1.A Case of Xanthoma Disseminatum Treated with CO2 Laser Vaporization and High Dose Steroid.
Jeong Deuk LEE ; Chung Eui YOU ; Sang Hyun CHO
Annals of Dermatology 2003;15(3):110-112
Xanthoma disseminatum (XD) is one of cutaneous nonhistiocytosis X, and characterized by multiple, widely distributed red, brown, yellowish papules and nodules that tend to coalesce. We present a case of XD with characteristic clinical findings and treated with the combination therapy of COz laser vaporization and high dose steroid.
Histiocytosis, Non-Langerhans-Cell*
;
Laser Therapy
;
Lasers, Gas*
;
Volatilization*
;
Xanthomatosis*
2.Expression of Androgen Receptor, bcl-2 Protein and Rb Protein in Breast Cancers as Related to Prognostic Factors.
Hyun Deuk CHO ; Young Sik KIM ; Insun KIM
Korean Journal of Pathology 1998;32(6):443-452
Breast cancer is the most common malignancy of women in industrialized countries and the third in Korean women. There have been a lot of studies on biologic behaviors as well as on the prognostic factors of the breast cancer. In this study, the expression of hormone receptors (estrogen receptor ; ER, progesterone receptor ; PR, and androgen receptor ; AR), bcl-2 and Rb proteins were immunostained on 60 infiltrating ductal carcinomas of the breast. The results were evaluated in relation with the age, histologic grade, tumor size, and status of lymph node metastasis. The expression of ER and PR had a significant inverse correlation with the histologic grade (p<0.001). The expression of AR was significantly correlated with the expression of ER (p=0.039) and PR (p=0.009), but not with other factors such as age, histologic grade, tumor size, and status of lymph node metastasis. There was no relationship between bcl-2 protein expresssion and other prognostic factors, except with the expression of ER. Rb protein expression had a significant positive relationship with PR (p=0.05) and the degree of positivity was correlated with histologic grade (p=0.002). In conclusion, this result suggests that expression of AR is well correlated with ER and PR. bcl-2 has no prognostic value. The significance of Rb protein expression remained to be studied.
Breast Neoplasms
;
Breast*
;
Carcinoma, Ductal
;
Developed Countries
;
Female
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Receptors, Androgen*
;
Receptors, Progesterone
;
Retinoblastoma Protein*
3.The Usefulness of Cytokeratin 7 and Colon Ovarian Tumor Antigen in the Differential Diagnosis of Primary and Metastatic Ovarian Tumors.
Eung Seok LEE ; Hyun Deuk CHO ; In Sun KIM
Korean Journal of Pathology 1998;32(3):201-207
Cytokeratin 7 has been known to be present in various types of human epithelial cells including the ovarian neoplasms, but not in colon cancers. The antibody to colon ovarian tumor antigen (COTA) has been introduced as a marker of colon and ovarian tumors. The aim of this study was to evaluate the usefulness of cytokeratin 7 and COTA in the differential diagnosis between ovarian primary and metastatic tumors. Nineteen primary ovarian epithelial tumors, seven metastatic carcinomas of the ovary from the stomach, three metastatic carcinomas of the ovary from the colon, one mucinous tumor of the ovary associated with a mucinous tumor of the appendix and pseudomyxoma peritonei, and nineteen colonic and twenty gastric adenocarcinomas were stained with monoclonal antibodies to cytokeratin 7 and COTA. The results are summerized as follows; In the primary ovarian tumors, 94.4% were positive for cytokeratin 7 and 50% were positive for COTA. In the primary colonic adenocarcinomas, 94.7% were negative for cytokeratin 7 and 68% were positive for COTA. In the metastatic ovarian tumor from the colonic adenocarcinomas, 100% were negative for cytokeratin 7 and positive for COTA. In the primary gastric adenocarcinomas, 40% were negative for cytokeratin 7 and 85% were negative for COTA. In the metastatic ovarian tumor from the gastric adenocarcinomas, 43% were negative for cytokeratin 7 and 14% were negative for COTA. From the results of this study, it could be concluded that in the differential diagnosis of primary ovarian tumors from metastatic colonic carcinomas, positive reaction for cytokeratin 7 suggests a primary ovarian tumor but a negative reaction for cytokeratin 7 and positive reaction for COTA suggest metastatic colonic carcinomas. The results of this study also reveal that cytokeratin 7 and COTA are not useful in the differential diagnosis of primary ovarian tumors from metastatic gastric carcinomas.
Adenocarcinoma
;
Antibodies, Monoclonal
;
Appendix
;
Colon*
;
Colonic Neoplasms
;
Diagnosis, Differential*
;
Epithelial Cells
;
Female
;
Humans
;
Keratin-7*
;
Keratins*
;
Mucins
;
Ovarian Neoplasms
;
Ovary
;
Pseudomyxoma Peritonei
;
Stomach
4.Molluscum Contagiosum Virus Infection in an Epidermal Cyst.
Hee Jin JUN ; Eujin CHO ; Sang Hyun CHO ; Jeong Deuk LEE
Korean Journal of Dermatology 2012;50(7):650-651
No abstract available.
Epidermal Cyst
;
Molluscum Contagiosum
;
Molluscum contagiosum virus
5.Two Cases of Injection Complication Following an Illegal Practice.
Seok Hoon MOON ; Jeong Deuk LEE ; Sang Hyun CHO ; Hei Sung KIM
Korean Journal of Dermatology 2016;54(5):393-394
No abstract available.
6.Annular Atrophic Lichen Planus.
Jeong Deuk LEE ; Chang Nam LEE ; Ji Eun KIM ; Sang Hyun CHO
Annals of Dermatology 2003;15(4):151-152
Annular atrophic lichen planus(AALP) is the most unusual variant of lichen planus that results from elastolytic activity of inflammatory cells. We report a case of AALP in 22-year-old man who had two annular pruritic plaques on the axilla. He had a two year history of skin lesions. Each lesion had elevated erythematous annular border with hyperpigmented atrophic macular center. Histopathologically, it showed typical features of lichen planus in the border of the lesion while a pattern of resolved lichen planus in its center. Elastic fibers was not found in the papillary dermis either at the border or at the center of the lesion.
Axilla
;
Dermis
;
Elastic Tissue
;
Humans
;
Lichen Planus*
;
Lichens*
;
Skin
;
Young Adult
7.A Case of Subcutaneous Juvenile Xanthogranuloma.
Jeong Deuk LEE ; Chung Eui YOU ; Chang Nam LEE ; Hoon KANG ; Sang Hyun CHO
Annals of Dermatology 2003;15(1):31-33
Juvenile xanthogranuloma is a congenital or perinatal tumor, 1 to 2 cm in diameter, usually located on the head. The extracutaneous lesions can occur on the eye, the lung, the epicardium, the oral cavity or the testicles. Subcutaneous form of juvenile xanthogranuloma has been reported very rarely in the literature. We report a unique case of a subcutaneous juvenile xanthogranuloma that showed 4 × 4 cm sized plaque and located on the extremity of 9-year-old girl.
Child
;
Extremities
;
Female
;
Head
;
Humans
;
Lung
;
Mouth
;
Pericardium
;
Testis
;
Xanthogranuloma, Juvenile*
8.A case of multiple furunculosis caused by methicillin-resistant staphylococcs aureus.
Kyung Deuk PARK ; Nam Joon CHO ; Dong Sik BANG ; Duck Hyun KIM
Korean Journal of Dermatology 1993;31(1):83-86
Staphylococcus aureus is one of many causative agents of the fu uncles. As the S. aureus strains resistant to penicillinase-repsistant penicillins (methicillin-resistant S. aureus, MRSA) are more frequently isolated, their accuiate identification became a very important step in selection of an appropriate therapeutic regimen. We report herein a case of multiple furunculosis caused by metkicillin-resistant S. aureus in a 11-year-old male patient, who was successfully treated with sulbactam/ampicillin and amikacin.
Amikacin
;
Child
;
Furunculosis*
;
Humans
;
Male
;
Methicillin Resistance*
;
Methicillin-Resistant Staphylococcus aureus
;
Penicillins
;
Staphylococcus aureus
10.E-Cadherin Expression in Renal Cell Carcinoma according to the Mainz Classification.
Ju Han LEE ; Hyun Deuk CHO ; Dale LEE ; Nam Hee WON
Korean Journal of Pathology 1999;33(12):1131-1138
According to the Mainz classification, renal cell carcinoma (RCC) consists of three subtypes: each has characteristic genetic alterations within the chromosomal or mitochondrial DNA. The three subtypes are: clear cell type, chromophil type, and chromophobe type. E-cadherin is a Ca++-dependent adhesion molecule which plays a major role in the maintenance of intercellular adhesion in epithelial tissues. In a normal kidney, E-cadherin is expressed in the distal tubule and the collecting duct, but not in the proximal tubule. We reclassified 110 cases of RCC according to mainz classification. Immunohistochemical staining for E-cadherin was done on twenty eight cases of RCC, including 18 cases of clear cell type, four cases of chromophil type, and six cases of chromophobe type. The results were as follows: 1) of the 110 cases of RCC, 96 cases (87.3%) were of clear cell type, four cases (3.6%) of chromophil type, and ten cases (9.1%) of chromophobe type, 2) there was no significant correlation between the nuclear grade and clinical stage according to each subtype, 3) E-cadherin expression showed a strong positive reaction along the cell membranes in all six cases of chromophobe type. The differential expression of E-cadherin in RCC may suggest that the chromophobe type may have different biologic characteristics from other types of RCC.
Cadherins*
;
Carcinoma, Renal Cell*
;
Cell Membrane
;
Classification*
;
DNA, Mitochondrial
;
Immunohistochemistry
;
Kidney
;
Population Characteristics