1.Two Cases of Benign Non - Familial Neonatal Convulsion.
Journal of the Korean Child Neurology Society 2009;17(1):97-101
Benign idiopathic neonatal convulsion is a rare disorder which has no family history of convulsion and develops before and after the 5th day in a healthy full-term neonate. Its characteristics appear focal, or multifocal clonic seizures but rare tonic seizures lasting about several minutes. It reveals non-specific findings in neurologic examination, neuroimaging and EEG(electroencephalography) so that it should be differentiated from those diseases such as eletronic imbalance, inborn errors of metabolism, other neonatal epileptic syndromes. We report two healthy full-term female neonates presented with multifocal clonic seizures before and after the 5th day after birth. They had no family history of convulsion, fetal asphyxia, fetal and maternal problems and the neurologic examination and neuroimagings were normal. The convulsions were controlled by intravenous phenobarbital injection. They had no more convulsions ever since and showed normal development at the follow-up performed one year later. We experienced a rare disorder, benign neonatal convulsion in healthy full-term neonates. We hope this report will help its diagnosis and treatment and prevent unnecessary long- term anticonvulsant medication.
Asphyxia
;
Epilepsy, Benign Neonatal
;
Female
;
Follow-Up Studies
;
Humans
;
Infant, Newborn
;
Metabolism, Inborn Errors
;
Neuroimaging
;
Neurologic Examination
;
Parturition
;
Phenobarbital
;
Seizures
2.The Incidence of the Epstein-Barr Virus Nuclear Antigen in Non-Hodgkin's Lymphomas of the Gastrointestinal Tract.
Seung Wook JUNG ; Hyun Jin CHO ; Ho Jong JEON
Journal of the Korean Surgical Society 1998;54(6):883-890
The Epstein-Barr virus(EBV) is known to play a causal role in oncogenesis and to be associated with endemic Burkitt's lymphomas, B cell lymphomas in immunocompromised patients, and nasopharyngeal carcinomas. More recently, EBV has also associated with Hodgkin's disease, B cell lymphomas in non-immunocompromised patients, and T-cell lymphomas. Twenty eight cases of a non-Hodgkin's lymphoma of gastrointestinal tract were investigated to determine both the immunophenotype by using immunohistochemical staining and the incidence of the EBV nuclear antigen by using the polymerase chain reaction. Twenty-four of the 28 cases(85.7%) were B-cell type, and 4 of the 28 cases(14.3%) are of T-cell type. The EBV nuclear antigen was detected in three of the 28 cases(10.7%), including two cases of B-cell lymphoma of the stomach and one case of T-cell lymphoma of the small bowel. The EBV nuclear antigen was more frequently found in malignant lymphomas arising in the intestine(1/4) than in stomach(2/16). EBV positivity (25%) in T-cell NHLs was rather higher than EBV positivity (8.3%) in B-cell NHLs. Further expanded evaluations on the role of EBV in the tumorigenesis of a gastrointestinal malignant lymphomas are necessary because the cases of gastrointestinal lymphomas examined were very limited.
B-Lymphocytes
;
Burkitt Lymphoma
;
Carcinogenesis
;
Gastrointestinal Tract*
;
Herpesvirus 4, Human*
;
Hodgkin Disease
;
Humans
;
Immunocompromised Host
;
Incidence*
;
Lymphoma
;
Lymphoma, B-Cell
;
Lymphoma, Non-Hodgkin*
;
Lymphoma, T-Cell
;
Polymerase Chain Reaction
;
Stomach
;
T-Lymphocytes
3.Cloning of Chromosomal Band Specific cDNA - cDNA related with neural development-.
Sun Hwa PARK ; Chang Mi KIM ; Hye Sun JUNG ; Yong Hyuck JEON ; Hyun KIM
Korean Journal of Anatomy 1997;30(2):109-120
Recently, surmountable amounts of genes are being cloned without information about them and it has become neccessary to develop new techniques for discovering genes with more informaiion like as chromosomal location and possible functions. We have developed one such a method and applied it to search for genes that may be related with the neural development. The mRNAs were extracted from cerebral cortex of 18 week old human fetus, cDNAs were made by reverse transcription from these mRNAs and Uni-amp cDNAs having Uni-amp adapters at both ends were made for subsequent PCR. To observe the distribution of the Uni-amp cDNAs on the chromosome, fluorescent in situ hybridization was performed with biotin labeled Uni-amp cDNAs. Among the chromosome bands showing strong hybridization with the cDNAs, 7q22 was microdissected from the chromosome hybridized with unlabeled Uni-amp cDNAs and amplified by PCR with Uni-amp primers. These amplified cDNA fragment were subcloned to vectors and the nucleic acid sequences were analysed. As a result, 46 different clones were obtained. They were categorized as 12 clones of well characterized genes, 14 clones showing low homology with known genes, 13 clones of simply registered uncharacterized human cDNAs, 7 clones of unknown genes. In situ hybridization histochemistry of 34 novel genes, except 12 known genes, were performed on developing and adult rat tissue sections to see the tissue specificity and developmental expression of these genes. The expression of several novel genes were restricted to the nervous system. From these results, it may be suggested that our technique is very useful to clone the genes expressed in the developing human braine with confirmed chromosomal location. In addition, this cloning technique can be used to discover the new genes related with neural development in combination with functional screening methods.
Adult
;
Animals
;
Biotin
;
Brain
;
Cerebral Cortex
;
Clone Cells
;
Cloning, Organism
;
DNA, Complementary*
;
Fetus
;
Humans
;
In Situ Hybridization
;
In Situ Hybridization, Fluorescence
;
Mass Screening
;
Microdissection
;
Nervous System
;
Organ Specificity
;
Polymerase Chain Reaction
;
Rats
;
Reverse Transcription
;
RNA, Messenger
4.Effective Treatment of Suspicious Riehl's Melanosis Using Low Fluence 1,064 nm Q-switched Nd:YAG Laser and 595 nm Pulsed Dye Laser.
Sung Kyu JUNG ; Jae Beom PARK ; Byoung Joon SO ; Jie Hyun JEON ; Hwa Jung RYU ; Il Hwan KIM
Korean Journal of Dermatology 2014;52(8):589-590
No abstract available.
Lasers, Dye*
;
Melanosis*
5.Treatment and Prognostic Factors for Traumatic Liver Injury.
Jung Min BAE ; Nak Hi KIM ; Hyun Kyu LEE ; Kyu Ha JEON ; Bong Choon JEON ; Jong Dae BAE ; Ho Keun JUNG ; Ki Hoon JUNG ; Byung Wook JUNG ; Sung Han BAE
Journal of the Korean Surgical Society 2004;66(6):490-495
PURPOSE: Due to its size and locatin, the liver is frequently injured in abdominal trauma. Recently, nonoperative management for liver injuries has been extended due to the development CT imaging, intensive care units, and their equipment and techniques. Herein, patients with traumatic liver injury were analyzed to evaluate its treatment and prognostic factors. METHODS: From 2001, January to 2003, July, 65 patients at our facility were confirmed to have traumatic liver injury. The operative or nonoperative managements were decided on the basis of the systolic blood pressure if no peritoneal irritation sign was noted. If the systolic blood pressure was stable, or recovered to within the normal range following hydration and transfusion at the emergency room, patients were managed nonoperatively. Hemodynamically unstable patients were managed operatively. The data were analysed using the SPSS program (Chi-squared tests and logistic regression analyses). RESULTS: 48 patients were treated nonoperatively, with 3 mortalities. The overall mortality rate was 15.8%, but only 6.4% in the nonoperative management group, compared to 67% in operative management group. In a Multivariate analysis the systolic blood pressure was found to be a reliable factor in traumatic liver injury and the mentality and ISS (injury severity score) reliable in finding complications in the nonoperative management group. The mentality was found statistically reliable for determining mortality in the operative management group, with the exception for the systolic blood pressure. CONCLUSION: The systolic blood pressure was an important indicator when considering the treatment plan in traumatic liver injury. An extensive study will be required that incorporates both nonoperative and operative management groups.
Blood Pressure
;
Emergency Service, Hospital
;
Humans
;
Intensive Care Units
;
Liver*
;
Logistic Models
;
Mortality
;
Multivariate Analysis
;
Reference Values
6.Two Cases of Primary Carcinoma of the Peritoneum.
Joong Sik SHIN ; Sam Hyun CHO ; Jung Bae YOO ; Seung Ryong KIM ; Soo Hyun CHO ; Kyung Tai KIM ; Youn Yeung HWANG ; Seok Hoon JEON ; Jung Dal LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(3):248-253
The primary malignant tumor of the peritoneum also known as primary peritoneal carcinoma or primary peritoneal papillary serous carcinoma is rare and involves the peritoneum, especially the pelvic peritoneum of female patients. It is difficult to differentiate histologically between papillary mesothelioma, primary ovarian tumor and primary peritoneal carcinoma. We report two cases of the primary peritoneal carcinoma with clinical presentation and histologic characteristics.
Diagnosis, Differential
;
Female
;
Humans
;
Mesothelioma
;
Peritoneum*
7.Correlation between Steroid Hormone Metabolites and Leiomyomas of Uterus.
Sang Wook BAI ; Byung Hwa JUNG ; Bong Chul CHUNG ; Jin Dong JEON ; Hyun Jung LEE ; Han Sung KWON ; Kyung Ah CHUNG ; Sei Kwang KIM ; Ki Hyun PARK
Korean Journal of Fertility and Sterility 2001;28(4):279-286
OBJETIVE: To elucidate 1) whether there are any differences in the urine concentrations of steroid hormone metabolites between patients with leiomyoma and normal controls 2) the correlation between urinary profiles of steroid hormones and leiomyomas of the uterus according to their type, location, volume, and weight. MATERIALS OF METHODS: The study population consisted of 37 premenopausal patients with uterine leiomyoma and the control group consisted of 25 premenopausal normal volunteer women without uterine leiomyoma. Confirmation of the existence of uterine leiomyoma was done by ultrasonography and histopathological examination after surgery. The volume of the leiomyoma was estimated by trans-abdominal and/or trans-vaginal ultrasonography. The Leiomyomas were divided into 3 types (subserosal, intramural and submucosal). Seventeen patients had subserosal type of leiomyoma, 10 with the intramural type and 10 with the submucosal type. The locations of the leiomyoma were also divided into 3 groups (fundus, body and isthmus). Seventeen patients showed a fundus location, 10 in body, and 10 in isthmus. We compared urinary profiles of the endogenous steroids between patients with leiomyomas and normal controls, and also investigated the relationship between urinary profiles of the endogenous steroids and leiomyomas according to their type, location, volume and weight by using highly sensitive Gas Chromatography-Mass Spectrometry (GC-MS) system. RESULTS: The mean ages of the patients with leiomyomas and the control group were 43.1+/-5.6 and 40.6+/-7.2 years, the weights were 63.4+/-7.3 and 59.4+/-8.1 kg, and their heights were 155.4+/-4.8 and 159.3+/-4.8 cm respectively. Seventeen patients had subserosal, 10 had intramural, and 10 had submucosal leiomyomas. There were 17 patients with leiomyoma located in fundus, 10 in body and 10 in isthmus. 17beta-estradiol, 5-AT, 11-keto ET, 11beta-hydroxy An, 11beta-hydroxy Et, THS, THA, THE, alpha-cortolone, alpha-cortol, beta-cortol, 11beta-OH Et/11beta-OH An and E2/E1 were significantly increased in patients with leiomyoma than in the control group. 17beta-estradiol was significantly increased in the intramural and the submucosal types than in the subserosal type. There was no significant difference in the concentrations of urinary steroids according to the locations of leiomyomas. There was no significant relationship between the concentration of urinary steroids and the volume of the leiomyomas. 17beta-estradiol significantly decreased as the weight of uterus increased (r=-0.322, p=0.04). CONCLUSION: The concentrations of steroid hormone metabolites were generally increased in patients with leiomyoma but were not significantly related to the volume and weight of the leiomyomas. Our study suggests that steroid hormones may be involved in the initiation of leiomyomas but may not be involved in their progression. In addition, the concentrations of steroid hormone metabolites are not related to the leiomyoma type and location.
Female
;
Gas Chromatography-Mass Spectrometry
;
Healthy Volunteers
;
Humans
;
Leiomyoma*
;
Steroids
;
Ultrasonography
;
Uterus*
;
Weights and Measures
8.Neuroprotective effect of erythropoietin on anesthesia-induced neurotoxicity through the modulation of autophagy in Caenorhabditis elegans
Bon-Wook KOO ; Hyun-Jung SHIN ; Sooyoung JEON ; Jung Hyun BANG ; Sang-Hwan DO ; Hyo-Seok NA
Korean Journal of Anesthesiology 2024;77(3):384-391
Background:
The anti-oxidative, anti-inflammatory, and anti-apoptotic effects of erythropoietin may provide neuroprotective effects. Erythropoietin also modulates autophagy signaling that may play a role in anesthesia-induced neurotoxicity (AIN). Herein, we investigated whether AIN can be attenuated by the neuroprotective effect of erythropoietin in the Caenorhabditis elegans (C. elegans).
Methods:
Synchronized worms were divided into the control, Iso, EPO, and EPO-Iso groups. The chemotaxis index (CI) was evaluated when they reached the young adult stage. The lgg-1::GFP-positive puncta per seam cell were used to determine the autophagic events. The erythropoietin-mediated pathway of autophagy was determined by measuring the genetic expression level of let-363, bec-1, atg-7, atg-5, and lgg-3.
Results:
Increased lgg-1::GFP puncta were observed in the Iso, EPO, and EPO-Iso groups. In the Iso group, only the let-363 level decreased significantly as compared to that in the control group (P = 0.009). bec-1 (P < 0.001), atg-5 (P = 0.012), and lgg-3 (P < 0.001) were expressed significantly more in the EPO-Iso group than in the Iso groups. Repeated isoflurane exposure during development decreased the CI. Erythropoietin could restore the decreased CI by isoflurane significantly in the EPO-Iso group.
Conclusions
Erythropoietin showed neuroprotective effects against AIN and modulated the autophagic pathway in C. elegans. This experimental evidence of erythropoietin-related neuroprotection against AIN may be correlated with the induced autophagic degradation process that was sufficient for handling enhanced autophagy induction in erythropoietin-treated worms.
9.The Significance of Nuclear Area in Localized Renal Cell Carcinoma.
Seung Hyun JEON ; Sun Ju LEE ; Sung Goo CHANG ; Jin Il KIM ; Yong Koo PARK ; Jung Sik HUH
Korean Journal of Urology 2000;41(11):1312-1315
No abstract available.
Carcinoma, Renal Cell*
10.Analysis of Treatment Failure for the Pulmonary and Neck Tuberculosis.
Chang Ho JEON ; Sang Chae LEE ; Dae Sung HYUN ; Jung Yoon CHOE ; Im Hee SHIN ; Jin Ho SOHN
Tuberculosis and Respiratory Diseases 2001;50(4):473-483
BACKGROUND: There are only a few studies regarding the causes of treatment failure for tuberculosis. Therefore, this study aimed to determine the causes of intractable tuberculosis. METHODS: M.tuberculosis, differentiated MOTT (Tycobacterium Other Than Tuberculosis) were isolated, and the RFLP (Restriction fragments length polymorphisms) pattern was analyzed from 204 patients with pulmonary tuberculosis and 53 suffering from neck tuberculosis. The IL-1β, IL-12, *1 IFNγ and *2 TNFαblood levels were measured. All patients were regularly followed for 18 months after treatment. RESULTS: There was no correlation between the RFLP patterns of M.tuberculosis treatment failure. From the 204 cases, 31.9% were intractable. The characteristics of patients with intractable tuberculosis were old age, being male and recurrent cases. The causes of treatment failure were identified as follows ; a decrease in the IL-12(59.4%) concentration, drug resistant strain(54.7%), irregular medication(15.4%), MOTT(6.2%) and a heavy infection(4.6%). The causes of all cases of intractable tuberculosis could be investigated. The IL-12 concentration in the blood was significantly lower in the intractable cases, where it disclosed a maximum sensitivity(64.7%) and specificity(75.4%) at 165.0 pg/ml. Most of the 53 cases on neck node tuberculosis were treated successfully. Therefore, we were unable to analyze the cause of treatment failure. CONCLUSION: A decrease in the blood IL-12 concentration and drug resistant strains were identified as the most significant causes of treatment failure for tuberculosis. In Korea, infection by clusters were prevalent, but no difference in the clinical course between clusters and non-clusters could be found.
Humans
;
Interleukin-12
;
Korea
;
Male
;
Neck*
;
Polymorphism, Restriction Fragment Length
;
Treatment Failure*
;
Tuberculosis*
;
Tuberculosis, Pulmonary