1.Statistical Consideration for Improving Quality of Medical Study.
Journal of the Korean Fracture Society 2014;27(2):167-172
No abstract available.
2.Statistical Considerations in Medical Journals.
Korean Journal of Otolaryngology - Head and Neck Surgery 2010;53(1):1-6
The proper use of statistics in medical studies is very important to draw an objective conclusion. The misuse and misunderstanding of statistics degrade the quality of scientific results. Authors should make an effort to choose proper statistical procedures and report the results appropriately. In this article, we review and summarize aspects of statistical consideration in preparing for publication in medical journals.
Publications
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Sample Size
3.High Altitude Remains Associated with Elevated Suicide Rates after Adjusting for Socioeconomic Status: A Study from South Korea.
Jaelim KIM ; Nari CHOI ; Yu Jin LEE ; Hyonggin AN ; Namkug KIM ; Ho Kyoung YOON ; Heon Jeong LEE
Psychiatry Investigation 2014;11(4):492-494
There have been several studies supporting a possible relationship between high suicide rate and high altitude. However socioeconomic status may confound this association because low socioeconomic status, which is known to be related to a high suicide rate, is also associated with living at high altitude. This study aims to explore whether the relationship between high altitude and high suicide rate remains after adjusting for socioeconomic status in South Korea. We collected demographic data of completed suicides, the mean altitude of the district where each suicide took place, and the mean income of each district. We analyzed the data using regression analysis before and after adjustment for mean income. We found that there is a positive correlation between altitude and suicide rate, even after adjustment for mean income. Thus, altitude appears to be an independent risk factor for suicide.
Altitude*
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Korea
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Risk Factors
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Social Class*
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Suicide*
4.The Impact of Celebrity Suicide on Subsequent Suicide Rates in the General Population of Korea from 1990 to 2010.
Juhyun PARK ; Nari CHOI ; Seog Ju KIM ; Soohyun KIM ; Hyonggin AN ; Heon Jeong LEE ; Yu Jin LEE
Journal of Korean Medical Science 2016;31(4):598-603
The association between celebrity suicide and subsequent increase in suicide rates among the general population has been suggested. Previous studies primarily focused on celebrity suicides in the 2000s. To better understand the association, this study examined the impacts of celebrity suicides on subsequent suicide rates using the data of Korean celebrity suicides between 1990 and 2010. Nine celebrity suicides were selected by an investigation of media reports of suicide deaths published in three major newspapers in Korea between 1990 and 2010. Suicide mortality data were obtained from the National Statistical Office of Korea. Seasonal autoregressive integrated moving average models with intervention analysis were used to test the impacts of celebrity suicides, controlling for seasonality. Six of the 9 celebrity suicides had significant impacts on suicide rates both in the total population and in the same gender- or the same age-subgroups. The incident that occurred in the 1990s had no significant impact on the overall suicide rates, whereas the majority of the incidents in the 2000s had significant influences for 30 or 60 days following each incident. The influence of celebrity suicide was shown to reach its peak following the suicide death of a renowned actress in 2008. The findings may suggest a link between media coverage and the impact of celebrity suicide. Future studies should focus more on the underlying processes and confounding factors that may contribute to the impact of celebrity suicide on subsequent suicide rates.
Adult
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Aged
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*Famous Persons
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Female
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Humans
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Male
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Middle Aged
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Newspapers as Topic
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Republic of Korea
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Suicide/psychology/*statistics & numerical data
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Young Adult
5.Mobile phone use and risk of glioma: a case-control study in Korea for 2002-2007.
Songyi YOON ; Jae Wook CHOI ; Eunil LEE ; Hyonggin AN ; Hyong Do CHOI ; Nam KIM
Environmental Health and Toxicology 2015;30(1):e2015015-
OBJECTIVES: There has been a growing concern about the possible carcinogenic effects of the electromagnetic radiofrequency fields emitted from mobile phones. The purpose of this study was to investigate the association between mobile phone use and the development of gliomas in Korea. METHODS: Our study methods were based on the International Interphone study that aimed to evaluate possible adverse effects of mobile phone use. This study included 285 histologically-confirmed Korean patients 15 to 69 years of age, with gliomas diagnosed between 2002 and 2007 in 9 hospitals. The 285 individually matched controls were healthy individuals that had their medical check-up in the same hospitals. Unconditional logistic regression was used to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for use of mobile phones. RESULTS: For the entire group, no significant relationship was investigated between gliomas and regular use of mobile phones, types of mobile phones, lifetime years of use, monthly service fee, and the other exposure indices. Analyses restricted to self-respondents showed similar results. For ipsilateral users, whose the body side for usual mobile phone use match the location of glioma, the aORs (95% CIs) for lifetime years of use and cumulative hours of use were 1.25 (0.55 to 2.88) and 1.77 (0.32 to 1.84), respectively. However, the contralateral users showed slightly lower risk than ipsilateral users. CONCLUSIONS: Our results do not support the hypothesis that the use of mobile phones increases the risk of glioma; however, we found a non-significant increase in risk among ipsilateral users. These findings suggest further evaluation for glioma risk among long-term mobile phone users.
Brain Neoplasms
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Case-Control Studies*
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Cell Phones*
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Electromagnetic Fields
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Fees and Charges
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Glioma*
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Humans
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Korea*
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Logistic Models
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Magnets
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Odds Ratio
6.Mobile phone use and risk of glioma: a case-control study in Korea for 2002-2007.
Songyi YOON ; Jae Wook CHOI ; Eunil LEE ; Hyonggin AN ; Hyong Do CHOI ; Nam KIM
Environmental Health and Toxicology 2015;30(1):e2015015-
OBJECTIVES: There has been a growing concern about the possible carcinogenic effects of the electromagnetic radiofrequency fields emitted from mobile phones. The purpose of this study was to investigate the association between mobile phone use and the development of gliomas in Korea. METHODS: Our study methods were based on the International Interphone study that aimed to evaluate possible adverse effects of mobile phone use. This study included 285 histologically-confirmed Korean patients 15 to 69 years of age, with gliomas diagnosed between 2002 and 2007 in 9 hospitals. The 285 individually matched controls were healthy individuals that had their medical check-up in the same hospitals. Unconditional logistic regression was used to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for use of mobile phones. RESULTS: For the entire group, no significant relationship was investigated between gliomas and regular use of mobile phones, types of mobile phones, lifetime years of use, monthly service fee, and the other exposure indices. Analyses restricted to self-respondents showed similar results. For ipsilateral users, whose the body side for usual mobile phone use match the location of glioma, the aORs (95% CIs) for lifetime years of use and cumulative hours of use were 1.25 (0.55 to 2.88) and 1.77 (0.32 to 1.84), respectively. However, the contralateral users showed slightly lower risk than ipsilateral users. CONCLUSIONS: Our results do not support the hypothesis that the use of mobile phones increases the risk of glioma; however, we found a non-significant increase in risk among ipsilateral users. These findings suggest further evaluation for glioma risk among long-term mobile phone users.
Brain Neoplasms
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Case-Control Studies*
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Cell Phones*
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Electromagnetic Fields
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Fees and Charges
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Glioma*
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Humans
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Korea*
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Logistic Models
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Magnets
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Odds Ratio
7.Locking Plate in Proximal Tibial Fracture: A Correlation between the Coronal Alignment of Tibia and Joint Screw Angle.
Jong Keon OH ; Jin Ho HWANG ; Lalrinliana VARTE ; Jae Han KO ; Chang Wug OH ; Duk Young JUNG ; Hyonggin AN ; Jae Woo CHO
Yonsei Medical Journal 2013;54(3):720-725
PURPOSE: The purpose of this study is to evaluate the relationship between the angle formed between the proximal most screw through the locking compression plate-proximal lateral tibia (LCP PLT) and the joint line, and to evaluate if this angle can be used intraoperatively as an assessment tool to determine normal alignment of the tibia in the coronal plane. MATERIALS AND METHODS: There are two parts to this study: in the first part, LCP PLT was applied to 30 cadaveric adult tibia. The angle between the joint line and the proximal most screw was measured and termed as the 'joint screw angle' (JSA). In the second part, 56 proximal tibial fractures treated with LCP PLT were retrospectively studied. Two angles were measured on the radiographs, the medial proximal tibial angle (MPTA) and the JSA. Their relationship was analyzed statistically. RESULTS: The average JSA was 1.16 degrees in the anatomical study. Statistical analysis of the clinical study showed that the normal MPTA had a direct correlation with an acceptable JSA. CONCLUSION: We therefore conclude that the JSA can be used intraoperatively to assess the achievement of a normal coronal axis.
Adult
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Aged
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Aged, 80 and over
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*Bone Screws
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Female
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Humans
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Male
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Middle Aged
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Orthopedic Procedures/*methods
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Retrospective Studies
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Tibial Fractures/radiography/*surgery
8.Prevalence of Loneliness and Its Association With Suicidality in the General Population: Results From a Nationwide Survey in Korea
Jimin LEE ; Sung Man CHANG ; Bong-Jin HAHM ; Jee Eun PARK ; Su Jeong SEONG ; Jin Pyo HONG ; Hong Jin JEON ; Hyonggin AN ; Byung-Soo KIM
Journal of Korean Medical Science 2023;38(36):e287-
Background:
Although it is known that a substantial proportion of the population experience loneliness, the consequence of loneliness remains unclear by countries and ages.Accordingly, this study aimed to assess the association between loneliness and suicidality in the general population of Korea.Method: A total of 5,511 Koreans aged 18–79 completed a tablet-assisted personal interview using the Korean version of the Composite International Diagnostic Interview and responded to questions about loneliness and lifetime suicidal ideation, plans, and attempts. A logistic regression analysis was used to examine the association between loneliness and suicidality.
Results:
Approximately one-third of the Korean general population reported loneliness.Being older, never married, widowed, separated, or divorced, unemployed, and having a parttime job were all significantly related to loneliness. After adjusting for sociodemographic factors, individuals with loneliness were significantly associated with increased suicidal ideation (adjusted odd ratio [aOR], 4.05; 95% confidence interval [CI], 3.36–4.88), suicidal plans (aOR, 4.91; 95% CI, 3.34–7.21), and suicidal attempts (aOR, 4.82; 95% CI, 3.03–7.66). Even after adjusting for sociodemographic factors and mental disorders, suicidality remained statistically significant. Moreover, frequent, moderate-to-severe, and long-term loneliness were all associated with increased ORs for suicidality, regardless of sociodemographic factors and mental disorders.
Conclusion
Loneliness was associated with suicidal ideation, plans, and attempts. This study lays the foundation for public health policymakers to establish early intervention and mental health care support for lonely people.
9.Acute Efficacy and Safety of Escitalopram Versus Desvenlafaxine and Vortioxetine in the Treatment of Depression With Cognitive Complaint: A Rater-Blinded Randomized Comparative Study
Seung-Hoon LEE ; Sang Won JEON ; Cheolmin SHIN ; Chi-Un PAE ; Ashwin A. PATKAR ; Prakash S. MASAND ; Hyonggin AN ; Changsu HAN
Psychiatry Investigation 2022;19(6):500-500
10.Acute Efficacy and Safety of Escitalopram Versus Desvenlafaxine and Vortioxetine in the Treatment of Depression With Cognitive Complaint: A Rater-Blinded Randomized Comparative Study
Seung-Hoon LEE ; Sang Won JEON ; Cheolmin SHIN ; Chi-Un PAE ; Ashwin A. PATKAR ; Prakash S. MASAND ; Hyonggin AN ; Changsu HAN
Psychiatry Investigation 2022;19(4):268-280
Objective:
This study aimed to compare the efficacy and safety of escitalopram, vortioxetine, and desvenlafaxine for acute treatment of major depressive disorder (MDD) with cognitive complaint (CC).
Methods:
A total of 129 patients with MDD who also complained of CC were randomized evenly to either escitalopram, vortioxetine, or desvenlafaxine group and underwent a multi-center, six-week, rater-blinded, and head-to-head comparative trial. Differences in depressive symptoms following treatment were measured using the Hamilton Depression Rating Scale (HAMD) and the Montgomery-Åsberg Depression Rating Scale (MADRS). Subjective cognitive function and the presence of adverse events were assessed.
Results:
The three antidepressant treatment groups did not show significant differences in the improvement of depressive symptoms as measured by HAMD and MADRS. Desvenlafaxine treatment was associated with a superior treatment response rate in depressive symptoms compared to vortioxetine or escitalopram treatment. However, no significant differences were found in the remission rate of depressive symptoms. The three antidepressant treatment groups did not show significant differences in the improvement of CC. Adverse profiles of each treatment group were tolerable, with no significant differences.
Conclusion
In acute antidepressant treatment for MDD with CC, escitalopram, vortioxetine, and desvenlafaxine presented similar efficacy in relief of depressive symptoms; however, desvenlafaxine was associated with a superior treatment. Further studies are needed to confirm these results by investigating the therapeutic efficacy and safety profile of long-term antidepressant treatment of MDD with CC (Clinical Trial Registry, http://cris.nih.go.kr/cris/en/: KCT0002173).