Study on 72 typical hyperplasia patients, preservative drug treatment with progestin (Organmetril). The subjects were detailed examined, then were implemented exploratory tests, treated and followed-up regularly 3-6 months. Results: hyperplasia was common disease in all of aged of woman’s fertilizable period, with non-ovule menstruation cycle, specially in peri-menopause. Clinical feature was menorrhagia. To diagnose exactly, medical professionals required to combine exploratory methods as vaginal cytology, mucosal uterus ultrasound, uterus chamber endoscopy, ana-pathology of mucosal uterus piece,… in which ana-pathology of mucosal uterus piece had the most important role.
Hyperplasia ; Diagnosis

The diagnosis of nodular melanomas can be sometimes difficult, in case they lack the conventional clinical features of melanoma. Herein, we report a case of malignant melanoma mimicking seborrheic keratosis. The clinical diagnosis was seborrheic keratosis. The histopathologic examination revealed nodular melanoma with features of reticulated form of epidermal hyperplasia, pseudohorn cysts, and irregular hyperkeratosis and acanthosis. The tumor was excised with 2.5 cm margins and no remnant of tumor cells was found in the microscopic examination.
Diagnosis ; Hyperplasia ; Keratosis, Seborrheic* ; Melanoma*

Sebaceous hyperplasia is not a rare disorder and commonly develops on the face over the age of forty. The typical clinical manifestations are 2 ~ 3mm sized, single or multiple, soft protuberant yellowish nodules with central umbilication and histology shows a group of mature sebaceous lobules and central sebaceous ducts. We report an exceptionally "giant" size of sebaceous gland hyperplasia which lead us to such clinical impressions as an acrochordon, intradermal nevus, and verruca vulgaris. Histologically, the lesion showed a greatly enlarged sebaceous gland composed of numerous lobules grouped around a wide sebaceous duct. Besides the extraordinarily large size of the nodule, the benign proliferating pattern led us to a diagnosis of giant sebaceous hyperplasia.
Diagnosis ; Hyperplasia* ; Nevus, Intradermal ; Sebaceous Glands* ; Warts

Primary neoplasms arising in vesical diverticula are rare and present special problems in diagnosis and treatment. We report a case of primary carcinoma arising in vesical diverticula with associated benign prostatic hypertrophy.
Diagnosis ; Diverticulum* ; Prostatic Hyperplasia ; Urinary Bladder Neoplasms

PURPOSE: Chronic prostatitis is clinically defined by symptoms consisting of pain, voiding complaints and sexual dysfunction. Determination of the severity and progression over time of the disease and an evaluation of the results of various therapies may be best assessed and monitored by a valid and reliable symptom scoring instruments. We evaluated the reliability, validity and responsiveness of the Korean version of NIH-CPSI and the characteristics of symptom index on chronic prostatitis. MATERIALS AND METHODS: All patients underwent a complete clinical evaluation and completed the Korean version of NIH-CPSI. The reliability of CPSI was examined by test-retest reliability and internal consistency for 41 chronic prostatitis patients. And the results in chronic prostatitis group were compared with those in 2 groups including 36 benign prostate hyperplasia patients and 46 healthy men. In 41 chronic prostatitis group including 28 IIIA and 13 IIIB patients, CPSI was reassessed after 6 weeks treatment and compared with those of pretreatment state. RESULTS: The Korean version of NIH-CPSI had excellent test-retest reliability (r=0.76 to 0.95) and high internal consistency (Crobach's alpha=0.86 to 0.97) during a 1 week period. The symptom score had significant difference in the each items and domains between chronic prostatitis and healthy control subjects (p<0.05). And the symptom score of each domains was sensitive to change with decreasing score after treatment (p<0.01). Chronic prostatitis had higher score of pain domain and BPH had higher score of urinary symptom domain. But the score of QOL domain was similar in both group. CONCLUSIONS: The NIH-CPSI is clinically reliable, valid, and responsive means of capturing the symptoms and impact of chronic prostatitis. It may be useful in clinical diagnosis and treatment of chronic prostatitis.
Diagnosis ; Humans ; Hyperplasia ; Male ; Prostate ; Prostatitis*

BACKGROUND: Endocervical glandular lesions include glandular atypia (GA), endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS), and invasive adenocarcinoma (IA). The diagnosis of malignant glandular lesions is occasionally difficult to distinguish from benign mimickers, and the morphologic features of EGD remain unsettled. METHODS: Immunohistochemical stains for MIB-1, p53 and CEA were performed on 81 cases of paraffin-embedded endocervical glandular lesions including 22 IA, 15 AIS, 15 EGD, 13 GA, 8 microglandular hyperplasia (MGH) and 8 tubal metaplasia (TM). RESULTS: The MIB-1 labelling index of IA was 59.68%, 69.53% for AIS, 26.60% for EGD, 16.03% for benign. p53 overexpression was noted in 4 (18%) cases of IA, 3 (20%) of AIS, but none of EGD and benign lesions. It was Interesting to note that one case of MGH showed p53 staining in low intensity. Diffuse strong cytoplasmic CEA positivity was present in all of IA and AIS, whereas seven (47%) of 15 EGD and 12 (41%) of 29 benign lesions showed focal cytoplasmic CEA positivity. There were significant differences in MIB-1 and CEA immunostainings among the adenocarcinoma, EGD, and benign glandular lesions. Adenocarcinoma was closely related to p53 overexpression, although occurring in a low percentage of the cases. CONCLUSION: MIB-1 immunostaining can be useful in differentiating among endocervical adenocarcinoma, endocervical glandular dysplasia and benign glandular lesions. p53 overexpression might be helpful in the diagnosis of adenocarcinoma.
Adenocarcinoma ; Coloring Agents ; Cytoplasm ; Diagnosis ; Hyperplasia ; Metaplasia

These patients were admitted to hospital due to diuretic difficulty, increasing frequency of micturition (89.63%) and retention of urine (10.37%). Histopathological examination: Most of lesion are benign prostatic hyperplasia (98%, 15%). Carcinoma was detected only in 10 cases (1.85%).
Prostate ; Prostatic Hyperplasia ; diagnosis ; anatomy & histology ; surgery

We experienced a case of fine-needle aspiration(FNA) cytology of breast which showed atypical proliferative lesion. It was very difficult to differentiate this case from malignancy, because of hypercellular smear and many clusters composed of large, atypical ductal cells. However, it showed other features favoring benignancy, such as tendency of cellular cohesiveness, only slightly increased nucleus/cytoplasm ratio and most importantly presence of myoepithelial cells. It's histologic diagnosis was intraductal hyperplasia with atypia. This case indicates that all atypical breast FNA specimen should lead to the suggestion of surgical biopsy for avoiding over- or under-diagnosis.
Biopsy ; Biopsy, Fine-Needle* ; Breast* ; Diagnosis ; Hyperplasia

BACKGROUND: This case report discusses the unusual presentation of limited mouth opening as a result of bilateral coronoid process hyperplasia. CASE PRESENTATION: A 14.5-year-old male patient of white Caucasian ethnicity presented with limited mouth opening, mandibular asymmetry, and dental crowding. Investigations confirmed bilateral coronoid process hyperplasia and management involved bilateral intraoral coronoidectomy surgery under general anaesthesia, followed by muscular rehabilitation. Mouth opening was restored to average maximum opening within 4 months of surgery. CONCLUSION: Limited mouth opening is a common presentation to medical and dental professionals. The rare but feasible diagnosis of coronoid impingement syndrome should not be overlooked.
Diagnosis ; Humans ; Hyperplasia ; Male ; Malocclusion ; Mouth ; Rehabilitation

Castleman's disease is an unusual condition of lymphoproliferation, still a rarer cause of isolated neck mass. Also known as angiofollicular lymph node hyperplasia, it is a pathological diagnosis, with three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric). We present a case of an isolated neck mass of long standing, which was treated by surgical excision and histopathologically confirmed as hyaline vascular type of Castleman's disease. The lesion showed distinct hypervascular features on imaging studies. Castleman's disease should be considered as a differential diagnosis in isolated hypervascular neck masses.
Diagnosis ; Diagnosis, Differential ; Giant Lymph Node Hyperplasia* ; Hyalin ; Neck*