1.5-Fluorouracil, Leucovorin ( FL ) Combination Chemotherapy in Advanced or Recurrent Colo - rectal Cancer.
Jeong Hwan CHO ; Hyuk Chan KWON ; Hyo Jin KIM
Journal of the Korean Cancer Association 1999;31(5):1003-1010
PURPOSE: We studied the effectiveness and toxicities of 5-fluorouracil+leucovorin, combination chemotherapy in advanced or recurred colo-rectal cancer patients, who didn't have previous chemotherapy and enrolled from August 1993 to July 1998. MATERIALS AND METHODS: All patients were treated with leucovorin followed by 5-fluorouracil for 5 consecutive days every 4 weeks. Among 43 patients who were enrolled, 40 patients received treatment at least 2 courses, and they were evaluable. Male to female ratio was 21 to 19. In serum CEA level, 27 patients were greater than 5 ng/ml and 13 were less than 5 ng/ml. And primary site was colon in 21 patients and rectum in 19 patients. RESULTS: The complete response rate was 7,5% and the partial response rate was 25%. The median survival duration was 14.7 months, the median response duration was 16.0 months, and median time to progression was 7.3 months. In the analysis of response, survival duration, time to progression according to various characteristics of patients, serum CEA level and liver involvement were revealed significant difference in survival duration, time to progression (p=0.0122, 00350 & 0.0202, 0.0123) on univariate analysis, but no significant difference on multivariates. Hematologic and non-hematologic toxicities were mild and tolerable. CONCLUSION: This study indicates that the combination of 5-fluorouracil (370 mg/m) and leucovorin (20 mg/m) is effective and tolerable regimen in advanced or recurred colo-rectal cancer patients without previous chemotherapy.
Colon
;
Drug Therapy
;
Drug Therapy, Combination*
;
Female
;
Fluorouracil*
;
Humans
;
Leucovorin*
;
Liver
;
Male
;
Rectal Neoplasms*
;
Rectum
2.The Analysis of Emergency Medical Transport by EMS Helicopter.
Hyoung Gon SONG ; Byeong Cheol KIM ; Keun Jeong SONG ; Yeon Kwon JEONG ; Baek Hyo SHIN
Journal of the Korean Society of Emergency Medicine 1998;9(4):543-550
BACKGROUND: The fast EMS helicopter was introduced to Korea in 1996 and from Dec. 1. 1997, it was used far transporting emergent patients. Authors, here upon, report the transporting experiences. METHODS: From Dec. 1, 1996 to Dec. 31,1997, Samsung Medical Centers EMS helicopter was used for air evacuation of critically ill patients. The patients data prospectively analyzed. RESULT: A total of 65 patients were transported. Male to female ratio was 1.95 : 1. The mean transport time was 64.1min(10-160 min). Majority of the evacuated patients was surgical patients (General Surgery'16, Orthopedic surgery : 10, Neurosurgery : 6, Infernal medicine 13, Pediatrics : 3, and others : 3). Twenty-one of the 65 patients transported were admitted to ICU and 31 did not require ICU care. During the air evacuation, one physician and one nurse trained for air evacuation amended The patients. No medical problems or deaths developed during the air evacuation period. CONCLUSION: The first EMS helicopter was introduced to Korea in 1996. From Dec. 1, 1996 to Dec. 31, 1997, Samsung Medical Center's EMS helicopter was used for air evacuation of critically ill patients. The patients data reported.
Aircraft*
;
Critical Illness
;
Emergencies*
;
Female
;
Humans
;
Korea
;
Male
;
Neurosurgery
;
Orthopedics
;
Pediatrics
;
Prospective Studies
3.The Relationship between Cerebral Reperfusion Flow and the Ischemic Histopathologic Damage after Incomplete Forebrain Ischemia in Rat Model.
Tae Sik HWANG ; Jeong Pill SEO ; Keun Jeong SONG ; Yeon Kwon JEONG ; Back Hyo SHIN ; Seung Ho KIM
Journal of the Korean Society of Emergency Medicine 1999;10(2):175-182
BACKGROUND: Experimental data indicate that low-flow reperfusion following prolonged cardiocirculatory arrest may aggravate early cerebral microcirculatory repefusion disorders. We investigated the influence of cerebral repefusion flow change to the ischemic histopathologic damage of brain tissue after incomplete forebrain ischemia in rats. MATERIALS AND METHOD: Anesthetized Sprague-Dawley rats were undergone ligation of both infernal carotid artery by microvascular clamp for 10 minutes. After release of the clamp, reperfusion was started with several different flow levels (0, 10, 20, 30, 50, and 100%) of infernal carotid artery comparing to pre-clamping phase using flowmeter. After 15minutes of reperfusion, rat brains were prepared by perfusion-fixation with 3% formaldehyde. Under light microscopic examination of Hematoxylin-Eosin stained tissue slide, histopathologic damage was examined at cortex, putamen, and hippocampus regions. Categorical hisotopathologic damage scores were derived in each regions by manual counts of ischemic neurons. RESULT: The histopathologic damage scores were 0, 10. 2+/-0.5, 7.6+/-1.5, 5.9+/-1.4, 5.0+/- 2.8, 3.5+/-0.7, and 1.0+/-0.0 in control, 0, 10, 20, 30, 50, and 100% reperfusion groups, respectively(p<0.05). CONCLUSION: Our insults showed significant increment of brain histopathologic damage scores along with decreasing amount of cerebral reperfusion know after incomplete forebrain ischemia. We believe restoration of repefusion flow to pre-ischemic level would be a critical component in attenuation of brain ischemic damage.
Animals
;
Brain
;
Carotid Arteries
;
Flowmeters
;
Formaldehyde
;
Hippocampus
;
Ischemia*
;
Ligation
;
Models, Animal*
;
Neurons
;
Prosencephalon*
;
Putamen
;
Rats*
;
Rats, Sprague-Dawley
;
Reperfusion*
4.Three Cases of Congenital Hypoplastic Anemia.
Heui Jeong KWON ; Myung Hyun LEE ; Jung Hwan CHOI ; Hyo Seop AHN ; Chang Yee HONG
Journal of the Korean Pediatric Society 1985;28(8):829-835
No abstract available.
Anemia, Hypoplastic, Congenital*
5.MR Findings of Knee Injuries in Skiing: Relation with the Mechanism of Injury.
Myung Jin SHIN ; Seung Mun JUNG ; Hyo Jeong LEE ; Soon Tae KWON
Journal of the Korean Radiological Society 1995;33(2):307-312
PURPOSE: To evaluate the MR findings of knee injuries in skiing and to explain the mechanism of injury with MR findings. MATERIALS AND METHODS: We reviewed MR findings of 18 patients with history of knee injuries in skiing. The MR images were evaluated retrospectively to identify the ligament injuries, bone lesions and meniscal injuries. RESULTS: Ligament injuries were seen in 16 patients, bone contusions in 16 patients, meniscal lesions in two patients. The most common group of injury was anterior cruciate ligament (ACL) and roedial collateral ligament (MCL) injuries with bone contusion on posterior lip of the lateral tibial plateau (LTP). The second common group of injury was isolated ACL injury with bone contusions on the lateral fernoral condyle (LFC) and posterior lip of the LTP. We considered that the mechanism of injury of the former group may be correlated with the valgus torque with secondary anterior displacement of the tibia and the latter group may be correlated with the pivot shift phenomenon. CONCLUSION: MR may play an important role in the diagnosis of knee injuries in skiing and its findings may explain the mechanism of injury.
Anterior Cruciate Ligament
;
Collateral Ligaments
;
Contusions
;
Diagnosis
;
Humans
;
Knee Injuries*
;
Knee*
;
Ligaments
;
Lip
;
Retrospective Studies
;
Skiing*
;
Tibia
;
Torque
6.Cervicofacial Necrotizing Fasciitis: Case Report
Kwan Soo PARK ; Ki Hoon JEONG ; Hyo Eon KIM ; Jeong Kwon JEONG ; Kyu Ho YOON ; In Seong JEON
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2001;23(1):77-81
Adult
;
Anti-Bacterial Agents
;
Communicable Diseases
;
Debridement
;
Early Diagnosis
;
Extremities
;
Fascia
;
Fasciitis, Necrotizing
;
Gangrene
;
Head
;
Humans
;
Male
;
Mortality
;
Neck
;
Necrosis
;
Perineum
;
Subcutaneous Tissue
7.Correction: Idiopathic Retroperitoneal Fibrosis With Myofascial Pain Syndrome: A Case Report.
Hyo Jeong KANG ; Mi Ryoung HWANG ; You Ha KWON
Annals of Rehabilitation Medicine 2017;41(5):903-903
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8.Cavernous Angioma;Natural History and Management Strategies.
Hyo Joo LIM ; Yang KWON ; Jae Sung AHN ; Jeong Hoon KIM ; Chang Jin KIM ; Jung Kyo LEE ; Byung Duk KWUN
Journal of Korean Neurosurgical Society 2000;29(8):1001-1007
No abstract available.
9.Statistical study of accidental pediatric patients in emergency room.
Hyo Jeong KIM ; Kwang Ik SONG ; Jin Bok HWANG ; Chang Ho HAN ; Hye Li CHUNG ; Young Dae KWON
Journal of the Korean Pediatric Society 1992;35(5):621-629
No abstract available.
Emergencies*
;
Emergency Service, Hospital*
;
Humans
;
Statistics as Topic*
10.A case of incontinentia pigmenti.
Kwang Ik SONG ; Hyo Jeong KIM ; Jin Bok HWANG ; Chang Ho HAN ; Hye Li CHUNG ; Young Dae KWON
Journal of the Korean Pediatric Society 1991;34(10):1446-1451
No abstract available.
Incontinentia Pigmenti*