BACKGROUND: Acne is a common chronic disease which most frequently affects the face. This visibility is a major cause for concern in affected individuals. OBJECTIVE: The purpose of this study was to investigate the quality of life of patients with acne. METHODS: We interviewed 130 acne patients, and determined the impact of acne on the quality of life with a questionnare. RESULTS: Among 130 cases of acne, the numbers of male and female patients were 52(40.0%) and 78(60.0%) respectively, and tbe mean age was 21 years. There was no difference between the sexes in the quality of life criteria used. The scores of social criteria of patients older than 20 years were significantly higher than thme of patients younger than 20 years. The severity of facial acne was correlated with the severity of chest acne but not with that of back acne. The severity of chest acne was correlated with that of back acne. The severity of facial acne was correlated with the scores of the physical, social and psychological criteria, and the severity of chest acne was correlated with that of physical and social criteria. However, the severity of back acne was not correlated with those of any of the criteria. The psychological well-being of the patients was moderately or highly affected by the acne more often than the other criteria. CONCLUSION: Acne has a substantial impact on the quality of life. The practical use of these indices are: (1) reveal areas of particulur concern in patients with acne; (2) to identify individuals who may require more intensive treaiment; and (3) to give a patient oriented inforrnation on the quality of life expected.
Acne Vulgaris* ; Chronic Disease ; Female ; Humans ; Male ; Quality of Life* ; Thorax

Metastatic tumors to the oral cavity from other parts of the body are rarely reported and representing about 1-4% of all oral malignancies. The most common primary tumor site of oral metastatic tumor was the breast followed by the lung, kidney, thyroid, prostate, and colon. Oral metastasis of primary esophageal carcinoma is extremly rare and only 11 cases were reported till now. Only one case was metastased to the maxilla. We experienced a mteastatic squamous cell carcinoma to the maxilla and the scalp in a 52-year-old male patient who previously diagnosed as esophageal carcinoma and performed operation with post operative radiation therapy. We report the case with literature review.
Breast ; Carcinoma, Squamous Cell ; Colon ; Humans ; Kidney ; Lung ; Male ; Maxilla* ; Middle Aged ; Mouth ; Neoplasm Metastasis ; Prostate ; Scalp* ; Thyroid Gland

No abstract available.
Thyroglobulin* ; Thyroid Gland*

The anti-inflammatory activity of a corticosteroid may mask the contact allergic reaction it is causing. This may be an important reason why contact allergy to corticosteroids has often been missed. A simple persistent aggravation of a dermatitis in a patient treated with one or more topical corticosteroids is sufficient to raise a suspicion of corticosteroid hypersensitivity. A 23-year-old male visited our department for the evaluation of his aggravated pruritic oozing erythematous papules, scales and edema of the face. Previously, he was treated with Dermatop ointment and Plancollotion. A Patch test showed positive reactions to prednicarbate 10%, 1%, hydrocortisone-17-butyrate 10%, and triamcinolone 10%. We conclude prednicarbate in Dermatop ointment, hydrocortisone-17-butyrate in Plancol lotion to be the etiological agents.
Adrenal Cortex Hormones ; Dermatitis ; Dermatitis, Allergic Contact* ; Edema ; Humans ; Hypersensitivity ; Male ; Masks ; Patch Tests ; Triamcinolone ; Weights and Measures ; Young Adult

BACKGROUND AND PURPOSE: The systemic inflammatory response syndrome(SIRS), as defied recently by critical-care specialists, may result from various etiologies including infection, bum, or trauma. The purpose of this study was to determine whether TNF- alpha is associated with the development of systemic inflammatory response syndrome caused by multiple trauma. METHODS: The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study Multiple blood samples were serially drawn to measure seam TNF-alpha level on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-alpha was measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value far serum TNF-alpha. RESULTS: Serum TNF-alpha. levels of SIRS group were persistency elevated above reference value until 3 days after on admission. Peak seam TNF-alpha level at 12 hours after admission was higher in SIRS group than non-SIRS group(p< 0.05). There was no significant correlation between injury severity score and TNF-alpha levels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16. CONCLUSION: the result of this study suggests that persistent elevation of TNF-alpha and degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.
Emergency Service, Hospital ; Enzyme-Linked Immunosorbent Assay ; Humans ; Injury Severity Score ; Multiple Trauma* ; Reference Values ; Specialization ; Systemic Inflammatory Response Syndrome* ; Tumor Necrosis Factor-alpha* ; Volunteers

No abstract available.
Thyroglobulin* ; Thyroid Gland*

BACKGROUND AND OBJECTIVES: Allergic rhinitis (AR) and rhinitis medicamentosa (RM) have different mucosal color and pathophysiology. To investigate whether the mucosal color and nasal blood flow are different between the diseases in spite of same symptoms, we designed this study. Materials and Methods: 20 patients with allergic rhinitis and 21 patients with rhinitis medicamentosa were compared with 20 normal volunteers using mucosal color grading and Laser Doppler flowmetry. The Laser Doppler flowmetry was performed with a Periflux 4001 (Perimed, Jrtlla, Sweden) and perfusion unit (PU), velocity unit (VU), and concentration Unit (CU) were measured. The Laser Doppler flowmetry data in AR and RM were compared with those of the normal subjects, and between AR and RM. RESULTS: The perfusion score of AR and RM were lower than the control (p<0.05) and it was statistically significant that the mucosal color of AR were pale and of RM were reddish, comparing to the control group (p<0.05). CONCLUSION: The nasal blood flow was decreased with AR and RM compared to control but the mucosal color of AR and RM were different because of the difference of pathophysiology of diseases. When diagnosing RM, observation of mucosal color and measurement of nasal blood flow will be helpful besides the history of long-term use of nasal decongestant.
Healthy Volunteers ; Humans ; Laser-Doppler Flowmetry* ; Perfusion ; Rhinitis*

The thioureylene drugs, propylthiouracil and methylmercaptoimidazol(MMI), exert their antithyroid effect primarily through inhibition of thyroid peroxidase-catalyzed iodination of thyroglobulin. Recently the interest about the effect to the thyroglobulin synthesis of these drugs have been increasing. So we studied the MMI effect to the thyroglobulin synthesis in cultured porcine thyroid cells. Porcine thyroid cells were isolated by sequential trypsinization in the presence of EGTA, seeded at high density(1X10^6 cells/cm^2) and cultured. One week later, MMI was added in different concentrations(0, 0.2, 1, 5mM) with TSH only or with 4H(b-TSH, Insulin, Transferrin, Hydrocortisone) or without hormone. Medias were collected after 24 hours and compared the amount of thyroglobulin secreted. And also pulse-labeling were performed with S^35 cysteine/methionine(1-2uCi/well) for 30, 60, 90min at the same conditions.There was no significant change in the amount of the secreted thyroglobulin by MMI, and there was no significant change in the pulse-labeled interacellular thyroglobulin by MMI. And also there was no significant change in the secretion of TSH-stimulated thyroglobulin by MMI. So we conclude that MMI has no effect on the thyroglobulin synthesis in cultured porcine thyroid cells and also MMI has no effect on the TSH-stimulated thyroglobulin synthesis in cultured porcine thyroid cell.
Antithyroid Agents ; Egtazic Acid ; Halogenation ; Insulin ; Methimazole ; Propylthiouracil ; Thyroglobulin ; Thyroid Gland ; Transferrin ; Trypsin

The amount of thyroglobulin synthesized from thyroid cells and stored in colloid space in very important in thyroid hormone synthesis. The thyroglobulin synthesis is mainly regulated by TSH secreted from the pituitary gland. But recently there were some reports about the possibility that iodine regulated the thyroid protein synthesis. So our studied were conducted to determined whether iodine could have inhibitory effect on thyroglobulin synthesis and methimazole could abolish the inhibitory effect of idoine.Porcine thyroid cells were isolated by sequential trypsinization in the presence of EGTA, seeded at high density(1X10^6 cells/cm^2) and cultured. One week later, Nal was added in different concentrations(10^-7, 10^-6, 10^-5, 10^-4M). 24hour medias were collected and checked the amount of thyroglobulin secreted. And also pulse-labeling were performed with[^35S] cysteine/methionine(1-2 uCi/well) for 1 hour at the same conditions. We used 3mM methimazole and 10^-4M NaI to observe the blocking effect of methimazol in iodine.The extracellular thyroglobulin secretion was significantly decreased by iodine in dose dependent manner(82.4%, 80.7%, 76.8% and 73.1% of control). And also intracellular thyroglobulin synthesis was significantly decreased by iodide in dose dependent manner(100.5%, 83.4%, 82.3% and 79.4% of control). The inhibitory effect of iodide was abolished by methimazole(74.7% to 101.3% of control). These data indicate that high iodide inhibit the thyroglobulin synthesis and secretion from the thyroid cells, and furthermore autoregulation by iodide may include thyroglobulin synthesis. And also this effect is dependent on the generation of an organic form of iodine because methimazole abolish the inhibitory effect of iodide.
Colloids ; Egtazic Acid ; Homeostasis ; Iodine ; Methimazole ; Pituitary Gland ; Thyroglobulin ; Thyroid Gland ; Trypsin

Background: Rosacea is a common chronic inflammatory skin disease, which primarily affects the central face. In 2002, the National Rosacea Society (NRS) committee developed the first diagnostic criteria for rosacea, based on its subtypes. The revised classification in 2017 prompted a proposal to transit from a subtyping to a phenotyping approach, reflecting current insights into rosacea pathogenesis, pathophysiology, and management. Objective: This study aimed to elucidate the clinical features of rosacea and compare two diagnostic criteria in rosacea patients. Methods: We performed a clinical study on 100 patients with rosacea diagnosed according to the 2002 NRS criteria. The age, sex, clinical features, subtypes, severity, and predisposing factors were evaluated using the questionnaire. In addition, we compared the 2002 and 2017 criteria, and evaluated patients if they met the revised criteria. Results: According to the 2002 NRS classification, the erythematotelangiectatic type (88.0%) was the most frequent, followed by the papulopustular (43.0%), ocular (13.0%), and phymatous (6.0%) types. There were 44 overlapping cases, including 38 cases with 2 subtypes mixed and 6 cases with three subtypes. Six patients were diagnosed with rosacea using the 2002 NRS criteria but they did not satisfy the revised 2017 criteria. Conclusion We found that the diagnostic features of the 2002 criteria are too ambiguous for the diagnosis of rosacea. Therefore, we recommend that dermatologists recognize the necessity of a transition from a subtyping to a phenotyping approach, according to the 2017 criteria for the diagnosis of rosacea.