Epithelial-myoepithelial carcinoma of intercalated duct(origin) is a recently described tumor characterized by its typical biphasic pattern of central duct like cell and peripheral clear cell. We described a case of epithelial-myoepithelial carcinoma in a 10-year-old boy. Microscopically, the tumor showed typical biphasic pattern, diffuse proliferation of clear cells and linining epithelial cells of tubular structures. Immunohistochemically, the clear cell showed positive reaction to S-100 protein, and the epithelial cells expressed cytokeratin indicating myoepithelial and epithelial differentiation respectively. Biphasic differentiation of the tumor cells could be also proved by electronmicroscopic study.

We present a patient who developed a pseudolymphoma after ear piercing. A patch test showed gold sensitivity. Therefore, long standing dermal exposure to gold from a pierced-type earring might have produced the patient's disease. This patient did not respond to an intralesional steroid injection and was finally treated with a complete resection of the lesion. It is proposed that every patient with a hyperplastic lesion in the ear lobe should be taken a biopsy in order to rule out the possibility of a pseudolymphoma. When a pseudolymphoma develops in the ear lobe, a complete surgical excision could be the treatment of choice, especially for the prevention of recurrence.
Biopsy ; Body Piercing* ; Ear* ; Humans ; Patch Tests ; Pseudolymphoma* ; Recurrence

No abstract available.
Pregnancy* ; Rheology* ; Uterine Artery*

Pancreatoblastoma has been described in children and characterized by unique histologic features and excellent clinical course. Ultrastructural and immunohistochemical studies of pancreatoblastoma reveal either exocrine alone or both endocrine and exocrine differentiation. We present two cases of pancreatoblastoma in children in which immunohistochemical and ultrastructural examination failed to demonstrate features of either enzyme or hormone production and which became worse in clinical course. We assume that pancreatoblastomas are tumors which differentiate more toward acinar or ductal elements than toward islet cell.
Carcinoma/*pathology/ultrastructure ; Child, Preschool ; Female ; Humans ; Pancreatic Neoplasms/*pathology/ultrastructure

No abstract available.
Pregnancy* ; Rheology* ; Umbilical Arteries*

Ectopic pancreas is a rare congenital anomaly defined by the presence of pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. A 11-year-old girl was admitted to the Department of Pediatrics, Yonsei University College of Medicine with the history of recurrent abdominal pain for 2 years. We performed fiberoptic endoscopy which showed a 1.5x1.5cm sized polypoid mass, and endoscopic polypectomy was performed. The diagnosis of ectopic pancreas of stomach was made by histologic examination which showed the normal gastric mucosa with the lobulated pancreatic tissue in the submucosa. The child did not have any recurrence of abdominal pain during follow-up period of one year after polypectomy. Ectopic pancreas of stomach is known to be very rare, and thus we report this case with the presentation of endoscopic and pathologic findings.
Abdominal Pain* ; Child* ; Diagnosis ; Endoscopy ; Female ; Follow-Up Studies ; Gastric Mucosa ; Humans ; Pancreas* ; Pediatrics ; Recurrence ; Stomach*

An increasing prevalence of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) causes a serious therapeutic problem in clinical setting. This study investigated the antimicrobial susceptibility, resistance mechanisms against aminoglycosides, and molecular epidemiology of 76 blood isolates of P. aeruginosa from two Korean hospitals. Thirty-four isolates were susceptible to all 13 antimicrobial agents tested, whereas 28 isolates showed a MDR or extensively drug-resistant phenotype. There was a significant difference in resistance rates of P. aeruginosa isolates against aztreonam, piperacillin-tazobactam, imipenem, meropenem, ciprofloxacin, and norfloxacin between two hospitals. Genes for aminoglycoside-modifying enzymes (AMEs), including aphA6 (n = 14), aadB (n = 11), aacA4 (n = 8), and aphA1 (n = 1), and 16S rRNA methylase armA (n = 6) were detected in 26 P. aeruginosa isolates resistant to aminoglycosides. There was no significant difference in carriage of genes for AME and 16S rRNA methylase between two hospitals, but aacA4 and aphA1 were specifically detected in P. aeruginosa isolates from one hospital. Seventy-six P. aeruginosa isolates were classified into 55 pulsotypes at similarity value of 0.85, and 31 and 24 pulsotypes were specifically detected in each hospital. This study demonstrates that differences in antimicrobial susceptibility of P. aeruginosa isolates between two hospitals are possibly due to the presence of diverse clones specific in each hospital.
Aminoglycosides ; Anti-Infective Agents ; Aztreonam ; Ciprofloxacin ; Clone Cells ; Imipenem ; Molecular Epidemiology ; Norfloxacin ; Phenotype ; Prevalence ; Pseudomonas aeruginosa* ; Pseudomonas*

BACKGROUND: Adenovirus (Ad) vectors have been widely used for many gene therapy applications because of their high transduction ability and broad tropism. However, their utility for cancer gene therapy is limited by their poor transduction into cancer cells lacking the primary receptor, coxsackievirus and adenovirus receptor (CAR). METHODS: To achieve CAR-independent gene transfer via Ad, we pretreated Ad with 1,2-dioleoyl-3- trimethylammonium propane (DOTAP) and analyzed their transduction efficiency into cancer cells in vitro and in vivo comparing with the virus alone. RESULTS: Treatment of DOTAP significantly increased adenoviral gene transfer in tumor cells in vitro. Moreover, DOTAP at an optimum dose (10 microngram/ml) enhanced IL-12 transgene expression by fivefold in tumor, and twofold in serum after intratumoral injection of adenovirus expressing IL-12N220L (Ad/IL-12N220L). In addition, cotreatment of DOTAP decreased tumor growth rate in the Ad/IL-12N220L-transduced tumor model, finally leading to enhanced survival rate. CONCLUSION: Our results strongly suggest that DOTAP could be of great utility for improving adenovirus-mediated cancer gene therapy.
Adenoviridae* ; Genes, Neoplasm ; Genetic Therapy ; Interleukin-12 ; Liposomes ; Propane ; Survival Rate ; Transgenes ; Tropism

The authors report 3 cases of intracranial cysticercosis simulating brain tumor. The 2 cases of them had parenchymatous huge cysts in the cerebral hemisphere and the other one had large cyst in the 4th ventricle. In one case of parenchymatous cysticercosis, angiographic finding was less significant though C-T scan revealed huge cystic shadow in the frontal lobe bilaterally and multiple small cystic shadow in occipital lobe and cerebellum. The 4th ventricular cysticercosis was well delineated with Conray ventriculography. All cases were proved as cerebral cysticercosis by operation and the patients were uneventful postoperatively.
Brain Neoplasms ; Cerebellum ; Cerebrum ; Cysticercosis* ; Frontal Lobe ; Humans ; Occipital Lobe

Distal femur fractures in elderly patients with osteoporosis are complicated because poor bone quality makes screw purchase and fixation less secure, presenting many clinical challenges to the orthopedic surgeon. Minimally invasive locked plating using an angularly stable locking compression plate has become an integral tool for achieving secure fixation in osteoporotic distal femur fractures with improved biomechanical performance. On the other hand, complications, such as implant failure and periplate fracture, have still occurred. This paper describes the principles of internal fixation in minimally invasive lateral locked plating in elderly patients with osteoporotic distal femur fractures as well as how to avoid complications.
Aged ; Femur ; Hand ; Humans ; Orthopedics ; Osteoporosis ; Osteoporotic Fractures