No abstract available.
Abdominal Pain*

No abstract available.
Female ; Female* ; Humans ; Infertility* ; Pelvic Inflammatory Disease*

No abstract available.
Abortion, Therapeutic* ; Female* ; Humans ; Pregnancy ; Sterilization, Reproductive*

No abstract available.

No abstract available.
Clomiphene*

No abstract available.
Clomiphene*

No abstract available.

OBJECTIVE: To elucidate the location of leptin and receptors of ovary specimens obtained from patients undergoing hysterectomy by immunohistochemical staining and to determine the effect of leptin on the steroidogenesis of cultured granulosa cells. METHOD: In the culturing process of the granulosa cells, FSH (1 IU/ml)and leptin (50 ng/ml), IGF-I (50 ng/ml) was administered to each study group (Group I: FSH; Group II: FSH, leptin; Group III: FSH, IGF-I, leptin), and the levels of estradiol, progesterone, androstenedione in the culture media was measured by radioimmunoassay. Statistical analysis was conducted by one-way ANOVA with Scheffe test. RESULTS: The results showed that leptin and leptin receptors were both found to be strongly stained in granulosa and theca cells, and also in some interstitial cells. Leptin receptors were also observed in cultured granulosa cells. While there was no statistically significant difference in the androstnedione concentrations between the groups, estradiol concentrations was significantly decreased in Group IV (2202.0+/-151.14 pg/ml) compared to Group III (2859.0+/-122.6 pg/ml), and progesterone concentrations were also significantly decreased in Group II(4696.3+/-190.6 ng/ml) and Group IV (4517+/-206.78 ng/ml) compared to Group III(5546.0+/-179.5 ng/ml). CONCLUSTION: The study result of this study suggest that leptin is directly involved in the regulation of ovarian functions, in particular steroidogenesis.
Androstenedione ; Culture Media ; Estradiol ; Female ; Granulosa Cells* ; Humans* ; Hysterectomy ; Insulin-Like Growth Factor I ; Leptin* ; Ovary ; Progesterone ; Radioimmunoassay ; Receptors, Leptin ; Theca Cells

The UGI studies had been performed to 238 patients below the age of 15 years during the period from Jan. 1979to Jul. 1983 in SCH hospital. The results are as follows; 1. Among 238 cases, 48 cases revealed peptic ulcers ofstomach or duodenum (20.2%). The ulcer was in 31/37 cases of male patients(22.6%), and in 17/101 cases of female(16.8). Below the age of 5 years, ulcer was noted in 9 cases among 61 cases (14.8%), whereas above 5 years, in 39cases among 177 patients (22.0%). 2. In the age group below 5 years, mostly the objective symptoms were discovered(8/9), but above 5 years, complained of subjective symtoms (30/39). 3. The predominant site of peptic ulcer wasgastric antrum in the age group below 5 years (7/9), whereas duodenal bulb above 5 years(33/43). 4. Gastric antrumor duodenal bulb deformity was revealed in 13 cases and most of them were in the age group above 5 years. 5. Alllesion so peptic ulcers in this study were benign in nature. 6. In follow up study after 1 or 2 months, ulcer wasdecreased in size strikingly(9/11).
Congenital Abnormalities ; Duodenum ; Follow-Up Studies ; Humans ; Male ; Peptic Ulcer ; Ulcer

OBJECTIVE: The purpose of this study attempts to determine the endocrinologic characteristics and changes in glucose metabolism before/during pregnancy according to different body weights in women with Polycystic ovarian syndrome (PCOS). METHODS: 94 women dia with PCOS were evaluated through measuring serum hormone levels and oral glucose tolerance tests preconceptionally and gestationally. RESULTS: In patients who were of normal weight showed significantly increased serum LH levels compared to those who were overweight (12.8+/-0.9 Vs. 7.1+/-0.8 mIU/ml, p= 0.000), and the serum levels of insulin was increased significantly in the overweight group (7.1+/-0.7 Vs. 15.2+/-2.8 ulU/ml, p= 0.000). the IGFBP-I (32.8+/-10.6 Vs. 8.3+/-2.5 ng/ml, p=0.034) and SHBG (55.8+/-4.2 Vs. 37.1+/-3.1 nmol/ml, p= 0.001) were significantly lower in the ovnweight group. The oral glucose tolerance test before/after pregnancy showed increased frequency of abnormal glucose metabolism, in both of the non-obese group (38.8%, 26,9%) and the obese group (64.2%, 53.9%) compared with normal population. CONCLUSION: It is thought that in the normal weight group with polycystic ovarian syndrome androgen production is stimulated in the theca cells by abnormally high LH secretion, while in the overweight group the hyperinsulinemia state which decreases the SHBG and IGFBP-I, lead to increase biologically active hee androgens and IGF-I and increase insulin binding to its receptor. And during/before pregnancy, women with PCOS showed that incidence of abnormal glucose metabolism was significantly increased in both of non-obese and obese groups.
Androgens ; Body Weight ; Female ; Glucose Tolerance Test ; Glucose* ; Humans ; Hyperinsulinism ; Incidence ; Insulin ; Insulin-Like Growth Factor I ; Metabolism* ; Obesity ; Overweight* ; Polycystic Ovary Syndrome* ; Pregnancy* ; Theca Cells