2.A Study on the State of Recognition and Experience of Love; Sex Knowledge; and Self-esteem of Youths.
Shin Ae PARK ; Myung Ja WANG ; Nam Hyun CHA
Journal of Korean Academy of Community Health Nursing 2006;17(2):242-252
No abstract available.
Adolescent*
;
Humans
;
Love*
3.The effect of both oophorectomy on serotonin level in cerebral cortex and hippocampus of the female Sprague-Dawley rat.
Eun Mi KO ; Hyun Ae JEON ; Man Chul PARK
Korean Journal of Obstetrics and Gynecology 2000;43(11):1926-1931
OBJECTIVE: The purpose of this study is to investigate the effect of chronic deprivation of estradiol on the serotonin level in Sprague-Dawley rat's cerebral cortex and hippocampus. METHODS: One hundred of female Sprague-Dawley rats were taken care for seven to eight weeks, then they were randomly assigned into two group; fifty rats underwent bilateral oophorectomy & the remaining rats were the control group. Six months after oophorectomy, brain tissue was extracted from cerebral cortex and hippocampus and then homogenated: this was done in the both groups. The upper layer of the homogenated substance was taken and frozen and finally dried up. The next process was marking with PITC, quantification through HPLC and comparing with authentic serotonin. Protein quantity was measured by using Bradford method. RESULTS: Comparison between the bilateral oophorectomy group and the control group for serotonin content in the cerebral cortex was 134.2+/-14.3 nmol/mg protein(mean+/-SEM) and 122.5+/-11.6 nmol/mg protein in each group. As for the serotonin content in the hippocampus was 148.8+/-13.9 nmol/mg protein and 132.9+/-13.7 nmol/mg protein in each group. It shows that, there was no significant difference in the serotonin level, in the two areas mentioned above. CONCLUSION: The effect of estradiol on the serotonin level may be dependent on the hormonal change duration. Chronic effect of hypoestrogenism might have no effect on tryptophan hydroxylase and monoamine oxidase, thus not changin the serotonin level. These data supported the previous findings that chronic hypoestrogenism had no effect on serotonin level.
Animals
;
Brain
;
Cerebral Cortex*
;
Chromatography, High Pressure Liquid
;
Estradiol
;
Female
;
Female*
;
Hippocampus*
;
Humans
;
Monoamine Oxidase
;
Ovariectomy*
;
Rats*
;
Rats, Sprague-Dawley*
;
Serotonin*
;
Tryptophan Hydroxylase
4.Carcinoma in situ of the urinary bladder in bladder washing cytology.
Doo Hyun CHUNG ; In Ae PARK ; Eui Keun HAM
Korean Journal of Cytopathology 1991;2(1):51-55
The diagnosis of carcinoma in situ of urinary bladder is difficult in that the symptoms and cystoscopic findings are nonspecific. The cytology of urine could be helpful for diagnosis of carcinoma in situ of urinary bladder. We present a case of bladder washing cytology of carcinoma in situ. A 54 year old man presented with dysuria for 1 year. Cystoscopic findings revealed multifocal reddish trabeculated lesions. The bladder washing cytology revealed rather uniform tumor cells which were singly scattered or forming syncytium in the clean background. The nuclei were round to oval with inconspicious nucleoli. The cystoscopic biopsy revealed typical histologic features of carcinoma in situ of urinary bladder.
Biopsy
;
Carcinoma in Situ*
;
Diagnosis
;
Dysuria
;
Giant Cells
;
Humans
;
Middle Aged
;
Urinary Bladder*
5.The Correlation of Neoadjuvant Chemotherapy Responsiveness with The Expression of BCL-2, Bax, VEGF, PCNA and The Pattern of Apoptosis in Cervical Cancer.
Yong Beom KIM ; Noh Hyun PARK ; In Ae PARK ; Hyo Pyo LEE
Korean Journal of Gynecologic Oncology and Colposcopy 2000;11(1):24-37
The purpose of this study was to identify the relationship between the clinical response to neoadjuvant chemotherapy and PCNA and VEGF protein expression, apoptosis and its related gene expression such as Bcl-2 and Bax in cervical cancer. We retrospectively reviewed 30 patients with locally advanced or bulky cervical cancer treated with three courses of neoadjuvant chemotherapy followed by radical hysterectomy or radiation therapy at Seoul National University Hospital from June 1995 to June 1998. The specimen were obtained before chemotherapy by colposcopy directed biopsy. The protein expressions of Bcl-2, Bax, VEGF and PCNA were examined by immunohisto- chemical staining and the apoptosis was examined by TUNEL staining. These results were compared with chemotherapeutical response which was evaluated by colposcopy or CT/MRI. There were 2 CR(complete response), 19 PR(partial response) and 9 NC(no change) and there was no progressive disease. There was no significant difference between responder and nonresponder according to the age, tumor size and FIGO stage. The 3 year survival rates of responder and nonresponder were 90.0% and 66.7% respectively and there was significant difference between two groups(p=0,015). The expression of Bcl-2 and Bax was positive in 23.3%(7/30) and 46.7%(14/30). The expression of VEGF was positive in 83.3%(25/30). PCNA PI(positive index), defined as PCNA positive cells in percentage was more than 25.0% in 20 cases. Apoptotic index, defined as the number of the cells undergoing apoptosis per 1,000 tumor cells, ranged from 3 to 53(mean 22.3). Although there was no significant relationship between the clinical response to neoadjuvant chemotherapy and the expre- ssion of Bcl-2, Bax, VEGF and PCNA PI, apoptotic index was significantly higher in responder than nonresponder when the cutoff value of positive was defined as apoptotic index more than 5(p=0.032). In conclusion, the evaluation of the pattern of apoptosis before neoadjuvant chemothera- py is potentially useful for the prediction ofz tumor response to neoadjuvant chemotherapy for cervical cancer.
Apoptosis*
;
Biopsy
;
Colposcopy
;
Drug Therapy*
;
Gene Expression
;
Humans
;
Hysterectomy
;
In Situ Nick-End Labeling
;
Proliferating Cell Nuclear Antigen*
;
Retrospective Studies
;
Seoul
;
Survival Rate
;
Uterine Cervical Neoplasms*
;
Vascular Endothelial Growth Factor A*
6.Drug Abuse Status and Its Determinants of Male High School Students in Taegu.
Jung Rak NAM ; Sin KAM ; Jae Yong PARK ; Chang Hyun HAN ; Young Ae HA
Korean Journal of Preventive Medicine 1996;29(3):451-470
To identify the drug abuse status and its determinant factors in high school boys in Taegu, the study was performed from April to May, 1995. Study population were selected by cluster sampling method and total 5,665 students replied to the self-administered questionnaire survey(2,207 in academic high school, 3,458 in business high school). The major findings were as follows; The proportion of drinking, smoking experience was 55.0%, 45.8%, respectively, and the proportion of current drinker, current smoker was 27.2%, 27.5%. The drinking, smoking experience rate of second grade students was higher than first grade and it was higher in business high school boys. The proportion of a stimulant, a hallucinogen, hemp leaf cigarets experience was 3.2%, 1.6%, 0.1%, respectively. Drug abuse had significant association with home environment(lower economic status, frequent move, death of father or mother, apart from family), parents environment(parents' indifference, parents' drinking and smoking, etc.), school life(lower school grades, intimate friend's drug abuse, etc.), generous attitude to drug abuse, higher level of stress. Students who replied that the law prohibited immature person(students) from drinking and smoking showed lower drug abuse rate. In multiple logistic regression analysis, second grade students, business high school students, parents' indifference, lower school grades, intimate friend's drug abuse, no recognition of the fact that the law prohibits high school students from drinking and smoking, generous attitude to drug abuse, higher level of stress were significantly related with alcohol abuse and smoking. Other drugs abuse were related with above factors. On consideration of above findings, to prevent students from drug abuse, we have to try together in house, school, and society.
Alcoholism
;
Cannabis
;
Commerce
;
Daegu*
;
Drinking
;
Fathers
;
Humans
;
Jurisprudence
;
Logistic Models
;
Male*
;
Mothers
;
Parents
;
Surveys and Questionnaires
;
Smoke
;
Smoking
;
Substance-Related Disorders*
7.Identifying Minimum Datasets for Pressure Ulcer Assessment and Analysis of Nursing Records in Home Nursing.
Hyun Young KIM ; Hyeon Ae PARK
Journal of Korean Academy of Community Health Nursing 2009;20(1):105-111
PURPOSE: The purpose of this study was to identify minimum datasets for ulcer assessment and to map the minimum datasets to paper-based nursing records for pressure ulcer care in homecare setting. METHODS: To identify minimum datasets for pressure ulcer assessment, the authors reviewed four guidelines for pressure ulcer care. The content validity of the minimum datasets was assessed by three homecare nurse specialists. To map the minimum datasets to nursing records, the authors examined 107 pressure ulcer events derived from 45 pressure ulcer patients who received home nursing from two hospitals in Gyeonggi Province. RESULTS: The minimum datasets for initial assessment were anatomical location, stage, size, tissue, exudate, condition of periwound skin, undermining, odor, and pain. 'Location' was recorded best, accounting for a complete recording rate of 98.1%. 'Exudate' and 'pain' showed the poorest record, accounting for 2.8% and 0%,respectively. The minimum datasets for progress assessment were wound size, tissue, and exudate, each accounted for 31.8%, 2.8%, and 4.7%, respectively. CONCLUSION: This study concluded that data on pressure ulcer assessment was not sufficient homecare and it can be improved by adopting minimum datasets as identified in this study.
Dataset*
;
Exudates and Transudates
;
Gyeonggi-do
;
Home Nursing*
;
Humans
;
Nursing Assessment
;
Nursing Records*
;
Odors
;
Pressure Ulcer*
;
Skin
;
Specialization
;
Ulcer
;
Wounds and Injuries
8.Focal hepatic lesions:Differential diagnosis with MRI.
Jong Sool IHM ; Kwi Ae PARK ; Woo Hyun AHN ; Bong Gi KIM ; Han Yong CHOI
Journal of the Korean Radiological Society 1993;29(4):747-755
Differentiation between benign and malignant hepatic lesions was attempted according to the shape of the lesion, internal architecture and characteristics of signal intensity on MR images. MR images. We retrospectively analyzed 20 cases of hemangiomas, 12 cases of hepatomas and 5 cases of cysts which were diagnosed by clinical, radiological and surgical methods (33 patients). On T1-weighted, proton weighted, and T2-weighted images, most hemangiomas (70%) and cysts (100%) had smooth margin and were round or oval in shape, while hepatocellular carcinomas had irregular (67%) or lobulated (33%) borders. Ninety percent of hemangiomas and 100% of cysts had homogeneous signal intensity, but 67% of hepatocellular carcinomas were inhomogeneous. Signal intensities of hepatocellular carcinomas were more variable. However, hemangionmas were isointense or hyperintense on proton weighted images, and markedly hyperintense on T2-weighted images . In conclusion, inhomogenous, irregular border, and variable signal intensity lesions had high likelihood of malignancy, while homogenous and markedly hyperintense lesions were more likely benign.
Carcinoma, Hepatocellular
;
Diagnosis*
;
Hemangioma
;
Magnetic Resonance Imaging*
;
Protons
;
Retrospective Studies
9.Focal hepatic lesions:Differential diagnosis with MRI.
Jong Sool IHM ; Kwi Ae PARK ; Woo Hyun AHN ; Bong Gi KIM ; Han Yong CHOI
Journal of the Korean Radiological Society 1993;29(4):747-755
Differentiation between benign and malignant hepatic lesions was attempted according to the shape of the lesion, internal architecture and characteristics of signal intensity on MR images. MR images. We retrospectively analyzed 20 cases of hemangiomas, 12 cases of hepatomas and 5 cases of cysts which were diagnosed by clinical, radiological and surgical methods (33 patients). On T1-weighted, proton weighted, and T2-weighted images, most hemangiomas (70%) and cysts (100%) had smooth margin and were round or oval in shape, while hepatocellular carcinomas had irregular (67%) or lobulated (33%) borders. Ninety percent of hemangiomas and 100% of cysts had homogeneous signal intensity, but 67% of hepatocellular carcinomas were inhomogeneous. Signal intensities of hepatocellular carcinomas were more variable. However, hemangionmas were isointense or hyperintense on proton weighted images, and markedly hyperintense on T2-weighted images . In conclusion, inhomogenous, irregular border, and variable signal intensity lesions had high likelihood of malignancy, while homogenous and markedly hyperintense lesions were more likely benign.
Carcinoma, Hepatocellular
;
Diagnosis*
;
Hemangioma
;
Magnetic Resonance Imaging*
;
Protons
;
Retrospective Studies
10.A family case of Cis AB.
Hee Sun JEON ; Hyun Tae KIM ; Dong Soo LEE ; Ae Ja PARK
Korean Journal of Blood Transfusion 1991;2(1):73-77
No abstract available.
Humans