Intermittent Exotropia has been treated by various surgical methods such as bilateral medial rectus resection, lateral rectus recession and medial rectus resection of deviating eye, and bilateral lateral rectus recession. However, the outcomes of such operations are unsatisfactory because of high incidence of postoperative undercorrection and overcorrection. Authors have performed a surgical method which is the medial rectus muscle resection of dominant eye and lateral rectus muscle recession of non-dominant eye in 68 patients. Authors considered the outcome successful if patients achieve deviation between 10 PD of exophoria and 5 PD of esophoria, good stereopsis, no suppression and no manifest deviation. The success rate was 83.8% (57/68) and there was no overcorrection over 6 months follow-up. As postoperative complications, 5 cases of temporary turning of face and 3 cases of asymmetric palpebral fissure were seen. Therefore, these results suggest that medial rectus resection of dominant eye and lateral rectus recession of non-dominant eye in intermittent exotropia may be an alternative surgical method for intermittent exotropia. However, further studies are necessary to determine the exact surgical amounts and mechanism of this surgical method.
Depth Perception ; Esotropia ; Exotropia* ; Follow-Up Studies ; Humans ; Incidence ; Postoperative Complications

No abstract available.
Incontinentia Pigmenti*

BACKGROUND: Understanding the differentiation and migrating character of the tympanic membrane, external auditory canal as well as cholesteatoma pathogenesis needs knowledge about epithelial generation center. OBJECTIVE: We investigated the distribution of the epithelial generation center in the tympanic membrane and external auditory canal using 5-bromo-2-deoxyuridine(BrdU) immunohistochemistry. MATERIALS AND METHODS: BrdU was injected into peritoneum of 10 Mongolian gerbils and gerbil's temporal bones were obtained and serial section was done. Anti-BrdU antibody immunohistochemical stain was done. RESULTS: The labeling index was highest at posterosuperior quadrant of pars tensa, higher at malleus handle attached area and annulus region. On pars flaccida, labeling index was high at entire area. The labeling index of deep meatal skin was higher than that of lateral meatal skin, especially near annulus area. According to results, epithelial generation centers are thought to be on pars flaccida, posterosuperior quadrant of pars tensa, malleus handle attached area and annulus region. CONCLUSION: These findings are similar to those of human tympanic membrane and external auditory canal, and gerbils can be used as a animal model for study of normal human tymapnic membrane, external auditory canal and cholesteatomas.
Bromodeoxyuridine ; Cholesteatoma ; Ear Canal* ; Gerbillinae* ; Humans ; Immunohistochemistry ; Malleus ; Membranes ; Models, Animal ; Peritoneum ; Skin* ; Temporal Bone ; Tympanic Membrane*

No abstract available.

Objectives: ：The purpose of this study is to compare bleeding tendency of selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitors (SNRI) using platelet function analyzer (PFA-100) in patients with major depressive disorder. Methods: ：This study is a prospective open-label study conducted by a single institution. A total of 41 subjects diagnosed with major depressive disorder under the DSM-5 diagnostic criteria participated in this study.The subjects were classified into SSRI (escitalopram) groups and SNRI (duloxetine) groups, respectively, according to random assignments. The closure time (CT) was measured using a platelet function analyzer (PFA-100) before each antidepressant was administered and after 6 weeks. Paired-sample t-test was conducted within each group to determine whether a specific antidepressant had an effect on closure time. In order to confirm the rela-tive change in platelet function between the two groups, an independent sample t-test was conducted to compare and analyze the change in closure time between the two groups. Results: ：There was no significant changes in closure time (CEPI-CT, CADP-CT) before and 6 weeks after drug administration in the SSRI and SNRI groups, and there was no difference in the amount of changes in closure time between the two groups. Conclusions ：Our results showed no difference in bleeding tendency between SSRI and SNRI. This study suggests that further large-scale studies on bleeding tendency for various antidepressants are needed in the future.

PURPOSE: To achieve maximal safe resection during brain tumor surgery, functional image-merged neuronavigation is widely used. We retrospectively reviewed our cases in which diffusion tensor image (DTI)-merged functional neuronavigation was performed during surgery. MATERIALS AND METHODS: Between November 2008 and May 2010, 123 patients underwent surgery utilizing DTI-merged neuronavigation. Anatomical magnetic resonance images (MRI) were obtained preoperatively and fused with DTI of major white matter tracts, such as the corticospinal tract, optic radiation, or arcuate fasciculus. We used this fused image for functional neuronavigation during brain tumor surgery of eloquent areas. We checked the DTI images together with postoperative MRI images and evaluated the integrity of white matter tracts. RESULTS: A single white matter tract was inspected in 78 patients, and two or more white matter tracts were checked in 45 patients. Among the 123 patients, a grossly total resection was achieved in 90 patients (73.2%), subtotal resection in 29 patients (23.6%), and partial resection in 4 patients (3.3%). Postoperative neurologic outcomes, compared with preoperative function, included the following: 100 patients (81.3%) displayed improvement of neurologic symptoms or no change, 7 patients (5.7%) experienced postoperative permanent neurologic deterioration (additional or aggravated neurologic symptoms), and 16 patients (13.0%) demonstrated transient worsening. CONCLUSION: DTI-merged functional neuronavigation could be a useful tool in brain tumor surgery for maximal safe resection. However, there are still limitations, including white matter tract shift, during surgery and in DTI itself. Further studies should be conducted to overcome these limitations.
Adolescent ; Adult ; Aged ; Brain Neoplasms/pathology/*surgery ; *Diffusion Tensor Imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; *Neuronavigation ; Neurosurgical Procedures/*methods ; Postoperative Period ; Preoperative Period ; Retrospective Studies

OBJECTIVES: The purpose of this study was to investigate the prevalence of sleep problems in Korean elementary school children and the differences in sleep problems related to their school grade and gender. METHODS: One public elementary school in Dae-gu, Korea was randomly selected. And, parents who agreed to participate this study were asked to complete a modified version of Tucson Children's Assessment of Sleep Apnea screening questionnaire (TuCASA). RESULTS: The most common sleep problem was 'falling asleep in a vehicle (44.2%)' and the prevalence rate of this problem differed by school grade. The prevalence rate of falling asleep while watching TV before 8 P.M. (8.0%), daytime fatigue (21.9%) and nocturnal enuresis during the past 6 months (5.3%) were significantly differed by school grade. The prevalence rate of falling asleep while doing home work, falling asleep during a lesson, snoring and bruxism were 12.6%, 1.0%, 26.7% and 13.2% respectively. Although these rates did not show any differences between grades, snoring was more in boys and daytime fatigue was more in girls.. CONCLUSION: This study demonstrates that many elementary school children may have various sleep problems. Lower grade elementary schoolers had sleep problems which related to neuro-developmental factors, whereas higher grade elementary schoolers had sleep problems related to sleep deprivation and stress. Finally, more female schooler showed signs of fatigue or sleepiness than male schoolers.
Bruxism ; Child ; Fatigue ; Female ; Humans ; Korea ; Male ; Mass Screening ; Nocturnal Enuresis ; Parents ; Prevalence ; Sex Characteristics ; Sleep Apnea Syndromes ; Sleep Deprivation ; Snoring ; Surveys and Questionnaires

Rhabdomyosarcoma originating from the chest wall is a rare malignant tumor in children and was considered to be guarded in prognosis previously. However, recent advances in multidisciplinary treatment of rhabdomyosarcoma in children have improved the disease free survival rate. Authors report a case of alveolar rhabdomyosarcoma, stage III, originating from the chest wall who is surviving free of disease for 15 months with aggressive chemotherapy and radiotherapy.
Child ; Disease-Free Survival ; Drug Therapy ; Humans ; Prognosis ; Radiotherapy ; Rhabdomyosarcoma ; Rhabdomyosarcoma, Alveolar* ; Thoracic Wall* ; Thorax*

No abstract available.
Humans ; Infant, Newborn* ; Liver*

PURPOSE: To evaluate the usefulness of the arterial dominant phase images of spiral CT in the detection and localization of pancreatic islet cell tumor. MATERIALS AND METHODS: Six patients with pathologically proven isletcell tumors of the pancreas were studied with two-phase spiral CT. Images of the arterial dominant phase and delayed phase were obtained at 30 and 180 seconds after the initiation of injection of 100 ml of contrast materialat a rate of 3ml/sec. The parameters of scanning were 3-mm thickness, table speed of 4mm/sec, and reconstruction at 2-mm intervals. Images were prospectively analyzed and the operative findings were used as the reference standard for tumor detection and localization. RESULTS: On arterial dominant phase images, lesions were definitely depicted in five patients(83%) and were suspicious in one (17%). In the delayed phase, only two tumors(33%) were demonstrated. CONCLUSION: The arterial dominant phase of spiral CT is useful in the preoperative detection and localization of islet cell tumor of the pancreas.
Adenoma, Islet Cell* ; Humans ; Islets of Langerhans* ; Pancreas* ; Prospective Studies ; Tomography, Spiral Computed*