BACKGROUND:Acute vestibular neuronitis is the disease of which the etiology and pathophysiology are largely unknown . But the viral infection and ischemia of the labyrinth and the vestibular nerve are considered as general etiology. This study was performed to support the viral infection rather than the ischemic theory. MATERIALS & METHODS:We studied seventy years old female patient who showed painful vesicles on left auricle and vertigo with spontaneous nystagmus to the right side. We performed physical examination, serologic test, ENG test, pure tone audiogram, brain magnetic resonance imaging and polymerase chain reaction. RESULTS:We found small vesicles and vascular injection in left EAC, herpes zoster IgG positive, spontaneous right beating in electronystagmograpy, 54% left canal paresis in Caloric test , decreasing left side Tc in velocity step rotatory test, decresed gain, deviation to left in symmetry and phase lead in sinusoidal harmonic acceleration test, normal range hearing in pure tone audiogram, microangiopathy on cortex in brain MRI and negative PCR. CONCLUSION:This case supports viral infection etiology rather than ischemia in vestibular neuritis. But more studies to find the etiology of vestibular neuronitis are required.
Acceleration ; Brain ; Caloric Tests ; Ear, Inner ; Female ; Hearing ; Herpes Zoster ; Herpes Zoster Oticus ; Humans ; Immunoglobulin G ; Ischemia ; Magnetic Resonance Imaging ; Paresis ; Physical Examination ; Polymerase Chain Reaction ; Reference Values ; Serologic Tests ; Vertigo ; Vestibular Nerve ; Vestibular Neuronitis

No Abstract Available.
Alopecia*

Small follicular cysts are common findings in the ovaries of prepubertal girls, and in most cases, they are of no clinical importance. Ocassionally these cysts may enlarge and continue to produce estrogen, resulting in signs of precocious sexual development and vaginal bleeding. We have experienced a case of a precocious pseudopuberty causing ovarian follicular cyst which was treated by exploratory laparotomy. we present this case with a brief review of literatures
Estrogens ; Female ; Follicular Cyst* ; Humans ; Laparotomy ; Ovary ; Sexual Development ; Uterine Hemorrhage

We report a case of multiple Bowen's disease of probable arsenic origin associated with internal malignancies. A 63-year-old man who had a history of arsenicals injections showed pruritic erythematous 11 8 cm sized psoriasiform plaque on the right flank and multiple keratotic plaques on the trunk and both extremities. He had operation on his bladder due to transitional cell carcinoma. He was found to have a bronchogenic carcinoma by chest X-ray and CT scan. We report this as an interesting case of atypical multiple Bowen's disease manifestating a psoriasiform large plaque associated with internal malignancies of lung and bladder.
Arsenic ; Arsenicals ; Bowen's Disease* ; Carcinoma, Bronchogenic ; Carcinoma, Transitional Cell ; Extremities ; Humans ; Lung ; Middle Aged ; Thorax ; Tomography, X-Ray Computed ; Urinary Bladder

BACKGROUND AND OBJECTIVE: : ?The etiology of atopic dermatitis is still not clear. Atopic dermatitis is known to develop through immunological and non-immunological pathomechanisms. The delayed hyper- sensitivity reaction in atopic dermatitis has been reported as decreasing due to disturbance of cellular immunity. However, in recent days, there is a dispute as to whether disturbed epidermal barrier of atopic dermatitis could elicit a delayed type hypersensitivity reaction by an acceleration in the penetration of allergen. The aim of this study was to determine whether transepidermal water loss (TEWL) increased in atopic dermatitis, and whether the TEWL differed with a presence of delayed type-skin reaction. In addition, the prevalence of positive patch test reaction and TEWL were measured in atopic dermatitis and normal controls. METHODS: We performed the patch test with 24 Korean standard allergens and 5 aeroallergens on 38 atopic dermatitis patients. TEWL was measured using DermaLab (Cortex technology, Denmark) on 38 patients with atopic dermatitis and 40 normal controls. RESULTS: 17 (44.7%) patients with atopic dermatitis had positive reactions on the patch test. The frequency of positive allergens was in the following order: nickel sulfate (18.4%), thimerosal (15.8%), D. pteronyssinus (15.8%), and potassium dichromate (13.1%). TEWL values of both clinically normal skin and eczematous skin in atopic dermatitis patients were higher than those of normal controls. There was no statistically significant difference in TEWL values of normal skin of atopic dermatitis between the positive patch test and negative patch test groups. In positive reaction sites of aeroallergen patch test, the TEWL increased in comparison with both the control site and the positive classical patch test reaction site but it was not statistically significant. CONCLUSION: These results revealed that epidermal barrier is disturbed in atopic patients and suggested that various allergens might easily penetrate the skin to induce the delayed-type hypersensitivity reaction.
Acceleration ; Allergens ; Dermatitis, Atopic* ; Dissent and Disputes ; Humans ; Hypersensitivity ; Immunity, Cellular ; Nickel ; Patch Tests* ; Potassium Dichromate ; Prevalence ; Skin* ; Thimerosal

Lead has been widely used in industry and contained in various household products. However, allergic reaction to lead is known to be extremely rare. A 23-year-old woman who had been working in an electronics company for 1 year presented with pruritic erythematous macules and papules on both arms and hands of 1 month duration. She was diagnosed as a contact dermatitis due to lead by patch test using lead nitrite(0.01% aq.). The cutaneous eruption subsided with treatment and has not recurred by changing the working place for 6 months. We report a case of contact dermatitis due to lead.
Arm ; Dermatitis, Contact* ; Female ; Hand ; Household Products ; Humans ; Hypersensitivity ; Patch Tests ; Young Adult

Lead has been widely used in industry and contained in various household products. However, allergic reaction to lead is known to be extremely rare. A 23-year-old woman who had been working in an electronics company for 1 year presented with pruritic erythematous macules and papules on both arms and hands of 1 month duration. She was diagnosed as a contact dermatitis due to lead by patch test using lead nitrite(0.01% aq.). The cutaneous eruption subsided with treatment and has not recurred by changing the working place for 6 months. We report a case of contact dermatitis due to lead.
Arm ; Dermatitis, Contact* ; Female ; Hand ; Household Products ; Humans ; Hypersensitivity ; Patch Tests ; Young Adult

Primary amenorrhea due to intrasella arachnoid cyst is a very rare disease and require careful and frequent evaluation because may produce intracranial hemorrhage, elevated intracranial pressure and rapid expansion. Surgical intervention is needed only when visual disturbance, hypopituitarism or enlarging lesion is shown. Thus, we present a case of primary amenorrhea due to intrasella arachnoid cyst which was resected through the transsphenoidal approach.
Amenorrhea ; Arachnoid* ; Female ; Hypogonadism* ; Hypopituitarism ; Intracranial Hemorrhages ; Intracranial Hypertension ; Rare Diseases

PURPOSE: Although the rotavirus-related neonatal death occurred in western part of Kyeonggi Province recently, there were just a few reports about rotavirus gastroentertis in domestic since 2000. We proposed to investigate changes of epidemiology and clinical features of rotavirus gastroenteritis for the last 2 years. METHODS: We selected 166 patients diagnosed as gastroenteritis from January, 2002 to July, 2003 and reviewed the admission records retrospectively such as age distribution, sex ratio, seasonal distribution, admission period, laboratory data and dehydration type in the rotavirus group (RVG) and non-RVG. RESULTS: The percentage of patient under 3 years was 77% on RVG. The non-RVG showed even age distribution (P< 0.05). In RVG, patients occurred in March frequently and 52% occurred from January to March. In non-RVG, patients occurred highly in February and July (P< 0.05). The average of admission period was higher in RVG than non-RVG (P< 0.05). The percentage of patient admitted for over 10 days was 8% in the RVG. In dehydration severity, the RVG showed mild (51%), moderate (44%) and severe (5%) respectively, but non-RVG showed only mild dehydration (P< 0.05). The laboratory findings' did not have statistic significance between RVG and non-RVG. CONCLUSION: Compared to the previous studies, seasonal peak prevalence of rotavirus gastroenteritis changed from autumn to spring and patients over 3 years increased. Therefore, we suggest that there are variable serotypes of rotavirus domestically and there is a need for reinvestigation about clinical features and serotypes of rotavirus gastroenteritis.
Age Distribution ; Dehydration ; Epidemiology ; Gastroenteritis* ; Gyeonggi-do ; Humans ; Prevalence ; Retrospective Studies ; Rotavirus* ; Seasons ; Sex Ratio

Apoptosis is a form of cell death in which the cells shrink and exhibit nuclear chromatin condensation and DNA fragmentation, and yet maintain membrane integrity. Many lines of evidence have shown that brain neurons are vulnerable to degeneration by apoptosis. Also it has been suggested that apoptosis is one of the mechanism contributing neuronal loss in Alzheimer's disease(AD), since the conditions in the disease(A beta peptide, oxidative stress, low energy metabolism) are the inducers that activate apoptosis. Indeed some neurons in vulnerable regions of the AD brain show DNA damage, chromatin condensation, and apoptic bodies. Consistently, mutations in AD causative genes(Amyloid precursor protein, Presenilin-1 and Presenilin-2) increase A beta peptide1-42(Abeta1-42) and sensitize neuronal cell to apoposis. However, several lines of evidence have shown that the location of neuronal loss and A beta peptide deposition is not correlated in AD brain and transgenic mice brain over-expressing Abeta1-42. Taken together, these data may indicated that A beta peptide(and other causative factors of AD) can interact with other cellular insults or risk factors to exacerbate pathological mechansim of AD through apoptosis. Thus, this review discusses possible role and mechanism of apoptosis in AD.
Alzheimer Disease* ; Amyloid beta-Peptides ; Animals ; Apoptosis* ; Brain ; Cell Death ; Chromatin ; DNA Damage ; DNA Fragmentation ; Membranes ; Mice ; Mice, Transgenic ; Neurons ; Oxidative Stress ; Presenilin-1 ; Presenilin-2 ; Risk Factors