Joo PARK ; Hye Ock JANG ; Moon Kyoung BAE ; Soo Kyung BAE
International Journal of Oral Biology 2017;42(3):91-97
Although anti-aging activities of melatonin, a hormone secreted by the pineal gland, have been reported in senescence-accelerated mouse models and several types of cells, its impact and mechanism on the senescence of human dental pulp cells (HDPCs) remains unknown. In this study, we examined the impact of melatonin on cellular premature senescence of HDPCs. Here, we found that melatonin markedly inhibited senescent characteristics of HDPCs after exposure to hydrogen peroxide (H₂O₂), including the increase in senescence-associated β-galactosidase (SA-β-gal)-positive HDPCs and the upregulation of p21 protein, an indicator for senescence. In addition, as melatonin attenuated H₂O₂-stimulated phosphorylation of c-Jun N-terminal kinase (JNK), while selective inhibition of JNK activity with SP600125 significantly attenuated H₂O₂-induced increase in SA-beta-gal activity. Results reveal that melatonin antagonizes premature senescence of HDPCs via JNK pathway. Thus, melatonin may have therapeutic potential to prevent stress-induced premature senescence, possibly correlated with development of dental pulp diseases, and to maintain oral health across the life span.
Aging*
;
Animals
;
Dental Pulp Diseases
;
Dental Pulp*
;
Humans*
;
Hydrogen Peroxide
;
JNK Mitogen-Activated Protein Kinases
;
MAP Kinase Signaling System
;
Melatonin*
;
Mice
;
Oral Health
;
Phosphorylation
;
Pineal Gland
;
Up-Regulation
8.Bronchial Artery Embolization for Massive Hemoptysis in a Patient with Behcet's Disease.
Yong Gil KIM ; Heung Kyu KO ; Ock Bae KO ; Taeg Soo KIM ; Hyun Woo KIM ; Chang Keun LEE ; Bin YOO ; Hee Bom MOON
The Journal of the Korean Rheumatism Association 2005;12(4):311-314
Behcet's disease is an important cause of fatal vasculitis in young adult males and vascular involvement has been reported in more than 25% of patients. Pulmonary vascular involvement has been found in 1~7.7% of patients and is known to be related to poor prognosis. A incidence of fatal hemoptysis is high in patients whose Behcet`s disease is complicated by pulmonary artery aneurysm (PAA). The recurrence of hemoptysis in PAA of Behcet's disease may result from inadequate medical therapy and complications of surgical treatment. We report a case with Behcet's disease whose fatal hemoptysis has been successfully treated with bronchial artery embolization.
Aneurysm
;
Bronchial Arteries*
;
Hemoptysis*
;
Humans
;
Incidence
;
Male
;
Prognosis
;
Pulmonary Artery
;
Recurrence
;
Vasculitis
;
Young Adult
9.Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells.
Hye Ock JANG ; Hyun Sup EOM ; Sung Bae ROH ; Il YUN
The Korean Journal of Physiology and Pharmacology 2005;9(1):55-62
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the present study, 3microliter of 0.1% dried crude extract or 2microliter of 0.1% dried aqueous fraction were shown to significantly accelerate the rate of differentiation of osteoblast. Also, the crude extract and aqueous fraction increased the [Ca2+]i of the cultured osteoblast cells: 3microliter of 0.1% dried crude extract and 2microliter of 0.1% dried aqueous fraction significantly increased the [Ca2+]i of the cultured osteoblast cells (8x104) to the extent that it deserves a considerable attention. Furthermore, the crude extract and aqueous fraction increased the [Ca2+]i of the cultured osteoblast cells, and 300microM Cd2+, specific calcium channel blocker, completely blocked the increase. Therefore, the increased [Ca2+]i of the cultured osteoblast cells by safflower seed component continued to activate calcium channel.
Calcium Channels
;
Calcium*
;
Carthamus tinctorius*
;
Deficiency Diseases
;
Osteoblasts*
;
Osteoporosis
10.Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells.
Yun Hee BAE ; Jong Hyo RYU ; Hyun Joo PARK ; Kwang Rok KIM ; Hee Jun WEE ; Ok Hee LEE ; Hye Ock JANG ; Moon Kyoung BAE ; Kyu Won KIM ; Soo Kyung BAE
The Korean Journal of Physiology and Pharmacology 2013;17(4):291-297
Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.
Apoptosis
;
Axis, Cervical Vertebra
;
Breast
;
Breast Neoplasms
;
Chromatin Immunoprecipitation
;
Curcumin
;
Down-Regulation
;
Humans
;
RNA, Small Interfering