The introduction of the strong clover-leafed nail combined with the principle of reaming out the medullary canal and the development of image intensifiers has been extended the indications of the in tramedullary nailing. In this report, an attempt was made to introduce the method and to verify the indications and advantage of retrograde intramedullary nailing of humeral shaft fractures, as compared with the conventionally accepted methods.
Fracture Fixation, Intramedullary ; Humerus ; Methods

Proliferative vitreoretinopathy (PVR) is a main cause of failure in retinal reattachment surgery. There have been many studies about the inhibition of proliferative vitreoretinophthy with several drugs. Authors investigated the inhibitory effect of proliferative vitreoretinopathy and retinal toxicity with various concentration of daunorubicin after intravitreal injection into the eyes of the pigmented rabbit. 7 pigment rabbit (11eyes) were used as subjects. After lensectomy and vitrectomy, control group was injected dermal fibroblast and F-BSS, and treatment group was injected dermal fibroblast and 5, 10, 15, 30 nmol Daunorubicin. At two weeks after intravitreal injection, both group were enucleated and examined with gross finding, light--microscopy, and electronmicroscopy. In all control group, proliferative vitreoretinopathy was found, but only preretinal membrane formation was found in 5, 10 nmol Daunorubicin injected group. In 15 nmol Daunorubicin injected group, the retina structure was preserved normally. In 30 nmol Daunorubicin injected group, the retinal outer segment was degenerated in microscopic finding. These results show that Daunorubicin has a potent effect on proliferative vitreoretinopathy, especially in 15 nmol, but retinal toxicity is suspected in marethan 30 nmol.
Daunorubicin* ; Fibroblasts ; Intravitreal Injections ; Membranes ; Retina ; Retinal Photoreceptor Cell Outer Segment ; Retinaldehyde ; Vitrectomy ; Vitreoretinopathy, Proliferative*

Authority estimated the concentration of fluorescein sodium in the blood, anterior chamber and vitreous after injection of 10% fluorescein sodium, 25mg/kg, according to the lapse of time. Also intravitreal fluorescein sodium concentration was measured after intravitreal injection of 0.1 % fluorescein sodium 10 micro liter according to the lapse of time. The results were as follows. 1. In the normal rabbits, the concentration of fluorescein sodium in the anterior chamber and vitreous were 159.3 +/- 101.7 X 10(-9) gm/ml and 3.6 +/- 4.7 X 10(-9) gm/ml, respectively after 1 hour of fluorescein sodium intravenous injection. The Cv/Ca was 0.02 +/- 0.028(Cv: concentration of fluorescein in the vitreous) (Ca: concentration of fluorescein in the ant. chamber). 2. After injection of sodium fluorescein in the normal rabbit, the concentration of fluorescein in the blood showed rapid decrease in logarithmic manner in the vitreous, the concentration peaked 1 hour and 2 hours after injection which persisted several hours. 3. The concentration of fluorescein sodium in the vitreous after intravitreal injection of fluorescein decreased at logarithmic rate which disappeared 24 hours after injection.
Anterior Chamber ; Ants ; Fluorescein* ; Injections, Intravenous ; Intravitreal Injections ; Pharmacokinetics* ; Rabbits

This study was carried out to evaluate the relations among workers' general characteristics, work-related behaviors and health related behaviors in a steel industry with 1,134 workers in Pohang. The results were as follows; 1. The mean age of workers was 50 years old and working duration was 15 years and over. Most of them were married(94 5%) and had studied beyond high school (53.0%). They performed three shift work and most of them(63.0%) had experienced industrial accidents. The frequency of noise and dust exposure was defined by a minimum of 6 hours per day, and workers complained about noise exposure(62.9%) and dust(55.6%). There were current smokers(67.7%), current drinkers(74.3%) and current exercising workers(32.3%) in the industry. The number of cigarette consumption in current drinkers was significantly high (13.6 +/- 8.4 pieces/day) and the alcohol consumption in current smokers was significantly high(l04.5 +/- 113.5 g/wk). And the number of cigarette consumption of exercisers was significantly low and the alcohol consumption of exercisers was higher than non-exercisers. 3. The ratio of current smokers on frequent noise in exposed workers versus non-exposed workers was not significantly high but the current drinkers in frequent noise and dust exposed workers was significantly higher than non--exposed. 4. The normal levels of SGOT workers in non-smokers were significantly higher than in current smokers, and the abnormal levels of LFT(SGOT, SGPT, gamma-GTP workers in nondrinkers were significantly high. The normal levels of SBP and DBP workers in current smokers were not significantly high but were significantly high in non-drinkers. 5. The ratio of current smokers in workers unsatisfied with their job and working condition was higher than non-smokers, but the ratio of current drinkers in workers satisfied with their job and working condition were higher. 6. The significant factors for SGOT and gamma-GTP were age, the drinking amount and BMI. But the only significant factor for r-GTP was BMI. The significant factors for DBP were age, the alcohol consumption and BMI And the significant factors for SBP were age, BMI.
Accidents, Occupational ; Alanine Transaminase ; Alcohol Drinking ; Aspartate Aminotransferases ; Drinking ; Dust ; Gyeongsangbuk-do ; Health Behavior* ; Humans ; Male* ; Middle Aged ; Noise ; Smoking ; Steel* ; Tobacco Products

Clostridium difficile is the most common nosocomial pathogen of the gastrointestinal tract. Pseudomembranous colitis occurs as a result of a severe inflammatory response to Clostridium difficile toxins. Pseudomembranous colitis is an increasingly frequent cause of morbidity and mortality among elderly hospitalized patients. Diarrhea is the most common manifestation. According to the literature, stools are almost never grossly bloody, and range from soft and unformed to watery or mucoid in consistency. We now report the cases of three patients with pseudomembranous colitis whose main clinical manifestation was hematochezia.
Aged ; Clostridium difficile ; Diarrhea ; Enterocolitis, Pseudomembranous ; Gastrointestinal Hemorrhage ; Gastrointestinal Tract ; Humans

In vitro PVR(Proliferative vitreoretinopathy) models allow identification of factor which may inhibit porliferation and contraction. In this study we evaluated the contraction of collagen matrix by choroidal fibroblast and the inhibition of contraction by antipoliferative drug. Each antiproliferative drug showed inhibition of collagen matrix contraction : Colchicine (0.1microgram/ml), Cytochalacin (0.05microgram/ml), Puromycin(10microgram/ml). Transmission electron microgram of collagen matrices containing colchicine, cytochalacin or puromycin showed no collagen fiber surrounding choroid fibroblast and showed cell destruction. Scanning electron microgram of collagen matrices containing colchicine, cytochalacin and puromycin showed that collagen fibers were well preserved without distortion. Colchicine, cytochalacin and puromycin are effective inhibitor of cell mediated contraction in additon to it`s potent antiproliferative effect wherease Interfereon has no anticontractile effect. The current study present a model to investigate the effect of antiproliferative drug on fibroblast mediated collagen matrix contraction.
Choroid ; Colchicine ; Collagen* ; Fibroblasts ; Interferons ; Puromycin ; Vitreoretinopathy, Proliferative

VEP(Visual Evoked Potential) is being widely used as a diagnostic method in amblyopia. In order to assess the visual improvement during occlusion therapy and VEP change between pre and post-occlusion therapy in amblyopia, 32 amblyopic chi1dren ranging from 3 to 13 years old were investigated. The results were as follows: 1. Among 21 cases of visual improvement above 2 lines with Han's visual acuity chart, occlusion therapy was effective in 73.7% of strabismic amblyopia, and 87.5% of anisometropic amblyopia. The mean period of visual improvement above 2 lines was 2.2 months. 2. As compared to non-amblyopic eye, VEP amplitude of amblyopic eye was significantly reduced. 3. There was no statistic significance of P3 latency between amblyopic and non-amblyopic eyes. 4. As compared to control group, the side difference of amblyopic group was significantly increased. 5. With visual improvement above 2 lines, increase of amplitude was revealed 87.5% and decrease of side difference was revealed 87.5% in 10 cases of investigating VEP change. 6. In 7 eyes of visual improvement above 2 lines, change of P2 latency between pre-occlusion and post-occlusion therapy revealed no significance statistically.
Adolescent ; Amblyopia* ; Humans ; Visual Acuity

The purpose of this study was to assess the energy value of breakfast and its relation to total daily nutrient intake and serum lipid. Dietary intakes were evaluated through the 3-day dietary recalls(interview for 1day and self-report for 2 days) from 333 Korean urban adults aged 20-49 year. Serum lipids in fasting blood samples were measured form 98 of those 333 adults. Low energy breakfast(<15% of daily energy intake) was consumed by 22.6% of males and 18.5% of females. 59.4 of males and 43.3% of females consumed a breakfast of average energy intake(15-25% daily energy intake) ; and 18.1 of males and 38.2% of females consumed a significant contribution to a total daily nutrient intake. The daily nutrient intake except crude fiber and vitamin A, B, B, and C in males and except vitamin C in females significantly increased as the energy value of breakfast increased. The differences in energy and nutrient intakes at breakfast were not made up for by other meals. To make matters worse, the satisfactory-energy breakfast group took more energy at dinner compared with the low-energy and average-energy breakfast group took more energy at dinner compared with the low-energy and average-energy breakfast groups in females. Among serum lipid parameters, TG was negatively correlated with energy provided at breakfast, and total cholesterol and LDL-cholesterol had a negative correlation with energy and carbohydrates provided at breakfast in males. For females TG was positively correlated with the ratio of carbohydrates to energy at breakfast but negatively correlated with the ratio of fat to energy at breakfast. These results suggest that satisfactory energy intakes at breakfast have positive effects on the adequacy of daily nutrient intake and may positively affect the serum lipid status.
Adult* ; Ascorbic Acid ; Breakfast* ; Carbohydrates ; Cholesterol ; Fasting ; Female ; Humans ; Male ; Meals ; Vitamin A

When an axon is severed, degenerative changes occur in the injured neuron as well as in those with which it has synaptic connections through transneuronal degeneration. Transneuronal degeneration includes all atrophic or degenerative changes that occur in nerve cells following the disappearance of their efferent (retrograde transneuronal degeneration) or afferent (anterograde transneuronal degeneration) connections. Previous studies have shown that transneuronal degeneration may occur in the neurons of various central nervous system following injury to their peripheral nerve. However, the effect of transneuronal degeneration on the neurons which are related with damaged neurons functionally and structurally is not elucidated yet. Denervation due to axonal degeneration or dysfunction of nerve cell bodies leads to physiological and biochemical changes in the skeletal muscles, and the extent of neuronal degeneration can be assessed through the muscle atrophy and the changes in muscle fiber type density. In order to identify the effect of transneuronal degeneration on the adjacent peripheral nerves as well as muscles, the left femoral nerve of Sprague -Dawley rats was transected, and changes in their spinal cords and hindlimb muscles were analysed morphologically and histochemically. The results obtained are as follows : 1. the motor neurons of ipsilateral anterior horn of femoral nerve transected rats showed reduction in size and degenerative features such as shriven shape and nucleus moved to periphery of the cell body. 2. All three muscle fiber types of rectus femoris and adductor longus were reduced in muscle fiber size, but no such changes were observed in semitendinosus. 3. In rectus femoris and adductor longus, type IIa muscle fiber was increased in number and the number of type IIb fiber was reduced, whereas no change was observed in all three muscle fiber types of semitendinosus. These findings indicate that damaged neurons following peripheral nerve injury can affect other adjacent neurons through transneuronal degeneration and cause the denervative changes in the muscles innervated by those adjacent neurons concomitantly, and such effects are only observed in the same spinal cord level.
Animals ; Axons ; Central Nervous System ; Denervation ; Femoral Nerve ; Hindlimb ; Horns ; Motor Neurons ; Muscle, Skeletal ; Muscles ; Muscular Atrophy ; Neurons ; Peripheral Nerve Injuries* ; Peripheral Nerves* ; Quadriceps Muscle ; Rats* ; Spinal Cord

PURPOSE: The morphogenic mechanism of tetralogy of Fallot is known to be an antero-superior deviation and hypertrophy of the subpulmonary infundibulum. We performed this study to measure the subpulmonary infundibulum in patients with tetralogy of Fallot and compare those with normal control. METHODS: Echocardiographic data and medical reports of 12 patients, with classical tetralogy of Fa11ot who were diagnosed echocardiographically from Dec. 1996 to Jan. 1999 in Kyungpook National University Hospital, were retrospectively reviewed. A control group consisted of 11 children who underwent a complete echocardiographic examination for a heart murmur and were found to be structually norrnal. Measurements of the subpulmonary infundibulum were performed in systolic still frames with the subxiphoid short axis view. RESULTS: Compared with the normal control children, the following indexed infundibular dimensions in patients with tetralogy of Fallot were significantly smaller' volume, length, cross-sectional area, diameters of pulmonary valve annulus, main, left and right pulmonary arteries, PA index and McGoon ratio. The following measurements were increased in tetralogy patients ' the angle between infundibular septum and ventricular septum, and infundibular free wall thickness. CONCLUSION: We confirmed both antero-superior deviation of infundibular septum and infundibular hypoplasia as morphologic abnormalities in tetralogy of Fallot. We also revealed relatively equal contributions of shortening of infundibular length, and increased infundibular septal and free wall thickness to infundibular hypoplasia.
Axis, Cervical Vertebra ; Child ; Echocardiography ; Gyeongsangbuk-do ; Heart Murmurs ; Humans ; Hypertrophy ; Pulmonary Artery ; Pulmonary Valve ; Retrospective Studies ; Tetralogy of Fallot* ; Ventricular Septum