1.Brief review about compatibility and their pharmacological effects of Chinese material medica as tranquilizer.
Qiong WANG ; Li-wei WANG ; Xin-min LIU
China Journal of Chinese Materia Medica 2007;32(22):2342-2346
The paper summarized the sedative pharmacological effects of CMM, which were reported in the past 10 years. Those sedative CMMs were found in several type of Chinese medicine, such as tranquilizing the mind, calming the liver to stop the wind, general tonic, blood-activating and stasis-resolving drugs, heat-clearing drugs, exterior-releasing drugs, drugs for resuscitation, diuresis-inducing and dampness-draining drugs, ect. Out of them, the general tonic drugs were used in many occasions. Two Chinese herbs, jujube seed and polygala were used popularly as sedative drugs. And their effects have something to do with heart Meridian and liver Meridian. The Locomotor activity, sleeping test and forcing swimming were used commonly to detect the sedative effects. The sedative mechanisms of those CMM were related with neuro-transmitters such as Dopamine (DA), 5-HT and gamma-GABA, etc.
Animals
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Drug Combinations
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Humans
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Hypnotics and Sedatives
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pharmacology
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therapeutic use
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Materia Medica
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pharmacology
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therapeutic use
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Medicine, Chinese Traditional
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Neurotransmitter Agents
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metabolism
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Sleep Wake Disorders
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drug therapy
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metabolism
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Tranquilizing Agents
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pharmacology
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therapeutic use
2.Pharmacodynamic Estimate of Propofol-Induced Sedation and Airway Obstruction Effects in Obstructive Sleep Apnea-Hypopnea Syndrome.
Bon Nyeo KOO ; Seokyung SHIN ; So Yeon KIM ; Young Ran KANG ; Kyu Hee JEONG ; Dong Woo HAN
Yonsei Medical Journal 2015;56(5):1408-1414
PURPOSE: Sedatives must be carefully titrated for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) as oversedation may lead to disastrous respiratory outcomes. This study aimed to investigate the relations between the effect-site concentration (Ce) of propofol and sedation and airway obstruction levels in patients with OSAHS. MATERIALS AND METHODS: In 25 patients with OSAHS, sedation was induced by 2% propofol using target-controlled infusion. Sedation and airway obstruction levels were assessed using the Observer's Assessment of Alertness/Sedation Scale and a four-category scale, respectively. The relationships between propofol Ce and sedation and airway obstruction were evaluated using a sigmoid Emax model. Pharmacodynamic modeling incorporating covariates was performed using the Nonlinear Mixed Effects Modeling VII software. RESULTS: Increased propofol Ce correlated with the depth of sedation and the severity of airway obstruction. Predicted Ce50(m) (Ce associated with 50% probability of an effect> or =m) for sedation scores (m> or =2, 3, 4, and 5) and airway-obstruction scores (m> or =2, 3, and 4) were 1.61, 1.78, 1.91, and 2.17 microg/mL and 1.53, 1.64, and 2.09 microg/mL, respectively. Including the apnea-hypopnea index (AHI) as a covariate in the analysis of Ce50(4) for airway obstruction significantly improved the performance of the basic model (p<0.05). CONCLUSION: The probability of each sedation and airway obstruction score was properly described using a sigmoid Emax model with a narrow therapeutic range of propofol Ce in OSAHS patients. Patients with high AHI values need close monitoring to ensure that airway patency is maintained during propofol sedation.
Adult
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Aged
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Airway Obstruction/*drug therapy
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Anesthesia
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Anesthetics, Intravenous/blood/pharmacokinetics/*pharmacology
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Female
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Humans
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Hypnotics and Sedatives/*pharmacology/therapeutic use
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Male
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Middle Aged
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Probability
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Propofol/*pharmacology/therapeutic use
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Sleep Apnea, Obstructive/physiopathology
3.Effect of dexmedetomidine on supraclavicular brachial plexus block: a randomized double blind prospective study.
Yan LI ; Hui WANG ; Ying DENG ; Yao YAO ; Min LI
Journal of Peking University(Health Sciences) 2018;50(5):845-849
OBJECTIVE:
To evaluate the effect of dexmedetomidine combined with ropivacaine on brachial plexus block in patients scheduled for elective shoulder arthroscopy.
METHODS:
Ninety patients with American Society of Anesthesiologists (ASA) I or II, scheduled for elective shoulder arthroscopy, were randomly divided into three groups. In group R (n=30), the patients were given 10 mL of 0.375% ropivacaine in branchial plexus block (interscalene approach guided by ultrasound), in group D1 (n=30), the patients were given 10 mL of 0.375% ropivacaine (interscalene approach guided by ultrasound) + dexmedetomidine 0.2 μg/(kg×h) (intravenous pump infusion), and in group D2 (n=30), the patients were given 10 mL of 0.375% ropivacaine (interscalene approach guided by ultrasound) + dexedetomidine 0.7 μg/(kg×h) (intravenous pump infusion). To evaluate the effect of brachial plexus block before general anesthesia. Group D1 and group D2 were given dexmedetomidine intravenously for 1.0 μg/kg during 10 min, then the drug was pumped by 0.2 μg/(kg×h) and 0.7 μg/(kg×h) respectively until 30 min before the operation finished. Changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and before anesthesia (T0), 10 min (T1), 30 min (T2) after giving dexmedetomidine, discontinue medication (T3), after operation (T4), and extubation (T5) were investigated. Motor and sensory block onset times, block durations, and duration of analgesia were recorded. The scores of pain after operation and the adverse effects of shiver, hypopiesia, drowsiness, and blood loss were recorded during operation.
RESULTS:
Compared with group R, the duration of analgesia and duration of sensory block in group D1 and group D2 were significant longer (P<0.01), there was no significant difference between groups D1 and D2 (P>0.05). Compared with group R, at each time point of T1-T5, the heart rate and systolic blood pressure in group D1 and group D2 were significantly decreased (P<0.01). Compared with D1 group, the incidence of hypotension and bradycardia in group D2 were significantly different (P<0.05).
CONCLUSION
Intravenous dexmedetomidine could prolong the duration of analgesia time and sensory block within the brachial plexus block, inhibiting the stress response during arthroscopic shoulder surgery. Compared with high-dose, low-dose can provide safer and better clinical effect and reduce the adverse effects of dexmedetomidine.
Analgesics, Non-Narcotic
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Anesthetics, Local/therapeutic use*
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Arthroscopy
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Brachial Plexus
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Brachial Plexus Block
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Dexmedetomidine/therapeutic use*
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Double-Blind Method
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Humans
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Hypnotics and Sedatives/pharmacology*
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Prospective Studies
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Ropivacaine/therapeutic use*
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Shoulder Joint/surgery*
4.Blood pressure changes of elderly hypertensive patients during dental extraction under sedation with continuous intravenous infusion of midazolam.
Ji-Zhi ZHAO ; Kuo WAN ; Quan JING ; Xi CHEN
Chinese Medical Sciences Journal 2007;22(2):132-135
OBJECTIVETo evaluate the changes in blood pressure (BP) of elderly hypertensive patients having dental extraction under sedation with continuous intravenous infusion of midazolam.
METHODSOne hundred elderly hypertensive patients undergoing dental extraction were recruited for this single-blind, randomized, controlled study. Patients in intervention group (n = 50) were given midazolam dissolved in glucose solution and patients in control group (n = 50) were given glucose solution only with communication technique. Systolic BP (SBP) and diastolic BP (DBP) were recorded in five time points.
RESULTSUnder basal conditions, intervention group did not show significant difference in BP compared with control group. Before sedation, mean values of SBP and DBP (especially SBP) significantly increased compared with basal conditions in both groups (P < 0.05). During dental extraction sessions, mean values of BP in intervention group significantly decreased than control group (P < 0.05), but coefficient of variation did show significant difference in both groups.
CONCLUSIONContinuous intravenous infusion of midazolam has been proved to be very successful in controlling BP of elderly patients having dental extraction.
Aged ; Blood Pressure ; drug effects ; physiology ; Diastole ; drug effects ; Humans ; Hypertension ; prevention & control ; Hypnotics and Sedatives ; pharmacology ; therapeutic use ; Infusions, Intravenous ; Midazolam ; pharmacology ; therapeutic use ; Systole ; drug effects ; Tooth Extraction ; methods
5.Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model.
Chun-Hay KO ; Chi-Man KOON ; Siu-Lung YU ; Kwok-Ying LEE ; Clara Bik-San LAU ; Edwin Ho-Yin CHAN ; Yun-Kwok WING ; Kwok-Pui FUNG ; Ping-Chung LEUNG
Chinese journal of integrative medicine 2016;22(5):335-343
OBJECTIVETo assess the biological effects of the six-herb mixture Anti-Insomia Formula (AIF) extract using caffeine-induced insomnia Drosophila model and short-sleep mutants.
METHODSCaffeineinduced insomnia wild-type Drosophila and short-sleep mutant flies minisleep (mns) and Hyperkinetic(Y) (Hk(Y)) were used to assess the hypnotic effects of the AIF in vivo. The night time activity, the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system. Sleep was defined as any period of uninterrupted behavioral immobility (0 count per minute) lasting > 5 min. Night time sleep was calculated by summing up the sleep time in the dark period. Number of sleep bouts was calculated by counting the number of sleep episodes in the dark period.
RESULTSAIF at the dosage of 50 mg/mL, effectively attenuated caffeine-induced wakefulness (P<0.01) in wild-type Canton-S flies as indicated by the reduction of the sleep bouts, night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep Hk(Y) mutant flies (P<0.01). However, AIF did not produce similar effect in mns mutants.
CONCLUSIONAIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel, but not rescuing the abnormal nerve firing caused by Shaker gene mutation. This study provides the scientific evidence to support the use of AIF in Chinese medicine for promoting sleep quality in insomnia.
Animals ; Caffeine ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drosophila melanogaster ; drug effects ; physiology ; Hypnotics and Sedatives ; pharmacology ; therapeutic use ; Mutation ; genetics ; Potassium Channels ; genetics ; Sleep ; drug effects ; Sleep Initiation and Maintenance Disorders ; drug therapy ; Wakefulness ; drug effects
6.Current research on angong niuhuang pills.
China Journal of Chinese Materia Medica 2004;29(2):119-122
Animals
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Anticonvulsants
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pharmacology
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Arsenicals
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Cerebrovascular Disorders
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drug therapy
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Drug Combinations
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Drugs, Chinese Herbal
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isolation & purification
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pharmacology
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therapeutic use
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Fever
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drug therapy
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Humans
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Hypnotics and Sedatives
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pharmacology
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Materia Medica
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isolation & purification
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pharmacology
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therapeutic use
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Mercury Compounds
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Plants, Medicinal
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chemistry
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Stroke
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drug therapy
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Sulfides
7.Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts.
Hai-Yan SUN ; Fu-Shan XUE ; Ya-Chao XU ; Cheng-Wen LI ; Jun XIONG ; Xu LIAO ; Yan-Ming ZHANG
Chinese Medical Journal 2009;122(24):3048-3054
BACKGROUNDThere are few studies to assess whether propofol attenuates myocardial ischemia-reperfusion injury via a mechanism related to nitric oxide (NO) route, so we designed this randomized blinded experiment to observe the changes of NO contents, nitric oxide synthase (NOS) activity, NOS contents in the myocardium, and cardiac function in ischemic reperfused isolated rat hearts, and to assess the relation between myocardial NO system and cardioprotection of propofol.
METHODSThe hearts of 30 Sprague-Dawley male rats were removed, mounted on a Langendorff apparatus, and randomly assigned to one of three groups (n = 10 each group) to be treated with the following treatments in a blinded manner: Group 1, control group, after perfusion with pure Krebs Henseleit bicarbonate (K-HBB) buffer solution for 15 minutes, hearts were subjected to 20 minutes global ischemia followed by 60 minutes reperfusion with pure K-HBB buffer; Group 2, after perfusion with K-HBB buffer solution containing propofol (10 microg/ml) for 15 minutes, the hearts underwent 20 minutes global ischemia followed by 60 minutes reperfusion with the same K-HBB buffer solution; Group 3, after perfusion with K-HBB buffer solution containing propofol (10 microg/ml) and L-NAME (100 micromol/L) for 15 minutes, the hearts underwent 20 minutes global ischemia followed by 60 minutes reperfusion with the same K-HBB buffer solution. The cardiac function was continuously monitored throughout the experiment. The coronary flow was also measured. An ISO-NO electrode was placed into the right atrium close to the coronary sinus to continuously measure NO concentration in the coronary effluent. The tissue samples from apex of hearts in Groups 1 and 2 were obtained to measure the NOS activity by spectrophotometry and the NOS contents by immunohistochemistry, respectively.
RESULTSThe cardiac function was significantly inhibited after ischemia and then gradually improved with reperfusion in all three groups. As compared with Group 1, the cardiac function variables and coronary flow at all the observed points were significantly improved in Group 2. The cardiac function variables and coronary flow were better in Group 3 than in Group 1, but were inferior in Group 3 than in Group 2. Both NO contents and NOS activity in the myocardium were significantly higher in Group 2 than in Group 1. However, NOS contents in the myocardium did not significantly differ between Groups 1 and 2.
CONCLUSIONSIn isolated rat hearts, propofol can improve cardiac functional recovery after ischemia-reperfusion by upregulating NOS activity in the myocardium. The NO system may play an important role in the preservation of myocardial ischemia-reperfusion injury produced by propofol.
Animals ; Coronary Circulation ; drug effects ; Enzyme Activation ; drug effects ; Heart ; drug effects ; Heart Function Tests ; Hypnotics and Sedatives ; pharmacology ; therapeutic use ; Immunohistochemistry ; In Vitro Techniques ; Male ; Myocardial Reperfusion Injury ; drug therapy ; enzymology ; Myocardium ; enzymology ; Nitric Oxide Synthase ; metabolism ; Propofol ; pharmacology ; therapeutic use ; Rats ; Rats, Sprague-Dawley