1.Prevalence of Widespread Pain and Its Influence on Quality of Life: Population Study in Korea.
Nam Han CHO ; Inje KIM ; Seung Hun LIM ; Hyun Ah KIM
Journal of Korean Medical Science 2012;27(1):16-21
The objective of this study was to examine the prevalence and risk factors for widespread pain and its influence on quality of life in residents of Korean communities. A rural and an urban community were selected, and 5,037 subjects were surveyed. Participants were asked if they had pain, aching, or stiffness in any of their joints on most days. Widespread pain was defined as pain above the waist, below the waist, on both sides of the body and in the axial region. The prevalence of widespread pain was 12% (16.2% and 5.5% in females and males, respectively). It was more frequent among females and increased with age in both genders. Age, female gender, and the presence of hand or knee arthritis were significantly associated with widespread pain after multivariate analysis. Except for mental health, all the items in the SF-12 were adversely affected in the widespread pain group after adjustment for confounding factors. Our findings show that the prevalence of widespread pain among residents of Korean communities is comparable to that reported among Caucasians. The significantly worse quality of life among subjects with widespread pain suggests that it may cause major health issues in the aging population.
Adult
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Age Factors
;
Aged
;
Demography
;
Female
;
Health Status
;
Humans
;
Male
;
Middle Aged
;
Odds Ratio
;
Pain/*epidemiology/psychology
;
Prevalence
;
*Quality of Life
;
Republic of Korea/epidemiology
;
Risk Factors
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Rural Population
;
Sex Factors
;
Urban Population
2.Mutational Analysis of 17beta-hydroxysteroid dehydrogenase type 2 gene in Breast Cancers.
Min Sun CHO ; Hyun Ah KIM ; Shi Nae LEE
Journal of Breast Cancer 2006;9(1):14-17
PURPOSE : The 17beta-hydroxysteroid dehydrogenases(17HSDs) play an important role in the regulation of the physiologic activities of sex steroid hormones. The predominance of 17HSD type 1 in the malignant breast tissue could increase the estrogen-dependent proliferation and stimulate the cancer progression. On the other hand, the oxidative 17HSD type 2 may protect the normal breast cells from an excessive estradiol effect. To identify the role of 17HSD type 2 in the carcinogenesis of breast cancer, we investigate the mutation of 17HSD type 2 in 35 breast cancers. METHODS : We analyzed the entire coding region of the 17 HSD type 2 gene for detection of the somatic mutations in 35 invasive ductal carcinomas of the breast by polymerase chain reaction, single strand conformation polymorphism, and DNA sequencing. RESULTS : We found one missense mutation in exon 6(2.86%). It revealed the CCT-->CTT (Pro-->Leu) transition type at codon 262 in exon 6. CONCLUSION : In present study, we found only a mutation of the 17beta -HSD type 2 gene in breast cancer and could not demonstrate the direct relationship between the mutation of the 17beta -HSD type 2 gene and the development of breast cancer. These results suggest that the mutation of 17HSD type 2 doesn? play a major role in the development of breast cancer.
Breast Neoplasms
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Breast*
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Carcinogenesis
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Carcinoma, Ductal
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Clinical Coding
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Codon
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Estradiol
;
Exons
;
Gonadal Steroid Hormones
;
Hand
;
Mutation, Missense
;
Oxidoreductases*
;
Polymerase Chain Reaction
;
Sequence Analysis, DNA
3.Mutational Analysis of 17beta-hydroxysteroid dehydrogenase type 2 gene in Breast Cancers.
Min Sun CHO ; Hyun Ah KIM ; Shi Nae LEE
Journal of Breast Cancer 2006;9(1):14-17
PURPOSE : The 17beta-hydroxysteroid dehydrogenases(17HSDs) play an important role in the regulation of the physiologic activities of sex steroid hormones. The predominance of 17HSD type 1 in the malignant breast tissue could increase the estrogen-dependent proliferation and stimulate the cancer progression. On the other hand, the oxidative 17HSD type 2 may protect the normal breast cells from an excessive estradiol effect. To identify the role of 17HSD type 2 in the carcinogenesis of breast cancer, we investigate the mutation of 17HSD type 2 in 35 breast cancers. METHODS : We analyzed the entire coding region of the 17 HSD type 2 gene for detection of the somatic mutations in 35 invasive ductal carcinomas of the breast by polymerase chain reaction, single strand conformation polymorphism, and DNA sequencing. RESULTS : We found one missense mutation in exon 6(2.86%). It revealed the CCT-->CTT (Pro-->Leu) transition type at codon 262 in exon 6. CONCLUSION : In present study, we found only a mutation of the 17beta -HSD type 2 gene in breast cancer and could not demonstrate the direct relationship between the mutation of the 17beta -HSD type 2 gene and the development of breast cancer. These results suggest that the mutation of 17HSD type 2 doesn? play a major role in the development of breast cancer.
Breast Neoplasms
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Breast*
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Carcinogenesis
;
Carcinoma, Ductal
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Clinical Coding
;
Codon
;
Estradiol
;
Exons
;
Gonadal Steroid Hormones
;
Hand
;
Mutation, Missense
;
Oxidoreductases*
;
Polymerase Chain Reaction
;
Sequence Analysis, DNA
4.Familial Types and Dietary Quality in Korean Elderly
Kyoungjoon YOUN ; Hyun Ah PARK ; Young Gyu CHO
Korean Journal of Health Promotion 2022;22(2):93-102
Background:
The aim of this study is to assess the relationships between familial types and dietary quality measured by the Korean Healthy Eating Index (KHEI) in representative Korean elderly.
Methods:
We used cross-sectional data from 4,260 Korean elderly, aged over 65 years, who had participated in the 2016-2018 Korea National Health and Nutrition Examination Survey. The 14-item KHEI scores were calculated from the Food Frequency Questionnaire and the Dietary Habit Survey from the Nutrition Survey.Familial type was categorized into three groups of Live alone (LA), Live with a partner with or without other(s) (LP), and Live with other(s) without a partner (LO) based on the Household Interview Survey.
Results:
LP had better dietary quality than LO for both sexes (both P<0.05). LA (64.5; standard error [SE], 1.0) had worse dietary quality than LP (66.7; SE, 0.6]) in elderly male (P<0.05) while they were not significantly different in elderly female. The percentages of subjects having poor dietary quality (total KHEI score of ≤50) in LA, LP, and LO were 20.6% (SE, 2.7), 7.3% (SE, 0.8), 8.9% (SE, 3.6) in elderly male, and 9.6% (SE, 1.2), 5.7% (SE, 0.8), 12.9% (SE, 1.8) in elderly female, respectively. The multivariate-adjusted odds ratios of having poor dietary quality compared with LP was 2.45 (95% confidence interval [CI], 1.66-3.60) for LA male, and 1.98 (95% CI, 1.19-3.28) for LO female.
Conclusions
Familial type affects dietary quality in Korean elderly. However, differential associations were shown between elderly male and female.
5.Temporal Change in the Use of Laboratory and Imaging Tests in One Week Before Death, 2006–2015
Hyun Ah KIM ; Minseob CHO ; Dae-Soon SON
Journal of Korean Medical Science 2023;38(12):e98-
Background:
To analyze the trends in laboratory and imaging test use 1 week before death among decedents who died in Korean hospitals, tests used per decedents from 2006 to 2015 were examined by using the National Health Insurance Service-Elderly Sample Cohort (NHISESC) dataset.
Methods:
The study population consisted of decedents aged ≥ 60 years old with a history of admission and death at a hospital, and tests recorded in the payment claims for laboratory and imaging tests according to the Healthcare Common Procedure Coding System codes were examined. Twenty-eight laboratory and 6 imaging tests were selected. For each year, crude rates of test use per decedents in each age and sex stratum were calculated. Regression analysis was used to examine the temporal changes in the test use.
Results:
During the follow-up period, 6,638 subjects included in the sample cohort died.The number of total laboratory and imaging tests performed on the deceased increased steadily throughout the study year from 10.3 tests/deceased in 2006 to 16.6 tests/deceased in 2015. The use of tests increased significantly in general hospitals, however, not in nursing hospitals. Laboratory tests showed yearly increase, from 9.46/deceased in 2006 to 15.57/ deceased in 2015, an annual increase of 7.39%. On the other hand, the use of imaging increased from 0.86/deceased in 2006 to 1.01/deceased in 2015, which was not statistically significant.
Conclusion
The use of tests, especially laboratory tests, increased steadily over the years even among those elderly patients at imminent death. Reducing acute healthcare at the end of life would be one target not only to support the sustainability of the health care budget but also to improve the quality of dying and death.
6.Health Status and Nutrient Intakes of 5th Grade Elementary Students in Seoul and Gyeonggi Province.
Ok Hyun KIM ; Hyun Ah PARK ; Young Gyu CHO ; Kyoung Woo KIM ; Yangim HUR ; Ji Hyun SONG ; Jae Heon KANG
Korean Journal of Community Nutrition 2010;15(6):717-726
This study was conducted to investigate health status and nutrient intakes among 5th grade elementary students at Korea Centers for Disease Control and Prevention 2010. This study was cross-sectional study on 1,384 children (687 boys, 697 girls) from nine elementary schools located in Seoul and Gyeonggi province. The average height, weight and BMI were 145 cm, 40.6 kg 19.2 kg/m2 for boys and 145.4 cm, 38.2 kg, 18.0 kg/m2 for girls. The prevalence of overweight and obesity were 11.3%, 5.2%, respectively. Serum AST, ALT, glucose, HDL-Cholesterol and RBC levels were significantly higher, while TG levels was significantly lower for boys than for girls. The average energy intake was 1772.4 kcal, which was 98.7% of Estimated Energy Requirement (EER). The boys consumed more energy intake (1800.4 kcal) than the girls (1744.7 kcal). Also, they took insufficient calcium and folate (69.1% and 83.3% of Recommended Intake (RI)) and excess sodium (297.6% of Adequate Intake (AI)) and 85.1% of the subjects had breakfast everyday. In general, the proportion of the children who consumed fruits and vegetables at least once or more a day was low. There was a higher proportion of children in boys who had ramyun and milk with sufficient physical activity than those in girls. As a result of this study, we can find risk factors on obesity and metabolic disorders, and the results can be used for an evidence of nutrition education program and the intervention program.
Breakfast
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Calcium
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Centers for Disease Control and Prevention (U.S.)
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Child
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Cross-Sectional Studies
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Energy Intake
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Folic Acid
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Fruit
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Glucose
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Humans
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Korea
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Milk
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Motor Activity
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Obesity
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Overweight
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Prevalence
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Risk Factors
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Sodium
;
Vegetables
7.Cerebral salt-wasting syndrome after hematopoietic stem cell transplantation in adolescents: 3 case reports.
Yeon Jin JEON ; Hyun Young LEE ; In Ah JUNG ; Won Kyoung CHO ; Bin CHO ; Byung Kyu SUH
Annals of Pediatric Endocrinology & Metabolism 2015;20(4):220-225
Cerebral salt-wasting syndrome (CSWS) is a rare disease characterized by a extracellular volume depletion and hyponatremia induced by marked natriuresis. It is mainly reported in patients who experience a central nervous system insult, such as cerebral hemorrhage or encephalitis. The syndrome of inappropriate antidiuretic hormone secretion is a main cause of severe hyponatremia after hematopoietic stem cell transplantation, whereas CSWS is rarely reported. We report 3 patients with childhood acute leukemia who developed CSWS with central nervous system complication after hematopoietic stem cell transplantation. The diagnosis of CSW was made on the basis of severe hyponatremia accompanied by increased urine output with clinical signs of dehydration. All patients showed elevated natriuretic peptide and normal antidiuretic hormone. Aggressive water and sodium replacement treatment was instituted in all 3 patients and 2 of them were effectively recovered, the other one was required to add fludrocortisone administration.
Central Nervous System
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Cerebral Hemorrhage
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Dehydration
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Diagnosis
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Encephalitis
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Fludrocortisone
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Hematopoietic Stem Cell Transplantation*
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Hematopoietic Stem Cells*
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Humans
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Hyponatremia
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Leukemia
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Natriuresis
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Polyuria
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Rare Diseases
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Sodium
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Water
8.Impact of Dim Artificial Light at Night (dALAN) Exposure during Sleep on Human Fatigue.
Ah Reum CHO ; Chul Hyun CHO ; Ho Kyoung YOON ; Joung Ho MOON ; Heon Jeong LEE ; Leen KIM
Sleep Medicine and Psychophysiology 2016;23(2):53-60
OBJECTIVES: Exposure to light at night has become pervasive in modern society. The impact of dim artificial light at night (dALAN) exposure on sleep and fatigue is not well recognized. We aim to study the impact of dALAN exposure during sleep on human fatigue. METHODS: 30 healthy young male volunteers from 21 to 29 years old were enrolled in the study. They were randomly divided into two groups depending on light intensity (Group A : 5 lux and Group B : 10 lux). Data were gathered from each participant after each night with no light (Night 1) followed by the next night (Night 2) with two different dim light conditions (5 or 10 lux) by means of self-reported fatigue scale. RESULTS: Exposure to dALAN during sleep was significantly associated with increased overall fatigue (F = 19.556, p < 0.001) and ocular discomfort (F = 5.671, p = 0.028). CONCLUSION: We found that dALAN during sleep likely affects human fatigue in some aspects. These findings indicate that dALAN during sleep exerts a negative effect on human fatigue.
Fatigue*
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Humans*
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Male
;
Volunteers
9.Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice.
Hye Rin SEO ; Ah Young LEE ; Kye Man CHO ; Eun Ju CHO ; Hyun Young KIM
Natural Product Sciences 2017;23(1):61-68
This study was performed to investigate the ameliorating effects of steamed soybeans (SS) and fermented SS (FSS) on lipid metabolism in high-fat diet-induced obese mice. ICR mice were divided into four groups and given the following different diets: normal diet (ND), high-fat diet (HFD), HFD with 1% SS (HFD + SS), and HFD with 1% FSS (HFD + FSS). After 14 weeks, the body weight gain was higher in the HFD group compared with the ND group but lower in the HFD + FSS group compared with the HFD group. Plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly higher in the HFD group compared to the ND group, but lower in the HFD + SS and HFD + FSS groups compared with the HFD group. In addition, leptin concentration in plasma was lower in the groups fed HFD + SS and HFD + FSS compared with the HFD group. The accumulation of hepatic TG and TC was significantly inhibited in the HFD + SS and HFD + FSS groups. Furthermore, SS and FSS attenuated lipid peroxidation and nitric oxide formation in the liver induced by the high-fat diet. These results suggest that soybeans, especially FSS, may be useful in preventing obesity-induced abnormalities in lipid metabolism.
Alanine Transaminase
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Animals
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Aspartate Aminotransferases
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Body Weight
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Cholesterol
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Diet
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Diet, High-Fat
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Leptin
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Lipid Metabolism
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Lipid Peroxidation
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Liver
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Mice
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Mice, Inbred ICR*
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Mice, Obese
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Nitric Oxide
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Obesity
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Oxidative Stress
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Plasma
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Soybeans*
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Steam*
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Triglycerides
10.Reliability and Validity of an Ultrasonic Device for Measuring Height in Adults
Seon Hwa CHO ; Young Gyu CHO ; Hyun Ah PARK ; A Ra BONG
Korean Journal of Family Medicine 2021;42(5):376-381
Background:
The ultrasonic stadiometer was originally developed as a device to measure and monitor children’s height. However, an ultrasonic stadiometer (InLab S50; InBody Co., Seoul, Korea) was used to measure adults’ height in the 2018 Korea Community Health Survey (KCHS). This study was conducted to assess the reliability and validity of the InLab S50 in adults.
Methods:
The study subjects were 120 adults (reliability test, n=20; validity test, n=100) who had visited a health screening center. The intra- and inter-rater reliabilities of InLab S50 were assessed using the intraclass correlation coefficient (ICC). The agreement between InLab S50 and an automatic stadiometer (HM-201; Fanics, Busan, Korea) was assessed using Pearson’s correlation coefficient and Bland-Altman analysis.
Results:
The intra- and inter-rater reliabilities of the InLab S50 were excellent (ICC=0.9999 and 0.9998, respectively). The correlation coefficient of the height measured by the two measurement devices was very high (r=0.996). The difference (Δheight [HM-201-InLab S50]) was -0.15±0.78 cm (95% limit of agreement [LOA], -1.69 to 1.38). After excluding the values outside 95% LOA, the difference was further reduced to -0.05±0.59 cm (95% LOA, -1.20 to 1.10).
Conclusion
This study showed that the InLab S50 is a reliable and valid device for the measurement of adults’ height. Therefore, we think that InLab S50 could be used to measure adults’ height in household health surveys such as the KCHS.