1.Unexpected Fatal Hypernatremia after Successful Cardiopulmonary Resuscitation with Therapeutic Hypothermia: A Case Report.
Sang Sik CHOI ; Won Young KIM ; Won KIM ; Kyung Su LIM
Journal of Korean Medical Science 2012;27(3):329-331
Central diabetes insipidus (DI), characterized by unexpected fatal hypernatremia, is a rare complication after successful cardiopulmonary resuscitation with therapeutic hypothermia, but may be potentially fatal if recognition is delayed. We describe here a patient who experienced cardiac arrest due to a pulmonary embolism, followed by successful resuscitation after induction of therapeutic hypothermia. The patient, however, suddenly developed unexpected hypernatremia with increased urine output and was diagnosed with central DI as a complication of cerebral edema, and eventually died. Our findings suggest that central DI should be considered as a possible complication following unexpected hypernatremia with increased urine output during therapeutic hypothermia and that desmopressin acetate should be used to treat central DI.
Adult
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Cardiopulmonary Resuscitation/*adverse effects
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Diabetes Insipidus, Neurogenic/diagnosis/etiology
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Fatal Outcome
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Female
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Heart Arrest/complications/therapy
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Humans
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Hypernatremia/*etiology
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Hypothermia, Induced/*adverse effects
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Pulmonary Embolism/complications
2.A Case of Myotonic Dystrophy with Electrolyte Imbalance.
Weon Jin KO ; Kwang Yeol KIM ; So Mi KIM ; Seung Jae HONG ; Sang Hoon LEE ; Ran SONG ; Hyung In YANG ; Yeon Ah LEE
Journal of Korean Medical Science 2013;28(7):1111-1113
Type 1 myotonic dystrophy (DM1) is an autosomal-dominant inherited disorder with a multisystem involvement, caused by an abnormal expansion of the CTG sequence of the dystrophic myotonia protein kinase (DMPK) gene. DM1 is a variable multisystem disorder with muscular and nonmuscular abnormalities. Increasingly, endocrine abnormalities, such as gonadal, pancreatic, and adrenal dysfunction are being reported. But, Electrolytes imbalance is a very rare condition in patients with DM1 yet. Herein we present a 42-yr-old Korean male of DM1 with abnormally elevated serum sodium and potassium. The patient had minimum volume of maximally concentrated urine without water loss. It was only cured by normal saline hydration. The cause of hypernatremia was considered by primary hypodipsia. Hyperkalemic conditions such as renal failure, pseudohyperkalemia, cortisol deficiency and hyperkalemic periodic paralysis were excluded. Further endocrine evaluation suggested selective hyperreninemic hypoaldosteronism as a cause of hyperkalemia.
Adult
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Humans
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Hyperkalemia/complications/*diagnosis
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Hypernatremia/complications/*diagnosis
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Hypoaldosteronism/complications/diagnosis
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Kidney Concentrating Ability
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Male
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Myotonic Dystrophy/complications/*diagnosis/*genetics
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Potassium/blood
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Protein-Serine-Threonine Kinases/*genetics
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Sodium/blood