1.Involvement of apoptotic signals in cyclosporin A-induced proliferation of human gingival fibroblast.
Tea Sul JEONG ; Hyun Ju CHUNG ; Won Jae KIM
The Journal of the Korean Academy of Periodontology 2005;35(3):731-745
No abstract available.
Humans
2.Incidence Density and Risk Factors of Low Back Pain among the Workers in a Welding Material Manufacturing Factory.
Korean Journal of Epidemiology 1999;21(1):36-52
This study was performed to understand the incidence density and detect the risk factors of occupational low back pain. A cross-sectional study was conducted with a questionnaire in a welding material manufacturing factory in October, 1993. Therefore, we selected 140 workers who had never complained of low back pain as cohorts. Also, we added 236 newly entered persons who had never complained of low back pain. The total number of cohorts were 376 workers. And then we continued with a questionnaire survey in October, 1996 and with a questionnaire survey and medical examinations by a specialist in October, 1997. Follow-ups were done for 337 workers. The number of newly developed low back pain among workers were 127. The characteristics of low back pain were as follows. The durations of pain were less than or equal to 2 days (42.6%), from 3 days to less than 1 week (8.7%), from 1 week to less than 1 month (11.0%), 1 month or more (6.2%). The frequency was everyday (7.9%), once per week (21.3%), once per month (14.2%), once per 2-3 months (9.4%), once per 5 months (11.0%). The severity of pain was slight (9.4%), mild (33.1%), moderate (13.4%), severe (10.2%) and very severe (1.6%). The onset of most low back pain was insidious (41.7%). The diagnosis of low back pain was muscle strain (37.8%), lumbar sprain (23.6%) and myofacial pain syndrome (3.9%). The number of newly developed low back pain among workers were 127, their incidence density was 15.7 per 100 person-years. In univariate analysis, age, marital status, educational level, smoking habit, category of job, tenures and frequency of stretching exercises showed a statistical significance. The multivariate logistic regression analysis confirmed that category of job and tenures (p<0.05) were independent risk factors for low back pain among workers. The number of newly developed occupational low back pain among production workers were 71, their incidence density was 11.3 per 100 person-years. In univariate analysis, age, marital status, educational level, regular exercise, tenures, posture of waist and lifting of heavy materials showed a statistical significance. The multivariate logistic regression analysis confirmed that posture of waist (p<0.05) and lifting of heavy materials (p<0.1) were independent risk factors for occupational low back pain among production workers.
Cohort Studies
;
Cross-Sectional Studies
;
Diagnosis
;
Exercise
;
Facial Neuralgia
;
Follow-Up Studies
;
Humans
;
Incidence*
;
Lifting
;
Logistic Models
;
Low Back Pain*
;
Marital Status
;
Posture
;
Risk Factors*
;
Smoke
;
Smoking
;
Specialization
;
Sprains and Strains
;
Welding*
;
Surveys and Questionnaires
3.Epidemiological Investigation of an Outbreak of Salmonellosis in Gyeongju, Korea.
Seok Ju YOO ; Hyun Sul LIM ; Kwan LEE
Journal of Preventive Medicine and Public Health 2014;47(3):177-181
OBJECTIVES: A salmonellosis outbreak occurred within a community of Gyeongju residents who ingested catered food from a wedding in June 2009. We aimed to epidemiologically investigate the probable vehicle of the infection. METHODS: We conducted a retrospective cohort study on 34 local residents who ingested the wedding food. RESULTS: Among the 34 residents, 31 (91.2%) reported symptoms of infection after eating the food. Among all of the wedding foods, pan-fried foods were highly associated with the diarrheal attack rate. On bacteriological examination, Salmonella species were detected in the pan-fried foods among the leftover foods and in 17 of the 31 stool specimens from the cases. There were five different types of pan-fried foods, but the onset of symptoms was independent of the ingredients used. We found that the pan-fried food was prepared at a food store in Seoul and that eggs were a common ingredient. CONCLUSIONS: The major cause of the salmonellosis in this population was presumed to be the pan-fried food prepared with contaminated eggs. These food items might have been partially undercooked because of their irregular shape, which allowed the Salmonella species to survive and multiply before ingestion.
Cohort Studies
;
*Disease Outbreaks
;
Eggs/microbiology
;
Feces/microbiology
;
*Food Microbiology
;
Fruit/microbiology
;
Humans
;
Republic of Korea/epidemiology
;
Retrospective Studies
;
Salmonella/*isolation & purification
;
Salmonella Food Poisoning/*epidemiology
;
Time Factors
4.Awareness of Zoonoses among Cattle Slaughterhouse Workers in Korea.
Hyun Sul LIM ; Seok Ju YOO ; Kwan LEE
Journal of Agricultural Medicine & Community Health 2009;34(1):101-112
OBJECTIVES: Cattle slaughterhouse workers are known as the high risk group for the zoonoses. We surveyed the awareness of zoonoses among cattle slaughterhouse workers to suggest direction of education and public relations. METHODS: We evaluated the epidemiological characteristics of zoonoses and the process of cattle slaughtering. We designed different questionnaires for the workers involved in slaughtering, the handlers of residual products, the inspectors and their assistants, and the grading testers and their assistants respectively. We visited 73 cattle slaughterhouses and 62 residual products handle houses across the country and conducted a questionnaire survey of the general characteristics and the awareness of zoonoses. The data collected was evaluated using the SPSS 17.0 statistical package. RESULTS: The awareness rate of brucellosis, Q fever and Enterohemorrhagic Escherichia coli (EHEC) were 83.9%, 18.5%, 62.7% among cattle slaughterhouse workers. The awareness rate of zoonoses among the workers involved in slaughtering and the handlers of residual products was lower than other workers. The awareness rate of zoonoses tended to increase as the school career. In the correct awareness rate of the transmission of zoonoses, 'transmission by tick bite', 'person to person' and 'air transmission' were lower than other transmission items. The most common reason why cattle slaughterhouse workers think that it is difficult to prevent zoonoses was the ignorance of how to prevent. CONCLUSIONS: An educational program is needed for the cattle slaughterhouse workers on zoonoses especially Q fever. And publicity activities about prevention of infection are needed for high risk groups.
Abattoirs
;
Animals
;
Brucellosis
;
Cattle
;
Enterohemorrhagic Escherichia coli
;
Humans
;
Korea
;
Q Fever
;
Ticks
;
Zoonoses
;
Surveys and Questionnaires
5.Awareness on Zoonoses among Pig Farmers in Korea.
Seok Ju YOO ; Hyun Sul LIM ; Kwan LEE
Journal of Agricultural Medicine & Community Health 2014;39(4):222-229
OBJECTIVES: Pig farmers are known as the high risk group for the zoonoses, but the study for pig farmers to zoonoses has been rare in Korea. So we surveyed the awareness on zoonoses among pig farmers to suggest directions for education. METHODS: We visited four regional spots (Gyeongsangnam-do, Gyeongsangbuk-do, Jeollanam-do, and Chungcheongnam-do) where the self education programs of Korea pork producers were convened. We conducted a questionnaire survey of the general, work-related characteristics and the awareness on zoonoses among 278 pig farmers. RESULTS: The awareness rate of zoonoses itself, brucellosis, tuberculosis and salmonellosis were 52.9%, 85.6%, 87.8%, 89.6%, respectively. The awareness rate of the content related to zoonoses, "Human can be infected by the disease of pig", was 46.9%. Awareness rate of zoonoses tended to increase as the school career, and awareness rate of salmonellosis tended to increase as working duration of pig raising. CONCLUSIONS: The pig is the principal reservoir of zoonoses. Therefore, effective working guidelines to prevent zoonoses for pig farmers must be developed and an educational program on zoonoses is needed for pig farmers. Furthermore, publicity activities about the prevention of zoonoses are needed for high-risk groups.
Brucellosis
;
Education
;
Gyeongsangbuk-do
;
Humans
;
Jeollanam-do
;
Korea
;
Salmonella Infections
;
Swine
;
Tuberculosis
;
Zoonoses*
;
Surveys and Questionnaires
6.Analysis of the Change of Health Status Among the Republic of Korea Air Force Soldiers During Military Service.
Seok Ju YOO ; Won Ju PARK ; Kwan LEE ; Hyun Sul LIM ; Hyun Jin KIM ; Suk Ho LEE
Journal of Preventive Medicine and Public Health 2014;47(4):230-235
OBJECTIVES: The aim of this study was to investigate whether the health status of Republic of Korea Air Force (ROKAF) soldiers changed after one year of military service. METHODS: We selected 483 ROKAF soldiers from the 11 749 recruits who participated in the 2011 physical examination. The selected soldiers underwent another physical examination in 2012 for advancement to senior airman. Data from 2011 and 2012 were merged. To collect data on lifestyle, a questionnaire was sent to all included subjects via the military intranet e-mail service. RESULTS: The percentage of recruits with an abnormal alanine transaminase level (normal range <40 IU/L) decreased from recruitment (13.7%) to the following year (2.7%). Moreover, the percentage of obese soldiers (body mass index > or =25 kg/m2) decreased from recruitment (20.5%) to the following year (10.4%). There was a significant change in mean duration of exercise carried out each day before (0.8+/-1.3 hours) and after (1.0+/-0.7 hours) joining the ROKAF service. CONCLUSIONS: These ROKAF soldiers were generally in good health before and after joining the armed service. After one year of military service, the health status of most soldiers improved, especially with respect to body mass index and alanine transaminase level.
Alanine Transaminase/blood
;
Asian Continental Ancestry Group
;
Body Mass Index
;
Exercise
;
*Health Status
;
Humans
;
Internet
;
Life Style
;
Military Personnel/*statistics & numerical data
;
Questionnaires
;
Republic of Korea
7.Expression of Aquaporin-3 in Ipsilateral Rat Kidney With Unilateral Partial Ureteral Obstruction.
Ji Yong LEE ; Ju Hyun SHIN ; Ki Hak SONG ; Jae Sung LIM ; Chong Koo SUL
Korean Journal of Urology 2013;54(4):266-270
PURPOSE: Aquaporin (AQP), a protein located in the cellular membrane, allows rapid passage of water across the cell membrane. Various AQP subtypes have been associated with ureteral obstruction. In particular, AQP3 has two functions: water and glycerol transport. The aim of this study was to investigate the expression of AQP3 in the ipsilateral rat kidney in unilateral partial ureteral obstruction (UPUO). MATERIALS AND METHODS: Sprague-Dawley rats (n=30, 200-250 g) were divided into two groups. A sham operation was performed in the control group (n=10) and UPUO of the left upper ureter with a silicone tube was induced in the UPUO group (n=20). The left kidney was obtained from both groups 7 days after the operations. The kidney specimens underwent immunofluorescent staining with AQP3 monoclonal antibody, and the density of AQP3 in the tissue was measured with an image analyzer. RESULTS: In the UPUO group, thinning of the epithelial layer and infiltration of inflammatory cells was seen along with the localized expression of AQP3 in the basolateral aspect of the principal collecting duct cells. The mean optical density of AQP3 was significantly lower in the UPUO group than in the control group (100.9+/-17.5 compared with 131.7+/-16.9; p<0.001). CONCLUSIONS: These results suggest that a decrease in the expression of AQP3 may be the result of a urinary stasis reaction caused by UPUO in response to local and intrarenal factors. These changes suggest that AQP3 may have a pathophysiological role in UPUO.
Animals
;
Aquaporin 3
;
Cell Membrane
;
Glycerol
;
Kidney
;
Membranes
;
Rats
;
Rats, Sprague-Dawley
;
Salicylamides
;
Silicones
;
Ureter
;
Ureteral Obstruction
8.A Case Report on the Meniscal Tear due to Repetitive Foot-Switch Stepping.
Sun Hee YU ; Hyun Sul LIM ; Doo Hie KIM ; Dong Ju CHAE ; Suk KANG
Korean Journal of Preventive Medicine 1997;30(4):805-814
Injuries to the menisci occur in a variety of ways, most commonly with a twist, pivot, squat, or valgus stress to the knee. Tear patterns are classified to longitudinal, horizontal, or transverse features according to the mechanism of injury. Work-related meniscal tear usually occurs with a repetitive usage of the foot, hence it can be classified as a cumulative traumatic disorder. We found a 47 year-old female worker who had been taking charge of repetitive foot-switch stepping for 8 years. She suffered from pain in the right knee since 5 months ago. Tenderness along the medial joint line of the right knee was observed and pain was aggravated with full flexion of the right knee. On magnetic resonance imaging, high signal intensity was observed at the posterior horn of the medial meniscus of the right knee. Degenerative longitudinal and transverse complex tear in the medial meniscus was observed on arthroscopy. Arthroscopic partial meniscectomy was performed. We surveyed the work process and the health status of co-workers. It turned out that the work process was compatible to injure the meniscus and nine out of fourteen co-workers(64.3%) complained pain of the knee. No other factors related to her meniscal tear could be found except for the situation at her work. Therefore, we conclude that meniscal tear is related to the repetitive stepping of foot switch.
Animals
;
Arthroscopy
;
Female
;
Foot
;
Horns
;
Humans
;
Joints
;
Knee
;
Magnetic Resonance Imaging
;
Menisci, Tibial
;
Middle Aged
9.Seroprevalence and Risk Factors of Brucellosis among Slaughterhouse Workers in Korea.
Seok Ju YOO ; Young Sill CHOI ; Hyun Sul LIM ; Kwan LEE ; Mi Yeoun PARK ; Chaeshin CHU ; Young A KANG
Journal of Preventive Medicine and Public Health 2009;42(4):237-242
OBJECTIVES: The incidence of zoonoses in Korea has increased recently. However, the study of high risk groups for zoonoses has not been conducted to date in Korea. Thus, we did this study to obtain data on brucellosis among slaughterhouse workers in Korea. METHODS: We evaluated the structure of slaughterhouses and the process of slaughtering by reviewing the relevant literature and doing field studies. We visited 73 slaughterhouses and 62 residual products handle houses across the country. In addition, we conducted a questionnaire survey of the work activities, and obtained blood samples in order to determine the seroprevalence and risk factors of brucellosis. The titers of brucellosis antibodies were measured using the standard tube agglutination test (SAT). We diagnosed subjects as seropositive for Brucellosis if the titers were more than 1:160. The data collected was evaluated using SPSS ver. 17.0. RESULTS: We included 1,503 subjects and obtained 1,482 blood samples among them: 849 workers involved in slaughtering, 351 handlers of residual products, 190 inspectors and their assistants, and 92 grading testers and their assistants. The seroprevalence of brucellosis among the slaughterhouse workers was 0.8% (95% CI=0.4-1.5). Broken down, the seroprevalence of brucellosis among the workers involved in slaughtering was 0.7% (95% CI=0.3-1.6), the handlers of residual products was 1.7% (95% CI=0.7-3.9) respectively. Risk factors for contracting brucellosis among slaughterhouse workers were being splashed with cattle blood around the mouth, cattle secretions around the body and not putting on protective apron while at work. CONCLUSIONS: An educational program is needed for high risk groups on zoonoses about the prevention of infection. Thus, effective working guidelines for workers who participate in the slaughter of animals must be developed in order to protect them from zoonoses.
*Abattoirs
;
Animals
;
Brucellosis/blood/*epidemiology
;
Cattle
;
Humans
;
Korea/epidemiology
;
Occupational Diseases/blood/*epidemiology/microbiology
;
*Occupational Exposure
;
Seroepidemiologic Studies
;
Zoonoses/epidemiology/microbiology
10.Psoriasis, Vitiligo and Crohn's Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?.
Sul Hee LEE ; Ye Seul KIM ; Hyun Ju KIM ; Young Lip PARK
Annals of Dermatology 2017;29(6):782-785
Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn's disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn's disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.
Autoimmune Diseases
;
Crohn Disease*
;
Humans
;
Lichen Planus, Oral
;
Necrosis
;
Psoriasis*
;
Vitiligo*