1.Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice.
Laboratory Animal Research 2018;34(4):203-210
Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple cellular signaling pathways. The primary cilium is a cellular organelle, which acts as a signaling center during development and neurogenesis in adult mice. However, it is not clear how the primary cilia are involved in the process of restraint (RST) stress response. Using a mouse model, we examined the role of primary cilia in repeated and acute RST stress response. Interestingly, RST stress increased the number of ciliated cells in the adult hippocampal dentate gyrus (DG). In our RST model, cell proliferation in the DG also increased in a time-dependent manner. Moreover, the analysis of ciliated cells in the hippocampal DG with cell type markers indicated that cells that were ciliated in response to acute RST stress are neurons. Taken together, these findings suggest that RST stress response is closely associated with an increase in the number of ciliated neurons and leads to an increase in cell proliferation.
Adult
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Animals
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Cell Proliferation
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Cilia
;
Dentate Gyrus
;
Hippocampus
;
Homeostasis
;
Humans
;
Mice*
;
Neurogenesis
;
Neurons*
;
Organelles
2.A Case of Rasmussen Aneurysm Treated by Pulmonary Arterial Embolization.
Sung Oh PARK ; Hyuk KO ; Su Hee KIM ; Wan PARK ; Deck Hee LEE ; Dae Sik RYU ; Bock Hyun JUNG
Tuberculosis and Respiratory Diseases 2001;51(1):53-58
A 42 year-old male with a history of multidrug-resistant pulmonary tuberculosis suddenly developed massive hemoptysis. Embolization of a bronchial artery branch and the collateral systemic arteries did not resolve the recurrent bleeding. Spiral computerized tomography(spiral CT) of the chest showed contrast enhanced nodules within a large cavity at the left lower lobe in the arterial phase suggesting a Rasmussen aneurysm. A pulmonary angiogram showed abnormal vascular nodules at that site. Coils were deployed at both the proximal and distal vessels of this aneurysmal sac for embolization. Transcatheter arterial embolization is a safe and effective means of controlling bleeding from this pulmonary arterial pseudoaneurysm. Here we report a case of a Rasmussen aneurysm diagnosed by spiral CT, which was successfully treated by pulmonary arterial embolization with a coil.
Aneurysm*
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Aneurysm, False
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Arteries
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Bronchial Arteries
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Embolization, Therapeutic
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Hemoptysis
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Hemorrhage
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Humans
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Male
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Respiratory Insufficiency
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Thorax
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Tomography, Spiral Computed
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Tuberculosis, Pulmonary
3.A Case of the Localized Tension Pneumothorax Mimicking Giant Bullae.
Hyuk KO ; Sung Ho PARK ; Su Hee KIM ; Wan PARK ; Chong Bin PARK ; Jong Wook KIM ; Dae Sik RYU ; Bock Hyun JUNG
Tuberculosis and Respiratory Diseases 2001;50(6):740-746
Background: A 35-year-old woman was admitted to the emergency room with sudden dyspnea that developed one day prior. The initial Chest X-ray showed multiple bullous changes at the right middle and lower lung field and long standing fibrotic tuberculous changes at the right upper lung field. The left lung field was totally collapesed by an fibrotic old tuberculous lesion. In spite of supportive medical care with oxygen therapy after admission, the radiographic lesions were no significant change but the respiratory distress had worsend. The patient suffered respiratory failure and receive mechanical ventilatory support. The HRCT showed a localized tension pneumothorax mimicking multiple giant bullae at the right lower lung field. Immediately after a closed thoracostomy with a 32 French chest tube and air drainage, her vital signs and dyspnea were gradually improved. The patient was successfully weaned from mechanical ventilation after 5 days of mechanical ventilatory support. The patient had receive talc pleurodesis through a chest tube to prevent the recurrence of the life-threatening localized pneumothorax. The patient was discharged without recurrence of the pneumothorax.
Adult
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Chest Tubes
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Drainage
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Dyspnea
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Emergency Service, Hospital
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Female
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Humans
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Lung
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Oxygen
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Pleurodesis
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Pneumothorax*
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Recurrence
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Respiration, Artificial
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Respiratory Insufficiency
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Talc
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Thoracostomy
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Thorax
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Vital Signs
4.A Case of Interstitial Lung Disease Associated with Juvenile Rheumatoid Arthritis.
Hyuk KO ; Soo Jung CHOI ; Hyun Kyu CHANG ; Jong Wan KIM ; Seong Reol KIM
The Journal of the Korean Rheumatism Association 2002;9(3):225-229
Juvenile rheumatoid arthritis (JRA) can develop the extra-articular manifestations, which are growth retardation, osteopenia, chronic uveitis, and rarely pleuropulmonary involvement. Approximately 30% of patients with JRA show abnormal pulmonary function test without pulmonary symptoms, in which the frequent abnormality is in carbon monoxide diffusing capacity, but clinically evident pulmonary parenchymal disease in JRA is extremely uncommon. We describe a 23-years-old female with JRA who presented with dyspnea due to interstitial lung disease and pulmonary hypertension. She had suffered from polyarthralgia and dyspnea since 8 years old.
Arthralgia
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Arthritis, Juvenile*
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Bone Diseases, Metabolic
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Carbon Monoxide
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Child
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Dyspnea
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Female
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Humans
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Hypertension, Pulmonary
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Lung Diseases, Interstitial*
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Respiratory Function Tests
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Uveitis
5.The Application and Effect of the Brown-Roberts-Wells Stereotactic System in the Management of Intracranial Lesions.
Choong Bae MOON ; Wan Shup KIM ; Sam Kyu KO ; Jowa Hyuk IHM ; Seung Chan BAEK ; Yung Chul CHI ; Byung Yearn CHOI ; Soo Ho CHO
Yeungnam University Journal of Medicine 1986;3(1):53-62
In the past 10 years, modern technology has made deep seated obscure lesions visible. With development of computer technology and various stereotaxic techniques, many new procedures, refinement of old procedures, and development of new applications are possible. The authors are intended to provide a detailed description of our experience with the Brown-Roberts-Wells (BRW) stereotactic system in the evaluation and management of 90 patients with intracranial lesions, and to provide cases presentation of various inaccessible intracranial lesions.
Humans
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Stereotaxic Techniques
6.Allergic bronchopulmonary aspergillosis associated with aspergilloma.
Su Hee KIM ; Sung Oh PARK ; Hyuk KO ; Wan PARK ; Dae Sik RYU ; Jong Wook KIM ; Jae Gul JUNG ; Bock Hyun JUNG
Korean Journal of Medicine 2002;63(1):92-97
Aspergilloma and Allergic Bronchopulmonary Aspergillosis (ABPA) are different types of spectrum of pulmonary aspergillosis. ABPA results from hypersensitivity reaction to Aspergillus species and is known to be usually associated with bronchial asthma and cystic fibrosis. Aspergilloma results from simple colonization of this fungus within cavitary lung lesion or bronchiectasis. But rarely some patients can present together with ABPA and aspergilloma. We experienced a case of ABPA associated with aspergilloma in a 38 year-old male. The diagnosis was confirmed by asthma, immediate cutaneous reactivity to A. fumigatus, IgG antibody to A. fumigatus, elevated total and specific IgE antibodies to A. fumigatus, central bronchiectasis and peripheral eosinophilia coincident with radiographic infiltrates. During follow-up management with steroid, left pneumonectomy was done because of spontaneous pneumothorax with persistent air-leak and multidrug resistance pulmonary tuberculosis in association with aspergilloma. His respiratory symptoms and ABPA activity was much more improved after removal of aspergilloma. These findings suggest that surgical resection of aspergilloma can be considered to reduce antigenic source of colonized fungi in ABPA patients when associated with aspergilloma.
Adult
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Antibodies
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Aspergillosis, Allergic Bronchopulmonary*
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Aspergillus
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Asthma
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Bronchiectasis
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Colon
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Cystic Fibrosis
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Diagnosis
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Drug Resistance, Multiple
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Eosinophilia
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Follow-Up Studies
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Fungi
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Humans
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Hypersensitivity
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Immunoglobulin E
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Immunoglobulin G
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Lung
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Male
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Pneumonectomy
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Pneumothorax
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Pulmonary Aspergillosis
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Tuberculosis
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Tuberculosis, Pulmonary
7.Assessment of early nutritional state in critical patients with intoxication and the effect of nutritional status on prognosis
Dong-wan KO ; Sangcheon CHOI ; Young-gi MIN ; Hyuk jin LEE ; Eun Jung PARK
Journal of The Korean Society of Clinical Toxicology 2021;19(2):93-99
Purpose:
Nutritional status and support in critically ill patients are important factors in determining patient recovery and prognosis.The aim of this study was to analyze the early nutritional status and the methods of nutritional support in critically ill patients with acute poisoning and to evaluate the effect of nutritional status on prognosis.
Methods:
A retrospective study was conducted in tertiary care teaching hospital from January 2018 to December 2020. in an emergency department of university hospital, 220 patients who were stayed more than 2 days of poisoning in intensive care unit were enrolled.
Results:
155 (70.5%) of patients with acute poisoning had low-risk in nutritional risk screening (NRS). Patients with malignancy had higher NRS (low risk 5.2%, moderate risk 18.5%, high risk 13.2%, p=0.024). Patients of 91.4% supplied nutrition via oral route or enteral route. Parenteral route for starting method of nutritional support were higher in patients with acute poisoning of herbicide or pesticide (medicine 3.2%, herbicide 13.8%, pesticide 22.2%, p=0.000). In multivariate logistic regression analysis, herbicide or pesticide intoxication, higher risk in NRS and sequential organ failure assessment over 4.5 were affecting factor on poor recovery at discharge.
Conclusion
NRS in patients intoxicated with herbicide or pesticide were higher than that in patients intoxicated with medicine intoxication. Enteral nutrition in patients intoxicated with herbicide or pesticide was less common. Initial NRS was correlated with recovery at discharge in patient with intoxication. It is expected to be helpful in finding patients with high-risk nutritional status in acute poisoning patients and establishing a treatment plan that can actively implement nutritional support.
8.Digital workflow for prosthetic restoration in the pan facial fracture patient: A case report
Seung-Wan KIM ; Geun-Taek PARK ; Yoon-Hyuk HUH ; Chan-Jin PARK ; Lee-Ra CHO ; Kyung-Ho KO
The Journal of Korean Academy of Prosthodontics 2022;60(4):395-403
In the fracture operation of pan facial fracture, there are many cases where the shape and position of the occlusal and oral structures are abnormally changed because the index for repositioning to the original position is insufficient. And trismus and gag reflex in patients with pan facial fractures increase the difficulty of dental treatment, and the difference in the position of the jaw bone makes it difficult to restore aesthetically and functionally. In this case, digital workflows for minimal intraoral work could be selected to reduce patient discomfort and the difficulty of dental treatment. This case is using a digital workflow from implant planning to final prosthesis production in a patient with acquired skeletal grade III, trismus, and gag reflex due to pan facial fracture 15 years ago. In this case report, the use of digital workflow in a patient who has difficulty in dental treatment was able to minimize patient discomfort and obtain esthetic and functionally appropriate results.
9.Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System.
Sun Ok SONG ; Chang Hee JUNG ; Young Duk SONG ; Cheol Young PARK ; Hyuk Sang KWON ; Bong Soo CHA ; Joong Yeol PARK ; Ki Up LEE ; Kyung Soo KO ; Byung Wan LEE
Diabetes & Metabolism Journal 2014;38(5):395-403
BACKGROUND: The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers. METHODS: The NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI. RESULTS: Metabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining. CONCLUSION: The NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.
Aging
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Chronic Disease
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Data Mining
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Delivery of Health Care
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Epidemiology
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Insurance, Health
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Insurance, Long-Term Care
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Korea
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Metabolic Diseases
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National Health Programs*
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Secondary Prevention
10.Korean Clinical Practice Guidelines for Aneurysmal Subarachnoid Hemorrhage
Won Sang CHO ; Jeong Eun KIM ; Sukh Que PARK ; Jun Kyeung KO ; Dae Won KIM ; Jung Cheol PARK ; Je Young YEON ; Seung Young CHUNG ; Joonho CHUNG ; Sung Pil JOO ; Gyojun HWANG ; Deog Young KIM ; Won Hyuk CHANG ; Kyu Sun CHOI ; Sung Ho LEE ; Seung Hun SHEEN ; Hyun Seung KANG ; Byung Moon KIM ; Hee Joon BAE ; Chang Wan OH ; Hyeon Seon PARK ; ; ; ;
Journal of Korean Neurosurgical Society 2018;61(2):127-166
Despite advancements in treating ruptured cerebral aneurysms, an aneurysmal subarachnoid hemorrhage (aSAH) is still a grave cerebrovascular disease associated with a high rate of morbidity and mortality. Based on the literature published to date, worldwide academic and governmental committees have developed clinical practice guidelines (CPGs) to propose standards for disease management in order to achieve the best treatment outcomes for aSAHs. In 2013, the Korean Society of Cerebrovascular Surgeons issued a Korean version of the CPGs for aSAHs. The group researched all articles and major foreign CPGs published in English until December 2015 using several search engines. Based on these articles, levels of evidence and grades of recommendations were determined by our society as well as by other related Quality Control Committees from neurointervention, neurology and rehabilitation medicine. The Korean version of the CPGs for aSAHs includes risk factors, diagnosis, initial management, medical and surgical management to prevent rebleeding, management of delayed cerebral ischemia and vasospasm, treatment of hydrocephalus, treatment of medical complications and early rehabilitation. The CPGs are not the absolute standard but are the present reference as the evidence is still incomplete, each environment of clinical practice is different, and there is a high probability of variation in the current recommendations. The CPGs will be useful in the fields of clinical practice and research.
Aneurysm
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Brain Ischemia
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Cerebrovascular Disorders
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Diagnosis
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Disease Management
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Hydrocephalus
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Intracranial Aneurysm
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Mortality
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Neurology
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Quality Control
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Rehabilitation
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Risk Factors
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Search Engine
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Subarachnoid Hemorrhage
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Surgeons