1.Contractile effect of manganes in uterine muscle strips of rat.
Korean Journal of Obstetrics and Gynecology 1993;36(7):1355-1363
No abstract available.
Animals
;
Female
;
Mice
;
Myometrium*
;
Rats*
2.Comparison of Left Ventricular Ejection Times by Various Methods of Measurement with Critical Review of the Methods.
Chung Jick YOON ; Wee Hyun PARK ; Hi Myung PARK
Korean Circulation Journal 1977;7(2):1-6
Left ventficular ejection times were measured by four different methods in 200 healthy males and females from the polygraphic tracings including an apexcardiogram, a phonocardiogram and a carotid pulse tracing. The results obtained by each method were compared and the adequacy of each method was critically reviewed. It was felt that the method measuring the left ventricular ejection time from the carotid pulse tracing was the most reasonable. However, there was a significant correlation between the carotid-derived values and those obtained by other methods, thus, regression equations for the relationship of the latter values to the fromer were obtainable.
Female
;
Humans
;
Male
3.Repair of Partial Thickness Cartilage Defects Using Cartilage Extracellular Matrix Membrane-Based Chondrocyte Delivery System in Human Ex Vivo Model.
Do Young PARK ; Byoung Hyun MIN ; Hyun Jung LEE ; Young Jick KIM ; Byung Hyune CHOI
Tissue Engineering and Regenerative Medicine 2016;13(2):182-190
Treatment options for partial thickness cartilage defects are limited. The purpose of this study was to evaluate the efficacy of the chondrocyte-seeded cartilage extracellular matrix membrane in repairing partial thickness cartilage defects. First, the potential of the membrane as an effective cell carrier was investigated. Secondly, we have applied the chondrocyte-seeded membrane in an ex vivo, partial thickness defect model to analyze its repair potential. After culture of chondrocytes on the membrane in vitro, cell viability assay, cell seeding yield calculation and cell transfer assay were done. Cell carrying ability of the membrane was also tested by seeding different densities of cells. Partial defects were created on human cartilage tissue explants. Cell-seeded membranes were applied using a modified autologous chondrocyte implantation technique on the defects and implanted subcutaneously in nude mice for 2 and 4 weeks. In vitro data showed cell viability and seeding yield comparable to standard culture dishes. Time dependent cell transfer from the membrane was observed. Membranes supported various densities of cells. Ex vivo data showed hyaline-like cartilage tissue repair, integrated on the defect by 4 weeks. Overall, chondrocyte-seeded cartilage extracellular membranes may be an effective and feasible treatment strategy for the repair of partial thickness cartilage defects.
Animals
;
Cartilage*
;
Cell Survival
;
Chondrocytes*
;
Extracellular Matrix*
;
Humans*
;
In Vitro Techniques
;
Lifting
;
Membranes
;
Mice
;
Mice, Nude
4.Hepatocellular Carcinoma Incidentally Discovered by Liver Abscess Associated with CBD Stone and Cholangitis.
Yong Jick SUNG ; Su Eun YU ; Sun Mi PARK ; Dong Bin KIM ; Si Hyun BAE ; Jin Il KIM ; Choon Sang BANG ; Young Min PARK ; Kyu Won CHUNG ; Hee Sik SUN ; Doo Ho PARK ; Sang Hoon LEE ; Eun Duck CHANG
The Korean Journal of Hepatology 1999;5(3):253-258
Hepatocellular carcinoma (HCC) is one of the most common fatal malignancies worldwide, especially in Korea. The recent advances in diagnostic techniques, such as serum tumor marker assay, ultrasonography, computerized tomography (CT), magnetic resonance imaging (MRI), and angiography, allow us to detect HCC at early stage. Even though, it remains difficult to distinguish malignant nodules from benign space-ccupying lesions of liver. Distinction of HCC from benign entities such as liver abscess is important because failure of prompt diagnosis could result in a missed opportunity for curative treatment. The differential diagnosis of HCC and liver abscess, especially HCC presenting as abscess, is sometimes very difficult. We report a case of HCC with liver abscess caused by secondary infection of CBD stone and cholangitis, that mimicked the dynamic CT findings of liver abscess, in an elderly patient with chronic hepatitis C virus infection.
Abscess
;
Aged
;
Angiography
;
Carcinoma, Hepatocellular*
;
Cholangitis*
;
Coinfection
;
Diagnosis
;
Diagnosis, Differential
;
Hepatitis C, Chronic
;
Humans
;
Korea
;
Liver Abscess*
;
Liver*
;
Magnetic Resonance Imaging
;
Ultrasonography
5.Hepatic Septal Fibrosis Induced by Long-term Use of Ketoconazole.
Jae Wan CHO ; Yoon Ho KO ; Yong Kyun KIM ; Young Chul KIM ; Yong Jick SUNG ; Si Hyun BAE ; Jin Il KIM ; Choon Sang BANG ; Byung Min AHN ; Young Min PARK ; Kyu Won CHUNG ; Hee Sik SUN ; Doo Ho PARK ; Boo Sung KIM ; Seok Jin KANG
The Korean Journal of Hepatology 2000;6(2):241-245
Ketoconazole, an imidazole derivative, is a broad spectrum antifungal agent which has been used widely in the treatment of systemic or local fungal infections. Mild asymptomatic elevation of plasma transaminase activities occurs in approximately 6% to 17.5% of patients who have used ketoconazole. However, the incidence of symptomatic hepatic injury is low and overt hepatitis develops in about 5% of the patients. Nausea and vomiting are the most frequent side reactions. Histopathological features of the reported ketoconazole induced hepatotoxicity are massive or submassive hepatocellular necrosis involving the acinar zone 3, destroyed lobular architecture with bridging necrosis and inflammatory cell infiltration on portal tracts. However, hepatic septal fibrosis with liver cirrhosis has not been reported yet. We experienced a case of hepatic septal fibrosis that developed after 9 months of ketoconazole administration.
Fibrosis*
;
Hepatitis
;
Humans
;
Incidence
;
Ketoconazole*
;
Liver Cirrhosis
;
Nausea
;
Necrosis
;
Plasma
;
Vomiting
6.A Case of Patent Ductus Arteriosus Associated with Pulmonary Valve Endocarditis.
Sang Hee KIM ; Hyun Young WOO ; Jick Hwan HA ; Won Chul KIM ; Youn Suk CHOI ; Dong Hyeon RHEE ; Ji Hoon KIM ; Chul Soo PARK ; Yong Seog OH ; Ho Joong YOUN ; Wook Sung CHUNG ; Soon Jo HONG
Journal of Cardiovascular Ultrasound 2006;14(1):33-35
Isolated infective endocarditis in the native pulmonary valve is unusual in non-intravenous drug user. Intravenous drug abuse, alcoholism, sepsis, catheter related infections and congenital heart diseases account for the majority of predisposing factors. We report a case of patent ductus arteriosus complicating infective endocarditis involving pulmonary valve. A 24-year-old female was admitted with fever of unknown origin Physical examination revealed continuous murmur at left 2nd intercostals space. Transthoracic and transesophageal echocardiography was performed and patent ductus arteriosus and vegetation at the pulmonary valve were noted. Chest CT scan revealed multiple patch infiltrate suggestive of septic emboli. After 4 weeks of antibiotic treatment, she had no clinical signs of fever, and blood culture be negative. Percutaneous trans-catheter closure of patent ductus arteriosus was done after 2 months.
Alcoholism
;
Catheter-Related Infections
;
Causality
;
Drug Users
;
Ductus Arteriosus, Patent*
;
Echocardiography, Transesophageal
;
Endocarditis*
;
Female
;
Fever
;
Fever of Unknown Origin
;
Heart Diseases
;
Humans
;
Physical Examination
;
Pulmonary Valve*
;
Sepsis
;
Substance Abuse, Intravenous
;
Tomography, X-Ray Computed
;
Young Adult
7.A Case of Patent Ductus Arteriosus Associated with Pulmonary Valve Endocarditis.
Sang Hee KIM ; Hyun Young WOO ; Jick Hwan HA ; Won Chul KIM ; Youn Suk CHOI ; Dong Hyeon RHEE ; Ji Hoon KIM ; Chul Soo PARK ; Yong Seog OH ; Ho Joong YOUN ; Wook Sung CHUNG ; Soon Jo HONG
Journal of Cardiovascular Ultrasound 2006;14(1):33-35
Isolated infective endocarditis in the native pulmonary valve is unusual in non-intravenous drug user. Intravenous drug abuse, alcoholism, sepsis, catheter related infections and congenital heart diseases account for the majority of predisposing factors. We report a case of patent ductus arteriosus complicating infective endocarditis involving pulmonary valve. A 24-year-old female was admitted with fever of unknown origin Physical examination revealed continuous murmur at left 2nd intercostals space. Transthoracic and transesophageal echocardiography was performed and patent ductus arteriosus and vegetation at the pulmonary valve were noted. Chest CT scan revealed multiple patch infiltrate suggestive of septic emboli. After 4 weeks of antibiotic treatment, she had no clinical signs of fever, and blood culture be negative. Percutaneous trans-catheter closure of patent ductus arteriosus was done after 2 months.
Alcoholism
;
Catheter-Related Infections
;
Causality
;
Drug Users
;
Ductus Arteriosus, Patent*
;
Echocardiography, Transesophageal
;
Endocarditis*
;
Female
;
Fever
;
Fever of Unknown Origin
;
Heart Diseases
;
Humans
;
Physical Examination
;
Pulmonary Valve*
;
Sepsis
;
Substance Abuse, Intravenous
;
Tomography, X-Ray Computed
;
Young Adult