1.Clinica Efficacy and Safety of Hyruan (Sodium Hyaluronate) in Patients with Osteoarthritis of the Knee.
Shin Seok LEE ; Yeong Shil JOO ; Wan Uk KIM ; Sung Hwan PARK ; Chul Soo CHO ; Ho Youn KIM ; Hyon Jeong KIM ; Sung Jae KIM
The Journal of the Korean Rheumatism Association 1999;6(1):53-61
OBJECTIVES: To assess the clinical efficacy and safety of Hyruan(sodium hyaluronate) in patients with osteoarthritis of the knee. METHODS: A 12-week open study of Hyruan was conducted in 48 patients with osteoarthritis(OA) of the knee. Hyruan was injected into knee joints weekly for 5 weeks. Clinical evaluations were performed using visual analog scale(VAS) for pain, Lequesne's index, tenderness and swollen joint counts weekly for the first 5 weeks and then monthly up to 3 months post-injection. RESULTS: Significant improvements in VAS, Lequesne's index, tenderness and swollen joint counts were noted from the first week and maintained until the end of 3 month follow-up period. At 3 months post-injection, 68.8% of patients had >20mm reduction in the VAS. The patients with Kellgren stage lIl showed significant response in VAS and Lequesne's index as patients with Kellgren stage I and II. The clinical improvement after treatment was slower in patients(n=16) with late(>5 years) OA than in patients(n=32) with early(<5 years) OA, but it was statistically significant in either groups, compared to baseline. There were no severe adverse reactions to Hyruan therapy and laboratory examinations revealed no evidence of toxicity. CONCLUSION: Hyruan has been shown to be effective and safe in the treatment of patients with osteoarthritis of the knee.
Follow-Up Studies
;
Humans
;
Hyaluronic Acid
;
Joints
;
Knee Joint
;
Knee*
;
Osteoarthritis*
2.Reactivities of Commercial Antisera for HLA Typing.
Dong Il WON ; Jae Woo SONG ; Ki Il PARK ; Hyon Uk KIM
Korean Journal of Clinical Pathology 2000;20(5):510-515
BACKGROUND: The most common problem in HLA typing is unsatisfactory quality of the antisera, or a lack of understanding of their reactivities. Therefore, commercial antisera must be verified under the conditions applied in a particular tissue typing laboratory. METHODS: We evaluated the antisera reactivities of a commercial HLA-yping tray, Lymphotype HLA-BC 72 oriental, the lot 7220999, 7230100 (Biotest, Germany), in about 300 samples from organ transplant recipients and healthy potential donors. RESULTS: The relatively weak antisera were those that defined A26, A33, Cw5, Cw14, B46, B58, B64 and B71 etc. Some of these antisera were not indicated as 'weak reaction' in the test result catalogue. The reactivities of each antisera indicated as 'extra reaction' or 'sometimes missing' were various. CONCLUSIONS: As for antisera reactivities, the data obtained by a laboratory itself are necessary in addition to those in the test result catalogue. These data will be helpful for the correct interpretation for laboratories using same commercial kits.
Histocompatibility Testing*
;
Humans
;
Immune Sera*
;
Tissue Donors
;
Transplants
3.Reactivities of Commercial Antisera for HLA Typing.
Dong Il WON ; Jae Woo SONG ; Ki Il PARK ; Hyon Uk KIM
Korean Journal of Clinical Pathology 2000;20(5):510-515
BACKGROUND: The most common problem in HLA typing is unsatisfactory quality of the antisera, or a lack of understanding of their reactivities. Therefore, commercial antisera must be verified under the conditions applied in a particular tissue typing laboratory. METHODS: We evaluated the antisera reactivities of a commercial HLA-yping tray, Lymphotype HLA-BC 72 oriental, the lot 7220999, 7230100 (Biotest, Germany), in about 300 samples from organ transplant recipients and healthy potential donors. RESULTS: The relatively weak antisera were those that defined A26, A33, Cw5, Cw14, B46, B58, B64 and B71 etc. Some of these antisera were not indicated as 'weak reaction' in the test result catalogue. The reactivities of each antisera indicated as 'extra reaction' or 'sometimes missing' were various. CONCLUSIONS: As for antisera reactivities, the data obtained by a laboratory itself are necessary in addition to those in the test result catalogue. These data will be helpful for the correct interpretation for laboratories using same commercial kits.
Histocompatibility Testing*
;
Humans
;
Immune Sera*
;
Tissue Donors
;
Transplants
4.Optimal Cut-Off Value of the Coracohumeral Ligament Area as a Morphological Parameter to Confirm Frozen Shoulder
Hyung Rae CHO ; Byong Hyon CHO ; Keum Nae KANG ; Young Uk KIM
Journal of Korean Medical Science 2020;35(15):e99-
Background:
Thickened coracohumeral ligament (CHL) is one of the important morphological changes of frozen shoulder (FS). Previous research reported that coracohumeral ligament thickness (CHLT) is correlated with anterior glenohumeral instability, rotator interval and eventually FS. However, thickness may change depending on the cutting angle, and measurement point. To reduce measurement mistakes, we devised a new imaging criteria, called the coracohumeral ligament area (CHLA).
Methods:
CHL data were collected and analyzed from 52 patients with FS, and from 51 control subjects (no evidence of FS). Shoulder magnetic resonance imaging was performed in all subjects. We investigated the CHLT and CHLA at the maximal thickened view of the CHL using our picture archiving and communications system. The CHLA was measured as the whole area of the CHL including the most hypertrophied part of the MR images on the oblique sagittal plane. The CHLT was measured at the thickest point of the CHL.
Results:
The average CHLA was 40.88 ± 12.53 mm2 in the control group and 67.47 ± 19.88 mm2 in the FS group. The mean CHLT was 2.84 ± 0.67 mm in the control group and 4.01 ± 1.11 mm in the FS group. FS patients had significantly higher CHLA (P < 0.01) and CHLT (P < 0.01) than the control group. The receiver operator characteristic analysis showed that the most suitable cut-off score of the CHLA was 50.01 mm2, with 76.9% sensitivity, 76.5% specificity, and area under the curve (AUC) of 0.87. The most suitable cut-off value of the CHLT was 3.30 mm, with 71.2% sensitivity, 70.6% specificity, and AUC of 0.81.
Conclusion
The significantly positive correlation between the CHLA, CHLT and FS was found. We also demonstrate that the CHLA has statistically equivalent power to CHLT. Thus, for diagnosis of FS, the treating physician can refer to CHLA as well as CHLT.
5.Ventilatory Dynamics according to Bronchial Stenosis in Bronchial Anthracofibrosis.
Seung Wook JUNG ; Yeon Jae KIM ; Gun Hyun KIM ; Min Seon KIM ; Hyuk Soo SON ; Jun Chul KIM ; Hyon Uk RYU ; Soo Ok LEE ; Chi Young JUNG ; Byung Ki LEE
Tuberculosis and Respiratory Diseases 2005;59(4):368-373
BACKGROUND: Bronchial anthracofibrosis usually manifest as a form of obstructive airway disease, and can be accompanied by parenchymal diseases such as pneumonia, and pulmonary tuberculosis. This study investigated the ventilatory dynamics according to the severity of bronchial stenosis in patients with bronchial anthracofibrosis. Method : One hundred and thirteen patients with bronchial anthracofibrosis that was confirmed by bronchoscopy and who had undergone a pulmonary function test were enrolled in this study group. The correlation coefficients between the pulmonary functional parameters and the number of lobes with bronchial stenosis were investigated. RESULTS: The incidence of ventilatory dysfunction was 56(49.6%) for obstructive, 8(7.1%) for restrictive, 2(1.8%) for mixed, and 47(41.6%) for a normal pattern. The FEV1/FVC, FEF25~75%, FEF25%, FEF50%, FEF75%, and PEF showed a significant negative correlation (p<0.05) and the Raw had a significant positive correlation with the number of lobes with bronchial stenosis(p<0.001). CONCLUSION: These findings suggest that the most common abnormality of the ventilatory function in bronchial anthracofibrosis is an obstructive pattern with a small airway dysfunction according to the severity of bronchial stenosis.
Airway Resistance
;
Bronchoscopy
;
Constriction, Pathologic*
;
Humans
;
Incidence
;
Pneumonia
;
Respiratory Function Tests
;
Tuberculosis, Pulmonary
6.Proton Magnetic Resonance Spectroscopy in Patients with Neuro-Behcet's Disease.
Hyong Ju KANG ; Hyon Jung TAE ; Myoung Cheol KIM ; Wan Uk KIM ; Sung Hwan PARK ; Chul Soo CHO ; Ho Youn KIM
The Journal of the Korean Rheumatism Association 2001;8(1):41-47
Magnetic resonance imaging (MRI)and computed tomography had been used to detect the neurologic lesions of the Behcet's disease.However,there are a number of cases which can not be detected by conventional imaging studies in neuro-Behcet's disease.To overcome this problem,magnetic resonance spectroscopy (MRS)has been introduced in several autoimmune diseases involving central nervous system such as neuropsychiatric lupus,but which was rarely performed in Behcet's disease.In the present study,we report two cases of neuro-Behcet's disease that showed normal MRI but abnormal proton MRS (1HMRS)findings.MRS in two cases revealed a reduction of the N-acetyl aspartate (NAA)/creatine (Cr)ratio in the substantia nigra and thalamus,respectively, which were the areas without abnormality on MRI,suggesting a functional defect of neurons in these areas.In a case with thalamic dysfunction,abnormal NAA/Cr ratio was normalized in parallel with clinical improvement after treatment with high-dose steroids and immuno-suppressive agents.These observa-tions suggest that MRS may be useful to early detect the functional abnormality in neuro-Behcet's disease and to monitor neurologic status after treatment with immuno-suppressive agents.
Aspartic Acid
;
Autoimmune Diseases
;
Central Nervous System
;
Humans
;
Magnetic Resonance Imaging
;
Magnetic Resonance Spectroscopy*
;
Neurons
;
Protons*
;
Spectrum Analysis
;
Steroids
;
Substantia Nigra
7.A Case of Protein Losing Enteropathy Caused by Primary Intestinal Lymphangiectasia.
Se Young LEE ; Ju Chun YEO ; Young Deuk YOUN ; Sae Rom KIM ; Young Lan KWON ; Hyon Uk RYU ; Jun Chul KIM ; Myung Kwon LEE ; Chang Keun PARK ; Sang Mun LEE
Korean Journal of Gastrointestinal Endoscopy 2006;33(5):307-312
Primary intestinal lymphangiectasia is a rare congenital cause of protein losing enteropathy that is characterized by chronic diarrhea, generalized edema, ascites, hypoproteinemia, hypoalbuminemia, and lymphopenia. We encountered an 18-year-old woman who suffered from longstanding diarrhea and progressive leg edema. The laboratory findings showed the typical features of this disorder. The presence of enteric protein loss was documented with the 24 hour fecal clearance of alpha(1)-antitrypsin and (99m)Tc human serum albumin scintigraphy. A duodenoscopy and biopsy showed scattered white spots and markedly dilated lymphatics in the tips of the villi, respectively. The patient's clinical symptoms improved after placing her on a high protein and low fat diet with medium chain triglyceride supplements.
Adolescent
;
Ascites
;
Biopsy
;
Dental Caries
;
Diarrhea
;
Diet
;
Duodenoscopy
;
Edema
;
Female
;
Humans
;
Hypoalbuminemia
;
Hypoproteinemia
;
Leg
;
Lymphopenia
;
Protein-Losing Enteropathies*
;
Radionuclide Imaging
;
Serum Albumin
;
Triglycerides
8.The Education Programs of Cardiopulmonary Resuscitation for Resident and their Effects Assessed by Anesthesiologists.
Ji Yeon KIM ; Dong uk KIM ; Won sik AHN ; Teo Jeon SHIN ; Jae Hyon BAHK
Korean Journal of Anesthesiology 2004;46(4):424-429
BACKGROUND: The survival rate of cardiopulmonary resuscitation (CPR) is low in Korea. We believe the cause of this low survival rate is caused by the absence of instrumentation, the lack of manpower and by poor education quality of in-hospital CPR. The purpose of this study was to evaluate the current state of resident education with respect to cardiopulmonary resuscitation and its likely effect. METHODS: We surveyed anesthesiologists who attended the Korean Society of Anesthesiologist Congress. The questionnaire items concerned the followings; 1) The type of supplementary materials used during CPR education; 2) The Duration and frequency of CPR education according to resident grades and hospital scales; 3) The actual CPR participation frequency in a year; 4) The composition of the CPR teams in wards and ICUs; and 5) The effectiveness of CPR education as assessed by anesthesiologists. RESULTS: Most of participating anesthesiologists in this survey worked at large hospitals with more than 500 beds. They had received an irregular schedule of CPR education. Most education programs consisted of lectures, and education time was less than 2 hours. The number of actual CPR participations was about 10 per year. Usually the trainees, other than certified anesthesiologists, had resuscitated patients in wards. Most of the responders believed that current education was ineffective. CONCLUSIONS: We conclude that CPR education is not fully effective. If we want to increase the survival rate of CPR, we should pay more attention to the education program and to its utility and training requirements.
Appointments and Schedules
;
Cardiopulmonary Resuscitation*
;
Education*
;
Humans
;
Korea
;
Lectures
;
Surveys and Questionnaires
;
Survival Rate
;
Weights and Measures
9.A Case of Pancreatic Cancer and Opioid Withdrawal after Endoscopic Ultrasound-guided Celiac Plexus Neurolysis.
Soo Hwan SEOL ; Hyun Soo KIM ; Byung Sik HWANG ; Dae Myung OH ; In Yub BAEK ; Min Kyu PARK ; Hyon Uk RYU ; Jong Kyu KWON
Korean Journal of Gastrointestinal Endoscopy 2011;42(5):323-326
Pancreatic cancer is usually unresectable upon diagnosis, and treatment aims to optimize the quality of the patient's life by managing symptoms, and, particularly, by providing adequate pain control. When the pain is refractory to opioids, interventions such as celiac plexus neurolysis (CPN) can be considered. Endoscopic ultrasound (EUS)-guided CPN has been introduced for pancreatic cancer. Reported herein is a case of a 75 year-old man with pancreatic cancer who was treated with opioids due to severe abdominal pain. EUS-guided CPN was performed for pain control, and the opioid administration was discontinued as the pain improved dramatically. However, the patient experienced opioid withdrawal symptoms, including anxiety, insomnia, nausea, and vomiting. Thus, although EUS-guided CPN successfully reduced pain in a patient undergoing such treatment and to whom opioid was administered, opioid administration should not be abruptly discontinued. Rather, the opioid dose should be reduced gradually to avoid drug withdrawal.
Abdominal Pain
;
Analgesics, Opioid
;
Anxiety
;
Celiac Plexus
;
Humans
;
Nausea
;
Pancreatic Neoplasms
;
Sleep Initiation and Maintenance Disorders
;
Substance Withdrawal Syndrome
;
Vomiting
10.Attempted Suicides in South Korea : A Multi-Center Analysis of Causes, Methods, and Psychiatric Diagnoses of Suicidal Attempters in 2013.
Hyeyoung KIM ; Bora KIM ; Seung Gul KANG ; Moon Doo KIM ; Min Hyuk KIM ; Soo In KIM ; Jae Min KIM ; Eunsoo MOON ; Joon Ho AHN ; Kyung Uk LEE ; Sang Hyuk LEE ; Seung Jae LEE ; Seong Hoon JEONG ; Young Chul CHUNG ; Hee Yeon JUNG ; Gawon JU ; Boseok CHA ; Tae Hyon HA ; Yong Min AHN
Journal of the Korean Society of Biological Psychiatry 2015;22(4):187-194
OBJECTIVES: To examine direct causes of attempted suicides, methods adopted to commit suicide, and psychiatric diagnoses among suicide attempters in South Korea. METHODS: A total of 1359 suicide attempters who had visited emergency department of 17 medical centers due to suicide attempt from May 2013 to Nov 2013 were interviewed using semi-structured questionnaires. RESULTS: Psychiatric symptoms were the most common cause of suicide attempts (62.2%), followed by interpersonal relationships (24.4%). Women attempted suicide more often for interpersonal reasons, whereas men were more likely to do so for financial and jobrelated reasons. Half of participants (55.8%) attempted suicide by drug intoxication, which was more prevalent among females and those who had previous history of psychiatric disease or previous suicide attempt. Men were more likely to use more lethal methods such as pesticide poisoning and gas inhalation than women. Pesticide poisoning was also prevalent among the elderly group and the rural population. Near ninety-five percent (94.5%) of participants received a psychiatric diagnosis : the most frequent diagnosis was depressive disorder. CONCLUSIONS: This is the first nationwide study of cases of attempted suicide. When stratified by age groups, gender, urbanicity, living alone or not, presence of physical illness, previous psychiatric history, and previous suicide attempt, there were significant differences with respect to causes, methods of attempted suicides and psychiatric diagnoses of suicide attempters.
Aged
;
Depressive Disorder
;
Diagnosis*
;
Emergency Service, Hospital
;
Female
;
Humans
;
Inhalation
;
Korea*
;
Male
;
Mental Disorders
;
Methods*
;
Poisoning
;
Rural Population
;
Suicide*
;
Suicide, Attempted