This report is a review of experience with 45 patients plication methods of redundant rectal mucosa by longitudinal over and over suture who were admitted in department of surgery at Dongsan sacred Heart Hospital during 1997. This new technique was indicated by incomplete rectal prolapse, first degree complete rectal prolapse (internal rectal intussusception), 3rd degree hemorrhoids, redundant rectal mucosa in operation field, anal prolapse and severe external anal skin tag. At first, entire hemorrhoid-bearing area was dissected by excision and ligation methods. Within upward 1cm from ligationpoint, No.3 chromic catgut suture was done including rectal submucosa. Starting from this, linear continueous overlapping locking suture was done until redundant mucosa was tented by Chromic suture traction in range of 1 to 1.5 cm widths. If there is wide redundant mucosa not corrected one time, another linear continuous overlapping locking suture especially not circular may be done. This method is very easy and few complication-bleeding, pain, infection, mucosa loss, etc. The patients who have incomplete defecation sensation, rectocele and skin tag were satisfied with operation. This method may be an easy, effective new technique in patients who have anal prolapse, skin tag, rectocele and constipation etc.
Catgut ; Constipation ; Defecation ; Heart ; Hemorrhoids ; Humans ; Ligation ; Mucous Membrane* ; Prolapse ; Rectal Prolapse ; Rectocele ; Sensation ; Skin ; Sutures* ; Traction

No abstract available.
Diagnosis* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

No abstract available.
Animals ; Embryonic Development* ; Embryonic Structures* ; Female ; Mice* ; Pregnancy

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system, and skin. Neurofibromatosis is characterized by cafe au lait macules, neurofi- bromas, Lisch nodules, optic gliomas, bony dysplasia, intertriginous freckling, and autosomal inheritance. Juvenile xanthogranuloma(JXG) is a benign, self-healing disorder of infants, children, and occa- sionally adults, characterized by yellowish papulonodular lesions located in the skin and other organs and consisting of an infiltrate of histiocytes with a progressively greater degree of lipidation in the absence of metabolic disorders. In 1954 Normland reported the first case of a JXG in a child with numerous cafe au lait macules. Royer, in 1958, reported the triple association of JXG, neurofibromatosis, and leukemia. It is estimated that children with neurofibromatosis and JXG have a higher risk for leukemia than do patients with neurofibromatosis who do not have JXG. In patients with both JXG and neurofibromatosis, long-term follow-up is required because of the additional association with leukemia. We report a case of JXG associated with neurofibromatosis.
Adult ; Child ; Follow-Up Studies ; Histiocytes ; Humans ; Infant ; Leukemia ; Nervous System ; Neurofibromatoses* ; Neurofibromatosis 1 ; Optic Nerve Glioma ; Skin ; Wills ; Xanthogranuloma, Juvenile*

Squamous cell carcinoma(SCC) is a recognized late complication of chronic discoid lupus erythematosus(CDLE). There are many case reports of SCC in white patients with chronic DLE. However, it is uncommon in blacks and Asians. The etiology of squamous cell carcinoma is multifactorial. The predisposing factors for the development of SCC in these patients include actinic keratosis, Bowen's disease, burn scars, arsenic keratosis, and chronic discoid lupus erythematosus. Of these causes, SCC developing in the lesions of CDLE is very rare. We report a patient who has been evaluated for ten years with a diagnosis of discoid lupus erythematosus and has squamous cell carcinoma.
African Continental Ancestry Group ; Arsenic ; Asian Continental Ancestry Group ; Bowen's Disease ; Burns ; Carcinoma, Squamous Cell* ; Causality ; Cicatrix ; Diagnosis ; Humans ; Keratosis ; Keratosis, Actinic ; Lupus Erythematosus, Discoid*

Dermal melanocytosis is characterized by the presence of ectopic melanocytes in the dermis and shows several morphological forms, including the mongolian spot, the blue nevus, the nevus of Ota, the nevus of Ito, and dermal melanocyte hamartoma. A 30-month-old boy had a gray blue patch on the left deltoid region, upper back, sacral area, the entire length of the right arm, and right hand. There was a bluish speckled patch on the right palm. The lesions were present at birth, and no appreciable change in appearance had occurred. He also had blue to brownish pigmentation on the right side of his face with dark bluish pigmentation of the right sclera. His Mental and physical development had been normal. The histopathological examination revealed dendritic dermal melanocytes, mainly in the upper and mid dermis. Clinically and pathologically, the patient was diagnosed as having Ota nevus, Ito nevus, mongolian spot, and dermal melanocyte hamartoma. To our knowledge, dermal melanocytosis with 4 different morphological forms in a patient has not previously been reported. We report this unique case of dermal melanocytosis with various morphological forms.
Arm ; Child, Preschool ; Dermis ; Hamartoma ; Hand ; Humans ; Male ; Melanocytes ; Mongolian Spot ; Nevus ; Nevus of Ota ; Nevus, Blue ; Parturition ; Pigmentation ; Sclera

Latency within the nervous system is a characteristic feature of herpesviridae infection. It is reactivated by triggering factors such as UV exposure, stress, and trauma. Simultaneous reactivation of herpes simplex and herpes zoster is uncommon, however, an observation provably explained by differences in the trigerring mechanism. Concurrent reactivation of herpes simplex virus (HSV) and varicella zoster virus (VZV) is occasionally encountered in immunosuppressed patients; on the other hand, it is rarely reported in immunocompetent individuals. We present the case of an immunocompetent 8-yr-old female patient with concurrent reactivation of HSV on the face and VZV on the right L2 dermatome.
Buttocks/pathology/virology ; Child ; Face ; Female ; Herpes Simplex/complications/diagnosis/pathology/*virology ; Herpes Zoster/complications/diagnosis/pathology/*virology ; Herpesvirus 3, Human/*physiology ; Humans ; Immunocompetence ; Simplexvirus/*physiology ; Thigh/pathology/virology ; *Virus Activation

BACKGROUND: Arbutin is a glycosylated hydroquinone found at high concentration in certain plants capable of surviving extreme and sustained dehydration. It has been suggested as an inhibitory compound of melanogenesis. OBJECTIVE: The purpose of this study was to investigate the effect of arbutin on melanogenesis in cultured human melanocytes and to evaluate the effectiveness of arbutin in patients with melasma. METHODS: I. In vitro study:we examine the cell number, SRB assay, tyrosinase activity, and melanin contents of cultured human melanocytes in control(absence of arbutin) and experimental groups (presence of 10(-5) M, 10(-4) M, and 10(-3) M arbutin). II. In vivo study:6 patients with melasma applied a 3 % arbutin solution twice daily for 8 weeks. Clinical response to treatment was evaluated by patients' subjective assessment and MASI(Melasma Area and Severity Index) score after 8 weeks of treatment. RESULTS: I. In vitro study 1. The number of melanocytes was decreased in groups treated with 10(-5) M, 10(-4) M, 10(-3) M arbutin for 2 days and 10(-4) M, 10(-3) M arbutin for 7 days. 2. On SRB assay, the proliferation of melanocytes was decreased in groups treated with 10(-5) M, 10(-4) M, 10(-3) M arbutin for 2 days and for 7 days. 3. Tyrosinase activity was decreased in groups treated wtih 10(-4) M, 10(-3) M arbutin for 2 days and 10(-5) M, 10(-4) M, 10(-3) M arbutin for 7 days. 4. The melanin contents were decreased in group treated with 10(-3) M arbutin for 7 days. II. In vivo study 1. On patients'subjective assessment, one showed moderate improvement, one showed mild improvement, and the other four showed no change. 2. On MASI score, there was less than 10% improvement in all 6 patients. 3. Side effects were not found in all 6 patients. CONCLUSION: Although arbutin showed an inhibitory effect on cell proliferation, tyrosinase activity, and melanin synthesis in cultured human melanocytes, there was no significant effect of depigmentation in the patients with melasma.
Arbutin* ; Cell Count ; Cell Proliferation ; Dehydration ; Humans ; Melanins ; Melanocytes ; Melanosis ; Monophenol Monooxygenase

This study was done to identify the association between serum copper and zinc levels and the cirrhosis and hepatocellular carcinoma(HCC), and to evaluate its diagnostic value on liver diseases. Sixty-three healthy persons, 60 patients with cirrhosis and 33 patients with hepatocellular carcinoma were rendomly selected and investigated for their general characteristics from October 1990 to August 1991. For analysis of the biochemical markers in liver function test and the serum copper and zinc levels, their fasting venous blood were sampled at 9:00 to 11:00 in the morning and centrifuged to separate the serum within one hour. All the samples were immediately analysed for biochemical markers and stored at -20 C in polypropylene tubes further copper and zinc analysis. Mean of serum copper levels was 91.97+/-4.76 microgram/dl in control, 106.21+/-2.73 microgram/dl in cirrhosis and 127.05+/-0.77 microgram/dl in HCC. The value of HCC was statistically significantly higher than that of the control and cirrhosis(p<0.05). Serum zinc levels were 110.82+/-7.24 microgram/dl in control, 68.10+/-5.43 microgram/dl in cirrhosis and 63.78+/-2.20 microgram/dl in HCC. The values of cirrhosis and HCC were statistically significantly different among three groups(p<0.05). Test total protein, albumin, ALP and total bilirubin of biochemical markers of liver function were statistically significantly different among three groups(p<0.05). Differences between cirrhosis and HCC for ALT and AST, and between the control and HCC for direct bilirubin were not statistically significant. Biochemical markers statistically significantly correlated with serum copper and zinc levels and Cu/Zn ratio(p<0.05), were variable in three groups. In multiple logistic regression, odds ratio of serum copper level and Cu/Zn ratio had no statistically significance on the cirrhosis and the HCC, but that of serum zinc was statistically significant as 0.951 and 0.952 (p<0.05). Serum copper and zinc levels and Cu/Zn ratio were not statistically significantly different between the cirrhosis and HCC. Albumin, ALP, zinc, total bilirubin and age among all variables were selected as main variables for three-group discriminant analysis. Percentage of "grouped" cases correctly classified by these five variables was 98.4 for control, 73.4 for cirrhosis, 75.7 for HCC and 84.0 for all subjects. This study suggests that zinc may has an independently inhibitory effect on the liver disease and serum zinc level is considered to play a role as diagnostic marker on the hepatic disorders and be more useful than serum copper level and Cu/Zn ratio in diagnosis of the liver diseases.
Bilirubin ; Biomarkers ; Carcinoma, Hepatocellular* ; Copper* ; Diagnosis ; Fasting ; Fibrosis ; Humans ; Liver Cirrhosis* ; Liver Diseases ; Liver Function Tests ; Liver* ; Logistic Models ; Odds Ratio ; Polypropylenes ; Zinc*

No abstract available.
Lymphangioma, Cystic* ; Turner Syndrome* ; Ultrasonography*