Adult ; Female ; Humans ; Hypercalcemia ; diagnosis ; Male ; Middle Aged

Adult ; Female ; Humans ; Hypercalcemia ; diagnosis ; surgery ; Hyperparathyroidism ; diagnosis ; surgery ; Male ; Middle Aged ; Parathyroid Neoplasms ; diagnosis ; surgery

Hypercalcemia of malignancy due to metastatic gastric adenocarcinoma is extremely rare; in fact, to the best of our knowledge, only three case reports of hypercalcemia associated with metastatic gastric adenocarcinoma have been published in the literature to date. Herein, we report a rare case involving a 61-year-old African-American female who had hypercalcemia at initial presentation and who was later diagnosed with poorly differentiated gastric adenocarcinoma with extensive liver metastases, without bone involvement. She was found to have elevated parathyroid hormone-related peptide and normal parathyroid hormone levels. Despite aggressive treatment, she died within a few months of diagnosis.
Adenocarcinoma* ; Diagnosis ; Female ; Humans ; Hypercalcemia* ; Liver ; Middle Aged ; Neoplasm Metastasis ; Parathyroid Hormone ; Parathyroid Hormone-Related Protein

Hypercalcemia due to hyperparathyroidism is a proposed mechanism of pancreatitis. The occurrence of acute pancreatitis caused by hypercalcemia represents a diagnostic clue for hyperparathyroidism. The incidence of acute pancreatitis caused by hyperparathyroidism appears to be decreasing, and it reflects the earlier diagnosis of hyperparathyroidism due to wide spread application of screening method. In a 71-year-old female patient who was admitted to hospital because of acute pancreatitis, hypercalcemia led to the discovery of the parathyroid adenoma. The patient recovered by parathyroidectomy with medical management of hypercalcemia.
Aged ; Diagnosis ; Female ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Incidence ; Mass Screening ; Pancreatitis* ; Parathyroid Neoplasms ; Parathyroidectomy

Williams syndrome was first reported in 1961, it is characterized by distinct facial changes, growth deficiency, mental retardation, congenital heart defect (particularly the supravalvular aortic stenosis), associated at times with infantile hypercalcemia. The diagnosis of this disease relied on phenotype, after recent acknowledgement of its genetic basis on the 7th chromosomal locus q11.23 involving elastin gene on the PCR. Recently, commercial probe of elastin gene for FISH was supplied and diagnosed this disease easier. Using PCR has some benefits concerning whether the origin of the genetic defect is maternal or paternal. The diagnosis of this disease is difficult due to low sensitivity, below 50%. But FISH is widely used because it is faster with high positive predictibility. We report Williams syndrome diagnosed by FISH with a brief review and related literatures.
Diagnosis ; Elastin ; Heart Defects, Congenital ; Hypercalcemia ; Intellectual Disability ; Phenotype ; Polymerase Chain Reaction ; Williams Syndrome*

The relationship between hypercalcemic crisis and pancreatitis, first described in patients with hyperparathyroidism, still remains controversial. Acute pancreatitis may complicate the clinical course of hyperparathyroidism, particularly when the degree of hypercalcemia is severe. The incidence of hyperparathyroidism presenting as acute pancreatitis appears to be steadily decreasing, possibly reflecting the earlier diagnosis of asymptomatic hyperparaparathyroidism due to widespread application of screening methods. Here, we report two patients with primary hyperparathyroidism manifesting clinically as acute pancreatitis. One patient died of progessive pancreatitis and uncontrolled sepsis. The other patient was fullly recovered by emergent parathyroidectomy followed by medical management of hypercalcemia.
Diagnosis ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Hyperparathyroidism, Primary ; Incidence ; Mass Screening ; Pancreatitis* ; Parathyroidectomy ; Sepsis

Primary hyperparathyroidism is a disease that causes hypercalcemia and abnormal bone metabolism due to an increase in parathyroid hormones, and the occurrence rate of bone fracturing is higher in patients with primary hyperparathyroidism. Parathyroid hormones have recently frequently been used as an osteogenesis catalyst treatment for osteoporosis in the elderly. This research study examined the case study that was experienced on the diagnosis and treatment of primary hyperparathyroidism caused by adenoma and extreme hypercalcemia that was discovered in menopausal women with bone fractures and extreme osteoporosis.
Adenoma ; Aged ; Diagnosis ; Female ; Fractures, Bone ; Humans ; Hypercalcemia ; Hyperparathyroidism, Primary ; Metabolism ; Osteogenesis ; Osteoporosis ; Teriparatide

To review the diagnosis and treatment of a case of hypercalcium crisis caused by primary hyperparathyroidism（PHPT） and prophylactic treatment of hungry bone syndrome. In a 32-year-old male with hypercalcemia, the main manifestations were loss of appetite, nausea, polyuria, polydipsia, fatigue, lethargy, etc. parathyroid hormone, serum calcium increased, thyroid function was normal, thyroid color ultrasound and MRI showed space-occupying behind the right thyroid, radionuclide examination showed abnormal imaging agent concentration in the right parathyroid area, there was a history of pathological fracture. Clinically diagnosed as hypercalcemia crisis secondary to PHPT.
Male ; Humans ; Adult ; Hypercalcemia/diagnosis* ; Hyperparathyroidism, Primary/surgery* ; Parathyroid Hormone ; Hypocalcemia/complications* ; Thyroid Gland ; Calcium

Concurrent hyperthyroidism and primary hyperparathyroidism in the same patient is rare. In most cases of concomitant hyperthyroidism and primary hyperparathyroidism, serum calcium levels are quite elevated. However, recently we diagnosed a patient who had hyperthyroidism [Triiodothyroxine 6.81 nmol/L (1.23-3.39), Free thyroxine 92.88 pmol/L (10.32-25.80), TSH 0.05 mU/L (0.2-7.0)] and primary hyperparathyroidism [parathyroid hormone 163 pg/mL (12-72)] with mild hypercalcemia 2.78 mmol/L (2.03-2.60)]. We treated this patient with propylthiouracil and pamidronate and normalized her thyroid function and serum calcium levels. We then performed subtotal thyroidectomy and removed two parathyroid glands and clipped one parathyroid gland using a hemoclip. The pathologic diagnosis was confirmed to be Graves' disease and parathyroid hyperplasia. The patient was healthy, and serum levels of PTH, calcium and phosphorus were normal after the operation.
Calcium ; Diagnosis ; Graves Disease ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Hyperparathyroidism, Primary ; Hyperplasia* ; Hyperthyroidism* ; Parathyroid Glands ; Phosphorus ; Propylthiouracil ; Thyroid Gland ; Thyroidectomy ; Thyroxine

Concurrent hyperthyroidism and primary hyperparathyroidism in the same patient is rare. In most cases of concomitant hyperthyroidism and primary hyperparathyroidism, serum calcium levels are quite elevated. However, recently we diagnosed a patient who had hyperthyroidism [Triiodothyroxine 6.81 nmol/L (1.23-3.39), Free thyroxine 92.88 pmol/L (10.32-25.80), TSH 0.05 mU/L (0.2-7.0)] and primary hyperparathyroidism [parathyroid hormone 163 pg/mL (12-72)] with mild hypercalcemia 2.78 mmol/L (2.03-2.60)]. We treated this patient with propylthiouracil and pamidronate and normalized her thyroid function and serum calcium levels. We then performed subtotal thyroidectomy and removed two parathyroid glands and clipped one parathyroid gland using a hemoclip. The pathologic diagnosis was confirmed to be Graves' disease and parathyroid hyperplasia. The patient was healthy, and serum levels of PTH, calcium and phosphorus were normal after the operation.
Calcium ; Diagnosis ; Graves Disease ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Hyperparathyroidism, Primary ; Hyperplasia* ; Hyperthyroidism* ; Parathyroid Glands ; Phosphorus ; Propylthiouracil ; Thyroid Gland ; Thyroidectomy ; Thyroxine