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It is suggested that renal prostaglandins influence intrarenal hemodynamics and tubular electrolyte excretions, so participate in calcium stone formation by regulating the renal tubular handling of calcium. To investigate the pathogenic role of renal prostaglandin in hypercalciuria, we assessed urinary excretion of sodium and calcium in 21 patients with idiopathic urolithiasis(13 normocalciuric and 8 hypercalciuric patients) and determined the change in calcium and sodium excretion following prostaglandin syntetase inhibition with indomethacin. The results obtained were summarized as follows: 1. In 13 normocalciuric patients, 24-hour urine calcium excretion was 154+/-63.8 mg/day (mean+/-S.D.) and in 8 hypercalciuric patients, 440+/-82.1 mg/day. 2. The urinary sodium excretion in the hypercalciuric group(172.6+/-32.6 mEq/day) was significantly higher than that in the normocalciuric group(123.5+/-44.4 mEq/day) (p<0.05). 3. In the hypercalciuric group, calcium excretion was significantly reduced by indomethacin (p<0.05). Sodium excretion was also reduced by indomethacin but there was no significance. 4. In the normocalciuric group, there was no significant change of sodium and calcium excretion after administration of indomethacin.
Calcium* ; Hemodynamics ; Humans ; Hypercalciuria ; Indomethacin ; Prostaglandins* ; Sodium ; Urinary Calculi ; Urolithiasis*

10.Excretion of urinary citric acid in stone patients.

Jong Woo HONG ; Sung Hyup CHOI

Korean Journal of Urology 1992;33(5):837-840

Urinary citric acid reduces urinary saturation of calcium oxalate and phosphate salts by forming complexes with calcium and retards crystallization of stone forming salts. Hypocitraturia, important factor in stone formation, has been 19-63% of stone patients in various reports. We measured the 24 hour excretion of citric acid. calcium and calcium/citric acid ratio in 100 renal stone patients and 30 healthy controls. The results were as follows: 1. The 24-hour urinary excretion of citric acid was lower in stone patients than in controls, but statistically insignificant (P>0.05). 2. The 24-trour urinary excretion of calcium was higher in stone patients significantly than in Controls (P<0.05). 3. In stone patients, hypocitraturia showed in 19 patients (19%), hypercalciuria in 22 patients (22%). 4. The 24-hour urinary excretion of citric acid had positive correlation with 24-hour urinary excretion of calcium in stone patients (P<0.05) 5. Urinary calcium/citric acid ratio was significantly higher in stone patients than in controls (P<0.05). As results, urinary calcium/citric acid ratio was more significant than the amount of citric acid in stone patients, furthermore it seems to be a useful measure for stone formation and recurrence.
Calcium ; Calcium Oxalate ; Citric Acid* ; Crystallization ; Humans ; Hypercalciuria ; Recurrence ; Salts

1.Hypercalciuria associated with nephropathy(diagnosis by renal biopsy).

2.Idiopathic Hypercalciuria in Children.

3.Hypercalciuria in children : presentation and pathogenesis.

4.Nephrocalcinosis and Hypercalciuria in Children.

5.Idiopathic hypercalciuria in children with hematuria.

6.Two Cases of Idiopathic Hypercalciuria in Children.

7.Osteocalcin Response to Calcium Restricted Diet for the Selective Therapy of Hypercalciuria.

8.Chronic arsenic poisoning in a child with idiopathic hypercalciuria.

9.Renal Prostaglandins and Calcium Excretion in Urolithiasis.

10.Excretion of urinary citric acid in stone patients.

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