The present study was undertaken to investigate the effect of ethanol administration on the resistance of mice to Cryptococcus neoformans, IL-2 production of murine splenocytes, active systemic anaphylaxis induced by ovalbumin (OVA), serum TNF-alpha production, nitric oxide (NO) production by peritoneal machrophages and B16F10 melanoma colonization in lungs in mice. It was found that ethanol administration significantly inhibited the resistance of mice to C. neoformans infection, IL-2 production, active systemic anaphylaxis induction, serum TNF- alpha production and NO production. Ethanol administration significantly enhanced lung colonization when it was administered before i.v. melanoma inoculation. These results demonstrate that ethanol may play a critical role in tumorigenesis and immunoregulation as an immunomodulator.
Anaphylaxis* ; Animals ; Carcinogenesis ; Colon ; Cryptococcus neoformans ; Cytokines* ; Ethanol ; Interleukin-2 ; Lung ; Melanoma* ; Mice ; Nitric Oxide* ; Ovalbumin ; Tumor Necrosis Factor-alpha

No abstract available.

No abstract available.
Animals ; Capsaicin* ; Colon* ; Cytokines* ; Lung* ; Melanoma, Experimental* ; Mice* ; RNA, Messenger*

PURPOSE: The study has been done to evaluate the significance of APR test predictive of neonatal infection. METHODS: A study was made on 76 cases of clinically infeected neonates who had been admitted at the NICU of Chungnam National Unoversity Hospital during the period from January, 1996 to July, 1996 in order to know the significance of APR test predictive of neonatal infection. RESULTS: 1)The APR test Of Control group (20 cases) shows negative results on 19 cases (95%) and positive result on 1 case (5%). 2) The APR test of Patient group (76 cases) shows negative results on 17 cases (22.3%) and positive results on 49 cases (77.7%). Of cases with positive result, one points were on 23 cases (30.5%), two points were 25 cases (32.8%), three points were on 11 cases (14.4%) and More than one point were of 59 cases. The sensitivity of APR test, WBC count and CRP is 77.7%, 35% and 62.496, respectivitly. As above result, APR test has a high sensitivity. 3) APR positive values are not significantly different between those of premature and fullterm patients. 4) APR values are more significant than WBC count or CRP value to predict the neonatal infection. 5) The APR test is rnore useful for prognostic correlation than other index. CONCLUSION: APR test is very sensitive and significantly useful predictive of neonatal infection.
Chungcheongnam-do ; Fever ; Humans ; Infant, Newborn

No abstract available.
Humans* ; Keratinocytes* ; Protein-Serine-Threonine Kinases* ; Serine* ; Threonine*

Dermatitis Herpetiformis rarely in childhood, and certain features of the disease in children differ from its manifestations in adults. Juvenile dermatitis herpetiformis appears not to be the same disease as the typical dermatitis herpetiformis of adults. Juvenile dermatitis herpetiformis has been described as a predomimantly bullous disease, but rarely papulovesicular eruptions. This bullous eruption in children must be considered in the several entities such as bullous pemphigoid and erythema multiforme. Juvenile bullous dermatitis herpetiformis has not responded routinely to sulfapyridine and sulfone therapy. A 15-month-old child whose skin lesions fulfilled clinical, histologic, and therapeutic criteria for Juvenile dermatitis hepetiformis is reported. The skin lesions showed bullous eruptions and also complained of severe itching sensation different from bullous Juvenile dermatitis herpetiformis.
Adult ; Child ; Dermatitis Herpetiformis* ; Dermatitis* ; Erythema Multiforme ; Humans ; Infant ; Pemphigoid, Bullous ; Pruritus ; Sensation ; Skin ; Sulfapyridine

Plastic surgeons have frequently encountered wide and long skin defects which require flap coverage. These include defects that occur after radical tumor resection of the head and neck region, release of severe bum scar contracture, and defects with exposure of the bone or tendons in upper and lower extremities. Lateral thigh fasciocutaneous flap, first introduced by Baek in 1983, has a long and wide skin territory. By using this flap, we performed 6 cases of burn scar contractures and 2 cases of head and neck cancer defects. In the flap elevation, it is not necessary to change the patient's position, therefore, the two-team approach shortens the operating time. The donor site can be closed primarily if the width of flap is not over 8 cm. The donor scar of the thigh is easily concealed. The lateral thigh flap can also be used as a composite or sensate flap. We conclude that, due to the lateral thigh flap being a thin and pliale fasciocutaneous flap which has a long and wide skin territory, it is very useful for reconstruction of large skin defects.
Burns ; Cicatrix ; Contracture ; Free Tissue Flaps* ; Head ; Head and Neck Neoplasms ; Humans ; Lower Extremity ; Neck ; Skin* ; Tendons ; Thigh* ; Tissue Donors

No abstract available.

Occasionally, a bony spine of variable size, the supracondylar process, projects distally from the anteromedial surface about 5cm proximal to the medial epicondyle, to which it is joined by a band of fibrous tissue. It was found in one per cent of living white subjects and less often in the colored races; only in rare instances it is associated with clinical signs, usually median nerve neuralgia. Here, we reported a case of incidental finding of supracondylar process without a definite symptom.
Continental Population Groups ; Humans ; Humerus ; Incidental Findings ; Median Neuropathy ; Spine

Of the shoulder syndromes, acute calcific tendinitis of the rotator cuff is the least difficult to differentiate, for the mechanical and inflammatory aspects combine to produce a picture of severe, and localized pain which presents in obvious distress, splinting the affected shoulder by holding the arm to his side. The radiologic picture corresponds poorly to the clinical picture, with visible calcium deposits ranging from thin crescents to large fluffy amorphous masses. Acute calcific tendinitis is a self-limited process with a natural history of 6 to 14 days. Relief is dramatic when the inflammatory and mechanical cycle is broken, but the potential remains for exacerbation as for more serious sequellae such as adhesive capsulitis. We expereinced 5 lesions of calcific tendinitis in supraspinatus tendon treated by surgical removal in 4 lesions and by conservative measure in one lesion.
Arm ; Bursitis ; Calcium ; Natural History ; Rotator Cuff ; Shoulder ; Splints ; Tendinopathy ; Tendons