Marked eosinophilia is a common finding in many disease, occurring most frequently in allergic and parasitic conditions. A Separate syndrome characterized by peripheral eosinophilia and multisystem eosinophilic infiltration has been reported by many authors with a variety of diagnoses. In 1968, Hardy and Anderson proposed the term hypereosinophilic syndrome to encompass the entire group and in 1975, Chusid reported 14 cases amd reviewed 57 cases in English literatures. We experienced a case of Hypereosinophilic syndrome which showed partial response to prenisolone therapy, and made a review of literatures.
Diagnosis ; Eosinophilia ; Eosinophils ; Hypereosinophilic Syndrome*

In 1968, Hardy and Anderson first described the term hypereosinophilic syndrome. This syndrome is characterized by persistent and prolonged eosinothila, with primarily hematologic, cardiac, neurologic and derrnatologic abnormalities. Cutaneous mmestations occur in 27-57% of patients. Two types of skin lesions have been noted: (1) erythrritous pruritic papules and nodules or (2) urticaria and angioedema. We report a case of hypereosinophilic syndrome with a vesicle eruption which is a rare skin lesion in tbis syndrome, in a 17 year old man. Diagnosis of hyprcsinophilic syndrome was established by clinical findings, rearked blood eosinophilia without a Brown cause, bone marrow aspiration and biopsy, liver scan and ultrasonography, and histopatholcgie findings of the skin.
Adolescent ; Angioedema ; Biopsy ; Bone Marrow ; Diagnosis ; Eosinophilia ; Humans ; Hypereosinophilic Syndrome* ; Liver ; Skin ; Ultrasonography ; Urticaria

The idiopathic hypereosinophilic syndrome (HES) is a disorder marked by the sustained overproduction of eosinophils. The disease is characterized by damage of multiple organ including heart, nerve system, skin and lung due to eosinophilic infiltration and the diagnosis is one of exclusion. Rheumatologic manifestations of HES are infrequent. In about 10~40% of rheumatoid arthritis (RA) patients, persistent eosinophilia is observed. That can be due to the RA itself and is often associated with active disease and extra-articular features. Sometimes, it is attributed to the drug therapy, especially gold and penicillamine. We would like to report a 37-year-old female patient with HES who developed seronegative RA 2 years later.
Adult ; Arthritis, Rheumatoid* ; Diagnosis ; Drug Therapy ; Eosinophilia ; Eosinophils ; Female ; Heart ; Humans ; Hypereosinophilic Syndrome* ; Lung ; Penicillamine ; Skin

Episodic angioedema with eosinophilia (Gleich's syndrome) is characterized by recurrent angioedema, fever, weight gain and peripneral eosinophilia. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement and a better prognosis. A transient variant, mainly reported in Japan, which is limited to a single attack, is usually less severe than the episodic type. Here we describe two young patients, one of those is the episodic type and the other is the transient type. We suggest that episodic angioedema with eosinophilia is not rare, and should be widely recognized as a new clinical entity for accurate and prompt diagnosis. Awareness and distinction from the hypereosinophilic syndrome is important because of the favorable prognosis and rapid response to corticosteroid therapy.
Angioedema* ; Diagnosis ; Eosinophilia* ; Fever ; Humans ; Hypereosinophilic Syndrome ; Japan ; Prognosis ; Weight Gain

A 25 year old man presinted with erythematous and inderated plaques on the upper and lower extermities that were preceded by insect bites while traveling in central Africa. The patient had a past histrory of Kimura's disease, asthma, and allergic rhinitis, Histologic examination revealed panniculitls showing massive eosinophilic infiltration. The dermis showed eosinopbilic infilreatiom without flame figyres. The patient responded well to oral conrticosteroids. This patient did not fit the diagnosis of eosinoplilic pannicylitis, eosinophilic cellylitis, hypereosinophilic syndrome or eosinophilic vascylitis.
Africa, Central ; Asthma ; Dermis ; Diagnosis ; Eosinophils* ; Humans ; Hypereosinophilic Syndrome ; Insect Bites and Stings ; Rhinitis, Allergic ; Skin*

A clinicopathological study was made on 17 case with leukemia cutis diagnosed in a period of 10 years frorn 1980 to 1989 in Seoul Xational University I-lospital. The results were summarized as follows : 1. There were 4 cases with acute lyrnphocytic leukernia, 7 with acute myelocytir. leukemia (AML), 5 with chronic myelocytic leukemia (CML), 1 with eosinophilic leukemia. 2. The clinical appearance of leukemia cutis included nodules (88.2%), papules, macules, plaques and ulcerative lesions. Leukemia cutis dis not show any discernible clinical qppearance with each different type of leukemia. 3. Leukemia cutis showed a wide spectrum of histopathologic features, diffuse infiltration, patchy infiltration with linear infiltration between collagen bundles, perivascular and peridnexal involvement, perivascular involvement, and mainly subcutaneous tissue involvement. There was no distinctive histopathologic pattern with each different type of leukemia. 4. The demonstration of intracytoplasmic chloroacetate esterase and lysozyme was helpful to refine the diagnosis of leukemia cutis.
Collagen ; Diagnosis ; Hypereosinophilic Syndrome ; Leukemia* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Muramidase ; Seoul ; Subcutaneous Tissue ; Ulcer

Hypereosinophilic syndrome is a rare disease, characterized by hypereosinophilia of the blood and by the presence of varying internal symptoms and neurological signs. We report a 70-year-old woman who was admitted with rapidly progressive cognitive dysfunction, which had begun 10 months earlier. On admission, she had hypereosinophilia with elevated IgE. Following steroid therapy, there was rapid improvement of dementia. Considering the possibility of irreversibility at delayed intervention, the early diagnosis and treatment of dementia due to hypereosinophilic syndrome cannot be overemphasized.
Aged ; Dementia* ; Early Diagnosis ; Female ; Humans ; Hypereosinophilic Syndrome* ; Immunoglobulin E ; Rare Diseases

Adult ; Humans ; Hypereosinophilic Syndrome ; complications ; drug therapy ; Lymphatic Diseases ; diagnosis ; etiology ; pathology ; Male ; Treatment Outcome

Anemia ; complications ; Child ; Female ; Fever ; complications ; Humans ; Hypereosinophilic Syndrome ; complications ; diagnosis ; therapy ; Splenomegaly ; complications

Anemia ; etiology ; Erythema ; etiology ; Fatal Outcome ; Female ; Fever ; etiology ; Humans ; Hypereosinophilic Syndrome ; complications ; diagnosis ; Infant