No abstract available.

The year 2021 marks the 60th anniversary of the foundation of the Korean Academy of Preventive Dentistry and Oral Health. In the oriental background, there is a belief that a new 60 years of history starts after the completion of 60 years. In other words, there is a brand new beginning every 60 years.The Korean Academy of Preventive Dentistry and Oral Health has set the 60th-anniversary slogan as “Past 60 Years of Oral Health, upcoming 100 Years of Dreaming Together’’ to look back on the past footprints and prepare for the future. We are putting in efforts to improve the nation’s oral health in the new era.Starting something new has a special meaning, but to pioneer something based on the past 60 years of history bestows measurable potential and power to move forward. This potential is what makes the 60th anniversary so remarkable.The role of journals in the development of an academy cannot be neglected. The Journal of Korean Academy of Oral Health (JKAOH) was first launched in 1967, and since then has been introducing various research achievements of the members. The journal website (www.jkaoh.org) provides easy access to the last 50 years’ worth of research articles with just one click.Studying preliminary research is one of the most crucial elements when brainstorming for a new project. If the study on preliminary research is not conducted adequately, it leads to a repetition of what others have already done, lacking originality. Therefore, making articles available through rich archives makes the research process easier and further accelerates the speed of academic development.Unlike in the past, sharing data and research articles is an active progress aided by many search engines. Nonetheless, a unique journal archive has its blend of research colors pursuing research direction that everyone can recognize.I am looking forward to every kind of research that the Korean Academy of Preventive Dentistry and Oral Health members will propose in the future. There will undoubtedly be new and innovative achievements contributing to the improvement of the nation’s oral health. I want to express my appreciation to the 60th anniversary of the Korean Academy of Preventive Dentistry and Oral Health and JKAOH, and I look forward to their developments in the future.

The year 2021 marks the 60th anniversary of the foundation of the Korean Academy of Preventive Dentistry and Oral Health. In the oriental background, there is a belief that a new 60 years of history starts after the completion of 60 years. In other words, there is a brand new beginning every 60 years.The Korean Academy of Preventive Dentistry and Oral Health has set the 60th-anniversary slogan as “Past 60 Years of Oral Health, upcoming 100 Years of Dreaming Together’’ to look back on the past footprints and prepare for the future. We are putting in efforts to improve the nation’s oral health in the new era.Starting something new has a special meaning, but to pioneer something based on the past 60 years of history bestows measurable potential and power to move forward. This potential is what makes the 60th anniversary so remarkable.The role of journals in the development of an academy cannot be neglected. The Journal of Korean Academy of Oral Health (JKAOH) was first launched in 1967, and since then has been introducing various research achievements of the members. The journal website (www.jkaoh.org) provides easy access to the last 50 years’ worth of research articles with just one click.Studying preliminary research is one of the most crucial elements when brainstorming for a new project. If the study on preliminary research is not conducted adequately, it leads to a repetition of what others have already done, lacking originality. Therefore, making articles available through rich archives makes the research process easier and further accelerates the speed of academic development.Unlike in the past, sharing data and research articles is an active progress aided by many search engines. Nonetheless, a unique journal archive has its blend of research colors pursuing research direction that everyone can recognize.I am looking forward to every kind of research that the Korean Academy of Preventive Dentistry and Oral Health members will propose in the future. There will undoubtedly be new and innovative achievements contributing to the improvement of the nation’s oral health. I want to express my appreciation to the 60th anniversary of the Korean Academy of Preventive Dentistry and Oral Health and JKAOH, and I look forward to their developments in the future.

No abstract available.
Biomedical Research ; Research Design ; Sex Characteristics ; Sex Factors ; Oral Health

No abstract available.

BACKGROUND: Although hypochlorhydria, hypergastrinemia and antiparietal cell antibody have been well documented in the patients with hyperthyroidism, a cause of hypochlorhydria or hypergastrinemia is unknown at the present time. Therefore, in order to clarify an inhibitory mechansim of gastric acid secretion in the patients with hyperthyroidism, interrelationship among hypochlorhydria, hypergastrinemia and antiparietal cell antibody was investigated in this study. METHODS: The gastric secretory function, fasting and postprandial plasma concentrations of gastrin and titer of antiparietal cell antibody in the plasma were determined in the patients with hyperthyroidism and normal subjects. Immunoblot analysis was performed to identify the gastric membrane protein, a possible gastric antigen to antiparietal cell antibody. Using a immunocytochemical technique with electron microscopy, intracellular structure of the parietal cell reacted with antiparietal cell antibody was observed. RESULTS: The basal and pentagastrin-stimulated maximal acid output were reduced in the patients with hyperthyroidism. The fasting and postprandial plasma concentrations of gastrin were markedly elevated in the patients. The plasma gastrin concentration in the patients with the antiparietal cell antibody was higher than that of the norrnal subjects as well as the patients without the antibody not only in the fasting state but also in the postprandial state. However, the plasma gastrin concentration of the patients without the antiparietal cell antibody was elevated in the fasting state only. There was no difference in the gastrin content of the antral mucosa between the norrnal subjects and the patients. The antiparietal cell antibody was detected in 5 (38.5 %) out of 13 patients by using the indirect immunofluorescence method. Patient IgG dose-dependently inhibited rabbit gastric H (+),K (+)-ATPase activity. Among proteins of the rabbit gastric mucosa membrane, four high molecular weight proteins (91, 140, 170 and 210 K dalton) were reacted to the patient IgG. The patient IgG positive peroxidase-antiperoxidase (PAP) activity was electron microscopically detected on the intracellular cannalicular membrane of the parietal cell CONCLUSION: We conclude that hypochlorhydria and hypergastrinemia in the patients with hyperthyroidism are partially related to the antiparietal cell antibody and that the antigen to the antiparietal cell antibody may be H (+),K (+)-ATPase in the intracellular canalicular membrane of the parietal cell.
Achlorhydria ; Fasting ; Fluorescent Antibody Technique, Indirect ; Gastric Acid* ; Gastric Mucosa ; Gastrins ; Humans ; Hyperthyroidism* ; Immunoglobulin G ; Membrane Proteins ; Membranes ; Microscopy, Electron ; Molecular Weight ; Mucous Membrane ; Plasma ; Rabeprazole

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign, uncommon disorder of unknown etiology, that usunlly appears as papules or nodules on the head and neck. Histopathologically, ALHE is a angioproliferating lesion which shows characteristically plump epithelioid or histiocytoid endothelial cells, accompanied by an inflammatory infiltrate that mainly consists of lymphocytes and eosinophils. We report a case of angiolymphoid hyperplasia with eosinophila associated with arteriovenous malformations in a 23-year-old man. In our patient, we observed arteriovenous malformation, changes which could have occurred by vascular repair due to a vascular malformation.
Angiolymphoid Hyperplasia with Eosinophilia ; Arteriovenous Malformations ; Endothelial Cells ; Eosinophils ; Head ; Humans ; Hyperplasia* ; Lymphocytes ; Neck ; Vascular Malformations ; Young Adult

A 67-year-old man noted a 4×6cm sized, erythematous, erosive, oozing patch on the penile shaft, which resisted conservative therapy for three years. Histopathologic examination revealed typical findings of extramammary Paget's disease. Interestingly, nests of Paget's cells in some hair follicular structures were shown in the middermis. The lesion was excised by microscopically controlled excision, using the fresh-tissue technique. There were histologically involved areas extending to quite a distance beyond the clinically normal appearing skin. Mohs micrographic surgery might offer the unique advantage of effective surgical treatment with microscopically controlled tumor free borders in the extramammary Paget's disease.
Aged ; Hair ; Humans ; Mohs Surgery ; Paget Disease, Extramammary* ; Skin

BACKGROUND: Desmosomes are adhesive intercellular junctions that form an important component of the junction complexes of epithelial cells. They provide intercellular links between the intermediate filament cytoskeletons of adjacent cells and are thus involved in maintaining the structural integrity of tissues. OBJECTIVE: Calcium and retinoids are major regulators of epidermal differentiation and their role on keratin proteins are well known. However, their effects on desmosome moleucles are unknown. To address this question we initiated a study of the effects of these epidermal differentiation regulators on desmosomal components, i.e., desmoplakin, desmoglein, and pemphigus antigens. METHODS: We used monoclonal antibodies against desmoplakin(DP) and desmoglein(DG), and sera from patients with pemphigus vulgaris(PV), pemphigus foliaceus(PF) and paraneoplastic pemphigus (PNP) to study the effects of calcium and retinoic acids, which are major regulators of epidermal differentation, on desmosomal protein formation in human cultured deratinocytes. We performed immunofluorescence, immunoblotting and immunoprecipitation study using human keratinocytes cultured in high calcium media with or without retinoic acid and in low calcium media with or without retinoic acid. RESULTS: 1. In low calcium (0.15mM) media, PV antigen and DG were produced in a small amount and it appeared that these desmosomal proteins were located in cytosol. Whereas in high calcium (1.8mM) media, production of these desmosomal proteins was increased not they were assembled at the desmosomal structures located in cell-cell contact margins. 2. PF antigen, which was identical to the DG, were not produced or expressed in cultured keratinocytes even when cultured in high calcium media. 3. PNP antigen and DP were produced in cultured keratinocytes grown in both high low calcium media but their production was increased in high calcium media and only in high calcium media they were assembled at the desmosomal structures. 4. Retinoic acids induced loosening of cell-cell contacts of cultured keratinocytes and decreased the production of desmosomal proteins. CONCLUSION: Our results suggests calcium is a major regulator of the production and assembly of desmosomal proteins including pemphigus antigens, but PF sera and monoclonal antibodies against DG show different antigen binding characteristics. It appears that retinoic acids inhibit production of desmosomal proteins.
Adhesives ; Antibodies, Monoclonal ; Calcium* ; Cytoskeleton ; Cytosol ; Desmogleins ; Desmoplakins ; Desmosomes* ; Epithelial Cells ; Fluorescent Antibody Technique ; Humans ; Immunoblotting ; Immunoprecipitation ; Intercellular Junctions ; Intermediate Filaments ; Keratinocytes ; Pemphigus ; Retinoids ; Tretinoin*