BACKGROUND: The confgurations of the skin surface, as characterized by surface furrows and plateaux, are known to change with ageing. There are many parameters to analyze the effects of ageing processes on the surface configuration. However, there are contradictory results among the authors. OBJECTIVE: The purpose of this study was to compare the sensitivity of various parameters being described in other reports with our new parameters used in evaluating the changes of the skin surface in the agein processes. METHODS: 112 healthy Korean males in 4 age groups participated in this study. Silicon skin replicas were taken from medial and lateral aspects of the forearm. Images of the skin replicas were analyzed by means of a digital image processing system (AIC, GA). Most parameters were calculated and measured in the primary skin axis. Image analyses were porformed by 3 different processes i.e., morphometry, densitometry (optical profilometry), and histograms. RESULTS: In Morphometry, the furrow count in the vertical section (VFC), the coefficient of the developed skin surface (CDSS) and mean width at maximal interception (MWMI) showed a tendencies to decrease with ageing.Irregularity of shadow shape (ISS) showed a tendency to increase with ageing. In Densitometry, the mean surface roughness(Ra) and mean depth of roughness(Rz) showed a tendency to increase with ageing. On histogram analysis, skewness was decreased with ageing but kurtosis did not show any significant changes. CONCLUSION:Ra, Rz, and ISS have shown a tendency to increase in the ageing processes (p<0. 05). VFC, CDSS, MWMI and skewness showed tendencies to decrease with ageing but the results were not statistically significant. The different results between morphometry and densitometry are likely to be due to increrr ent angles in the skin furrows with ageing.
Axis, Cervical Vertebra ; Densitometry ; Forearm ; Humans ; Male ; Silicones ; Skin*

BACKGROUND: With the development of medical science and technology, the proprotion of the aged has been significantly increasecl. Therefore it needs to be studied the fuadamental epidemiologic survey of dermatologic diseases and akin care in the elderly. OBJECT: Our purpose was to provide clinically relevant data regaring both dermatologic diseases and skin care in the aged population. MEHTODS: Total 172 volunteers aged 51 to 90 were enrolled in a study of 32-item questionnaire and total cutaneous examination. RESULTS: The sex ratio of male to female of 172 elderly volunteers as 1:1.4 and population of 7th and 8th decades occupied 76.5% with their mean age 74.4. The dermatologic findings which showed higher incidence in this study were seborrheic keratosis, senile lentigines, xerosis, cherry angioma, and generalized pruritus. Through the interviews of 172 elderly, the mot fequent dermatologic complaint was generalized pruritus. As the mean age of the population increasec, the number of the population showing xerosis and complaing of pruritus was elevated(r=0.976. 0.917 respectively). And there was a significant stastical correlation between the finding of xerosis and the the presence of pruritus(P<0.005). CONCLUSION: This study suggests that dermatologic problems in the elilerly are very common ancl further dermatologic studies including substantial medical care will be needed.
Aged ; Epidemiology ; Female ; Hemangioma ; Humans ; Incidence ; Keratosis, Seborrheic ; Lentigo ; Male ; Prunus ; Pruritus ; Sex Ratio ; Skin Care* ; Skin Diseases* ; Skin* ; Volunteers

Recurrent infantile digital fibroma is a peculiar fibrous tumiir that may be single or multiple on fingers and toes of infants and children. We report a 5-year-old gril with recurrent infantile digital fiber oma which was recurrent on the left 5th toe. The lesion had noted at the age of 6 months. and was excised surgically when the child was 3 year old. 2 years after operation, the lesion was recurred in operation site. Microscopically, nodular fibrous mass is attached to flattened,pidermis. The underlying nodule is composed of proliferating fibroblasts surrounded by derse collagenous tissue. We could find eosinophilic inclusion bodies in the cytoplasm of fibro ilast. It was stained pink with H&E, bright red with Massons trichrome and purple with PTAH.
Child ; Child, Preschool ; Collagen ; Cytoplasm ; Eosinophils ; Fibroblasts ; Fibroma* ; Fingers ; Humans ; Inclusion Bodies ; Infant ; Toes

No abstract available.
Heart Septal Defects, Atrial* ; Humans

No abstract available.
Rhytidoplasty*

Puromycin aminonucleoside (PAN) nephropathy was induced in a group of Sprague-Dawley rat by a single dose of intraperitoneal injection to study an ultrastructural alteration of glomerular anionic sites by stain with polyethyleneimine (PEI) as a cationic probe and to examine whether proliferation of podocytes occur by immunohistochemical stain for proliferating cell nuclear antigen (PCNA). The experimental rats developed proteinuria three days after PAN injection. Electron microscopic studies of glomeruli showed the loss of epithelial foot processes, formation of cytoplasmic vacuoles, microvillous formation and increased numbers of lyso- somes in the cytoplasm of podocytes. PEI method seems to selectively stain heparan sulfate proteogly-can in basement membrane and has been widely used to evaluate the changes of basement membrane in human disease as well as in experimental work. The anionic sites on the basement membrane with foot process fusion were mostly indistinguishable from those seen in control rats, but focal areas of loss or disarray of anionic sites were noted. The anionic sites were not seen on the basement membrane where the overlying epithelium was detached. It is strongly suggested that proteinuria in PAN nephrosis may be primarily due to a glomerular epithelial lesion, leading to focal disarray of anionic sites or focal defects in the epithelial covering of the basement membrane. The loss of anionic s'ites in the basement mernbrane may be resulted partially from the foot process fusion and mostly from the epithelial detachment. The increased numbers of PCNA positive cells after the injection of PAN is suggestive of possibility of podocytic proliferation or regeneration.
Animals ; Basement Membrane* ; Cytoplasm ; Epithelial Cells* ; Epithelium ; Foot ; Heparitin Sulfate ; Humans ; Injections, Intraperitoneal ; Nephrosis ; Podocytes ; Polyethyleneimine ; Proliferating Cell Nuclear Antigen ; Proteinuria ; Puromycin Aminonucleoside* ; Puromycin* ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Vacuoles

No abstract available.
Cervix Uteri* ; Female

The present study was carried out to investigate the HHsAg in the normal skin, dis- eased skin and skin specimens of window period of HBsAg positive patients in their serum with normal liver function. This study was done by immunoperoxidase techniques using the monoclonal antibody to hepatitis E3 surface antigen and by electron microscopy. Immunoperoxidase staining was dane on twenty specimeris of normal skin Group .D twenty specimens of diseased skin (15 cases of dermographism, 2 cases of purpura, 1 case of follicuht,is and 1 cases of morbilliform eruption) (Ciroup II ) and three specimens of normal skin af window period (Group III ) of HBsAp positive patients in their serum. Twelve cases of Group I, eleven cases of Group IL (1(J cases of dremographism and 1 rase of purpura) and two cases of Group II were stained positively for HBsAg. Positive sites were keratinocyte of epidermis, sweat gland, blood vessel and hair follicle. Electron microscopy failed to reveal viral particle, The above resuts suggest the possibility of transmission of viral hepatitis B thraugh the skin and skin appendages.
Antigens, Surface ; Blood Vessels ; Epidermis ; Hair Follicle ; Hepatitis B Surface Antigens ; Hepatitis B* ; Hepatitis* ; Humans ; Immunoenzyme Techniques ; Keratinocytes ; Liver ; Microscopy, Electron ; Purpura ; Skin* ; Sweat Glands ; Virion

We report a case of juvenile xanthogranuloma associated with neurofibromatosis. The patient was a 10-month-old female who had multiple yellowish papules on the face and shoulders A Biopsy of these lesions revealed foamy histiocytes with an admixture of inflammatory cells and Touton giant cells. Multiple, more than 6, cafe-au-lait spots, measuring more than 1.5cm in diameter were scattered on the trunk and buttocks Retardation of physical growth and development was observed.
Biopsy ; Buttocks ; Cafe-au-Lait Spots ; Female ; Giant Cells ; Growth and Development ; Histiocytes ; Humans ; Infant ; Neurofibromatoses* ; Shoulder ; Xanthogranuloma, Juvenile*

We report a case of juvenile xanthogranuloma associated with neurofibromatosis. The patient was a 10-month-old female who had multiple yellowish papules on the face and shoulders A Biopsy of these lesions revealed foamy histiocytes with an admixture of inflammatory cells and Touton giant cells. Multiple, more than 6, cafe-au-lait spots, measuring more than 1.5cm in diameter were scattered on the trunk and buttocks Retardation of physical growth and development was observed.
Biopsy ; Buttocks ; Cafe-au-Lait Spots ; Female ; Giant Cells ; Growth and Development ; Histiocytes ; Humans ; Infant ; Neurofibromatoses* ; Shoulder ; Xanthogranuloma, Juvenile*