1.Stress Fracture of the Proximal Clavicle after Parallel Bars Exercise in a Young Male
Jieun KWON ; Ye Hyun LEE ; Joon Hee CHO
The Journal of the Korean Orthopaedic Association 2019;54(3):287-291
Although acute traumatic fractures of the clavicle are relatively common, stress fractures of the proximal clavicle are extremely rare. Stress fractures of the clavicle have often been reported after a radical neck dissection or radiation but rarely occur during excessive repetitive exercise in professional athletes. The authors report a case of a stress fracture of the proximal clavicle during exercise in a young man with no specific preceding factors, which has not been reported in the Korean literature.
Athletes
;
Clavicle
;
Fractures, Stress
;
Humans
;
Male
;
Neck Dissection
2.An investigation of reosseointegration according to time course after mechanical loosening of the osseointegrated implant fixtures.
Sun Hae YE ; Jin Hyun CHO ; Cheong Hee LEE
Journal of Dental Rehabilitation and Applied Science 2015;31(3):203-211
PURPOSE: The purpose of this study was to investigate the reosseointegration periods when the rough surface implants, which had complete bone-implant ankylosis, suddenly losed the osseointegration. MATERIALS AND METHODS: The implants with RBM surface treatment were inserted into both tibias of 23 rabbits. Two implants were submerged into each side. After six weeks, the primary removal torque was measured by Digital torque gauge, and then the implants were replaced and submerged to estimate the level of reosseointegration. After assigned healing periods for each group, the removal torque was measured again. BIC (Bone-Implant contact, %) ratio was measured through histomorphometric analysis.Paired t-test was processed by SPSS 14.0. One-way ANOVA and Tukey's post-hoc test was processed to analyze statistically significant differences among the groups. RESULTS: In comparison with the primary removal torque, the secondary removal torque was increased after 11 days and significantly increased from 2 weeks. In fluorochrome labeling, the origin of mineralization was observed after 7 days, which showed as fluorescent bands around the boneimplant interfaces. After 11 days, the bone formation was apparent, and it is increased continuously with the passage of the time. CONCLUSION: In 11 days after the implant replacement, the secondary removal torque was almost as same as the primary value, and was significantly higher from 2 weeks. The mineralized shapes were observed in 7 days after the implant replacement, and then thebone formation appeared visibly in 11 days.
Ankylosis
;
Osseointegration
;
Osteogenesis
;
Rabbits
;
Tibia
;
Torque
3.The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years.
Tae Ho LEE ; Ah Reum KWON ; Ye Jin KIM ; Hyun Wook CHAE ; Ho Seong KIM ; Duk Hee KIM
Journal of Korean Medical Science 2013;28(9):1340-1344
This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
Adolescent
;
Body Mass Index
;
Body Weight
;
C-Peptide/*blood
;
Child
;
Child, Preschool
;
Diabetes Complications
;
Diabetes Mellitus, Type 1/blood/*diagnosis
;
Diabetic Ketoacidosis/epidemiology
;
Diabetic Retinopathy/epidemiology
;
Female
;
Follow-Up Studies
;
Hemoglobin A, Glycosylated/analysis
;
Humans
;
Incidence
;
Infant
;
Male
;
Peripheral Nervous System Diseases/epidemiology
;
Retrospective Studies
4.Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria.
Nami Shrestha PALIKHE ; Seung Hyun KIM ; Young Hee NAM ; Young Min YE ; Hae Sim PARK
Allergy, Asthma & Immunology Research 2011;3(4):273-276
Acetyl salicylic acid (ASA) is metabolized by UDP-glucuronosyltransferase 1A6 (UGT1A6), cytochrome P4502C9 (CYP2C9), and N-acetyl transferase 2 (NAT2). Variations in the activities of these enzymes may modulate adverse ASA-related symptoms such as urticaria. We examined whether polymorphisms in the UGT1A6, CYP2C9, and NAT2 genes are related to ASA-intolerant urticaria (AIU). The genotypes of 148 subjects with AIU (AIU group) and 260 normal healthy control subjects (NC group) were analyzed with respect to the following single nucleotide polymorphisms: CYP2C9 -1188T>C and CYP2C9*3A1075C; UGT1A6 T181A A>G and UGT1A6 R184S A>C; and NAT2 9796A>T, NAT2 197G>A, NAT2 286G>A, NAT2 9601A>G, and NAT2 9306A>G. There were significant differences in the allele frequencies for the CYP2C9 polymorphisms between the two groups. The frequency of the minor allele CYP2C9 -1188T>C was significantly higher in the AIU group than in the NC group (P=0.005). The frequency of the variant genotype CC was higher in the AIU group compared with the controls in both the co-dominant (P=0.007) and recessive models (P=0.012). The frequency of haplotype 2 [CA] was also significantly higher in the AIU group in both the co-dominant (P=0.006) and dominant models (P=0.012). There was no significant difference in genotype frequencies for any of the UGT1A6 or NAT2 polymorphisms between the two groups. Clinical parameters did not differ according to genotype. These results suggest that the C allele of CYP2C9 -1188T>C may be associated with AIU.
Alleles
;
Aspirin
;
Cytochromes
;
Gene Frequency
;
Genotype
;
Haplotypes
;
Idoxuridine
;
Salicylic Acid
;
Transferases
;
Urticaria
5.Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation.
Hyun Hee YE ; Chang Won CHO ; Mi Young JEON ; Dae Jo KIM
Journal of Korean Neurosurgical Society 2007;41(3):186-189
Metastasizing mixed tumors (MMT) of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.
Mortality
;
Neoplasm Metastasis*
;
Recurrence
;
Salivary Glands*
;
Skull
;
Spine
6.IL-4 Receptor alpha Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.
Gyu Young HUR ; Young Min YE ; Dong Hee KOH ; Seung Hyun KIM ; Hae Sim PARK
Allergy, Asthma & Immunology Research 2013;5(6):371-376
PURPOSE: The IL-4 and IL-4 receptor alpha (IL-4Ralpha) genes are the key candidate genes for atopy and asthma susceptibility. Exposure to wheat flour can cause IgE sensitization and respiratory symptoms in bakery workers. Therefore, we hypothesized that IL-4 and IL-4Ralpha single nucleotide polymorphisms (SNPs) may be involved in the pathogenic mechanism of baker's asthma. METHODS: Clinical and genetic data from 373 bakery workers were analyzed. A survey questionnaire, spirometry, and skin prick tests with wheat flour were performed. Serum-specific IgE, IgG1, and IgG4 to wheat flour were determined using ELISA. Five candidate IL-4 (-729 T>G, 589 T>C, and 33 T>C) and IL-4Ralpha (Ile75Val A>G and Gln576Arg A>G) SNPs were genotyped and analyzed. RESULTS: Workers with the G allele of IL-4Ralpha Ile75Val A>G had a significantly higher prevalence of work-related lower respiratory symptoms than those with the AA genotype (P=0.004, 16.0% vs. 2.9%). In the skin prick test, workers with the AA genotype of IL-4Ralpha Gln576Arg A>G had a significantly higher positive rate to wheat flour (P=0.015, 8.2% vs. 1.1%) than those with AG/GG genotype. No significant associations were found in the three genetic polymorphisms of IL-4. For the predicted probabilities, workers with the AA genotype of Gln576Arg A>G had a higher prevalence of IgG1 and IgG4 in response to wheat flour, according to increased exposure intensity (P=0.001 for IgG1 and P=0.003 for IgG4). CONCLUSIONS: These findings suggest that the IL-4Ralpha Ile75Val and Gln576Arg polymorphisms may be associated with work-related respiratory symptom development.
Alleles
;
Asthma
;
Enzyme-Linked Immunosorbent Assay
;
Flour
;
Genotype
;
Immunoglobulin E
;
Immunoglobulin G
;
Interleukin-4
;
Polymorphism, Genetic
;
Polymorphism, Single Nucleotide
;
Prevalence
;
Receptors, Interleukin-4
;
Skin
;
Spirometry
;
Triticum
;
Surveys and Questionnaires
7.IL-4 Receptor alpha Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers.
Gyu Young HUR ; Young Min YE ; Dong Hee KOH ; Seung Hyun KIM ; Hae Sim PARK
Allergy, Asthma & Immunology Research 2013;5(6):371-376
PURPOSE: The IL-4 and IL-4 receptor alpha (IL-4Ralpha) genes are the key candidate genes for atopy and asthma susceptibility. Exposure to wheat flour can cause IgE sensitization and respiratory symptoms in bakery workers. Therefore, we hypothesized that IL-4 and IL-4Ralpha single nucleotide polymorphisms (SNPs) may be involved in the pathogenic mechanism of baker's asthma. METHODS: Clinical and genetic data from 373 bakery workers were analyzed. A survey questionnaire, spirometry, and skin prick tests with wheat flour were performed. Serum-specific IgE, IgG1, and IgG4 to wheat flour were determined using ELISA. Five candidate IL-4 (-729 T>G, 589 T>C, and 33 T>C) and IL-4Ralpha (Ile75Val A>G and Gln576Arg A>G) SNPs were genotyped and analyzed. RESULTS: Workers with the G allele of IL-4Ralpha Ile75Val A>G had a significantly higher prevalence of work-related lower respiratory symptoms than those with the AA genotype (P=0.004, 16.0% vs. 2.9%). In the skin prick test, workers with the AA genotype of IL-4Ralpha Gln576Arg A>G had a significantly higher positive rate to wheat flour (P=0.015, 8.2% vs. 1.1%) than those with AG/GG genotype. No significant associations were found in the three genetic polymorphisms of IL-4. For the predicted probabilities, workers with the AA genotype of Gln576Arg A>G had a higher prevalence of IgG1 and IgG4 in response to wheat flour, according to increased exposure intensity (P=0.001 for IgG1 and P=0.003 for IgG4). CONCLUSIONS: These findings suggest that the IL-4Ralpha Ile75Val and Gln576Arg polymorphisms may be associated with work-related respiratory symptom development.
Alleles
;
Asthma
;
Enzyme-Linked Immunosorbent Assay
;
Flour
;
Genotype
;
Immunoglobulin E
;
Immunoglobulin G
;
Interleukin-4
;
Polymorphism, Genetic
;
Polymorphism, Single Nucleotide
;
Prevalence
;
Receptors, Interleukin-4
;
Skin
;
Spirometry
;
Triticum
;
Surveys and Questionnaires
8.A Case of Rhematogenous Retinal Detachment in Children with Nephrotic Syndrome during Systemic Corticosteroid Therapy.
Ju Ye KIM ; Ji Hyun KIM ; Byung Soo CHO ; Seung Young YU ; Hyung Woo KWAK
Journal of the Korean Society of Pediatric Nephrology 2001;5(2):210-212
Retinal detachment is a rare disease in children but cases of serous retinal detachment due to use of systemic corticosteroids have been reported in and out country. Rhematogenous retinal detachment has developed in a child with oral and steroid pulse therapy due to nephrotic syndrome. He was treated with laser and buckling in right and left eye respectively. Currently he is under observation through the out patient department.
Adrenal Cortex Hormones
;
Child*
;
Humans
;
Nephrotic Syndrome*
;
Rare Diseases
;
Retinal Detachment*
;
Retinaldehyde*
9.Surgical Outcome of Degenerative Spinal Stenosis Clinical: Clinical Correlation of Patient Satisfaction and Surgical Results.
Joo Hee HAN ; Jae Lim CHO ; Ye Soo PARK ; Chang Nam KANG ; Yong Hyun CHOI
Journal of Korean Society of Spine Surgery 2001;8(1):21-26
STUDY DESIGN: This study is a retrospective evaluation of the surgical outcome by the patient satisfaction and Oswestry low back pain questionnaire. OBJECTIVE: The goal of this study was to evaluate the clinical correlations of various factors with the patient's satisfaction and with the surgical results in degenerative spinal stenosis. SUMMARY OF LITERATURE REVIEW: The patients satisfaction and surgical outcome of the degenerative spinal stenosis by the objective method have not been well described in the literature. MATERIAL AND METHODS: Mean follow-up period was 4.8 years after surgery in 114 patients. Outcome was based on subjective disability using Oswestry low back pain questionnaire. Patient satisfaction degree was rated to 'very satisfied(1)', 'somewhat satisfied(2)', 'somewhat dissatisfied(3)' and 'very dissatisfied(4)'. Several factors that might be associated with patient satisfac-tion and outcome were investigated. RESULTS: Of the one hundred and fourteen patients, 84(73.9%) were satisfied to the surgery and mean satisfaction degree was 1.94. Ninety two patients(80.7%) had excellent-to-good results with the mean Oswestry disability score 26.9. There were 7 complications including dural tear in 3 cases, pseudarthrosis in 1 case, dissociation between rod and screw in 1 case, pedicle screw breakage in 1 case and termination of operatin due to massive bleeding during operation in 1 case. CONCLUSION: Clinical results and patient satisfaction were better in the cases with short segments fusion than long segments fusion and the patients with preoperative leg symptom as major symptom had significantly lower Oswestry disability score.
Follow-Up Studies
;
Hemorrhage
;
Humans
;
Leg
;
Low Back Pain
;
Patient Satisfaction*
;
Pseudarthrosis
;
Surveys and Questionnaires
;
Retrospective Studies
;
Spinal Stenosis*
10.Thymic Carcinoma: Report of Eight Cases.
Young Don JOO ; Joon Hee KIM ; Chang Hak SON ; Ye Hoe KIM ; Chan Hwan KIM ; Hyun Sook SEO
Journal of the Korean Cancer Association 1998;30(4):743-751
Thymic carcinoma is a rare malignant neoplasm of the thymic epithelium, distinguished from benign or invasive thymoma by the presence of malignant cytology and a greater incidence of local invasion and embolic metastases. The true incidence of this neoplasm is unknown. Nearly three fourth of their patients had symptoms of an anterior mediastinal mass, including cough, chest pain, and superior vena cava syndrome. These patients rarely have myasthenia gravis or other thymoma-associated paraneoplastic syndromes. The treatment of thymic carcinoma remains a controversial matter. We report eight cases of thymic carcinoma treated in our institution from 1990 to 1997.
Chest Pain
;
Cough
;
Epithelium
;
Humans
;
Incidence
;
Mediastinum
;
Myasthenia Gravis
;
Neoplasm Metastasis
;
Paraneoplastic Syndromes
;
Superior Vena Cava Syndrome
;
Thymoma*