1.Control Mechanisms of Follicle Rupture during Ovulation in Mammals.
Sang Yong CHUN ; Hyuk Bang KWON ; Yu Il LEE
Journal of Korean Society of Endocrinology 2001;16(6):529-541
No abstract available.
Female
;
Mammals*
;
Ovulation*
;
Rupture*
2.Analysis of Heavy Metals in 201TlTlCl Injection Using Polarography.
Kwon Soo CHUN ; Yong Sup SUH ; Seung Dae YANG ; Soon Hyuk AHN ; Sang Wook KIM ; Kang Hyuk CHOI ; Dong Hoon LEE ; Sang Moo LIM ; Kook Hyun YU
Korean Journal of Nuclear Medicine 2000;34(4):336-343
PURPOSE: Thallous-201 chloride produced at Korea Cancer Center Hospital(KCCH) is used in detecting cardiovascular disease and cancer. Thallium impurity can cause emesis, catharsis and nausea, so the presence of thallium and other metal impurities should be determined. According to USP and KP, their amounts must be less than 2 ppm in thallium and 5 ppm in total. In this study, the detection method of trace amounts of metal impurities in [201Tl]TlCl injection with polarography was optimized without environmental contamination. MATERALS AND METHODS: For the detection of metal impurities, Osteryoung Square Wave Stripping Voltammetry method was used in Bio-Analytical System (BAS) 50W polarograph. The voltammetry was composed of Dropping Mercury Electrode (DME) as a working electrode, Ag/AgCl as a reference electrode and Pt wire as a counter electrode. Square wave stripping method, which makes use of formation and deformation of amalgam, was adopted to determine the metal impurities, and pH 7 phosphate buffer was used as supporting electrolyte. RESULTS: T1, Cu and Pb in thallous-201 chloride solution were detected by scanning from 300 mV to -800 mV. Calibration curves were made by using TlNO3, CuSO4 and Pb(NO3)2 as standard solutions. Tl was confirmed at -450 mV peak potential and Cu at -50 mV. Less than 2 ppm of Tl and Cu was detected and Pb was not detected in KCCH-produced thallous-201 chloride injection. CONCLUSION: Detection limit of thallium and copper is approximately 50 ppb with this method. As a result of this experiment, thallium and other metal impurities in thallous-201 chloride injection, produced at Korea Cancer Center Hospital, are in the regulation of USP and KP. Polarograph could be applied for the determination of metal impurities in the quality control of radiopharmaceuticals conveniently without environmental contamination.
Calibration
;
Cardiovascular Diseases
;
Catharsis
;
Copper
;
Electrodes
;
Hydrogen-Ion Concentration
;
Korea
;
Limit of Detection
;
Metals, Heavy*
;
Nausea
;
Polarography*
;
Quality Control
;
Radiopharmaceuticals
;
Thallium
;
Vomiting
3.Radiologic Evaluation of Intraabdomenal Masses in Childhood.
Hyuk Po KWON ; Woo Mok BYUN ; Mi Soo HWANG ; Son Yong KIM ; Jae Chun CHANG ; Bok Hwan PARK
Yeungnam University Journal of Medicine 1988;5(1):33-42
The abdominal tumors in children are different from those of adult. These tumors are the third most common one, preceded by leukemia and brain tumors, in children under 15 years. X-ray examination is the most important method among diagnostic approaches. The role of diagnostic imaging is to identify the precise anatomic location and extent of pathologic process with the minimal number of imaging procedures. 23 cases of abdominal tumors were reviewed in respect of age incidence, site of origin, radiologic findings. The results are briefly summarized as follows: 1. Neuroblastoma was the most common (6 cases) and wilm's tumor (5 cases), choledocal cyst (4 cases), ovarian mass (3 cases), hydronephrosis (2 cases), were descending order in frequency. 2. The most common site was retroperitoneum (60%) Kidney was the single most common site of origin. 3. Radiologic findings. The most common findings of plain radiography was ill defined soft tissue mass and this method was helpful in the presence of calcification especially in neuroblastoma. Ultrasonographic pattern was anechoic (cystic), echoic or mixed pattern, but this method provide less precise anatomical details, nevertheless Ultrasonography was particularly useful imaging modality for the pediatric abdominal tumors. IVP findings were renal displacement, caliceopelvic system distortion or nonvisualization of kidney, these information was helpful in determining the location of tumors. CT scan showed homogenous or inhomogeneous, cystic or solid, mass with their anatomic location. 4. Ultrasonography was the most widely used specific diagnostic method, but had limited value in detecting the anatomic location of tumors. CT scan was superior to ultrasound for determining the extent of tumors.
Adult
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Brain Neoplasms
;
Child
;
Diagnostic Imaging
;
Humans
;
Hydronephrosis
;
Incidence
;
Kidney
;
Leukemia
;
Methods
;
Neuroblastoma
;
Radiography
;
Tomography, X-Ray Computed
;
Ultrasonography
;
Wilms Tumor
4.Characteristics of Trigeminal Evoked Potential and It's Pathway in the Rat.
Se Hyuk KIM ; Chun Zhi ZHAO ; Oh Kyoo KWON ; Bae Hwan LEE ; Yong Gou PARK ; Sang Sup CHUNG
Journal of Korean Neurosurgical Society 2000;29(8):985-994
No abstract available.
Animals
;
Evoked Potentials*
;
Rats*
5.Clinical Efficacy of Glucagon Like Peptide-1 (GLP-1) Analogues.
Journal of Korean Diabetes 2013;14(3):125-127
Recently, incretin hormone-based therapies, including glucagon-like peptide-1 (GLP-1) analogues and dipeptidyl peptidase-4 (DPP-4) inhibitors, have become the main therapeutic tools in the hyperglycemia management in patients with type 2 diabetes mellitus. These therapeutic agents could fill an important gap in glycemic control for patients with type 2 diabetes because the incretin response is blunted in type 2 diabetes mellitus. GLP-1 analogues can be classified as exendin-4 backbone (Exenatide, Exenatide LAR and Lixisenatide) and human GLP-1 backbone (Liraglutide, Taspoglutide and Albiglutide). Among these, Exenatide, Exenatide LAR and Liraglutide are currently available. This review will focus on the clinical efficacies of GLP-1 analogues in glycemic control for patients with diabetes.
Diabetes Mellitus, Type 2
;
Glucagon
;
Glucagon-Like Peptide 1
;
Humans
;
Hyperglycemia
;
Incretins
;
Peptides
;
Venoms
;
Liraglutide
6.Correlation between Arterial Vascularity by Radiologic Study and Structural Histopathologic Type in Resected Hepatocellular Carcinoma(HCC).
Yong Woo LEE ; Jae Chun CHANG ; Jae Ho CHO ; Jin Wook LEE ; Yoo Song JANG ; Sang Jin LEE ; Hyuk Pyo KWON
Journal of the Korean Radiological Society 1994;31(6):1093-1099
PURPOSE: To analize the correlation between dynamic vascular pattern and structural histologic type of HCC. MATERIALS AND METHODS: The materials consisted of 35 cases of HCC, which could be classified by structural histologic type and had available preoperative arterial dominant images. Excluding one case of pseudoglandular type, we compared structural histologic type of the tumors(trabecular group;13 cases, mixed group;10 cases, and nontrabecular group ;11 cases) with dynamic vascular pattern such as degrees of tumor staining, severity of tumor vessels on hepatic angiography, and with enhancing degrees of early phase relative to late phase on two-phase incremental bolus dynamic CT. RESULTS: In hepatic anglogram, trabecular group showed stronger tumor staining and more prominant dilatation and irregularity of tumor vessels than those of nontrabecular group, and In two-phase incremental bolus dynamic CT, and trabecular group showed more prominant tumor enhancement in early phase than those in late phase. CONCLUSION: The trabecular type(typical) and non-ti'abecular type of HCC showed radiologically different vascular patterns and therefore we believe that this maybe the basis with which diagnosis and treatment policy of radiologically atypical HCC could be made.
Angiography
;
Diagnosis
;
Dilatation
7.A Study on the Synthesis and Its Biodistribution of C - 11 and F - 18 Labelled Choline.
Seung Dae YANG ; Sang Wook KIM ; Yong Sup SUH ; Kwon Soo CHUN ; Soon Hyuk AHN ; Min Goo HUR ; Sang Moo LIM ; Sung Woon HONG ; Kook Hyun YU
Korean Journal of Nuclear Medicine 2001;35(3):185-191
No abstract available.
Choline*
8.CT findings of the Mediastinal tumors.
Ho Son CHUNG ; Sang Jin LEE ; Mi Young SON ; Hyuk Po KWON ; Mi Soo HWANG ; Son Yong KIM ; Jae Chun CHANG ; Bok Hwan PARK
Yeungnam University Journal of Medicine 1989;6(2):79-90
Computerized Tomography is now well established and important noninvasive method of diagnosting mediastinal mass lesions because of its superior imaging of their size, location and internal composition. Authors analyzed and present CT findings of 30 surgically proven mediastinal tumors and cysts that were studied and treated at the Yeungnam University Hospital during recent 6 years. The most common tumor was thymoma (9 cases), and teratoma (6 cases), lymphoma (6 cases), bronchogenic cyst (4 cases), neurogenic tumor (4 cases), pericardial cyst (1 case) were next in order of frequency. There were 5 cases of thymoma showing homogenous solid density mass, 2 cases were malignant thymoma and myasthenia gravis was present in 2 cases. A case of thymolipoma and a case of thymic carcinoma were included. All teratomas were cystic masses but pathognomonic fat, and calcified density were seen only in 4 cases. 5 cases were located in anterior mediastinum and 1 case was in posterior mediastinum. Lymphoma (3 Hodgkin's and 3 non-Hodgkin's) appeared as irregular lobulated mass in anterior mediastinum. Neurogenic tumor (2 ganglioneuroma and 2 neurilemmoma) appeared as homogenous density mass located in posterior mediastinum. Among the 4 bronchogenic cysts, 2 were located in retrotracheal area, 1 was located in subcarinal and 1 was in parathoracic area. One case of pericardial cyst was oval shaped cystic mass located in left pericardiac border.
Bronchogenic Cyst
;
Ganglioneuroma
;
Lymphoma
;
Mediastinal Cyst
;
Mediastinum
;
Methods
;
Myasthenia Gravis
;
Teratoma
;
Thymoma
9.A Rare but Fatal Instance of Gastrointestinal Bleeding: Primary Aortoenteric Fistula.
Hyun Kyung PARK ; Bong Hak CHOI ; Min Seong KWON ; Woong JUNG ; Sung Hyuk PARK ; Myung Chun KIM
Journal of the Korean Society of Emergency Medicine 2010;21(3):398-401
Primary aortoenteric fistula (PAEF) is a rare but catastrophic cause of gastrointestinal bleeding. The diagnosis of PAEF is difficult to make. The classic triad of symptoms, i.e. gastrointestinal bleeding, abdominal pain, and a pulsating abdominal mass is overemphasized, as it occurs in less than 11~25% of the patients. For two thirds of the patients, the diagnosis is made in the operating room. Endoscopic and radiographic studies are very helpful, but the absence of abnormalities can not exclude the diagnosis. PAEF is a clinical and surgical challenge associated with high mortality. A high index of suspicion, early diagnosis and prompt and appropriate surgical intervention are essential to patient survival. Two primary aortoenteric fistulas (aortoduodenal and aortoesophageal) cases are presented and the related literature are reviewed.
Abdominal Pain
;
Aorta, Abdominal
;
Aortic Aneurysm, Abdominal
;
Early Diagnosis
;
Fistula
;
Gastrointestinal Hemorrhage
;
Hemorrhage
;
Humans
;
Intestinal Fistula
;
Operating Rooms
;
Vascular Fistula
10.The effect of viscosity, specimen geometry and adhesion on the linear polymerization shrinkage measurement of light cured composites.
In Bog LEE ; Ho Hyun SON ; Hyuk Chun KWON ; Chung Moon UM ; Byeong Hoon CHO
Journal of Korean Academy of Conservative Dentistry 2003;28(6):457-466
OBJECTIVES: The aim of study was to investigate the effect of flow, specimen geometry and adhesion on the measurement of linear polymerization shrinkage of light cured composite resins using linear shrinkage measuring device. METHODS: Four commercially available composites - an anterior posterior hybrid composite Z100, a posterior packable composite P60 and two flowable composites, Filtek flow and Tetric flow - were studied. The linear polymerization shrinkage of composites was determined using 'bonded disc method' and 'non-bonded' free shrinkage method at varying C-factor in the range of 1~8 by changing specimen geometry. These measured linear shrinkage values were compared with free volumetric shrinkage values. The viscosity and flow of composites were determined and compared by measuring the dropping speed of metal rod under constant load. RESULTS: In non-bonded method, the linear shrinkage approximated one third of true volumetric shrinkage by isotropic contraction. However, in bonded disc method, as the bonded surface increased the linear shrinkage increased up to volumetric shrinkage value by anisotropic contraction. The linear shrinkage value increased with increasing C-factor and approximated true volumetric shrinkage and reached plateau at about C-factor 5~6. The more flow the composite was, reduced linear shrinkage was measured by compensation radial flow.
Anisotropy
;
Compensation and Redress
;
Composite Resins
;
Polymerization*
;
Polymers*
;
Viscosity*