1.Anal malignant melanoma: a case report and review of literatures.
Byeong Ryong SEOL ; Hyun Duk BAE ; Chae Won LEE
Journal of the Korean Surgical Society 1993;44(2):306-314
No abstract available.
Melanoma*
2.Contribution of Color Doppler Scoring System to Diagnosis of Ovarian Malignancy.
Duk Soo BAE ; Jong Dae WHANG ; Seon Hye PARK ; Bo Hyun KIM ; In Sook JOO ; Chang Soo PARK ; Je Ho LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(3):271-278
The purpose of this prospective study was to evaluate the diagnostic value of color Doppler scoring system in characterization of ovarian masses. We performed transabdominal or transvaginal color Doppler sonopaphy on 82 women with ovarian masses and analyzed the sonographic findings. Ovarian lesions were assessed by means of morphological and color Doppler scoring system by Kurjak. Tumors were characterized by ultrasonographic findings as benign or suspected of being malignant. Then the results of each scoring systems were correlated with histopathological findings. The results were as follows; Of 82 ovarian masses, 64 were benign lesions(13 mucinous cystadenomas, 16 endometriomas, 20 teratomas, 8 serous cystadenomas, and 13 other abnormalities), and 18 were malignant(12 cancers and 6 borderline tumors). The color Doppler scoring system was useful in distinguishing malignant from benign masses, with a sensitivity of 88.2%, compared with the morphological scoring system of 86.7%. The specificity of color Doppler and morphological scoring system were 95.4% and 92.5%, respectively. The sensitivity of combination of both scoring systems was 88.9%, with a specificity of 96.9%. In conclusion, color Doppler scoring system is a useful tool in predicting the malignancy of ovarian lesions especially combined with morphological scoring system.
Cystadenoma, Mucinous
;
Cystadenoma, Serous
;
Diagnosis*
;
Endometriosis
;
Female
;
Humans
;
Prospective Studies
;
Sensitivity and Specificity
;
Teratoma
;
Ultrasonography
3.Effects on osteoclast in periodontal ligament space by denerveation of inferior alveolar nerve in young and adult rats.
Kyung Duk PARK ; Jae Hyun SUNG ; Yong Chul BAE ; Hee Moon KYUNG
Korean Journal of Orthodontics 2004;34(6):506-513
Osteoclast action is necessary for alveolar bone remodeling in orthodontic tooth movement. The nervous system has also been reported to be associated with bone remodeling. This study was aimed to investigate the changes of osteoclasts in the periodontal ligament (PDL) space after surgical resection of the inferior alveolar nerve (IAN). Experimental rats were divided into young and adult groups. A surgical resection procedure of the IAN was carried out in the left side of the mandible and a sham operation in the right side of the mandible. The number of osteoclasts on the bundle bone surface and the resorption activity of the osteoclasts were histomorphometrically measured. The changes in distribution of substance P (SP) immunoreactive (IR) nerve fiber were evaluated in the PDL and pulp. SP-IR nerve fiber was depleted in both the PDL and pulp of the IAN resection side in both groups, which confirmed the resection of IAN to be successfully conducted. The number of osteoclasts in the IAN resection side was significantly reduced in both the young and adult groups (p<0.01 and p<0.05), whereas the resorption activity of osteoclasts did not show any significant difference between the IAN resection side and the sham operation side in both groups (p>0.05 and p>0.05). The adult group showed that the number of osteoclasts reduced significantly (p<0.01) and the resorption acitvity didn't change in comparison with the young group (p>0.05). These results suggest that surgical resection of the IAN and aging reduce the population of the recruited osteoclasts within the PDL, but don't affect on the osteoclastic resorption activity.
Adult*
;
Aging
;
Animals
;
Bone Remodeling
;
Denervation
;
Humans
;
Mandible
;
Mandibular Nerve*
;
Nerve Fibers
;
Nervous System
;
Osteoclasts*
;
Periodontal Ligament*
;
Rats*
;
Substance P
;
Tooth Movement
4.Comparative Effects of Paclitaxel and Nitric Oxide on Superficial Murine Bladder Tumor Cells.
Byoung Sun AHN ; Hyun Jeong KWAK ; Hyun Ock BAE ; Ji Chang YOO ; Chang Duk JUN ; Jeong Sik RIM ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):235-245
No abstract available.
Nitric Oxide*
;
Paclitaxel*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
5.The Diagnostic Value of Dipyriddamole99mTc-MIBI SPECT in the Diagnosis of Coronary Artery Disease : Comparison with Coronary Angiography.
Ju Il LEE ; Do Young KANG ; Duk Kyu KIM ; Hyun Kook DO ; Moo Hyun KIM ; Young Dae KIM ; Jong Seong KIM ; Sang Kyun BAE
Korean Circulation Journal 1995;25(4):794-802
BACKGROUND: The purpose of this study is to assess the ability of dipyridamole99mTc-MIBI SPECT to identify and localize coronary artery disease(CAD). METHODS: The study population consists of 60 patients(37 males, 23 females : mean age 57+/-10 years) including 30 with prior myocardial infarction who underwent both dipyridamole99mTc-MIBI SPECT and coronary angiography for the evaluation of chest pain. RESULTS: The sensitivities for detection of CAD(> or =50% and > or =70% coronary stenosis by angiography) by dipyridamole99mTc-MIBI SPECT are 96% and 98% respectively, and specifities are 71% and 73% respectively. The sensitivities for detection of individual diseased vessels(> or =50% and > or =70%) are 79% and 90% for left anterior descending artery(LAD), 53% and 59% for left circumflex artery(LCX), 45% and 53% for right coronary artery(RCA), 64% and 77% for LCX/RCA, 63% and 72% for total. The specificities for detection of individual diseased vessels(> or =50% and > or =70%) are 62% for LAD, 98% and 98% for LCX, 92% and 89% for RCA, 91% and 89% for LCX/RCA, 87% and 86% for total. The concordances for ditection of individual didseased vessels beteen coronary angiography and dipyridamole99mTc-MIBI SPECT are all fair for SAD(Kappa=0.4 in > or =50% stenosis, 0.54 in > or =70% stenosis)LCX(Kappa=0.56,0.63),RCA(Kappa=0.4,0.44) and LCX/RCA(Kappa=0.56,0.67). CONCLUSION: Dipyriddamole99mTc-MIBI SPECT appers to be an useful noninvasive test for both identification and localization of coronary artery disease.
Chest Pain
;
Constriction, Pathologic
;
Coronary Angiography*
;
Coronary Artery Disease*
;
Coronary Stenosis
;
Coronary Vessels*
;
Diagnosis*
;
Female
;
Humans
;
Male
;
Myocardial Infarction
;
Tomography, Emission-Computed, Single-Photon*
6.DNA-based Prenatal Diagnosis of Epidermolytic Palmoplantar Keratoderma in Two Pregnancies at Risk in One large Pedigree.
Jun Mo YANG ; Jang Hyun SHIN ; Mi Ook CHO ; Duk Soo BAE ; Soon H YANG ; Jae Hyun CHUNG ; Joo Heung LEE
Annals of Dermatology 2001;13(2):96-101
BACKGROUND: Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant disease of cornification which presents as severe thickening of the palms and soles with prominent epidermolytic hyperkeratosis pathologically. Recent studies have shown that EPPK is caused by mutations in the keratin 9 (K9) gene which is expressed essentially only in the palms and soles. Previously, We have reported that patients in one large pedigree of EPPK have an R162W substitution in the K9 protein. In this pedigree, two women whose husbands are both EPPK patients had become pregnant. OBJECTIVE: Since both women were concerned about this genetic disorder, we have performed prenatal diagnosis by biopsy analysis of chorionic villi tissue. METHODS: Chorionic villi biopsies were performed at 12 weeks gestation. Since the skin lesions are strictly confined to the palms and soles of the babies, the prenatal diagnosis of EPPK by ultrastructural analysis of fetal skin biopsy or amniotic fluid cells is highly problematic. Polymerase chain reaction amplification of specific allele (PASA) assay and direct DNA sequencing analyses were performed whether the fetuses carried mutant allele of K9 gene. RESULTS: PASA assay and direct DNA sequencing analyses showed that one fetus was normal, but the other fetus carried the abnormal allele. Subsequently, the mother of the unaffected fetus delivered a normal child, but the mother of the affected fetus terminated the pregnancy. CONCLUSION: We describe the analysis of the K9 mutation in the two fetuses at risk for EPPK. We believe that this is the first report of prenatal diagnosis for EPPK. But, we have to think about the ethical problems before we decide to perform the prenatal diagnosis of any kind of skin diseases.
Alleles
;
Amniotic Fluid
;
Biopsy
;
Child
;
Chorionic Villi
;
Chorionic Villi Sampling
;
Female
;
Fetus
;
Humans
;
Hyperkeratosis, Epidermolytic
;
Keratin-9
;
Keratoderma, Palmoplantar, Epidermolytic*
;
Mothers
;
Pedigree*
;
Polymerase Chain Reaction
;
Pregnancy*
;
Prenatal Diagnosis*
;
Sequence Analysis, DNA
;
Skin
;
Skin Diseases
;
Spouses
7.A Clinical Study of Tissue Valve Failure.
Duk Hyun KANG ; Ihn Ho CHAI ; Myoung Chan CHO ; Young Kwon KIM ; Duk Kyung KIM ; Dae Won SOHN ; Myoung Mook LEE ; Young Bae PARK ; Yun Shik CHOI ; Jung Don SEO ; Young Woo LEE
Korean Circulation Journal 1990;20(4):679-686
On reoperations for tissue valve failure from December 1981 to December 1989, we had diagnosed 71 cases as primary tissue failure. In those cases we found out risk factors of accelerated primary tissue failure and increased thrombogenecity. We reviewed also long-term follow-ups of 542 patients after tissue valve replacement from 1978 to 1982, and durability of tissue valve was evaluated with the freedom rate from primary tissue failure. The results were as follows. 1) Eight patients had undergone reoperation by Dec. 1989 ; 71 cases(80.7%) for primary tissue failure, 11 cases(12.5%) for prosthetic valve endocarditis, 4 cases(4.5%) for thromboembolism, and 2 cases(2.3%) for paravalvular leakage. primary tissue failure was the main cause(80.7%) of tissue valve failure. 2) Primary tissue failure occurred at a mean postoperative interval of 89.7 months(range : 19.9-143.2 months). 3)In children under the age of 18, mean implantation time was 62 months, and in adults mean implantation time was 96 months. In the child group primary tissue failure occurred earlier than in the adult group by 34 months(p<0.01) 4) Actuarial freedom from primary tissue failure was 97.6%+/-0.6% at 5 years and 84.4%+/-2.2% at 10 years. 5) The types and locations of prosthetic tissue valves resulted in no significant difference in durability. 6) Primary tissue failure was mainly caused by calcification of the cusps(76%) 7) In atrial fibrillation the incidence of atrial thrombi was 31.3% and left atrial thrombi was the most common finding(60%) In conclusion, 1) Durability of tissue valve for 10 years is acceptable, but the limited durability of tissue may be a major concern after 10 years. 2) In children under the age of 18, tissue valve should be avoided due to accelerated tissue failure. 3) Atrial fibrillation clearly increases the risk of thromboembolism and anticoagulation is considered to be required in patients with atrial fibrillation.
Adult
;
Atrial Fibrillation
;
Child
;
Endocarditis
;
Follow-Up Studies
;
Freedom
;
Humans
;
Incidence
;
Reoperation
;
Risk Factors
;
Thromboembolism
8.A Common Genetic Variant of the Angiotensin Converting Enzyme(ACE) Gene and Pregnancy InducedHypertensive Disorders.
Cheong Rae ROH ; Duk Kyung KIM ; Byung Koo YOON ; Soon Ha YANG ; Jae Hyun CHUNG ; Duk Soo BAE ; Je Ho LEE
Korean Journal of Obstetrics and Gynecology 1997;40(6):1189-1199
BACKGROUND: The angiotensin coverting enzyme(ACE) gene(encoding kininase II, EC3.4.15.1) contains a polymorphism based on the presence(insertion [I]) or absence(deletion[D]) within an intron of a 287bp nonsense DNA domain, resulting in three genotypes(D/I) and I/I homozygotes, and I/D heterozygotes). Alu insertion is associated with lowerACE level than deletion allele(D) and it was observed that D/D individuals have twice theACE activity of I/I patients. Pregnancy induced hypertension(PIH) probably results fromdominating pressor systems owing to loss of antagonizing vasodilator autacoids. AngiotensinII is an extremely potent arteriolar vasoconstrictor. Overactivity or failure to supressresponsiveness to the increased activity of angiotensin II, which is generated by ACE,would seem to be a reasonable basis for the vasoconstriction of PIH. The aim of this studyis to evaluate the relationship between ACE genotype and PIH. METHODS: Blood sampling was taken from 39 patients with PIH. The hypertensivedisorders, confirmed at postpartum follow up, were classified as gestational hypertensionwithout proteinuria, preeclampsia(mild and severe) and eclampsia. The diagnosis ofpreeclampsia was made according to the American College of Obstetrics and Gynecology criteriaof hypertension and proteinuria(>300 mg/24 hr urine). Genomic DNA was extractedfrom blood sample. After PCR amplification of the respective fragments from intron 16 ofthe ACE gene, size fractionation and visualization by electrophoresis were performed. RESULTS: PIH group(including gestational hypertension, mild and severe preeclampsia: frequency of I allele 0.756 and D allele 0.244) had more I allele and less D allele whencompared with normal population(frequency of I allele 0.609 and D allele 0.391)(p < 0.05).And PIH group had more I/I homozygote individuals showing significant distortion fromHardy-Weinberg equilibrium of ACE genotype(p < 0.05). Moreover, severe preeclampsiagroup alon(frequency of I allele 0.759 and D allele 0.241) had more I allele and less Dallele when compared with normal population and had significantly more I/I homozygoteindividuals. CONCLUSION: As pregnancies with PIH had more ACE I allele and I/I homozygoteindividuals. PIH could be associated with I allele of the ACE gene. Considering the observedcodominant association between the D-I polymorphism and plasma ACE activity, our resultis in favor of the thesis that PIH primarily arises from defective synthsis of vasodilatingautacoids and renin-angiotensin system exerts secondary vasoconstrictive action. However,the relationship between ACE genotype and defective vasodilating mechanism during pregnancyis unknown at present.
Alleles
;
Angiotensin II
;
Angiotensins*
;
Autacoids
;
Diagnosis
;
DNA
;
Eclampsia
;
Electrophoresis
;
Female
;
Follow-Up Studies
;
Genotype
;
Gynecology
;
Homozygote
;
Humans
;
Hypertension
;
Hypertension, Pregnancy-Induced
;
Introns
;
Obstetrics
;
Peptidyl-Dipeptidase A
;
Plasma
;
Polymerase Chain Reaction
;
Postpartum Period
;
Pre-Eclampsia
;
Pregnancy*
;
Proteinuria
;
Renin-Angiotensin System
;
Vasoconstriction
9.A Protocol-Based Decision for Choosing a Proper Surgical Treatment Option for Carotid Artery Stenosis.
E Wook JANG ; Joonho CHUNG ; Kwon Duk SEO ; Sang Hyun SUH ; Yong Bae KIM ; Kyung Yul LEE
Journal of Cerebrovascular and Endovascular Neurosurgery 2015;17(2):101-107
OBJECTIVE: There are two established surgical treatment options for carotid artery stenosis. Carotid endarterectomy (CEA) has been accepted as a gold standard for surgical treatment while carotid artery stenting (CAS) has recently become an alternative option. Each treatment option has advantages and disadvantages for the treatment outcomes. We propose a protocol for selection of a proper surgical treatment option for carotid artery stenosis. MATERIALS AND METHODS: A total of 192 published articles on management of carotid artery stenosis were reviewed. Preoperatively considerable factors which had been repeatedly noted in those articles for the risk/benefits of CEA or CAS were selected. According to those factors, a protocol with four categories was established. RESULTS: CEA or CAS is indicated when the patient has a symptomatic stenosis > or = 50%, or when the patient has an asymptomatic stenosis > or = 80%. Each treatment option has absolute indications and favorable indications. Each absolute indication is scored with three points, and each favorable indication, one point. Based on the highest scores, a proper treatment option (CEA or CAS) is selected. CONCLUSION: We have been treating patients according to this protocol and evaluating the outcomes of our protocol-based decision because this protocol might be helpful in assessment of risk/benefit for selection of a proper surgical treatment option in patients with carotid artery stenosis.
Carotid Arteries
;
Carotid Stenosis*
;
Constriction, Pathologic
;
Endarterectomy, Carotid
;
Humans
;
Stents
10.Differential Lung Ventilation Therapy for Reexpansion Pulmonary Edema: Report of 2 cases.
Duk Sil KIM ; Sung Wan KIM ; Dae Hyun KIM ; Eung Bae LEE ; Sang Hoon JHEON
The Korean Journal of Thoracic and Cardiovascular Surgery 2003;36(7):527-530
Reexpansion pulmonary edema is a rare complication of the treatment of lung collapse secondary to pneumothorax, pleural effusion, or atelectasis. But occasionally, severe morbidity and death may result. Reexpansion pulmonary edema occurs when chronically collapsed lung is rapidly reexpanded by evacuation of large amounts of air or fluid. In the treatment of the chronically collapsed lung, physicians must remember the possible events and prevent the complications. When the difference in airway resistance or lung compliance between the two lungs is exaggerated, conventional mechanical ventilation might lead to preferential ventilation with hyperexpansion of one lung and gradual collapse of the other. Differential ventilation has been advocated to avert this problem. By differential lung ventilation, we successfully treated a severe reexpansion pulmonary edema in two patients. Therefore we suggest that differential lung ventilation is the treatment of choice for severe reexpansion pulmonary edema.
Airway Resistance
;
Humans
;
Lung Compliance
;
Lung*
;
Pleural Effusion
;
Pneumothorax
;
Pulmonary Atelectasis
;
Pulmonary Edema*
;
Respiration, Artificial
;
Ventilation*