1.Poor weight gain, recurrent metabolic alkalosis and hypokalemia in a neonate.
Miao QIAN ; Shu-Ping HAN ; Zhang-Bing YU ; Xiao-Hui CHEN
Chinese Journal of Contemporary Pediatrics 2017;19(7):812-815
The study reports a female neonate with a gestational age of 29weeks and a birth weight of 1 210 g. Ten minutes after birth, the neonate was admitted to the hospital due to shortness of breath. Several days after birth, the neonate presented with hyperglycemia, polyuria, and poor weight gain, accompanied by azotemia, hypochloremic metabolic alkalosis, hypokalemia, and hyponatremia. Laboratory examinations showed elevated levels of aldosterone, renin, and angiotensin II. Gene detection revealed SLC12A1 gene mutation. Neonatal Bartter syndrome was thus confirmed. The neonate was treated with sodium and potassium supplements, and was followed up for 8 months. During the follow-up, the mental and neural development of the neonate was almost normal at the corrected age, and regular reexaminations showed slight metabolic alkalosis and almost normal electrolyte levels. For the neonates who have the symptoms of unexplainable polyurine and electrolyte disorders, it is important to examine the levels of aldosterone, renin and angiotensin. A definite diagnosis of neonatal Bartter syndrome can be made based on the presence of SLC12A1 gene mutation.
Acidosis
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etiology
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Bartter Syndrome
;
etiology
;
therapy
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Female
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Humans
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Hypokalemia
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etiology
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Infant, Newborn
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Recurrence
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Weight Gain
2.A young woman with hypogonadism, hypertension and hypokalaemia.
The Medical Journal of Malaysia 2009;64(3):242-3
We report a case of a 16 years old girl who presented sequentially with primary amenorrhoea, hypertension and hypokalaemia. Eight years later, she was finally diagnosed with 17alpha-hydroxylase deficiency congenital adrenal hyperplasia. Previous antihypertensive medications were stopped. Hydrocortisone alone successfully maintained normotension and normokalaemia.
Adrenal Hyperplasia, Congenital/*diagnosis
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Adrenal Hyperplasia, Congenital/*etiology
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Diagnosis, Differential
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Hypertension/etiology
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Hypogonadism/etiology
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Hypokalemia/etiology
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Steroid Hydroxylases/*deficiency
4.Liddle's syndrome: a report in a middle-aged woman.
Yonsei Medical Journal 2000;41(2):276-280
A 54-year-old woman with diabetes mellitus was hospitalized with generalized edema and weakness. She was also found to have hypertension, hypokalemia and metabolic alkalosis. Detailed examination showed subnormal plasma renin activity and plasma aldosterone concentration. Adrenal CT scanning revealed no adrenal tumor. A successful treatment with amiloride established the diagnosis of Liddle's syndrome for the patient. Liddle's syndrome, a rare hereditary disease usually found in young patients, should be considered in the differential diagnosis of hypertension even in elderly individuals.
Aldosterone/deficiency*
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Aldosterone/blood
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Alkalosis/genetics*
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Case Report
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Female
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Human
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Hypertension/etiology
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Hypokalemia/genetics*
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Middle Age
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Renin/deficiency*
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Renin/blood
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Syndrome
5.Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma.
Bernhard GLODNY ; Alexandar TZANKOV ; Germar-Michael PINGGERA ; Johannes PETERSEN ; Ralf HERWIG
Asian Journal of Andrology 2006;8(2):247-250
A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case, cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides, aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma.
Adult
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Choristoma
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surgery
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Hemangioma
;
etiology
;
Humans
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Hypertension
;
chemically induced
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Hypokalemia
;
complications
;
Male
;
Postoperative Complications
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Renin
;
blood
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Testis
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Tomography, X-Ray Computed
6.The effects of hypokalemia on the Na+ channel in cardiac tissue--a computer simulation study.
Li MA ; Lin YANG ; Yinbin JIN ; Xiaozhen CHEN
Journal of Biomedical Engineering 2009;26(1):1-5
In order to explore the reason why hypokalemia could increase the vulnerable window (VW) for unidirectional conduction block in Long QT Syndromes (LQTS), we observed the effect of hypokalemia on the spatial gradients of Na channel conductance (G(Na)) and gating factors by using the LR91 1-dimensional heterogeneous virtual cardiac ventricular tissue model quatitively. The computer simulation experiments were divided into two groups, namely control and LQTS groups. The action potential was elicited after the basic stimulus S1 (-70 microA/microF, 1.5 ms) was given 10 times with basic cycle length (BCL) 500, 1000 and 2000 ms. To test the VW in unit of time (VWtime), the S1-S2 programmed stimuli were used with shortening S1S2 interval at the decrement of 1 ms. At the same time, the spatial gradients of Na channel conductance (G(Na)) and gating factors, m, h, j, were investigated. The APD and ionic channel currents were also detected under the conditions of normal and lower concentration of K+ outside of cell. We found that hypokalemia, LQTS and slow pacing rate enhanced the spatial gradient of G(Na) by increasing the spatial gradient of inactive gating factors h x j. The results also showed that hypokalemia deduced the peak values of I(K) and I(K1), which prolonged the action potential duration and enlarged the repolarization dispersion in this 1-D tissue cable model. Possibly these are the important factors to cause the spatial gradient of h x j and G(Na). enlargement. These changes increase the incidence of unidirectional conduction block of VW, and are vital reasons to increase the possibility of ventricular arrhythmia generation.
Computer Simulation
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Extracellular Space
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metabolism
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Humans
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Hypokalemia
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metabolism
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Long QT Syndrome
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etiology
;
metabolism
;
physiopathology
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Models, Biological
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Myocardium
;
metabolism
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Sodium Channels
;
metabolism
7.Propofol associated with hypokalemia causes electro storm.
Jian-Hua YU ; Kui HONG ; Kai-Cheng CHENG
Chinese Journal of Cardiology 2007;35(11):1057-1057
8.Effect of hypokalemia on glucose metabolism in primary hyperaldosteronism.
Jing ZHANG ; Zheng-pei ZENG ; Ya-ru ZHOU ; An-li TONG ; Lin LU ; Ai-ling SONG ; Zhao-li YAN ; Shi CHEN ; Wei LIANG ; Yu-xiu LI ; Shu-wen QIN
Acta Academiae Medicinae Sinicae 2006;28(6):745-749
OBJECTIVETo investigate the effect of potassium deficiency on glucose and insulin metabolism in primary hyperaldosteronism, including aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA).
METHODSTotally 178 patients who were diagnosed as primary hyperaldosteronism (103 patients with APA and 75 with IHA) were divided into hypokalemia group and normal potassium group according to their serum potassium levels. All patients received 3 hours of oral glucose tolerance test and aldosterone test to observe the relationship among glucose, insulin and serum potassium.
RESULTSArea under curve of serum potassium, area under curve of plasma insulin, and fasting serum insulin were significantly lower in the hypokalemia group than in the normal potassium group (P <0. 05, P <0. 01); area under curve of glucose and aldosterone level were significantly higher in the hypokalemia group than in the normal potassium group ( P < 0. 05 ) . The prevalence of metabolic syndrome was significantly higher in IHA than in APA (57. 3% vs 38. 8% ; P < 0. 05).
CONCLUSIONHypokalemia may play an important role in inhibiting insulin secretion in primary hyperaldosteronism.
Adult ; Blood Glucose ; metabolism ; Female ; Glucose Tolerance Test ; Humans ; Hyperaldosteronism ; complications ; metabolism ; Hypokalemia ; complications ; Insulin ; metabolism ; Male ; Metabolic Syndrome ; etiology ; Middle Aged
9.Mediation of serum albumin in the association of serum potassium with mortality in Chinese dialysis patients: a prospective cohort study.
Naya HUANG ; Yuanying LIU ; Zhen AI ; Qian ZHOU ; Haiping MAO ; Xiao YANG ; Yuanwen XU ; Xueqing YU ; Wei CHEN
Chinese Medical Journal 2023;136(2):213-220
BACKGROUND:
The clinical importance of hypokalemia is likely underrecognized in Chinese dialysis patients, and whether its clinical effect was mediated by serum albumin is not fully elucidated. This study aimed to explore the association between serum potassium and mortality in dialysis patients of a Chinese nationwide multicenter cohort, taking albumin as a consideration.
METHODS:
This was a prospective nation-wide multicenter cohort study. Restricted cubic splines were used to test the linearity of serum potassium and relationships with all-cause (AC) and cardiovascular (CV) mortality and a subsequent two-line piecewise linear model was fitted to approach the nadir. A mediation analysis was performed to examine relations of albumin to potassium and mortalities.
RESULTS:
A total of 10,027 patients were included, of whom 6605 were peritoneal dialysis and 3422 were hemodialysis patients. In the overall population, the mean age was 51.7 ± 14.8 years, 55.3%(5546/10,027) were male, and the median dialysis vintage was 13.60 (4.70, 39.70) months. Baseline serum potassium was 4.30 ± 0.88 mmol/L. After a median follow-up period of 26.87 (14.77, 41.50) months, a U-shape was found between potassium and mortality, and a marked increase in risk at lower potassium but a moderate elevation in risk at higher potassium were observed. The nadir for AC mortality risk was estimated from piecewise linear models to be a potassium concentration of 4.0 mmol/L. Interestingly, the significance of the association between potassium and mortality was attenuated when albumin was introduced into the extended adjusted model. A subsequent significant mediation by albumin for potassium and AC and CV mortalities were found ( P < 0.001 for both), indicating that hypokalemia led to higher mortality mediated by low serum albumin, which was a surrogate of poor nutritional status and inflammation.
CONCLUSIONS
Associations between potassium and mortalities were U-shaped in the overall population. The nadir for AC mortality risk was at a potassium of 4.0 mmol/L. Serum albumin mediated the association between potassium and AC and CV mortalities.
Adult
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Aged
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Female
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Humans
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Male
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Middle Aged
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East Asian People
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Hypokalemia/etiology*
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Kidney Failure, Chronic/mortality*
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Potassium/blood*
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Prospective Studies
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Renal Dialysis
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Serum Albumin/analysis*
10.Lactic acidosis associated with the usual theophylline dose in a patient with asthma.
The Korean Journal of Internal Medicine 2002;17(2):147-149
Metabolic and electrolyte abnormalities, including hypokalemia, hyperglycemia and lactic acidosis, are associated with theophylline overdose. However, we report an unusual case of sinus tachycardia, lactic acidosis, hypokalemia and hyperglycemia associated with the usual theophylline dose in a patient with asthma. The theophylline dose was 200 mg orally twice daily. Three hours after administration of the third dose, the patient experienced palpitation. An electrocardiogram showed a sinus tachycardia. Arterial blood gas analysis revealed a mixed metabolic acidosis and respiratory alkalosis. Serum lactate level was 51 mmol/L (normal 0.7~2.1 mmol/L). Biochemistry results were sodium 136 mEq/L, chloride 99 mEq/L, potassium 1.9 mEq/L and glucose 204 mg/dL. Our case suggests that a possibility of theophylline-associated metabolic abnormalities should be considered when an asthmatic patient given the usual theophylline dose presents with lactic acidosis, hypokalemia and hyperglycemia of unknown etiology.
Acidosis, Lactic/*chemically induced
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Adult
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Asthma/drug therapy
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Bronchodilator Agents/administration & dosage/*adverse effects
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Case Report
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Female
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Human
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Hyperglycemia/chemically induced
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Hypokalemia/etiology
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Tachycardia, Sinus/chemically induced
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Theophylline/administration & dosage/*adverse effects