1.Hyphema, angle recession and macular hemorrhage induced by air bag.
Jae Hyoung PARK ; Han Mo KOO ; Sang Moon CHUNG
Journal of the Korean Ophthalmological Society 1995;36(3):521-524
Air bag has gained increasing acceptance as a device that reduce serious head and chest injury in vehicle accident. Although air bag reduces incidence and severity of facial and periorbital trauma, the possibility of ocular trauma by air bag inflation itself cannot be trivialized. We experienced a patient who developed hyphema, angle recession and macular hemorrhage after air bag inflation, and reviewed the available literatures regarding this type of injury.
Air Bags*
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Head
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Hemorrhage*
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Humans
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Hyphema*
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Incidence
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Inflation, Economic
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Thoracic Injuries
2.Prognostic Value of Preoperative Positron Emission Tomography-Computed Tomography in Surgically Resected Gastric Cancer.
Ki Seung KIM ; Seok Reyol CHOI ; In Cheol PARK ; Tae Hyoung KOO ; Joon Mo KIM
The Korean Journal of Gastroenterology 2014;63(6):348-353
BACKGROUND/AIMS: The diagnostic value of PET-CT, in gastric cancer is well known, but the prognostic value of pretreatment PET-CT has not been adequately evaluated. This study aimed to investigate the preoperative prognostic value of PET-CT in gastric cancer patients. METHODS: A total of 107 patients underwent surgical treatment for gastric cancer from April 2007 to December 2010 at Dong-A University Medical Center after confirming the presence of F-18 fluorodeoxyglucose (FDG) uptake on preoperative PET-CT. Among these patients, the following subjects were excluded: follow-up loss (13), palliative resection (5), neoadjuvant chemotherapy (1), and unrelated death (1). The remaining 87 patients were included in this study and data were collected by retrospectively reviewing the medical records. The median follow-up duration, defined as the period from operation to last imaging study date, was 34.2+/-14.8 months. FDG uptake values were represented by maximal standardized uptake value (SUVmax). In order to assess the correlation between SUVmax and recurrence, Kaplan-Meier's survival analysis with log-rank test and cox proportional hazard model were performed. Receiver operating characteristic (ROC) curve was employed to determine the optimal cutoff value of SUVmax. RESULTS: The result of Kaplan-Meier's survival analysis with log-rank test were significantly different between high SUVmax group and low SUVmax group (p=0.035), the cutoff value of which was 5.6. However, in multivariate analysis with cox proportional hazard model, T-staging, N-staging and SUVmax did not show statistical significance (p=0.190, p=0.307, and p=0.436, respectively). CONCLUSIONS: High SUVmax on PET-CT in gastric cancer can be a useful prognostic factor.
Adult
;
Aged
;
Area Under Curve
;
Female
;
Fluorodeoxyglucose F18
;
Follow-Up Studies
;
Humans
;
Kaplan-Meier Estimate
;
Male
;
Middle Aged
;
Neoplasm Grading
;
Neoplasm Staging
;
Positron-Emission Tomography
;
Prognosis
;
Proportional Hazards Models
;
ROC Curve
;
Radiopharmaceuticals
;
Retrospective Studies
;
Risk Factors
;
Stomach Neoplasms/*diagnosis/mortality/surgery
;
Tomography, X-Ray Computed
3.Prognostic Value of Preoperative Positron Emission Tomography-Computed Tomography in Surgically Resected Gastric Cancer.
Ki Seung KIM ; Seok Reyol CHOI ; In Cheol PARK ; Tae Hyoung KOO ; Joon Mo KIM
The Korean Journal of Gastroenterology 2014;63(6):348-353
BACKGROUND/AIMS: The diagnostic value of PET-CT, in gastric cancer is well known, but the prognostic value of pretreatment PET-CT has not been adequately evaluated. This study aimed to investigate the preoperative prognostic value of PET-CT in gastric cancer patients. METHODS: A total of 107 patients underwent surgical treatment for gastric cancer from April 2007 to December 2010 at Dong-A University Medical Center after confirming the presence of F-18 fluorodeoxyglucose (FDG) uptake on preoperative PET-CT. Among these patients, the following subjects were excluded: follow-up loss (13), palliative resection (5), neoadjuvant chemotherapy (1), and unrelated death (1). The remaining 87 patients were included in this study and data were collected by retrospectively reviewing the medical records. The median follow-up duration, defined as the period from operation to last imaging study date, was 34.2+/-14.8 months. FDG uptake values were represented by maximal standardized uptake value (SUVmax). In order to assess the correlation between SUVmax and recurrence, Kaplan-Meier's survival analysis with log-rank test and cox proportional hazard model were performed. Receiver operating characteristic (ROC) curve was employed to determine the optimal cutoff value of SUVmax. RESULTS: The result of Kaplan-Meier's survival analysis with log-rank test were significantly different between high SUVmax group and low SUVmax group (p=0.035), the cutoff value of which was 5.6. However, in multivariate analysis with cox proportional hazard model, T-staging, N-staging and SUVmax did not show statistical significance (p=0.190, p=0.307, and p=0.436, respectively). CONCLUSIONS: High SUVmax on PET-CT in gastric cancer can be a useful prognostic factor.
Adult
;
Aged
;
Area Under Curve
;
Female
;
Fluorodeoxyglucose F18
;
Follow-Up Studies
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Humans
;
Kaplan-Meier Estimate
;
Male
;
Middle Aged
;
Neoplasm Grading
;
Neoplasm Staging
;
Positron-Emission Tomography
;
Prognosis
;
Proportional Hazards Models
;
ROC Curve
;
Radiopharmaceuticals
;
Retrospective Studies
;
Risk Factors
;
Stomach Neoplasms/*diagnosis/mortality/surgery
;
Tomography, X-Ray Computed
4.A Comparison of Adjacent Segment Diseases Above One Versus Above Two Vertebral Segment after Spinal Fusion of the Degenerative Lumbar Disease.
Sung Woo CHOI ; Joonghyun AHN ; Jae Chul LEE ; Hyoung Mo KOO ; Byung Joon SHIN
Journal of Korean Society of Spine Surgery 2013;20(4):135-142
STUDY DESIGN: Retrospective study. OBJECTIVE: To compare patients who underwent spinal revision surgery of adjacent segment degeneration with above one and above two vertebral segment preceded by initial spinal fusion surgery. SUMMARY OF LITERATURE REVIEW: The adjacent segment disease(ASD) occurs more frequently at the more proximal segment of the spinal fusion. Also, the preexisting degenerative segments (with discs or facet joints) not included in the fusion procedure, fusion segmental sagittal angle, fixed appliances method, gender, and age, have been accepted as the causes. MATERIALS AND METHODS: The patients were watched over a year after the spinal revision operation followed by initial spinal fusion of single or multiple segments; the subjects were limited to 41 patients. The average age, entity of diseases, average duration between the initial spinal fusion and the revision surgery, multiple clinical and radiographic parameters were evaluated and compared. RESULTS: Using the UCLA grade of intervertebral disc degeneration, the average grade of 1 level upper segment was 2.2 in group A and 1.9 in group B without statistical significance(p=0.426). However, the average grade of 2-level upper segment was 1.8 in group A and 2.4 in group B with significant difference(p=0.021). There was no statistical difference in other factors between the two groups. CONCLUSIONS: Patients with ASD of above two-vertebral segment after spinal fusion were more severe in disc degeneration than those with ASD of above one vertebral segment before initial spinal fusions.
Humans
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Intervertebral Disc Degeneration
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Retrospective Studies
;
Spinal Fusion*
5.Current Levels of Conflict of Interest Disclosure in Medical Publications from Korea.
Bo Hyoung KANG ; Jae Young MOON ; Youjin CHANG ; Young Mo KOO ; Younsuck KOH
Journal of Korean Medical Science 2013;28(7):978-982
Medical research should be fully transparent. The aims of this study were to determine the prevalence of author-related conflict of interest (COI) policies and evaluate the actual state of COI disclosure in Korean medical journals. To determine the prevalence of author-related COI policies, we examined the 198 medical journals listed in the KoreaMed database. To investigate the actual state of COI disclosures in published papers, we analyzed the publications in a representative medical journal, the Journal of the Korean Medical Science, from the perspective of the relevance of the ethics of COI disclosure. A total of 164 (82.8%) journals required an author's statement of COI as a criterion for publication. Of these 164, most of them focused on financial COI, with 101 (61.6%) presenting the information related to COI disclosures as a separate paragraph with a clear title. We identified 114 articles published by the Journal of the Korean Medical Science over a seven-year period, from January, 2006 to December, 2012. Of these, 65 papers (57%) included an author's statement of COI. We found that the policies of Korean medical journals regarding the disclosure of author COIs are still behind the internationally suggested level.
*Conflict of Interest
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Disclosure/*ethics
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Editorial Policies
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Periodicals as Topic/ethics
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Publishing/ethics
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Republic of Korea
6.Increased risk of gastric cancer in workers with occupational dust exposure
Mo-Yeol KANG ; Jiyoun JUNG ; Jung-Wan KOO ; Inah KIM ; Hyoung-Ryoul KIM ; Jun-Pyo MYONG
The Korean Journal of Internal Medicine 2021;36(Suppl 1):S18-S26
Background/Aims:
Workers who are exposed to dust in the workplace tend to show a higher incidence of gastric cancer. Nevertheless, scientific evidence to support an association between dust exposure and the risk of gastric cancer is inadequate. This study aimed to investigate whether or not occupational dust exposure influences the risk of gastric cancer.
Methods:
We collected the electronic data from the Pneumoconiosis Health Examination (PHE) program, provided by the Ministry of Employment and Labor and the Korea Workers’ Compensation and Welfare Service from 2002 to 2017. The PHE database was linked to the National Health Insurances databases. The age-standardized incidence ratio (SIR) and 95% confidence intervals (CIs) of the risk of gastric cancers were evaluated in workers with occupational dust exposure, and the results were compared to those in the general population.
Results:
From 2004 to 2015, 1,543 cases of gastric cancer were observed in the male participants, as compared with 1,174 of expected cases, which yielded an SIR of 1.314 (95% CI, 1.249 to 1.380). Under dust exposure, the risk of gastric cancer was increased 23.9% in the male participants (95% CI, 19.9 to 27.5), and the degree of impairment of lung function was inversely related to the risk of gastric cancer.
Conclusions
Workers with occupational dust exposure were at higher risk of developing gastric cancer than the general population. Thus, future efforts for the prevention of gastric cancer are necessary for dust exposed workers.
7.Clinical Outcomes in Patients with Deferred Coronary Lesions according to Disease Severity Assessed by Fractional Flow Reserve.
Ki Bum WON ; Chang Wook NAM ; Yun Kyeong CHO ; Hyuck Jun YOON ; Hyoung Seob PARK ; Hyungseop KIM ; Seongwook HAN ; Seung Ho HUR ; Yoon Nyun KIM ; Sang Hyun PARK ; Jung Kyu HAN ; Bon Kwon KOO ; Hyo Soo KIM ; Joon Hyung DOH ; Sung Yun LEE ; Hyoung Mo YANG ; Hong Seok LIM ; Myeong Ho YOON ; Seung Jea TAHK ; Kwon Bae KIM
Journal of Korean Medical Science 2016;31(12):1929-1936
Data on the clinical outcomes in deferred coronary lesions according to functional severity have been limited. This study evaluated the clinical outcomes of deferred lesions according to fractional flow reserve (FFR) grade using Korean FFR registry data. Among 1,294 patients and 1,628 lesions in Korean FFR registry, 665 patients with 781 deferred lesions were included in this study. All participants were consecutively categorized into 4 groups according to FFR; group 1: ≥ 0.96 (n = 56), group 2: 0.86–0.95 (n = 330), group 3: 0.81–0.85 (n = 170), and group 4: ≤ 0.80 (n = 99). Primary endpoint was major adverse cardiac events (MACE), a composite of all-cause death, myocardial infarction, and target vessel revascularization. The median follow-up period was 2.1 years. During follow-up, the incidence of MACE in groups 1–4 was 1.8%, 7.6%, 8.8%, and 13.1%, respectively. Compared to group 1, the cumulative rate by Kaplan-Meier analysis of MACE was not different for groups 2 and 3. However, group 4 had higher cumulative rate of MACE compared to group 1 (log-rank P = 0.013). In the multivariate Cox hazard models, only FFR (hazard ratio [HR], 0.95; P = 0.005) was independently associated with MACE among all participants. In contrast, previous history of percutaneous coronary intervention (HR, 2.37; P = 0.023) and diagnosis of acute coronary syndrome (ACS) (HR, 2.35; P = 0.015), but not FFR, were independent predictors for MACE in subjects with non-ischemic (FFR ≥ 0.81) deferred coronary lesions. Compared to subjects with ischemic deferred lesions, clinical outcomes in subjects with non-ischemic deferred lesions according to functional severity are favorable. However, longer-term follow-up may be necessary.
Acute Coronary Syndrome
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Coronary Artery Disease
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Diagnosis
;
Follow-Up Studies
;
Humans
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Incidence
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Kaplan-Meier Estimate
;
Myocardial Infarction
;
Percutaneous Coronary Intervention
;
Prognosis
;
Proportional Hazards Models
8.Stepwise Treatment Using Corticosteroids Alone and in Combination with Cyclosporine in Korean Patients with Idiopathic Membranous Nephropathy.
Dong Ho SHIN ; Mi Jung LEE ; Hyung Jung OH ; Hyang Mo KOO ; Fa Mee DOH ; Hyoung Rae KIM ; Jae Hyun HAN ; Jung Tak PARK ; Seung Hyeok HAN ; Kyu Hun CHOI ; Tae Hyun YOO ; Shin Wook KANG
Yonsei Medical Journal 2013;54(4):973-982
PURPOSE: We undertook an observational study to investigate the effects of immunosuppressive treatment on proteinuria and renal function in 179 Korean idiopathic membranous nephropathy patients with nephrotic syndrome. MATERIALS AND METHODS: The primary outcome was regarded as the first appearance of remission and the secondary outcomes as a decline in estimated glomerular filtration rate (eGFR) >50% or initiation of dialysis, and all-cause mortality. Seventy-two (40.2%) and 50 (27.9%) patients were treated with corticosteroids alone (C) and corticosteroids plus cyclosporine (C+C), respectively, whereas 57 (31.8%) did not receive immunosuppressants (NTx). Cyclosporine was added if there was no reduction in proteinuria of >50% from baseline by corticosteroids alone within 3 months. RESULTS: There were no differences in baseline renal function and the amount of proteinuria among the three groups. Overall, complete remission (CR) was achieved in 88 (72.1%) patients by immunosuppressants. In a multivariate analysis adjusted for covariates associated with adverse renal outcome, the probability of reaching CR was significantly higher in the C [hazard ratio (HR), 4.09; p<0.001] and C+C groups (HR, 2.57; p=0.003) than in the NTx group. Kaplan-Meier analysis revealed that 5-year CR rates of C, C+C, and NTx groups were 88.5%, 86.2%, and 56.7% (p<0.001). Ten-year event-free rates for the secondary endpoints in these three groups were 91.7%, 79.9%, and 57.2% (p=0.01). CONCLUSION: Immunosuppressive treatment was effective in inducing remission and preserving renal function in these patients. Therefore, stepwise treatment using corticosteroids alone and in combination with cyclosporine is warranted in these patients.
Adrenal Cortex Hormones/adverse effects/*therapeutic use
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Adult
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Aged
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Cyclosporine/adverse effects/*therapeutic use
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Drug Administration Schedule
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Female
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Glomerular Filtration Rate/drug effects
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Glomerulonephritis, Membranous/*drug therapy/mortality
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Humans
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Immunosuppressive Agents/adverse effects/*therapeutic use
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Kaplan-Meier Estimate
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Kidney/drug effects/physiology
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Male
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Middle Aged
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Proteinuria/chemically induced
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Treatment Outcome
9.Clinical and Angiographic Outcomes of the First Korean-made Sirolimus-Eluting Coronary Stent with Abluminal Bioresorbable Polymer.
Hyoung Mo YANG ; Kyoung Woo SEO ; Junghan YOON ; Hyo Soo KIM ; Kiyuk CHANG ; Hong Seok LIM ; Byoung Joo CHOI ; So Yeon CHOI ; Myeong Ho YOON ; Seung Hwan LEE ; Sung Gyun AHN ; Young Jin YOUN ; Jun Won LEE ; Bon Kwon KOO ; Kyung Woo PARK ; Han Mo YANG ; Jung Kyu HAN ; Ki Bae SEUNG ; Wook Sung CHUNG ; Pum Joon KIM ; Yoon Seok KOH ; Hun Jun PARK ; Seung Jea TAHK
Korean Circulation Journal 2017;47(6):898-906
BACKGROUND AND OBJECTIVES: This trial evaluated the safety and efficacy of the Genoss drug-eluting coronary stent. METHODS: This study was a prospective, multicenter, randomized trial with a 1:1 ratio of Genoss drug-eluting stent (DES)™ and Promus Element™. Inclusion criteria were the presence of stable angina, unstable angina, or silent ischemia. Angiographic inclusion criteria were de novo coronary stenotic lesion with diameter stenosis >50%, reference vessel diameter of 2.5–4.0 mm, and lesion length ≤40 mm. The primary endpoint was in-stent late lumen loss at 9-month quantitative coronary angiography follow-up. Secondary endpoints were in-segment late lumen loss, binary restenosis rate, death, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), and stent thrombosis during 9 months of follow-up. RESULTS: We enrolled 38 patients for the Genoss DES™ group and 39 patients for the Promus Element™ group. In-stent late lumen loss at 9 months was not significantly different between the 2 groups (0.11±0.25 vs. 0.16±0.43 mm, p=0.567). There was no MI or stent thrombosis in either group. The rates of death (2.6% vs. 0%, p=0.494), TLR (2.6% vs. 2.6%, p=1.000), and TVR (7.9% vs. 2.6%, p=0.358) at 9 months were not significantly different. CONCLUSION: This first-in-patient study of the Genoss DES™ stent showed excellent angiographic outcomes for in-stent late lumen loss and major adverse cardiac events over a 9-month follow-up.
Angina, Stable
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Angina, Unstable
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Constriction, Pathologic
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Coronary Angiography
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Coronary Artery Disease
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Drug-Eluting Stents
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Follow-Up Studies
;
Humans
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Ischemia
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Mortality
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Myocardial Infarction
;
Polymers*
;
Prospective Studies
;
Sirolimus
;
Stents*
;
Thrombosis
10.A Comparison of Tiotropium 18microgram, Once Daily and Ipratropium 40microgram, 4 Times Daily in a Double-Blind, Double-Dummy, Efficacy and Safety Study in Adults with Chronic Obstructive Pulmonary Disease.
Seung Joon KIM ; Myung Sook KIM ; Sang Haak LEE ; Young Kyoon KIM ; Hwa Sik MOON ; Sung Hak PARK ; Sang Yeub LEE ; Kwang Ho IN ; Chang Youl LEE ; Young Sam KIM ; Hyung Jung KIM ; Chul Min AHN ; Sung Kyu KIM ; Kyung Rok KIM ; Seung Ick CHA ; Tae Hoon JUNG ; Mi Ok KIM ; Sung Soo PARK ; Cheon Woong CHOI ; Jee Hong YOO ; Hong Mo KANG ; Won Jung KOH ; Hyoung Suk HAM ; Eun Hae KANG ; O Jung KWON ; Yang Deok LEE ; Heung Bum LEE ; Yong Chul LEE ; Yang Keun RHEE ; Won Hyuk SHIN ; Sung Yeon KWON ; Woo Jin KIM ; Chul Gyu YOO ; Young Whan KIM ; Young Soo SHIM ; Sung Koo HAN ; Hye Kyung PARK ; Yun Seong KIM ; Min Ki LEE ; Soon Kew PARK ; Mi Hye KIM ; Won Yeon LEE ; Suk Joong YONG ; Kye Chul SHIN ; Byoung Whui CHOI ; Yeon Mok OH ; Chae Man LIM ; Sang Do LEE ; Woo Sung KIM ; Dong Soon KIM ; Sung Soo JUNG ; Ju Ock KIM ; Young Chun KO ; Young Chul KIM ; Nam Soo YOO
Tuberculosis and Respiratory Diseases 2005;58(5):498-506
BACKGROUND: This study compared the bronchodilator efficacy and safety of tiotropium inhalation capsules (18microgram once daily) with a ipratropium metered dose inhaler (2 puffs of 20microgram q.i.d.) in patients with chronic obstructive pulmonary disease (COPD). METHOD: After the initial screening assessment and a two-week run-in period, patients received either tiotropium 18microgram once daily or ipratropium 40microgram four times daily over a period of 4 weeks in a double blind, double dummy, parallel group study. The outcome measures were the lung function, the daily records of the peak expiratory flow rate (PEFR), the patients' questionnaire, and the use of concomitant salbutamol. The forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC) were measured 5 minutes before inhalation, and 0.5, 1, 2 and 3 hours after inhaling the study drug on days 0, 14 and 28. RESULT: In 16 centers, 134 patients with a mean (SD) age of 66 (7) years and a predicted FEV1 of 42 (12)% were analyzed. The trough FEV1 response was significantly higher in the tiotropium group than in the ipratropium group after a four-week treatment period. The weekly mean morning PEFR of the tiotropium group was consistently higher than that of the ipratropium group during the 4-week treatment period with differences ranging from 12.52 to 13.88 l/min, which were statistically significant. Tiotropium was well tolerated by the COPD patients during the 4-week treatment period and had a similar safety profile to ipratropium. CONCLUSION: This study shows that tiotropium administrated once daily has a superior bronchodilator effect with a similar safety profile in treating COPD patients compared with ipratropium, inhaled four times daily.
Adult*
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Albuterol
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Bronchodilator Agents
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Capsules
;
Forced Expiratory Volume
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Humans
;
Inhalation
;
Ipratropium*
;
Lung
;
Mass Screening
;
Metered Dose Inhalers
;
Outcome Assessment (Health Care)
;
Peak Expiratory Flow Rate
;
Pulmonary Disease, Chronic Obstructive*
;
Surveys and Questionnaires
;
Vital Capacity
;
Tiotropium Bromide