1.Preliminary study on histologic changes in the nerve and surrounding tissues after inferior alveolar nerve transposition in rabbits.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1999;25(4):351-356
PURPOSE: The purpose of this study was 1) to find nerve damage after inferior alveolar nerve transposition and 2) to examine whether the soft tissue or bone changes around the nerve produce the compression to the nerve in the healing period. MATERIALS AND METHOD: Inferior alveolar nerve was exposed through the bony window and the scratch was made in the bone to be thought as the inferior alveolar canal. Suture was made after the nerve was repositioned. The nerve and surrounding tissues were examined with the light microscope and the fluorescent microscope before surgery and at 1 month, 3 months, and 5 months after surgery. RESULTS: After surgery, the epineurium was damaged and the nerve was divided to several fascicles covered with the perineurium The newly formed fibrous connective tissue and vessels were seen around fascicles. There was new bone formation. However the nerve was not compressed by the connective tissue or the new bone. CONCLUSION: The results of this study suggest that neurosensory disturbances after inferior alveolar nerve transposition are resulted by the direct trauma in surgery rather than the compression to the nerve by the scar or new bone formation in the healing period.
Cicatrix
;
Connective Tissue
;
Mandibular Nerve*
;
Osteogenesis
;
Peripheral Nerves
;
Rabbits*
;
Sutures
2.The efficacy of fetal biophysical profile scoring in the diagnosis of fetal acidosis.
Bo Hyun YOON ; Hyun Jin SONG ; Pyl Ryang LEE ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(1):30-38
No abstract available.
Acidosis*
;
Diagnosis*
3.The Postoperative Analgesic Effect of Transdermal Fentanyl with Patch in Total Abdominal Hysterectomy.
Hyang Mi KIM ; Jae Kyoung KIM ; Hye Sin HYUN ; Hyun Chul SONG
Korean Journal of Anesthesiology 1997;33(2):342-347
BACKGROUND: Compared with conventional routes of delivering potent analgesics to postoperative patients, transdermal administration of fentanyl offers the advantages of simplicity and noninvasiveness. The analgesic efficacy and safty of transdermal fentanyl patch (TDFP) were evaluated postoperatively. METHOD: TDFP releasing 25 mcg/hr (Group 1) or placebo (Group 2) were applied to 40 women 6 hours before total abdominal hysterectomy under the general anesthesia. Postoperatively, self-administered intravenous fentanyl was maintained with a 20-mcg incremental dose and a 10-min. locking interval. Each group was assessed following 48 hours with respects to vital signs, VAS pain scores, hourly-used fentanyl doses, satisfaction scores and side effects. RESULT: VAS observed 24 hours, 36 hours after operation were significantly lower in group 1 than group 2. Hourly-used fentanyl doses were significantly lower in group 1 than group 2 at 2 hours, 6 hours, 12 hours and 24 hours after operation. The incidence of side effects were similar between group 1 and group 2. CONCLUSION: TDFP-25 mcg applied 6 hours before operation provides supplementary analges-ia after the postoperative period without significant side effects such as respiratory depression.
Administration, Cutaneous
;
Analgesics
;
Anesthesia, General
;
Female
;
Fentanyl*
;
Humans
;
Hysterectomy*
;
Incidence
;
Postoperative Period
;
Respiratory Insufficiency
;
Vital Signs
4.Bilateral aorto-renal bypasses: report of one case.
Young Chul YOON ; Jung Geun SONG ; Chul Hyun PARK ; Shin Yeong LEE ; Sang Joon OH ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(2):200-204
No abstract available.
5.Biologic Wet Dressing with Amnion in Muscle Necrosis of Lower Extremity Caused by Acute Limb Ischemia.
Go Woon WOO ; Chul Woong MOON ; Sang Eun SONG ; Hyun Chul KIM
Journal of the Korean Surgical Society 2006;70(4):334-339
Early treatment to facilitate the muscular blood flow can avert myonephropathic metabolic syndrome (MNMS) and major amputation for patients suffering with acute limb ischemia. Delayed reperfusion or microemboli in the small vessels can aggreviate: ischemic changes and lead to irreversible muscle necrosis. Amnion is an excellent biological dressing, and we tried using it to treat anterior compartment muscle necrosis (ACMN). The amnions were aseptically collected from caesarean sections. Additional betadine (1 : 3 solution) and vaseline-soaked gauzes were applied over the amnion as a daily biologic wet dressing. The amnion was replaced every three days. Finally, split skin grafting was performed on the healthy granulation tissue. We treated two patients who happened to have shin muscle necrosis. A 65-year-old man with a femoro-femoral arterial bypass showed graft thrombosis. Thirteen days after performing balloon angioplasty with stent insertion in the right femoral artery, new emboli were found in the stent and in the left popliteal artery. There was an attack of myocardial infarction the next day after embolectomy. The severe MNMS and ACMN at the right shin occurred after cardiopulmonary resuscitation. The dry gangrene was excised 3 months later, and this was followed by a skin graft 4 months later. An 81-year-old woman with atrial fibrillation showed left common femoral arterial obstruction and ACMN on the left shin during the management of congestive heart failure. The dry gangrene was excised 2 months later, and this was followed by a skin graft 3 months later. The amnion dressing shows promises for providing healthy granulation tissue for split skin grafts when treating muscle necrosis of the leg. Biologic dressing with using amnion is an option for limb salvage in the case of muscle necrosis that is caused by acute limb ischemia, although the treatment takes a long time.
Aged
;
Aged, 80 and over
;
Amnion*
;
Amputation
;
Angioplasty, Balloon
;
Atrial Fibrillation
;
Bandages*
;
Biological Dressings
;
Cardiopulmonary Resuscitation
;
Cesarean Section
;
Embolectomy
;
Extremities*
;
Female
;
Femoral Artery
;
Gangrene
;
Granulation Tissue
;
Heart Failure
;
Humans
;
Ischemia*
;
Leg
;
Limb Salvage
;
Lower Extremity*
;
Myocardial Infarction
;
Necrosis*
;
Popliteal Artery
;
Povidone-Iodine
;
Pregnancy
;
Reperfusion
;
Skin
;
Skin Transplantation
;
Stents
;
Thrombosis
;
Transplants
6.SR (Slow-Replase) Lanreotide Treatment in Acromegalic Patients.
Jae Hyun NAM ; Sung Kil LIM ; Sun Ho KIM ; Chul Woo AHN ; Song Chul LEE ; Young Duk SONG ; Kyung Rae KIM ; Hyun Chul LEE ; Ki Hyun PARK ; Kap Bum HUH
Journal of Korean Society of Endocrinology 1999;14(3):472-482
BACKGROUND: Several clinical studies reported the efficacy of the long-acting SRIH analog, octreotide (Octreotide, Sandoz) in the treattnent of acromegaly. Recently, another SRIH analog (BIM 23014, Ipsen Biotech) was shown to decrease plasma GH levels in acromegalic patients. The recent availability of a long-acting formulation of BIM 23014 [slow release (SR) lanreotide] could avoid repeated sc injections or continuous sc infusions. The objective of this study was to determine the tolerability and effectiveness of the slow release (SR) somatostatin analog, SR lanreotide in active acromegaly. METHOD: Between March 1998 and May 1998, 10 patients were recruited in the prospective study carried out at Yonsei University. The effects of 6 weeks of SR lanreotide, given every 14 days at a dosage of 30 mg, im, were analyzed. All the patients completed the 6-week period of therapy. RESULTS: SR lanreotide injection produced 45% suppression of area under the curve of GH levels from the basal value on oral glucose tolerance test(OGTT). GH values on OGTT were normalized (< 2ng/mL) in 30% of patients after 6 weeks, whereas insulin-like growth factor I (IGF-I) levels were normalized in 50% of patients. No correlation was found between pretreatment GH levels and GH response to SR lanreotide or between changes in GH and IGF-I during therapy, The significant differences in response to SR lanreotide were shown between the patients with residual mass and no visible mass. During treatment, there was the significant reduction in the percentage of patients complaining of joint pain, hyperhydrosis, and paresthesias. Changes in soft tissue swelling were documented by a significant decrease in the diameter of fingers. Mild diarrhea and fatigue were the most frequent side-effects (20 30%) when SR lanreotide therapy was started. However, these side effects decreased progressively. Significant changes were noted in carbohydrate tolerance. CONCLUSIONS: These data indicate that SR lanreotide at a dose of 30 mg, im, every 14 days is an effective treatment in most unselected acromegalic patients, especially in patients with no visible mass. Tolerability to SR lanreotide therapy is high. The use of a new sustained release formulation of somatostatin analog is clearly advantageous in improving patient compliance with medical treatment for acromegaly.
Acromegaly
;
Arthralgia
;
Diarrhea
;
Fatigue
;
Fingers
;
Glucose Tolerance Test
;
Humans
;
Insulin-Like Growth Factor I
;
Octreotide
;
Paresthesia
;
Patient Compliance
;
Plasma
;
Prospective Studies
;
Somatostatin
7.A Case of Giant Verrucous Desmoplastic Spitz Nervus.
Jeong Sun HYUN ; Jong Kyu YANG ; Jong Yuk YI ; Chul Jong PARK ; Kye Yong SONG
Korean Journal of Dermatology 2000;38(5):679-680
No Abstract Available.
8.A case of thanatophoric dysplasia.
Tae Wook SONG ; Sang Chul HAN ; Jang Hyun NAM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1992;35(5):765-773
No abstract available.
Thanatophoric Dysplasia*
10.A survey of inpatients in family medicine department.
Joon Soo SONG ; Sung Hyun KIM ; Young Sik KIM ; Chul Joon KIM
Journal of the Korean Academy of Family Medicine 1992;13(3):246-253
No abstract available.
Humans
;
Inpatients*