No abstract available.
Teratoma*

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and repair of function. For more than a decade there have been many efforts to develop materials and methods of treatment to promote periodontal wound healing. Recently many efforts are concentrated on the regeneration potential of material used in oriental medicine. In some in vitro and in vivo experiments, there have been many evidences that these materials have an effect on bone regeneration. The purpose of this study was to evaluate histologically and radiologically in Sprague-Dawley rats the effects of safflower seed extracts on the regeneration of the calvarial defects surgically produced. So in this study, the critical size defects were surgically produced in the calvarial bone of 30 Sprague-Dawley rats using the 8mm trephine bur. The safflower seed extract was applied into the defect of each rat in experimental group, whereas nothing was applied into the defect of each rat in control group. Rats were sacrificed at 2, 4, 8 weeks following operation and histomorphometric and radiodensitometric analysis were performed. 1. The newly formed bone length was 102.91+/-22.05, 178.29+/-24.40 at 2 week in the each control, experimental group, 130.95+/-39.24, 242.62+/-50.33 at 4 week and 181.53+/-76.35, 240.36+/-22.00 at 8 week(unit, micrometer). In the 2, 4 week, there were statistically significant difference between control and experimental group(P<0.05). 2. The newly formed bone area was 2962.06+/-1284.48, 10648.35+/-1284.48 at 2 week, 5103.25+/-1375.88, 9706.78+/-1481.81 at 4 week, 8046.02+/-818.99, 12057.06+/- 740.47 at 8 week(unit, micrometer2). In every week, there were statistically significant difference between control and experimental group(P<0.05). 3. The radiopacity was 14.26+/-.33, 25.47+/-4.33 at 2 week, 20.06+/-9.07, 26.61+/-2.78 at 4 week, 22.99+/-3.76, 27.29+/-1.54 at 8 week(unit, %). In the 2 week, there was statistically significant difference between control and experimental group(P<0.05). In conclusion, the results of the present study suggest that safflower seed extract initially has an effect on the newly formed bone area, length and radiopacity when it is applied to the calvarial defect of Sprague - Dawley rat. Then. the material has an effect on newly formed bone area and length.
Animals ; Bone Regeneration ; Carthamus tinctorius* ; Medicine, East Asian Traditional ; Osteogenesis* ; Rats* ; Rats, Sprague-Dawley ; Regeneration ; Wound Healing

BACKGROUND: Five year survival rate of postoperative stage I non-small lung cancer(NSCLC) reaches to 66%. In the remaining one third of patients, however, cancer recurs and overall survival of NSCLC remains dismal. To evaluate clinical and pathologic characteristics of recurred NSCLC, we studied patterns and factors for postoperative recurrence in patients with staged I, II NSCLC. METHOD: A retrospective analysis was performed in 234 patients who underwent radical resection for pathologic stage I, II NSCLC. All patients followed for at least one year were included in this study. RESULTS: 1) There were 177 men and 57 women. The median age was 63. The median duration of follow up was 732 days (range 365~1,695 days). The overall recurrence rate was 26.5% and the recurrence occurred at 358.8 +/- 239.8 days after operation. 2) The age of recurred NSCLC patients were higher (63.2 +/- 8.8 years) than that of non-recurred patients (60.3 +/- 9.8 years)(p=0.043). The recurrence rate was higher in stage II (46.9%) than in stage I (18.8%, p<0.001) NSCLC. The size of primary lung mass was larger in recurred (5.45 +/- 3.22 cm) than that of non-recurred NSCLC (3.74 +/- 1.75 cm, p<0.001). Interestingly, there were no recurrent cases when the resected primary tumors were less than 2cm. 3) Distant recurrence was more frequent than locoregional recurrence (66.1% vs. 33.9%). Distant recurrence rate was more frequent in female and adenocarcinoma. Brain metastasis was more frequent in patients with adenocarcinoma than squamous cell carcinoma (p=0.024). CONCLUSION: The tumor size and stage were two important factors for recurrence. Considering that distant brain metastasis was more frequent in patients with adenocarinoma, prospective study should follow to evaluate the effectiveness of preoperative brain imaging.
Adenocarcinoma ; Brain ; Carcinoma, Non-Small-Cell Lung* ; Carcinoma, Squamous Cell ; Female ; Follow-Up Studies ; Humans ; Lung ; Male ; Neoplasm Metastasis ; Neuroimaging ; Prognosis ; Recurrence ; Retrospective Studies ; Survival Rate