1.Correlation between Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS) in Measurement of Pruritus Intensity.
Young Woon PARK ; Dong Young KIM ; Hyoseung SHIN ; Kyu Han KIM
Korean Journal of Dermatology 2014;52(7):514-515
No abstract available.
Pruritus*
2.A Case of Keratosis Follicularis Squamosa Occurring on the Underwear Friction Area.
Tae Han KIM ; Nam Hee SUNG ; Do Hun KIM ; Hyoseung SHIN ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2016;54(1):71-73
No abstract available.
Darier Disease*
;
Friction*
;
Keratosis*
;
Minocycline
3.A Case of Giant Folliculosebaceous Cystic Hamartoma on the Forehead.
Do Hun KIM ; Tae Han KIM ; Nam Hee SUNG ; Seung Ho LEE ; Ai Young LEE ; Hyoseung SHIN
Korean Journal of Dermatology 2015;53(7):566-567
No abstract available.
Forehead*
;
Hamartoma*
4.A Case of Lupus Vulgaris Diagnosed with Interferon-gamma Release Assay.
Do Hun KIM ; Nam Hee SUNG ; Sang Yun JIN ; Hyoseung SHIN ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2014;52(4):279-281
No abstract available.
Interferon-gamma Release Tests*
;
Lupus Vulgaris*
5.A Case of Erythema Nodosum Migrans.
Dohun KIM ; Gwang Hoon KIM ; Tae Han KIM ; Nam Hee SUNG ; Hyoseung SHIN ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2016;54(1):79-80
No abstract available.
Erythema Nodosum*
;
Erythema*
6.A Case of Chronic Paronychia Accompanied by Cutaneous Ossification.
Nam Hee SUNG ; Do Hun KIM ; Hyoseung SHIN ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2014;52(11):806-808
Cutaneous bone formation may be primary or secondary. If it is primary, there are no preceding cutaneous lesions. If it is secondary, bone forms through metaplasia within a preexisting lesion caused by inflammation, traumatic injury, and a neoplastic tumor. Paronychia is inflammation of the proximal nail fold and presents as painful periungual erythema, sometimes with associated purulence. Chronic paronychia is most commonly related to mechanical or chemical factors. Here, we report a case of chronic paronychia accompanied by cutaneous ossification in a 33-year-old woman who presented with a 2-year history of recurrent paronychia on the left first finger.
Adult
;
Erythema
;
Female
;
Fingers
;
Humans
;
Inflammation
;
Metaplasia
;
Osteogenesis
;
Paronychia*
7.Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth.
Hyoseung SHIN ; Soon Jin CHOI ; A Ri CHO ; Dong Young KIM ; Kyu Han KIM ; Ohsang KWON
Annals of Dermatology 2016;28(5):600-606
BACKGROUND: Stress is a known cause of hair loss in many species. OBJECTIVE: In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured. Mast cell staining was performed on the biopsied tissue. In addition, Western blot and quantitative real time polymerase chain reaction were used to assess mast cell tryptase and cytokine expression, respectively in rat skin biopsies. RESULTS: Stress-serum treatment reduced significantly the number of viable hDPCs and arrested the cell cycle in the G1 phase, compared to serum from unrestrained rats (p<0.05, respectively). Moreover, restrained rats had significantly higher levels of cortisol in serum than unrestrained rats (p<0.01). Acute stress serum increased mast cell numbers and mast cell tryptase expression, as well as inducing interleukin (IL)-6 and IL-1β up-regulation. CONCLUSION: These results suggest that acute stress also has an inhibitory effect on hair growth via cortisol release in addition to substance P-mast cell pathway.
Animals
;
Biopsy
;
Blotting, Western
;
Cell Cycle
;
Corticotropin-Releasing Hormone
;
G1 Phase
;
Hair*
;
Humans
;
Hydrocortisone
;
In Vitro Techniques
;
Interleukins
;
Mast Cells*
;
Models, Animal
;
Rats
;
Real-Time Polymerase Chain Reaction
;
Skin
;
Tryptases
;
Up-Regulation
8.Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols.
Hyoseung SHIN ; A Ri CHO ; Dong Young KIM ; Semchin MUNKHBAYER ; Soon Jin CHOI ; Sunhyae JANG ; Seong Ho KIM ; Hyeon Cheol SHIN ; Ohsang KWON
Annals of Dermatology 2016;28(1):15-21
BACKGROUND: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts. OBJECTIVE: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. METHODS: MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. RESULTS: Treatment with 10 microg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30.3% more than in the negative control (p<0.001). Furthermore, 0.1 microg/ml PPE extended the human hair shaft 30.8% longer than the negative control over 9 days (p<0.05). Insulin-like growth factor-1 (IGF-1) mRNA expression increased 3.2-fold in hDPCs following treatment with 6 microg/ml PPE (p<0.05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2.0-fold by 3 microg/ml PPE (p<0.05). Treatment with 10 microg/ml PPE reduced oxidative stress in hDPCs (p<0.05). CONCLUSION: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.
Carotenoids
;
Fibroblasts
;
Hair Follicle
;
Hair*
;
Humans*
;
Insulin-Like Growth Factor I
;
Intercellular Signaling Peptides and Proteins
;
Oxidative Stress
;
Polyphenols*
;
Real-Time Polymerase Chain Reaction
;
RNA, Messenger
;
Vascular Endothelial Growth Factor A
9.Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study.
Seong Jin JO ; Hyoseung SHIN ; Seung Hwan PAIK ; Sun Jae NA ; Yingji JIN ; Won Seok PARK ; Su Na KIM ; Oh Sang KWON
Annals of Dermatology 2013;25(2):218-222
BACKGROUND: Graying of hair-a sign of aging-raises cosmetic concerns. Individuals with gray hair often look older than others their age; therefore, some dye their hair for aesthetic purposes. However, hair colorants can induce many problems including skin irritation, allergic reaction and hair-breakage. OBJECTIVE: This randomized, double-blind clinical trial was performed in order to examine the effects of APHG-1001, a compound including an extract from Pueraria lobata, on graying hair. METHODS: A total of 44 female subjects were randomly treated with either APHG-1001 or placebo twice daily for 24 weeks. Using the phototrichogram analysis, a count of newly developed gray hair was estimated. Investigator assessment and subject self-assessment were also performed in order to evaluate the efficacy of the compound. RESULTS: The mean number of newly developed gray hair at 24 weeks was 6.3/cm2 in the APHG-1001 group and 11.4/cm2 in the placebo group; the difference was statistically significant (p<0.05). However, the investigator assessment and subject self-assessment did not show any significant change in the gross appearance of hair grayness by the end of the study. No severe adverse events in either group were observed. Moreover, the incidence of adverse events did not differ between the groups. CONCLUSION: This clinical trial revealed that APHG-1001, which contains an extract of P. lobata, could prevent the development of new gray hair without any remarkable adverse effects. Thus, it can be considered as a viable treatment option for the prevention of gray hair.
Aging
;
Antioxidants
;
Cosmetics
;
Female
;
Hair
;
Hair Color
;
Hair Dyes
;
Humans
;
Hypersensitivity
;
Incidence
;
Pueraria
;
Research Personnel
;
Self-Assessment
;
Skin
10.The Pattern of Hair Dyeing in Koreans with Gray Hair.
Seong Jin JO ; Hyoseung SHIN ; Seung Hwan PAIK ; Jae Woo CHOI ; Jong Hee LEE ; Soyun CHO ; Ohsang KWON
Annals of Dermatology 2013;25(4):401-404
BACKGROUND: Hair graying is considered as a part of normal ageing process. Nonetheless, this process raises a significant cosmetic concern, especially among ethnic Korean elderly whose baseline hair color is black. For this reason, Korean elderly dye their hair with frequency despite the risk of dermatologic problems such as allergic contact dermatitis. OBJECTIVE: In this study, the authors investigate the prevalence and pattern of hair dyeing and its relation with scalp diseases in Korea. METHODS: Six hundred twenty subjects (330 men and 290 women) with graying hair were given a questionnaire survery and underwent a physical examination. RESULTS: Of the 620 total, 272 subjects (43.9%) dyed their hair. Hair dyeing was significantly more frequent among women than among men (p<0.001). Subjects from 50 to 69 years of age showed higher prevalence of hair dyeing when compared to either younger or older groups. Subjective self-assessment of the extent of hair graying was associated with increased prevalence of hair dyeing, that is, individuals who feel graying has advanced by more than 20% of the overall hair were much more likely to dye their hair (p<0.001). Hair dyeing did not correlate with either alopecia or scalp disease. CONCLUSION: Our survey has found that the prevalence of hair dyeing is higher among Korean women than men. People in their fifties and sixties and people with more than 20% extent of grayness were more likely to dye their hair than otherwise. Hair dyeing was not associated with any increase in the prevalence of scalp diseases.
Aged
;
Alopecia
;
Female
;
Hair Color
;
Hair Dyes
;
Hair*
;
Humans
;
Male
;
Prevalence
;
Scalp
;
Self-Assessment
;
Surveys and Questionnaires