The effect of radiation therapy, either alone or combined with surgery or chemotherapy is accepted well in the treatment of metastatic carcinoma, multiple myeloma, reticulum cell sarcoma and Ewing's sarcoma. But its effect on osteosarcoma and chondrosarcoma is less clear. The authors reviewed 90 patients treated with radiation therapy, 62 cases with primary bone tumor and 28 cases with multiple myeloma, from 1969 to 1988. There were 20 Ewing's sarcoma, 12 osteosarcoma, 12 chondrosarcoma, 9 Histiocytosis-X and 3 reticulum cell sarcoma among 62 primary bone tumors. And 40 patients with more than three months follow-up were analyzed for the primary response of tumor three months after radiation therapy and the long term effect of the radiation therapy. When the radiation therapy was done alone, the primary response was poor in osteogenic sarcoma, chondrosarcoma, Ewing's sarcoma and reticulum cell sarcoma. But with the multimodal therapy, the primary response was rslatively good in reticulum cell sarcoma and chondrosarcoma. In 15 patients, more than one year follow-up was done. The status of these patients at the last follow-up was poor in all cases trearted with radiation therapy alone than the multimodal therapy except Histiocytosis-X. In multiple myeloma, the effect of radiation therapy for the relief of pain was analyzed. There were complete relief of pain in 14.3%, partial relief in 71.4% and no relief in 10.7%.
Chondrosarcoma ; Drug Therapy ; Follow-Up Studies ; Histiocytosis, Langerhans-Cell ; Humans ; Lymphoma, Non-Hodgkin ; Multiple Myeloma ; Osteosarcoma ; Sarcoma, Ewing

No abstract available.

The cause of pemphigus vulgaris is autoimmune. The serum containes antibodies against the intercellular substance of stratified epithelium, as demonstrated by means of immunofluorescent staining. Therefore antigen-antibody reaction takes place in the intercellalar spaces of squamous epithelium and leads to acantholysis. The association of pemphigus with malignant conditions was frequently reported. Thus there is now increasing evidence of an association between malignaney and the production of pemphigus antibodies by a tumor itaelf. By the evidence that pemphigus is autoimmune disease, it is used to treat with corticosteroid and immunosuppressive drugs, such as methotrexate. Very high doses of corticosteroid appear to he necesaary for an adequate control of the disease. Even though large doae repersents an effective treatment of pemphigus vulgaris, side effects from thia form of therapy have heen quite significant. Two cases of pemphigus vulgaris are reported. .First patient, a 33 year-old housewife, with flaccid bullae and rupture to form erosions of 3 months duration especialIy on buccal mueosa and genitlia. Second patient, a 66 year-old female, with above skin lesions of 6 months duration on buccal mucosa and whole body. Clinically and histopathologically their eruptions were consistent with pemphigus vulgaris. Large initial dose of predniaolone was employed in these treatment. These patients were improved with treatment prednisolone. Prednisolone therapy gave rise to a large numbar of side effects of varying degrees of severity, such as iatrogenic diabetea mellitus, oral candidiasis, hypokalemia, and pychosis etc. At admission 57days, first case complained of lower abdominal pain and tenderness. At this point it was found clinically that the mass on vaginal vault is present. Punch biopsy was p rformed and confirmed epidermoid carcinoma poorly differentiated (stage V). Cystoscopy showed tumor mass of cervix with extension to bladder posterior wall. We advised. External radiation therapy for carcinoma for about 5 weeks (5,000 Rads) but hopeless she was discharged. Second. Patient was much improved without recurrence. Side effects of prednisolone were also controlled.
Abdominal Pain ; Acantholysis ; Adult ; Aged ; Antibodies ; Antigen-Antibody Reactions ; Autoimmune Diseases ; Biopsy ; Candidiasis, Oral ; Carcinoma, Squamous Cell ; Cervix Uteri ; Cystoscopy ; Epithelium ; Female ; Humans ; Hypokalemia ; Methotrexate ; Mouth Mucosa ; Pemphigus* ; Prednisolone ; Recurrence ; Rupture ; Skin ; Urinary Bladder

Pretibial myxedema is a rare condition whieh may occur following the active or treated hyperthyroidism. The preeise cause of pretibial myxedema is not known, but it is now established the Long Acting Thyroid Stimulator(LATS) is 7S-gammaglobulin, that it is present in the serum of 80% of patients with hyperthyroidism and that its activity is as being an autoantibody against a thyroid antigen, retroorbital tissues and in the skin. A 28-year old pregnant housewife was well until age 24 when she developed hyperthyroidism with swelling of the thyroid gland, exopbthalmos and clubbing of the fingers. She was treated with subtotal thyroidectomy 2 years ago at other clinic. The skin lesions revealed circumscribed, firm, and elevated nodules with excess hair growth on shin and dorsum of feet since their onset of one and half years to visit to our hospital. The hiatologic findings showed considerable amounts of mucin especially in the midportion of the dermis. The leaions were improved by the local application of 0.01% Fluocinolone acetonide(Synalar') ointment with occlusive dressing technique.
Adult ; Dermis ; Fingers ; Foot ; Hair ; Humans ; Hyperthyroidism ; Mucins ; Myxedema* ; Occlusive Dressings ; Skin ; Thyroid Gland ; Thyroidectomy

No abstract available.
Pyelonephritis*

No abstract available.

No abstract available.
Maxillary Sinus* ; Wegener Granulomatosis*

No abstract available.
Antigens, Human Platelet* ; Blood Platelets*

Cigarette smoke is a complex mixture of 4,000 chemical compounds, including 43 known carcinogens. It is well known that smoke acts as the initiator and promoter in the process of carcinogenesis, and the risk of cancer is directly proportional to the amount and duration of smoking. Tobacco is the cause of 30% of all cancer deaths and one of the major risk factors for coronary heart disease, along with high blood pressure and hyperlipidemia. Cigarette smoking is estimated to be responsible for more than 20% of all coronary heart disease deaths in men over 86 years of age and for approximately 45% of such deaths in men aged less than 65 years. About 80% of mortality from chronic obstructive lung disease is attributable to cigarette smoking, and the age-adjusted death rate for COPD is 10-times higher in current smokers than in nonsmokers. Peptic ulcer disease, osteoporosis, skin wrinkling, and retarded fetal growth are all associated with cigarette smoking. Through passive smoking, 69% of individuals develop eye irritation, 29% have nasal symptoms, 32% have headaches, and 25% develop a cough. The infant admission rate increases with mother’s smoking amount, and the relative risk of lung cancer is 1.8 in smoker’s spouse. Tobacco is the single, chief, avoidable cause of death in our society, and the most important public issue of our time.
Carcinogenesis ; Carcinogens ; Cause of Death ; Coronary Disease ; Cough ; Fetal Development ; Headache ; Humans ; Hyperlipidemias ; Hypertension ; Infant ; Lung Neoplasms ; Male ; Mortality ; Osteoporosis ; Peptic Ulcer ; Pulmonary Disease, Chronic Obstructive ; Risk Factors ; Skin Aging ; Smoke ; Smoking* ; Spouses ; Tobacco ; Tobacco Products* ; Tobacco Smoke Pollution

No abstract available.
Osteoarthritis*