No abstract available.
Osteoarthritis*

BACKGROUND AND OBJECTIVES: Body lateropulsion with falling to one side is a well-known clinical feature of stroke in the posterior circulation. Body lateropulsion as an isolated or predominant manifestation of a pontine stroke has not previously been reported. To elucidate the possible mechanisms of patients presenting with body lateropulsion as an isolated or predominant symptom of isolated pontine infarction. MATERIALS AND METHOD: Between May 2004 and February 2006, out of 134 admitted patients with an isolated pontine stroke we identified 8 consecutive patients (6.0%) in the Keimyung University Stroke Registry who had body lateropulsion as the main presenting symptom. RESULTS: All lesions were localized to the paramedian tegmentum just ventral to the 4th ventricle. All except 1showed a uniform pattern of body lateropulsion, in which the direction of falling was away from the side of infarct. In 2 patients, body lateropulsion was the sole clinical manifestation, whereas the other patients had other neurological signs. All but 1 had contraversive tilting of the subjective visual vertical (SVV). In all cases, the direction of SVV tilt corresponded to the direction of body lateropulsion. The mean net tilt angle was 6.1 CONCLUSION: Based on the known anatomy of ascending vestibular pathways, the SVV tilting, and MRI findings, body lateropulsion probably results from damage to the graviceptive pathway ascending through paramedian pontine tegmentum.
Humans ; Infarction* ; Magnetic Resonance Imaging ; Pons ; Stroke

Cerebral venous infarction is associated with a wide variety of clinical symptoms and signs, which may often delay appropriate diagnosis. Unilateral vestibular deficit as a presenting sign of cerebral venous infarction has rarely been reported. We report a patient with cerebral venous infarction who had severe prolonged vertigo, vomiting, occipital headache, positive head thrust testing, and unilateral caloric weakness as main clinical features. Although the patient had occipital headache, overall symptoms and signs closely mimicked those of acute peripheral vestibulopathy.
Diagnosis ; Head Impulse Test ; Headache ; Humans ; Infarction* ; Vertigo ; Vestibular Neuronitis ; Vomiting

Vestibular neuritis (VN) is an idiopathic peripheral vestibular syndrome characterized by acute isolated prolonged vertigo. In most cases, it results from inflammation of the vestibular nerve presumably of viral origin. There has been no previous report of VN associated with a vascular cause. We here report a patient with VN of vascular origin who presented with acute onset of prolonged isolated vertigo, a unilateral decreased caloric response, and simultaneously with acute infarcts on brain MRI that were unrelated to patient's vertigo.
Brain ; Humans ; Inflammation ; Magnetic Resonance Imaging ; Vertigo ; Vestibular Nerve ; Vestibular Neuronitis*

No abstract available.
Mass Screening* ; Stomach Neoplasms* ; Stomach*

With the emergency of the MeToo movement, some medical professionals have courageously expressed their experiences with sexual harassment and violence, but victims' fear of retaliation or career damage is still a major reason for which they may hesitate to come forward with their experiences. Manuals presenting standards for sexual harassment and sexual violence in each hospital should be standardized, so that the victims can solve these problems within the system. Taking steps to prevent sexual harassment and sexual violence in medical institutions and implementing procedures for reporting and responding to sexual harassment and sexual violence will contribute to gender equality and the eradication of sexual harassment and sexual violence in the medical system.
Emergencies ; Sex Offenses ; Sexual Harassment ; Violence

With the emergency of the MeToo movement, some medical professionals have courageously expressed their experiences with sexual harassment and violence, but victims' fear of retaliation or career damage is still a major reason for which they may hesitate to come forward with their experiences. Manuals presenting standards for sexual harassment and sexual violence in each hospital should be standardized, so that the victims can solve these problems within the system. Taking steps to prevent sexual harassment and sexual violence in medical institutions and implementing procedures for reporting and responding to sexual harassment and sexual violence will contribute to gender equality and the eradication of sexual harassment and sexual violence in the medical system.

Dyskeratosis congenita is a rare genodermatosis of ectodermal dysplasia, which is characterized by the diagnostic triad consisting of reticulated hyperpigmentation, dystrophic nails, and leukoplakia. There is a predisposition to malignancy, particularly at sites of leukoplakia. Bone marrow failure can occur in about a half of the cases. A 16-year-old boy was presented with asymptomatic reticulated pigmentation of the neck and nail dystrophy. The patient also had leukoplakia on the tongue, nasolacrimal duct obstruction and cataract. The histopathological findings taken from the reticulated lesion were consistent with poikiloderma atrophicans vasculare. These clinical and histopathological findings were typical features of dyskeratosis congenita.
Adolescent ; Bone Marrow ; Cataract ; Dyskeratosis Congenita* ; Ectodermal Dysplasia ; Humans ; Hyperpigmentation ; Leukoplakia ; Male ; Nasolacrimal Duct ; Neck ; Pigmentation ; Tongue

No abstract available.
Plasmapheresis* ; Prednisolone* ; Purpura, Thrombotic Thrombocytopenic*

OBJECTIVE: The physiological and pathogenetic role of microRNAs (miRNAs) in the maintenance of joint homeostasis and in the development of arthritis is recently being elucidated. In this study, we attempted to identify differentially expressed miRNAs in human osteoarthritis (OA) chondrocytes in response to interleukin (IL)-1beta. In addition, simultaneous profiling of miRNA and mRNA expression was performed to get an integrated analysis of miRNA and mRNA expression. METHODS: Monolayer cultured chondrocytes obtained from knee cartilages of OA patients were stimulated with IL-1beta for 4 hours and RNA was isolated. One microgram of total RNA was polyadenylated and converted to cDNA and miRNA microarray was performed. Seven hundred thirty five oligos were used, corresponding to 470 well-annotated human miRNA sequences and 265 potential miRNAs that were identified recently. mRNA microarray was performed simultaneously using the RNA samples that were used for miRNA array. Both sequence and expression information was used to identify regulatory relationship between miRNA and mRNA pairs. RESULTS: Expression profiling of miRNA extracted from IL-1beta treated chondrocytes identified 25 miRNA which showed differential expression. We also identified 7190 mRNAs differentially regulated by IL-1beta treatment. Among the 25 miRNAs differentially regulated, 13 miRNAs had targets searched by MiRANDA scheme. By combining target search and miRNA-mRNA pairing, we could identify 1043 miRNA-mRNA target pairs. MiR-200a was found to be expressed in human OA and normal cartilages, with downregulation in OA lesion cartilages. CONCLUSION: It is suggested that miRNA may play a role in the regulation of cartilage degradation in OA.
Arthritis ; Cartilage ; Chondrocytes ; DNA, Complementary ; Down-Regulation ; Homeostasis ; Humans ; Interleukin-1 ; Interleukins ; Joints ; Knee ; MicroRNAs ; Osteoarthritis ; RNA ; RNA, Messenger