No abstract available.
Fibroblast Growth Factor 7* ; Humans* ; Hyperpigmentation* ; Keratinocytes* ; Lentigo* ; Melanosis*

No abstract available.
Hyperpigmentation*

No Abstract Available.
Hyperpigmentation*

BACKGROUND

Disorders of hyperpigmentation can affect the quality of life and pose a significant psychological burden for patients. However, little is known about sun protective behaviors within patient populations with hyperpigmentation disorders.

This study aimed to evaluate the knowledge, attitudes, and practices on sun exposure and protection among patients with cutaneous hyperpigmentation.

This was a single center analytical cross-sectional study which used a self-administered questionnaire on knowledge, attitudes, and practices on sun exposure and protection. Study subjects were 135 patients aged 13-59 years old who sought consult at a tertiary hospital and diagnosed with cutaneous hyperpigmentation. The level of knowledge, type of attitude, and practices on sun exposure and protection were determined. The association between the sociodemographic factors and knowledge, attitudes, and practices was determined using multivariate logistic regression model.

In this study, majority of the patients have adequate knowledge (80%), desirable attitudes (82%), and good practices (79%) towards sun exposure and protection. None of the demographic factors were found to be significantly associated with knowledge. The odds of having a desirable attitude among those in the construction sector was 803 times the odds for those in the transportation sector. Only the attribution of hyperpigmentation to the sun was a factor found to be significantly associated with good practices.

This study recommends that dermatologists caring for patients with cutaneous hyperpigmentation continue to emphasize patient education on sun exposure and protection since adequate knowledge consistently translates to good practices for this group of highly motivated patients.

Aberrant breast tissue is a subset of accessory breast tissue, and it exhibits similar consistency to that of the adjacent normal breast tissue, but it lacks an associated nipple complex. It is a developmental anomaly defined as the persistence of breast tissue along the embryonic mammary line. Aberrant breast tissue is most commonly located in the axilla, though it may be present anywhere along the embryonic mammary line. We report here on an 11-year-old girl with aberrant breast tissue and acanthosis nigricans. She had tender masses that became noticeable with the onset of menarche and mottled hyperpigmentation on both axillae. The histopathologic finding of the lesion revealed the typical features of aberrant breast tissue with acanthosis nigricans.
Acanthosis Nigricans ; Axilla ; Breast ; Child ; Female ; Humans ; Hyperpigmentation ; Menarche ; Nipples

The Q-switched ruby laser has been used in clinics since the early 1980s. It was tried to remove tattoos at first with good effects. Thereafter, some physicians reported the usefulness of the laser in the treatment of some kinds of pigmented lesions such as nevus of Ota, freckles and lentigines. The reason why the Q-switched ruby laser has a lot of effect on tattoos and some pigmented lesions is that the laser has the function of selective photothermolysis on those cutaneous lesions. The authors have treated 185 patients with tattoos and cutaneous pigmented lesions using the Q-switched ruby laser during last 4 years ago. Patients had tattoos, nevus of Ota, freckles, lentigines, melasma, postinflammatory hyperpigmentation, and were followed up over 5 months after the end of the laser treatment. The authors analysed the results and compared them with other's results in Caucasians, and we intended to present a guide of the treatment using Q-switched ruby laser in Koreans. The results were as follows 1. Tattoos showed good results after the treatment because the most of tattoos are black or dark blue in color and cheated by amateur. We repeated the laser treatments with the interval of 2 weeks. 2. Nevus of Ota, freckles and lentigines showed good results after treatment of the Q-switched ruby laser 3. Melasma showed no improvement after the treatment. 4. The treatment of postinflammatory hyperpigmentation using the Q-switched ruby laser must be confined within a part of the lesion at the first visit of patient, because the therapeutic effects were observed in some patients only and the degree of depigmention after treatment was diverse. 5. The most common complication after Q-switched ruby laser treatment was pigmentary change, including hyperpigmentation in most of the cases and hypopigmentation in some cases. However, there was no visible scar or remarkable change of skin texture in all of the cases.
Asian Continental Ancestry Group ; Cicatrix ; Humans ; Hyperpigmentation ; Hypopigmentation ; Lasers, Solid-State* ; Lentigo ; Melanosis ; Nevus of Ota ; Skin

BACKGROUND: Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder characterized by grouped multiple lentigines on otherwise normal skin that histologically have the typical features of lentigo. This entity has been only rarely reported in the Korean population. OBJECTIVE: The purpose of this study was to evaluate clinical and histopathologic characteristics, association with other disorders, and differential diagnosis of PUL. METHODS: We reviewed our experiences of thirteen cases of PUL which had been collected in our dermatology clinic during the 6-year period between 1993 and 1998. RESULTS: Twelve patients were female and one was male. In 3 patients the lesions appeared after the age of 20 years. Ten patients had the lesions on the upper part of the body, the neck being the most common location. No bias was shown in terms of the side of the body affected. Cafe-au-lait macules (one to three) were found in six patients, axillary freckles were observed in two. Histopathologic examination of biopsy specimens commonly showed hyperpigmentation of the basal layer, elongation of rete ridges, and an increased number of melanocytes. There ,was no evidence of associated disorders or family history. CONCLUSION: Based on this data, we confirmed that PUL is a benign, idiopathic lentiginosis with no commonly associated abnormalities. Furthermore, we believed that PUL is not uncommon in Korean people.
Bias (Epidemiology) ; Biopsy ; Dermatology ; Diagnosis, Differential ; Female ; Humans ; Hyperpigmentation ; Lentigo ; Male ; Melanocytes ; Melanosis ; Neck ; Skin

Melasma is a common acquired symmetric hypermelanosis characterized by irregular light to dark brown macules and patches on sunexposed areas of the skin. Its histopathologic characteristics are important for treatment. Melasma is characterized by epidermal hyperpigmentation possibly by both the increased number of melanocytes and the increased function of melanogenic enzymes over the dermal solar changes. Until now, curative measures are not available for melasma. Current therapies include topical agents (retinoic acid, hydroquinone, steroids), peeling (Combes solution, glycolic acid, TCA), and lasers(Co2, Erbium-Yag, Q-switched).
Hyperpigmentation ; Melanocytes ; Melanosis* ; Skin ; Skin Lightening Preparations

A progressive zosteriform macular pigmented lesion (PZMPL) is a chronic pigmentary dermatosis similar to progressive cribriform and zosteriform hyperpigmentation (PCZH), but characteristically accompanied by pruritus as a prodromal symptom and histologic findings, such as pigmentary incontinence. PZMPL was described by Simoes in 1980 and manifests a uniformly tanned macular pigmented lesion in a zosteriform distribution. PZMPL is usually preceded by multiple pruritic macular pigmentation in a part of the dermatome for a period of time. Despite the difficulty in differentiation among other pigmentary disorders with unilateral distribution, such as linear and whorled nevoid hypermelanosis, partial unilateral lentiginosis, and Becker's melanosis, PZMPL can be diagnosed by clinical symptoms and signs, the pattern of lesions, and histologic features. A 6-year-old Korean girl presented with unilaterally located brown macules and patches on the left side of the chest, arm, and back. From childhood, the pigmented macules appeared and coalesced into patches on the left back. The arm and chest lesions extended along the Blaschko's line in a zosteriform distribution. She had no history of previous skin diseases, injuries, or inflammation. The histologic findings revealed increased melanin pigment in the basal layer and focal pigmentary incontinence in the upper dermis. We report a rare case of PZMPL thought to be the same case reported by Simoes.
Arm ; Child ; Dermis ; Humans ; Hyperpigmentation ; Inflammation ; Lentigo ; Melanins ; Melanosis ; Pigmentation ; Prodromal Symptoms ; Pruritus ; Skin Diseases ; Thorax ; Triacetoneamine-N-Oxyl

One case of malignant acanthosis nigricans associated with internal malignancy has been presented and the suhject of malignant acanthosis nigricans has been revieived. The patient who was 50 year old man had been affected generalized hyperpigmentation with pnpillomatosis especially on forehead, neck, axilla, umbilical area, anogenital area, palm and soles and associated with highly malignant adenocarcinoma of stomach. Diagnosis was confirmed by characteristic clinical appearance, explorative laparatomy and histopathologically
Acanthosis Nigricans* ; Adenocarcinoma ; Axilla ; Diagnosis ; Forehead ; Humans ; Hyperpigmentation ; Middle Aged ; Neck ; Stomach