No abstract available.
Hyperkeratosis, Epidermolytic*

Epidermolytic Ichthyosis (EI) is a rare non-syndromic keratinopathic ichthyosis without definitive treatment. This is a case of EI in a 5-year-old Filipino female who presented with hyperkeratotic scales sparing the palms and soles. Histopathology revealed epidermolytic hyperkeratosis. A trial of treatment with isotretinoin 0.3 mg/kg/day, together with keratolytic agents, urea lotion and lactic acid lotion, resulted in a marked decrease in the thickness of the scales and odor. Interestingly, rebound effects were noted at 0.6 mg/kg/day. Taking into account that EI presents with more skin fragility compared to non-EHK ichthyosis, the authors surmise that there may be a smaller treatment window for patients with EI, which is notably lower than recommended for ichthyosis in general.
Hyperkeratosis, Epidermolytic ; Isotretinoin

The hereditary epidermolytic palmoplantar keratoderma (Vorner"s kerato derma) is characterized by autosomal dominantly inherited, marked, symmetrical thickening of the palms and soles. The presence of epidermolytic hyperkeratosis in skin biopsy differentiates hereditary epidermolytic palmoplantar keratoderma from Unna-Thost keratoderma. We report a case of hereditary epidermolytic palmoplantar keratoderma with literature reviews focused on the differential points from other palmoplantar keratodermas.
Biopsy ; Hyperkeratosis, Epidermolytic ; Keratoderma, Palmoplantar ; Keratoderma, Palmoplantar, Epidermolytic* ; Skin

Epidermolytic acanthoma is a rare benign tumor, which may occur in both isolated and disseminated forms. Clinically, this asymptomatic lesion resembles a verruca or molluscum. Histopathologically, it is characterized by epidermolytic hyperkeratosis, also referred to as granular degeneration. We, herein, report a case of isolated epidermolytic acanthoma on the scrotum in a 36-year-old man for its rarity in Korean dermatologic literature.
Acanthoma* ; Adult ; Humans ; Hyperkeratosis, Epidermolytic ; Scrotum ; Warts

Female ; Humans ; Hyperkeratosis, Epidermolytic ; pathology ; Infant, Newborn

We present a case of bullous congenital ichthyosiform erythroderma in a two year old female, in whom no hereditary background was found. The skin lesion was characterized clinically by blister formation with generalized erythematous hyperkeratosis which was especially prominent on the flexural surfaces of extremities and intertriginous areas. The histopathologic examination revealed marked hyperkeratosis, cavity changes of the malpighian cells with perinuclear vacuoles and markedly thickened granular layer containing many keratohyaline granules.
Blister ; Extremities ; Female ; Humans ; Hyperkeratosis, Epidermolytic* ; Skin ; Vacuoles

Epidermolytic acanthoma is an uncommon benign tumor characterized histologically by epidermolytic hyperkeratosis. Clinically, the tumor resembles a verruca or seborrheic keratosis and may occur in either isolated or disseminated forms. Herein, we present a case of a 46-year-old male who developed multiple seborrheic keratosis or verruca like papules on his trunk which showed epidermolytic hyperkeratosis upon microscopic examination. Following clinical and histological findings, the patient was diagnosed as having disseminated epidermolytic acanthoma.
Acanthoma* ; Humans ; Hyperkeratosis, Epidermolytic ; Keratosis, Seborrheic ; Male ; Middle Aged ; Warts

Epidermolytic Hyperkeratosis is a rare variant of ichthyosis, transmitted as autosomal dominant inheritance. A 2-year-old male baby, in whom no hereditary back ground was found, showed typical clinical and histopathological features of Epiderrnolytic Hyperkeratosis. The possibility of occuring the disease without hereditary back grcund, clinical features, and histological characteristics of the disease are discussed.
Child, Preschool ; Humans ; Hyperkeratosis, Epidermolytic* ; Ichthyosis ; Male ; Wills

A 34-year-old female patient presented multiple 1-2mm sized dark brown coloured keratin plugs, within dilated follicles on the lower extremities from the birth. Histopathological findings showed a wide and deep invagination of the epidermis filled with keratin plugs which is a typical feature of nevus comedonicus, and the presence of epidermolytic hyperkeratosis on the epidermis and follicular wall. On another area, histopathological findings showed the presence of hyperkeratosis, acanthosis and epidermolytic hyperkeratosis of the epidermis; there are common changes of systematized epidermal nevus. We herein report a case of nevus comedonicus with epidermolytic hyperkeratosis.
Adult ; Epidermis ; Female ; Humans ; Hyperkeratosis, Epidermolytic* ; Lower Extremity ; Nevus* ; Parturition

We report a case of disseminated epidermolytic acanthoma in a 69-year-old male who presented numerous, small dark brown verrucous papules on both popliteal fossae, inguinal areas, and abdomen. Although each lesion clinically resembled seborrheic keratosis, light microscopic examination revealed features of epidermolytic hyperkeratosis.
Abdomen ; Acanthoma* ; Aged ; Humans ; Hyperkeratosis, Epidermolytic ; Keratosis, Seborrheic ; Male