2.Clinical analysis of childhood cavernous transformation of the portal vein.
Ying LI ; Yue-Hua LI ; Li-Juan ZHANG ; Heng-Ming PAN
Chinese Journal of Contemporary Pediatrics 2006;8(1):75-76
Child
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Child, Preschool
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Female
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Humans
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Hypertension, Portal
;
diagnosis
;
etiology
;
therapy
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Infant
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Male
;
Portal Vein
;
pathology
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Venous Thrombosis
;
diagnosis
;
etiology
;
therapy
3.Hepatic venous pressure gradient: clinical use in chronic liver disease.
Clinical and Molecular Hepatology 2014;20(1):6-14
Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase in HVPG to >10 mmHg. In this condition, the complications of portal hypertension might begin to appear. HVPG measurement is increasingly used in the clinical fields, and the HVPG is a robust surrogate marker in many clinical applications such as diagnosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension. Patients who had a reduction in HVPG of > or =20% or to < or =12 mmHg in response to drug therapy are defined as responders. Responders have a markedly decreased risk of bleeding/rebleeding, ascites, and spontaneous bacterial peritonitis, which results in improved survival. This review provides clinical use of HVPG measurement in the field of liver disease.
Chronic Disease
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Hemodynamics
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Hemorrhage/etiology
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Hepatic Veins/physiology
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Humans
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Hypertension, Portal/complications
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Liver Cirrhosis/diagnosis
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Liver Diseases/complications/*physiopathology
;
Portal Pressure
4.Portal vein flow rate used as a early predictor of portal vein thrombosis after periesophagastric devascularization.
Yu ZHANG ; Tian-Fu WEN ; Zhe-Yu CHEN ; Lü-Nan YAN ; Guan-Lin LIANG ; Guo LI ; Xian-Hua ZHANG ; Shun RAN ; Zhi-Xua LIAO
Chinese Journal of Surgery 2009;47(11):825-828
OBJECTIVETo evaluate the predictive value of portal vein flow rate preoperative for portal vein thrombosis (PVT) after periesophagastric devascularization in hepatitis B cirrhosis-related portal hypertension.
METHODSFrom January 2007 to July 2008, 45 patients with portal hypertension caused by hepatitis B cirrhosis were performed splenectomy with peri-esophagogastric devascularization in the same medical group in West China Hospital of Sichuan University. The portal vein flow rate and the diameter of portal vein were measured with doppler sonography respectively before and after the operation. At the same time, the level of PT and PLT were detected. The weight of spleens were measured after operation.
RESULTSThirteen cases suffered from PVT postoperatively. Portal vein flow rate was significantly lower in patients with PVT postoperation than that in patients without PVT (P < 0.01). In patients with PVT (n = 13) postoperation, the preoperative portal vein flow rate was (19.5 +/- 5.3) cm/s. Among the 13 cases, there were 12 cases whose flow rate were lower than 25 cm/s, and 1 case whose flow rate was 32. 3 cm/s; In patients without PVT (n = 32), the preoperative portal vein flow rate was (9.6 +/- 8.0) cm/s. In patients with lower rate (n = 17), the incidence rate of PVT was 70.6%; in patients with higher rate (n = 28), the incidence rate of PVT was 3.6%. The incidence rate of PVT in patients with lower rate was significantly lower than patients with higher rate (P < 0.01). The diameter of portal vein in patients with PVT was significantly wider than patients without PVT. The diameter of portal vein was negative correlative with the portal vein flow rate. The value 25 cm/s was of diagnostic efficiency, the sensitivity was 92.3%, and specificity was 70.6%.
CONCLUSIONSThe portal vein flow rate preoperative can be used as an early predictor of portal vein thrombosis after periesophagastric devascularization in hepatitis B cirrhosis-related portal hypertension to give a guide to clinical work.
Adult ; Aged ; Blood Flow Velocity ; Female ; Humans ; Hypertension, Portal ; etiology ; physiopathology ; surgery ; Liver Cirrhosis ; complications ; Male ; Middle Aged ; Portal Vein ; diagnostic imaging ; physiopathology ; Postoperative Complications ; diagnosis ; etiology ; Preoperative Care ; Risk Factors ; Splenectomy ; Ultrasonography ; Venous Thrombosis ; diagnosis ; etiology
6.The Adverse Effect of Indirectly Diagnosed Portal Hypertension on the Complications and Prognosis after Hepatic Resection of Hepatocellular Carcinoma.
Min AN ; Joong Won PARK ; Jeong A SHIN ; Joon Il CHOI ; Tae Hyun KIM ; Seong Hoon KIM ; Woo Jin LEE ; Sang Jae PARK ; Eun Kyoung HONG ; Chang Min KIM
The Korean Journal of Hepatology 2006;12(4):553-561
<0.01). The cumulative 3-year recurrence-free survival rate showed no statistical difference between the two groups. However, the cumulative 3-year survival rate was significantly higher in the non-portal hypertension group (82.8% vs. 53%, respectively, P=0.014). CONCLUSION: Indirectly diagnosed portal hypertension is correlated with the development of complications and poor prognosis after the surgical resection of HCC.
Adult
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Aged
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Carcinoma, Hepatocellular/complications/*surgery
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Female
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Humans
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Hypertension, Portal/*diagnosis/etiology
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Liver Neoplasms/complications/*surgery
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Male
;
Middle Aged
;
Postoperative Complications/*diagnosis
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Prognosis
;
Survival Rate
8.Progress in the diagnosis and treatment of hepatic hydrothorax.
Hong-cui LI ; Xiao LI ; Cheng-wei TANG
Chinese Journal of Hepatology 2009;17(12):958-960
Ascites
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diagnosis
;
etiology
;
therapy
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Diagnostic Imaging
;
methods
;
Humans
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Hydrothorax
;
diagnosis
;
etiology
;
therapy
;
Hypertension, Portal
;
complications
;
Liver Cirrhosis
;
complications
;
Liver Transplantation
;
Pleural Effusion
;
diagnosis
;
etiology
;
therapy
;
Portasystemic Shunt, Transjugular Intrahepatic
9.Construction of Transjugular Intrahepatic Portosystemic Shunt: Bare Metal Stent/Stent-graft Combination versus Single Stent-graft, a Prospective Randomized Controlled Study with Long-term Patency and Clinical Analysis.
Chang-Ming WANG ; Xuan LI ; Jun FU ; Jing-Yuan LUAN ; Tian-Run LI ; Jun ZHAO ; Guo-Xiang DONG
Chinese Medical Journal 2016;129(11):1261-1267
BACKGROUNDBalanced adjustment of the portal vein shunt volume during a transjugular intrahepatic portosystemic shunt (TIPS) is critical for maintaining liver perfusion and decreasing the incidence of liver insufficiency. A stent-graft is proved to be superior to a bare metal stent (BMS) for the construction of a TIPS. However, the clinical results of the combination application of stents and stent-grafts have not been determined. This study aimed to compare the technique of using a combination of stents and stent-grafts with using a single stent-graft to construct a TIPS.
METHODSFrom April 2011 to November 2014, a total of fifty patients were randomly assigned to a stents-combination group (Group I, n = 28) or a stent-graft group (Group II, n = 22). Primary patency rates were calculated. Clinical data, including the technical success rate, bleeding control results, incidence of encephalopathy, liver function preservation, and survival rate, were assessed.
RESULTSTechnically, the success rate was 100% for both groups. The primary patency rates at 1, 2, and 3 years for Group I were 96%, 84%, and 77%, respectively; for Group II, they were 90%, 90%, and 78%, respectively. The survival rates at 1, 2, and 3 years for Group I were 79%, 74%, and 68%, respectively; for Group II, they were 82%, 82%, and 74%, respectively. The incidence of hepatic encephalopathy was 14.3% for Group I and 13.6% for Group II. The Child-Pugh score in Group I was stable at the end of the follow-up but had significantly increased in Group II (t = -2.474, P = 0.022).
CONCLUSIONSThe construction of a TIPS with either the single stent-graft or BMS/stent-graft combination is effective for controlling variceal bleeding. The BMS/stent-graft combination technique is superior to the stent-graft technique in terms of hepatic function preservation indicated by the Child-Pugh score. However, considering the clinical results of the TIPS, the two techniques are comparable in their primary shunt patency, incidence of encephalopathy and patient survival during the long-term follow-up.
Aged ; Female ; Hepatic Encephalopathy ; diagnosis ; etiology ; Humans ; Hypertension, Portal ; complications ; mortality ; surgery ; Male ; Middle Aged ; Polytetrafluoroethylene ; Portal Vein ; surgery ; Portasystemic Shunt, Transjugular Intrahepatic ; adverse effects ; methods ; Postoperative Complications ; Prospective Studies ; Stents ; Treatment Outcome
10.Portal Hypertensive Gastropathy and Gastric Antral Vascular Ectasia.
The Korean Journal of Gastroenterology 2010;56(3):186-191
Portal hypertensive gastropathy (PHG) is a term used to define the endoscopic findings of gastric mucosa with a characteristic mosaic-like pattern with or without red spots, and a common finding in patients with portal hypertension. These endoscopic findings correspond to dilated mucosal capillaries without inflammation. The pathogenesis of PHG in not well known, but portal hypertension and some humoral factors seem to be crucial factors for its development. Pharmacological (e.g. propranolol), or interventional radiological (such as transjugular intrahepatic portosystemic shunt) procedures may be useful in preventing re-bleeding from PHG. The classic features of gastric antral vascular ectasia (GAVE) syndrome include red, often haemorrhagic lesions predominantly located in the gastric antrum which can result in significant blood loss. Although the pathogenesis of GAVE is not clearly defined, it seems to be a separate disease entity from PHG, because GAVE generally does not respond to a reduction of portal pressures. Endoscopic ablation (such as argon plasma coagulation) is the first-line treatment of choice. This review will focus on the incidence, clinical importance, etiology, pathophysiology, and treatment of PHG and GAVE syndrome in the setting of portal hypertension.
Esophageal and Gastric Varices/*diagnosis/etiology/therapy
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Gastric Antral Vascular Ectasia/*diagnosis/etiology/therapy
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Gastric Mucosa/metabolism/pathology
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Humans
;
Hypertension, Portal/*complications
;
Portasystemic Shunt, Transjugular Intrahepatic
;
Vasodilator Agents/therapeutic use