No abstract available.
Antigens, Surface*

No abstract available.
Female ; Mammals* ; Ovulation* ; Rupture*

No abstract available.
Diabetes, Gestational/*metabolism ; Female ; Humans ; Insulin/*secretion ; *Insulin Resistance ; Pregnancy

No abstract available.
Tuberculosis*

Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.
Atherosclerosis ; Biomarkers ; Cardiovascular Diseases ; Coronary Artery Disease ; Diabetes Mellitus ; Inflammation ; Oxidative Stress ; Peripheral Arterial Disease ; Rupture ; Stroke

A recent report from International Diabetes Federation estimates that 366 million people have diabetes in 2011 and this will have risen to 552 million by 2030. That means one adult in 10 will have diabetes. The prevalence of diabetes among Korean adults aged 20 to 79 years in 2010 was estimated at 9.4% (3.3 million). Diabetes mellitus has thus become a social and economic burden in Korea. However, the percentage of patients to reach their target goal for glycemic control (hemoglobin A1c <7%) is only 40.3%. That indicates further effort for management of diabetic patients is needed. Current diabetic medication includes sulfonylurea, metformin, alpha-glucosidase inhibitor, thiazolidinedione and dipeptidyl peptidase-4 inhibitor as well as insulin. In this review article, we examine the clinical effects upcoming new diabetes medications and their differences from previous medications.
Adult ; Aged ; alpha-Glucosidases ; Diabetes Mellitus ; Humans ; Hyperglycemia ; Insulin ; Korea ; Metformin ; Prevalence ; Thiazolidinediones

The number of patients with diabetes mellitus in Korea has exceeded 6 million. Considering approximately 15.83 million patients in the prediabetic stage, more than 20 million Koreans have diabetes or are at risk of diabetes. In this study, we investigated the prevalence and treatment status of diabetes mellitus in Korea based on sex and age.Current Concepts: The prevalence of diabetes mellitus in Korea is higher in men than in women. Men develop diabetes at a younger age (30s and 40s), whereas women develop diabetes in their 50s after menopause. The rate of comorbidities, including abdominal obesity, hypertension, and hypercholesterolemia is higher in women than in men. Globally, more men develop diabetes than women; however, men develop diabetes at a younger age and at a lower body mass index. In contrast, women develop diabetes at a later age because female sex hormones play a protective role against obesity and metabolic diseases until menopause after which women tend to gain weight and develop insulin resistance. Therefore, women with diabetes have poorer metabolic markers such as abdominal obesity, hypertension, and dyslipidemia than those observed in men.Discussion and Conclusion: Prevention and control measures for patients with diabetes should be age- and sex-specific. The high prevalence of diabetes and prediabetes in men aged <50 years suggests that prevention measures are more important. In contrast, women aged <50 years with premenopausal diabetes should be more vigilant regarding weight, comorbidity, and diabetes management.