No abstract available.
Epidemiologic Studies* ; Female ; Humans

No abstract available.
Reference Values*

Multilocular cyst of the kidney is a rare pathologic entity, noninherited benign renal neoplasm occurring in the both children and adults. The entities commonly were known as multilocular cyst of the kidney or multilocular cystic nephroma. The controversy over the pathogenesis of multilocular cyst-neoplasm versus developmental anomaly- is still unsettled. We report two cases of multilocular renal cyst, one in a 8-year-old child with a chief complaint of gross hematuria and another in a 44-year-old woman with epigastric discomfortness. They were preoperatively suspected multilocular cyst by ultrasonography and computed tomography. We performed a simple nephrectomy as the treatment of choice because of the difficulty in accurate diagnosis and the documented association with renal neoplasia.
Adult ; Child ; Diagnosis ; Female ; Hematuria ; Humans ; Kidney ; Kidney Neoplasms ; Nephrectomy ; Ultrasonography

We analyzed the mRNA expression patterns of major potassium channel genes to determine the mechanism of hypokalemia in familial hypokalemic periodic paralysis. We used quantitative RT-PCR to examine the mRNA levels of both inward (KCNJ2, KCNJ6, and KCNJ14) and delayed rectifi er (KCNQ1 and KCNA2) potassium channel genes in skeletal muscle cells from both normal and patient groups, prior to and after exposure to 4 mM and 50 mM potassium buffers. Quantitative RT-PCR analysis revealed no changes in the mRNA levels of these genes in normal and patient cells on exposure to 4 mM potassium buffer. However, after exposure to 50 mM potassium buffer, which was used to induce depolarization, normal cells showed a signifi cant decrease in KCNJ2, KCNJ6, and KCNJ14 expression, but no change in KCNQ1 and KCNA2 expression. In contrast, patient cells showed no change in KCNJ2 and KCNJ6 expression, but an increase in KCNJ14 expression. Furthermore, KCNQ1 and KCNA2 showed decreased expression. We found that the expression levels of both inward and delayed rectifi er potassium channel genes in patient cells differ from those in normal cells. Altered potassium channel gene expression in patient cells may suggest a possible mechanism for hypokalemia in familial hypokalemic periodic paralysis.

The management of asthma focuses on the reduction of airway inflammation accompany with symptomatic care after recognition. Glucocorticosteroid is the most important drug to reduce airway inflammation, and it has been used inhaled, orally and systemically. New knowledge about the pathogenesis of allergy and asthma has made the development and clinical trial of target or immunomodulator therapy. It includes cytokine, cytokine blockers, specific cytokine receptor blocker, and immunostimulatory oligodeoxynucleotides. These agents are thought to hold the promise for more beneficial outcomes in the future, although it showed limited therapeutic benefits only for patients, especially intractable or severe asthma, until now.
Asthma ; Humans ; Hypersensitivity ; Immunomodulation ; Inflammation ; Oligodeoxyribonucleotides ; Receptors, Cytokine

PURPOSE: Chromosomal abnormality is the major cause of male infertility. We evaluated the usefulness of chromosome analysis for searching the etiology of male infertility. MATERIALS AND METHODS: Karyotypes of 375 cases with male infertility except postvasectomy infertility were analyzed. The comparison between sexchromosomal abnormality and autosomal abnormality in various clinical parameters, serum hormonal levels and sperm density was done. RESULTS: Of 375 cases, 57 cases(15.2%) of chromosomal abnormalities were found, consisting of 42 cases(73.7%) of sex chromosomal abnormality(38 Klinefelter's syndrome with mosaicism, 1 sex reverse syndrome, 1 true hermaphroditism, 1 Y chromosome deletion, and 1 sex-chromosome translocation with autosome), 13 cases(22.8%) of autosomal abnormality(7 translocation and 6 inversion) and 2 cases(3.5%) of normal variant. Of various clinical parameters and serum hormonal levels, only testicular volume and serum testosterone level revealed significant statistical difference between sex chromosomal and autosomal abnormality. CONCLUSIONS: We suggest that the chromosomal analysis should be the first line aid in searching etiology of the male infertility.
Chromosome Aberrations* ; Humans ; Infertility ; Infertility, Male* ; Karyotype ; Klinefelter Syndrome ; Male ; Male* ; Mosaicism ; Ovotesticular Disorders of Sex Development ; Spermatozoa ; Testosterone ; Y Chromosome

Pressure sore is usually developed by repeated or persistent pressure given to fixed regions. Due to increase in old ages, paraplegia or quadriplegia by traffic accidents and industrial accidents, the incidence of pressure sore is increasing. V.A.C.(R)(vacuum assisted closure, KCI Inc, U.S.A.) has been highly effective for accelerating wound healing, however, high cost and the use of special equipment have been preventing it from popular use. We applied the negative pressure of wall suction (100-150mmHg) with Medifoam B(R)(Hydrophilic polyurethane foam, Ildong Pharm, Co., Korea) on pressure sore wound instead of expensive dressing foam of V.A.C.(R) So, we could accelerate wound healing without special equipment or incurring high cost. We were able to reduce the cost to 10% with Medifoam B(R) and wall suction dressing compared with V.A.C.(R) In this aspect, the technique explained above seems to be clinically useful.
Accidents, Occupational ; Accidents, Traffic ; Bandages ; Incidence ; Paraplegia ; Polyurethanes ; Pressure Ulcer* ; Quadriplegia ; Suction ; Wound Healing ; Wounds and Injuries

Untill now, dermofat graft has usually been used for repair or supplement of soft tissue for cosmetic cause. Generally, scar in the center portion of neck, left after tracheostomy, may cause skin traction and discomfort during swallowing due to adhesion in trachea or cricoid cartilage in high rates. In these cases, usual scar revision techniques maybe cannot correct the skin retraction and swallowing discomfort. We, therefore, solved the problems of skin traction and discomfort during swallowing, by first removing the preexisting scar in the center portion of neck, then, dissecting the surroundings after performing autodermofat graft. From September 2002 to September 2003, we performed autodermofat graft in 6 cases having skin traction and discomfort during swallowing. In all cases, symptoms were resolved, and adverse effects of infection, hematoma and calcifications did not occur. In the results of 10 months follow-up, there were no recurrence and cosmetic and functional results were acceptable.
Cicatrix* ; Cricoid Cartilage ; Deglutition ; Follow-Up Studies ; Hematoma ; Neck* ; Recurrence ; Skin ; Trachea ; Tracheostomy ; Traction ; Transplants*

We present a case of urachal actinomycosis. Twenty four year-old female patient presented with low abdominal pain and a palpable mass. MRI showed an irregular shaped mass extending from the umbilicus to the dome of the bladder, just beneath the rectus muscle. Exploration revealed a hard fibrotic mass which was adhered tightly with appendix, dome of the bladder, left ovary, fallopian tube and sigmoid colon. The ill-defined fibrotic mass with the adhered organ was removed as en bloc. Actinomycosis was diagnosed from the postoperative specimen. Penicillin G was administered postoperatively. At 1 year followup, she is well without subjective symptom except mild frequency and lymphocele in right pelvis, which was aspirated.
Abdominal Pain ; Actinomycosis* ; Appendix ; Colon, Sigmoid ; Fallopian Tubes ; Female ; Follow-Up Studies ; Humans ; Lymphocele ; Magnetic Resonance Imaging ; Ovary ; Pelvis ; Penicillin G ; Umbilicus ; Urachus ; Urinary Bladder

No abstract available.